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HUMAN:FOXO3
Contents |
| Species (Taxon ID) | Homo sapiens (Human). ([1]) | |
| Gene Name(s) | FOXO3 (synonyms: FKHRL1, FOXO3A) | |
| Protein Name(s) | Forkhead box protein O3
AF6q21 protein Forkhead in rhabdomyosarcoma-like 1 | |
| External Links | ||
| EMBL | AF032886 AL391646 AL365509 AL365509 AL391646 CH471051 CH471051 BC020227 BC021224 BC068552 AJ001589 AJ001590 | |
| IPI | IPI00012856 | |
| RefSeq | NP_001446.1 NP_963853.1 | |
| UniGene | Hs.220950 | |
| PDB | 2K86 2UZK | |
| PDBsum | 2K86 2UZK | |
| ProteinModelPortal | O43524 | |
| SMR | O43524 | |
| DIP | DIP-29723N | |
| IntAct | O43524 | |
| MINT | MINT-89098 | |
| STRING | O43524 | |
| PhosphoSite | O43524 | |
| PRIDE | O43524 | |
| Ensembl | ENST00000343882 ENST00000406360 | |
| GeneID | 2309 | |
| KEGG | hsa:2309 | |
| UCSC | uc003psk.2 | |
| CTD | 2309 | |
| GeneCards | GC06P106448 | |
| H-InvDB | HIX0006119 | |
| HGNC | HGNC:3821 | |
| HPA | CAB004074 | |
| MIM | 602681 | |
| neXtProt | NX_O43524 | |
| PharmGKB | PA162388869 PA28239 | |
| eggNOG | prNOG19446 | |
| HOGENOM | HBG714085 | |
| HOVERGEN | HBG057789 | |
| InParanoid | O43524 | |
| OMA | MGHEKFP | |
| OrthoDB | EOG4N8R4G | |
| PhylomeDB | O43524 | |
| Pathway_Interaction_DB | pi3kcipathway pi3kciaktpathway foxopathway il2_pi3kpathway insulin_pathway smad2_3nuclearpathway hdac_classiii_pathway kitpathway pi3kplctrkpathway | |
| Reactome | REACT_111045 REACT_111102 | |
| NextBio | 9379 | |
| ArrayExpress | O43524 | |
| Bgee | O43524 | |
| CleanEx | HS_FOXO3 | |
| Genevestigator | O43524 | |
| GermOnline | ENSG00000118689 | |
| GO | GO:0005829 GO:0005667 GO:0008301 GO:0003690 GO:0010843 GO:0019901 GO:0003705 GO:0043565 GO:0003704 GO:0016566 GO:0008134 GO:0001547 GO:0006915 GO:0009790 GO:0008543 GO:0042593 GO:0006917 GO:0001544 GO:0008286 GO:0000122 GO:0048011 GO:0001556 GO:0001542 GO:0007389 GO:0048015 GO:0045648 GO:0045944 GO:0042127 GO:0051090 GO:0009888 | |
| InterPro | IPR001766 IPR018122 IPR011991 | |
| Gene3D | G3DSA:1.10.10.10 | |
| KO | K09408 | |
| Pfam | PF00250 | |
| PRINTS | PR00053 | |
| SMART | SM00339 | |
| PROSITE | PS00657 PS00658 PS50039 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0001542 |
ovulation from ovarian follicle |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000050683 |
P |
Seeded From UniProt |
|||
| GO:0001542 |
ovulation from ovarian follicle |
PANTHER:PTHR11829_AN115 |
P |
Seeded From UniProt |
||||
| GO:0001544 |
initiation of primordial ovarian follicle growth |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000050683 |
P |
Seeded From UniProt |
|||
| GO:0001544 |
initiation of primordial ovarian follicle growth |
PANTHER:PTHR11829_AN115 |
P |
Seeded From UniProt |
||||
| GO:0001547 |
antral ovarian follicle growth |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000050683 |
P |
Seeded From UniProt |
|||
| GO:0001547 |
antral ovarian follicle growth |
PANTHER:PTHR11829_AN115 |
P |
Seeded From UniProt |
||||
| GO:0001556 |
oocyte maturation |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000050683 |
P |
Seeded From UniProt |
|||
| GO:0001556 |
oocyte maturation |
PANTHER:PTHR11829_AN115 |
P |
Seeded From UniProt |
||||
| GO:0003677 |
DNA binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003677 |
DNA binding |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000050683 |
F |
Seeded From UniProt |
|||
| GO:0003690 |
double-stranded DNA binding |
PANTHER:PTHR11829_AN0 |
F |
Seeded From UniProt |
||||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000050683 |
F |
Seeded From UniProt |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0003705 |
sequence-specific distal enhancer binding RNA polymerase II transcription factor activity |
PANTHER:PTHR11829_AN0 |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005624 |
membrane fraction |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000050683 |
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000050683 |
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000000327 |
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0191 |
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_12572 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005667 |
transcription factor complex |
PANTHER:PTHR11829_AN0 |
C |
Seeded From UniProt |
||||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000050683 |
C |
Seeded From UniProt |
|||
| GO:0005737 |
cytoplasm |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005737 |
cytoplasm |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005829 |
cytosol |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000000327 |
C |
Seeded From UniProt |
|||
| GO:0005829 |
cytosol |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0091 |
C |
Seeded From UniProt |
|||
| GO:0005829 |
cytosol |
PANTHER:PTHR11829_AN111 |
C |
Seeded From UniProt |
||||
| GO:0006351 |
transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006351 |
transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000050683 |
P |
Seeded From UniProt |
|||
| GO:0006355 |
regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000050683 |
P |
Seeded From UniProt |
|||
| GO:0006915 |
apoptosis |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006915 |
apoptosis |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0006917 |
induction of apoptosis |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000050683 |
P |
Seeded From UniProt |
|||
| GO:0006917 |
induction of apoptosis |
PANTHER:PTHR11829_AN115 |
P |
Seeded From UniProt |
||||
| GO:0006974 |
response to DNA damage stimulus |
PANTHER:PTHR11829_AN111 |
P |
Seeded From UniProt |
||||
| GO:0007389 |
pattern specification process |
PANTHER:PTHR11829_AN1 |
P |
Seeded From UniProt |
||||
| GO:0008134 |
transcription factor binding |
PANTHER:PTHR11829_AN0 |
F |
Seeded From UniProt |
||||
| GO:0008286 |
insulin receptor signaling pathway |
PANTHER:PTHR11829_AN111 |
P |
Seeded From UniProt |
||||
| GO:0008301 |
DNA bending activity |
PANTHER:PTHR11829_AN1 |
F |
Seeded From UniProt |
||||
| GO:0008543 |
fibroblast growth factor receptor signaling pathway |
Reactome:REACT_9470 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0009790 |
embryo development |
PANTHER:PTHR11829_AN1 |
P |
Seeded From UniProt |
||||
| GO:0009888 |
tissue development |
PANTHER:PTHR11829_AN1 |
P |
Seeded From UniProt |
||||
| GO:0019901 |
protein kinase binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0019901 |
protein kinase binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0030330 |
DNA damage response, signal transduction by p53 class mediator |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000050683 |
P |
Seeded From UniProt |
|||
| GO:0042127 |
regulation of cell proliferation |
PANTHER:PTHR11829_AN111 |
P |
Seeded From UniProt |
||||
| GO:0042593 |
glucose homeostasis |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000050683 |
P |
Seeded From UniProt |
|||
| GO:0042593 |
glucose homeostasis |
PANTHER:PTHR11829_AN115 |
P |
Seeded From UniProt |
||||
| GO:0043565 |
sequence-specific DNA binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0043565 |
sequence-specific DNA binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0043565 |
sequence-specific DNA binding |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000050683 |
F |
Seeded From UniProt |
|||
| GO:0043565 |
sequence-specific DNA binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0045648 |
positive regulation of erythrocyte differentiation |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000050683 |
P |
Seeded From UniProt |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0048011 |
nerve growth factor receptor signaling pathway |
Reactome:REACT_11061 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0048015 |
phosphatidylinositol-mediated signaling |
Reactome:REACT_12464 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0051090 |
regulation of sequence-specific DNA binding transcription factor activity |
PANTHER:PTHR11829_AN0 |
P |
Seeded From UniProt |
||||
| GO:0061039 |
ovum-producing ovary development |
IDA: Inferred from Direct Assay |
P |
figure 3 |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Heinke J et al. (2008) BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis. Circ Res 103: 804-12 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Bakker WJ et al. (2004) FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1. J Cell Biol 164: 175-84 PubMed GONUTS page
- ↑ Brunet A et al. (2004) Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303: 2011-5 PubMed GONUTS page
- ↑ Madureira PA et al. (2006) The Forkhead box M1 protein regulates the transcription of the estrogen receptor alpha in breast cancer cells. J Biol Chem 281: 25167-76 PubMed GONUTS page
- ↑ Fu G & Peng C (2011) Nodal enhances the activity of FoxO3a and its synergistic interaction with Smads to regulate cyclin G2 transcription in ovarian cancer cells. Oncogene 30: 3953-66 PubMed GONUTS page
- ↑ Rizki G et al. (2011) The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO. PLoS Genet 7: e1002235 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 7.4 7.5 Brunet A et al. (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96: 857-68 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Lehtinen MK et al. (2006) A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell 125: 987-1001 PubMed GONUTS page
- ↑ Morishita D et al. (2008) Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels. Cancer Res 68: 5076-85 PubMed GONUTS page
- ↑ Hillion J et al. (1997) AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily. Blood 90: 3714-9 PubMed GONUTS page
