HUMAN:FGFR3

From GONUTS

Jump to: navigation, search

Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	FGFR3 ( synonyms: JTK4 )
Protein Name(s)	Fibroblast growth factor receptor 3 FGFR-3
External Links
UniProt Identifier	FGFR3_HUMAN
UniProt Accessions	P22607, D3DVP9, D3DVQ0, Q14308, Q16294, Q16608, Q59FL9,
EMBL	M58051, AF245114, AB209441, AY768549, CH471131, CH471131, CH471131, CH471131, M64347, M59374, S76733, X84939, U22410,
PIR	A38576,
RefSeq	NP_000133.1, NP_001156685.1, NP_075254.1,
PDB	1RY7,
IntAct	P22607,
Ensembl	ENST00000260795, ENST00000440486,
Pfam	PF07679, PF00047, PF07714,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005887	integral to plasma membrane		TAS: Traceable Author Statement		C	Source: ProtInc
	GO:0005524	ATP binding		IEA: Inferred from Electronic Annotation		F	Source: UniProtKB-KW
	GO:0017134	fibroblast growth factor binding		IPI: Inferred from Physical Interaction		F	Source: MGI
	GO:0005007	fibroblast growth factor receptor activity		NAS: Non-traceable Author Statement		F	Source: UniProtKB
	GO:0042802	identical protein binding		IPI: Inferred from Physical Interaction		F	Source: IntAct
	GO:0016049	cell growth		NAS: Non-traceable Author Statement		P	Source: UniProtKB
	GO:0007259	JAK-STAT cascade		TAS: Traceable Author Statement		P	Source: ProtInc
	GO:0000165	MAPKKK cascade		TAS: Traceable Author Statement		P	Source: ProtInc
	GO:0008284	positive regulation of cell proliferation		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0006468	protein amino acid phosphorylation		IEA: Inferred from Electronic Annotation		P	Source: InterPro
	GO:0001501	skeletal system development		TAS: Traceable Author Statement		P	Source: ProtInc
	GO:0060348	bone development	PMID:20582225^[1]	IMP: Inferred from Mutant Phenotype		P	Figure 4b and c: homozygous Fgfr3 null mice showed increased length of long bone.	complete
	GO:0070977	bone maturation	PMID:20582225^[1]	IMP: Inferred from Mutant Phenotype		P	Figure 4c: Decrease in bone density resulting from the knock out of fgfr3 in fgfr3 null homozygous mice.	complete
	GO:0016458	gene silencing	PMID:20582225^[1]	EXP: Inferred from Experiment		P	Tissue-specific inactivation of the Fgfr3 conditional allele by a Col2a1-Cre transgene in tissues containing cartilage was revealed by PCR analysis.	complete
	GO:0035121	tail morphogenesis	PMID:20582225^[1]	IMP: Inferred from Mutant Phenotype		P	Fgfr3floxneo/floxneo mice showed kinky tails, which is also found in Fgfr3 knock out mice.	complete
	GO:0045926	negative regulation of growth	PMID:20582225^[1]	IMP: Inferred from Mutant Phenotype		P	Figure 4b and c: homozygous Fgfr3 null mice showed increased length of long bone.	complete
	GO:0000165	MAPKKK cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	P
	GO:0000165	MAPKKK cascade	PMID:10918587^[2]	TAS: Traceable Author Statement		P
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0001501	skeletal system development	PMID:8601314^[3]	TAS: Traceable Author Statement		P
	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	P
	GO:0002009	morphogenesis of an epithelium	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	P
	GO:0002089	lens morphogenesis in camera-type eye	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	P
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001245	F
	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008266	F
	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020635	F
	GO:0004713	protein tyrosine kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0829	F
	GO:0004713	protein tyrosine kinase activity	Reactome:REACT_9419	TAS: Traceable Author Statement		F
	GO:0004713	protein tyrosine kinase activity	Reactome:REACT_9519	TAS: Traceable Author Statement		F
	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:2.7.10.1	F
	GO:0004872	receptor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0675	F
	GO:0005007	fibroblast growth factor receptor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016248	F
	GO:0005007	fibroblast growth factor receptor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	F
	GO:0005007	fibroblast growth factor receptor activity	PMID:10918587^[2]	TAS: Traceable Author Statement		F
	GO:0005007	fibroblast growth factor receptor activity	PMID:7923141^[4]	NAS: Non-traceable Author Statement		F
	GO:0005515	protein binding	PMID:14667819^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y4H4	F
	GO:0005515	protein binding	PMID:14732692^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P05230	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016248	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017441	F
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F
	GO:0005764	lysosome	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	C
	GO:0005886	plasma membrane	Reactome:REACT_21248	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_21258	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_21307	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_21329	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_21339	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_21344	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_21357	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_21365	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_21372	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_21398	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_21411	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_244	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_9419	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_9459	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_9489	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_9519	TAS: Traceable Author Statement		C
	GO:0005887	integral to plasma membrane	PMID:10918587^[2]	TAS: Traceable Author Statement		C
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001245	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008266	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016248	P
	GO:0007259	JAK-STAT cascade	PMID:10918587^[2]	TAS: Traceable Author Statement		P
	GO:0008284	positive regulation of cell proliferation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016248	P
	GO:0008284	positive regulation of cell proliferation	PMID:8663044^[7]	IGI: Inferred from Genetic Interaction	UniProtKB:P05230	P
	GO:0008284	positive regulation of cell proliferation	PMID:8663044^[7]	IGI: Inferred from Genetic Interaction	UniProtKB:P08620	P
	GO:0008284	positive regulation of cell proliferation	PMID:8663044^[7]	IGI: Inferred from Genetic Interaction	UniProtKB:P09038	P
	GO:0008284	positive regulation of cell proliferation	PMID:8663044^[7]	IGI: Inferred from Genetic Interaction	UniProtKB:P12304	P
	GO:0008284	positive regulation of cell proliferation	PMID:8663044^[7]	IGI: Inferred from Genetic Interaction	UniProtKB:P31371	P
	GO:0008284	positive regulation of cell proliferation	PMID:8663044^[7]	IGI: Inferred from Genetic Interaction	UniProtKB:P55075	P
	GO:0008285	negative regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	P
	GO:0008286	insulin receptor signaling pathway	Reactome:REACT_498	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016248	P
	GO:0008543	fibroblast growth factor receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	P
	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:10918587^[2]	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:7923141^[4]	NAS: Non-traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[7]	IGI: Inferred from Genetic Interaction	UniProtKB:P05230	P
	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[7]	IGI: Inferred from Genetic Interaction	UniProtKB:P08620	P
	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[7]	IGI: Inferred from Genetic Interaction	UniProtKB:P09038	P
	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[7]	IGI: Inferred from Genetic Interaction	UniProtKB:P12304	P
	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[7]	IGI: Inferred from Genetic Interaction	UniProtKB:P31371	P
	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[7]	IGI: Inferred from Genetic Interaction	UniProtKB:P55075	P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9396	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9439	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9470	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9508	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9510	TAS: Traceable Author Statement		P
	GO:0009898	internal side of plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	C
	GO:0014003	oligodendrocyte development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	P
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016020	membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0162	C
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016248	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0016021	integral to membrane	GO_REF:0000029	NAS: Non-traceable Author Statement		C
	GO:0016049	cell growth	GO_REF:0000029	NAS: Non-traceable Author Statement		P
	GO:0016301	kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	F
	GO:0016310	phosphorylation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	P
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F
	GO:0016772	transferase activity, transferring phosphorus-containing groups	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F
	GO:0017134	fibroblast growth factor binding	PMID:12815063^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P05230	F
	GO:0017134	fibroblast growth factor binding	PMID:12815063^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P05230	F
	GO:0021762	substantia nigra development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	P
	GO:0022010	central nervous system myelination	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	P
	GO:0030154	cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	P
	GO:0030900	forebrain development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	P
	GO:0031398	positive regulation of protein ubiquitination	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	P
	GO:0035019	somatic stem cell maintenance	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	P
	GO:0042802	identical protein binding	PMID:14732692^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P22607	F
	GO:0043065	positive regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	P
	GO:0043066	negative regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	P
	GO:0043410	positive regulation of MAPKKK cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	P
	GO:0045597	positive regulation of cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	P
	GO:0045839	negative regulation of mitosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	P
	GO:0045879	negative regulation of smoothened signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	P
	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	C
	GO:0048546	digestive tract morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	P
	GO:0048640	negative regulation of developmental growth	PMID:20582225^[1]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q61851	P
	GO:0048678	response to axon injury	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	P
	GO:0048712	negative regulation of astrocyte differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	P
	GO:0048839	inner ear development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	P
	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	P
	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	P
	GO:0051216	cartilage development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	P
	GO:0060113	inner ear receptor cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	P
	GO:0060349	bone morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	P
	GO:0060385	axonogenesis involved in innervation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	P
	GO:0061144	alveolar secondary septum development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	P
	GO:0070307	lens fiber cell development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	P
	GO:0070977	bone maturation	PMID:20582225^[1]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q61851	P
	GO:0072148	epithelial cell fate commitment	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	P
	GO:0090102	cochlea development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	P
	GO:0090263	positive regulation of canonical Wnt receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000110053	P
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Su N et al. (2010) Generation of Fgfr3 conditional knockout mice. Int J Biol Sci 6: 327-32 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Hart KC et al. (2000) Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4. Oncogene 19: 3309-20 PubMed GONUTS page
↑ Deng C et al. (1996) Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell 84: 911-21 PubMed GONUTS page
↑ ^4.0 ^4.1 Murgue B et al. (1994) Identification of a novel variant form of fibroblast growth factor receptor 3 (FGFR3 IIIb) in human colonic epithelium. Cancer Res 54: 5206-11 PubMed GONUTS page
↑ Lehner B et al. (2004) Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. Genomics 83: 153-67 PubMed GONUTS page
↑ ^6.0 ^6.1 Olsen SK et al. (2004) Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity. Proc Natl Acad Sci U S A 101: 935-40 PubMed GONUTS page
↑ ^7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 Ornitz DM et al. (1996) Receptor specificity of the fibroblast growth factor family. J Biol Chem 271: 15292-7 PubMed GONUTS page
↑ ^8.0 ^8.1 Olsen SK et al. (2003) Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs. J Biol Chem 278: 34226-36 PubMed GONUTS page

[PMID:20582225-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Su N et al. (2010) Generation of Fgfr3 conditional knockout mice. Int J Biol Sci 6: 327-32 PubMed GONUTS page

[PMID:10918587-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Hart KC et al. (2000) Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4. Oncogene 19: 3309-20 PubMed GONUTS page

[PMID:8601314-2] Deng C et al. (1996) Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell 84: 911-21 PubMed GONUTS page

[PMID:7923141-3] 4.0 ^4.1 Murgue B et al. (1994) Identification of a novel variant form of fibroblast growth factor receptor 3 (FGFR3 IIIb) in human colonic epithelium. Cancer Res 54: 5206-11 PubMed GONUTS page

[PMID:14667819-4] Lehner B et al. (2004) Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. Genomics 83: 153-67 PubMed GONUTS page

[PMID:14732692-5] 6.0 ^6.1 Olsen SK et al. (2004) Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity. Proc Natl Acad Sci U S A 101: 935-40 PubMed GONUTS page

[PMID:8663044-6] 7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 Ornitz DM et al. (1996) Receptor specificity of the fibroblast growth factor family. J Biol Chem 271: 15292-7 PubMed GONUTS page

[PMID:12815063-7] 8.0 ^8.1 Olsen SK et al. (2003) Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs. J Biol Chem 278: 34226-36 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

HUMAN:FGFR3

Contents

Annotations

Notes

References

a

b

c

d

e

f

g

h

i

j

k

l

m

n

o

p

p cont.

r

s

t

v

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Cacao

Journal Clubs

page contributors

Toolbox