HUMAN:FGF8

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	FGF8 ( synonyms: AIGF )
Protein Name(s)	Fibroblast growth factor 8 FGF-8 Androgen-induced growth factor AIGF Heparin-binding growth factor 8 HBGF-8
External Links
UniProt Identifier	FGF8_HUMAN
UniProt Accessions	P55075, A1A514, Q14915, Q15766,
EMBL	S78466, S78462, S78463, S78464, S78465, D38752, U46213, U46212, U46211, U47011, U47009, U47010, U47011, U47009, U47010, U47011, U47009, U47010, U36223, U36228, U36225, U36226, U36227, U47011, U47009, U47010, U56978, AB014615, AF520763, CH471066, BC128235,
RefSeq	NP_006110.1, NP_149353.1, NP_149354.1, NP_149355.1,
PDB	2FDB,
Ensembl	ENST00000344255,
Pfam	PF00167,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0001656	metanephros development	PMID:18437684^[1]	IEP: Inferred from Expression Pattern		P
	GO:0001823	mesonephros development	PMID:18437684^[1]	IEP: Inferred from Expression Pattern		P
	GO:0005105	type 1 fibroblast growth factor receptor binding	PMID:16384934^[2]	IDA: Inferred from Direct Assay		F
	GO:0005111	type 2 fibroblast growth factor receptor binding	PMID:16384934^[2]	IDA: Inferred from Direct Assay		F
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C
	GO:0005576	extracellular region	PMID:10579907^[3]	EXP: Inferred from Experiment		C
	GO:0005576	extracellular region	PMID:10629055^[4]	EXP: Inferred from Experiment		C
	GO:0005576	extracellular region	PMID:10652257^[5]	EXP: Inferred from Experiment		C
	GO:0005576	extracellular region	PMID:11294897^[6]	EXP: Inferred from Experiment		C
	GO:0005576	extracellular region	PMID:11353842^[7]	EXP: Inferred from Experiment		C
	GO:0005576	extracellular region	PMID:12660731^[8]	EXP: Inferred from Experiment		C
	GO:0005576	extracellular region	PMID:14534538^[9]	EXP: Inferred from Experiment		C
	GO:0005576	extracellular region	PMID:16597617^[10]	EXP: Inferred from Experiment		C
	GO:0005576	extracellular region	PMID:1697263^[11]	EXP: Inferred from Experiment		C
	GO:0005576	extracellular region	PMID:9045692^[12]	EXP: Inferred from Experiment		C
	GO:0005576	extracellular region	PMID:9139660^[13]	EXP: Inferred from Experiment		C
	GO:0005576	extracellular region	Reactome:REACT_21307	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_21357	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_21365	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_9419	TAS: Traceable Author Statement		C
	GO:0005615	extracellular space	PMID:8891346^[14]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:8891346^[14]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:8891346^[14]	IDA: Inferred from Direct Assay		C
	GO:0007369	gastrulation	PMID:8700553^[15]	NAS: Non-traceable Author Statement		P
	GO:0008083	growth factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002348	F
	GO:0008083	growth factor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0339	F
	GO:0008083	growth factor activity	PMID:17265164^[16]	IDA: Inferred from Direct Assay		F
	GO:0008083	growth factor activity	PMID:8891346^[14]	IDA: Inferred from Direct Assay		F
	GO:0008083	growth factor activity	PMID:8891346^[14]	IDA: Inferred from Direct Assay		F
	GO:0008083	growth factor activity	PMID:8891346^[14]	IDA: Inferred from Direct Assay		F
	GO:0008284	positive regulation of cell proliferation	PMID:17265164^[16]	IDA: Inferred from Direct Assay		P
	GO:0008286	insulin receptor signaling pathway	Reactome:REACT_498	TAS: Traceable Author Statement		P
	GO:0008406	gonad development	PMID:18596921^[17]	IMP: Inferred from Mutant Phenotype		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:17133345^[18]	EXP: Inferred from Experiment		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[19]	IGI: Inferred from Genetic Interaction	UniProtKB:P21802	P
	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[19]	IGI: Inferred from Genetic Interaction	UniProtKB:P22607	P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9396	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9413	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9439	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9452	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9470	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9483	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9508	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9510	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9515	TAS: Traceable Author Statement		P
	GO:0009653	anatomical structure morphogenesis	PMID:8595889^[20]	NAS: Non-traceable Author Statement		P
	GO:0042476	odontogenesis	PMID:17394220^[21]	IEP: Inferred from Expression Pattern		P
	GO:0051781	positive regulation of cell division	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0497	P
	GO:0060348	bone development	PMID:18596921^[17]	IMP: Inferred from Mutant Phenotype		P
	GO:0060563	neuroepithelial cell differentiation	PMID:17309880^[22]	IDA: Inferred from Direct Assay		P
	GO:0071542	dopaminergic neuron differentiation	PMID:15193767^[23]	IDA: Inferred from Direct Assay		P
	GO:0001656	metanephros development	PMID:18437684^[1]	IEP: Inferred from Expression Pattern		P
	GO:0001823	mesonephros development	PMID:18437684^[1]	IEP: Inferred from Expression Pattern		P
	GO:0004713	protein tyrosine kinase activity	Reactome:REACT_9419	TAS: Traceable Author Statement		F
	GO:0004713	protein tyrosine kinase activity	Reactome:REACT_9474	TAS: Traceable Author Statement		F
	GO:0004713	protein tyrosine kinase activity	Reactome:REACT_9498	TAS: Traceable Author Statement		F
	GO:0004713	protein tyrosine kinase activity	Reactome:REACT_9519	TAS: Traceable Author Statement		F
	GO:0005105	type 1 fibroblast growth factor receptor binding	PMID:16384934^[2]	IDA: Inferred from Direct Assay		F
	GO:0005111	type 2 fibroblast growth factor receptor binding	PMID:16384934^[2]	IDA: Inferred from Direct Assay		F
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C
	GO:0005576	extracellular region	Reactome:REACT_21248	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_21258	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_21307	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_21329	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_21333	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_21339	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_21344	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_21357	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_21365	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_21372	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_21398	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_21411	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_244	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_9419	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_9432	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_9447	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_9459	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_9460	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_9474	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_9477	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_9489	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_9498	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_9519	TAS: Traceable Author Statement		C
	GO:0005615	extracellular space	PMID:8891346^[14]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:8891346^[14]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:8891346^[14]	IDA: Inferred from Direct Assay		C
	GO:0007369	gastrulation	PMID:8700553^[15]	NAS: Non-traceable Author Statement		P
	GO:0008083	growth factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002348	F
	GO:0008083	growth factor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0339	F
	GO:0008083	growth factor activity	PMID:17265164^[16]	IDA: Inferred from Direct Assay		F
	GO:0008083	growth factor activity	PMID:8891346^[14]	IDA: Inferred from Direct Assay		F
	GO:0008083	growth factor activity	PMID:8891346^[14]	IDA: Inferred from Direct Assay		F
	GO:0008083	growth factor activity	PMID:8891346^[14]	IDA: Inferred from Direct Assay		F
	GO:0008284	positive regulation of cell proliferation	PMID:17265164^[16]	IDA: Inferred from Direct Assay		P
	GO:0008286	insulin receptor signaling pathway	Reactome:REACT_498	TAS: Traceable Author Statement		P
	GO:0008406	gonad development	PMID:18596921^[17]	IMP: Inferred from Mutant Phenotype		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[19]	IGI: Inferred from Genetic Interaction	UniProtKB:P21802	P
	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[19]	IGI: Inferred from Genetic Interaction	UniProtKB:P22607	P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9390	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9396	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9413	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9439	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9452	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9470	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9483	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9508	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9510	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9515	TAS: Traceable Author Statement		P
	GO:0009653	anatomical structure morphogenesis	PMID:8595889^[20]	NAS: Non-traceable Author Statement		P
	GO:0042476	odontogenesis	PMID:17394220^[21]	IEP: Inferred from Expression Pattern		P
	GO:0051781	positive regulation of cell division	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0497	P
	GO:0055026	negative regulation of cardiac muscle tissue development	PMID:20702560^[24]	IMP: Inferred from Mutant Phenotype		P
	GO:0060348	bone development	PMID:18596921^[17]	IMP: Inferred from Mutant Phenotype		P
	GO:0060563	neuroepithelial cell differentiation	PMID:17309880^[22]	IDA: Inferred from Direct Assay		P
	GO:0071542	dopaminergic neuron differentiation	PMID:15193767^[23]	IDA: Inferred from Direct Assay		P
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Carev D et al. (2008) Involvement of FGF and BMP family proteins and VEGF in early human kidney development. Histol Histopathol 23: 853-62 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Olsen SK et al. (2006) Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain. Genes Dev 20: 185-98 PubMed GONUTS page
↑ Carpenter G & Ji Q (1999) Phospholipase C-gamma as a signal-transducing element. Exp Cell Res 253: 15-24 PubMed GONUTS page
↑ Ong SH et al. (2000) FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors. Mol Cell Biol 20: 979-89 PubMed GONUTS page
↑ Cross MJ et al. (2000) Tyrosine 766 in the fibroblast growth factor receptor-1 is required for FGF-stimulation of phospholipase C, phospholipase D, phospholipase A(2), phosphoinositide 3-kinase and cytoskeletal reorganisation in porcine aortic endothelial cells. J Cell Sci 113 ( Pt 4): 643-51 PubMed GONUTS page
↑ Hart KC et al. (2001) Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation. Mol Biol Cell 12: 931-42 PubMed GONUTS page
↑ Ong SH et al. (2001) Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins. Proc Natl Acad Sci U S A 98: 6074-9 PubMed GONUTS page
↑ Koyasu S (2003) The role of PI3K in immune cells. Nat Immunol 4: 313-9 PubMed GONUTS page
↑ Agazie YM et al. (2003) The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3. Oncogene 22: 6909-18 PubMed GONUTS page
↑ Zhang X et al. (2006) Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. J Biol Chem 281: 15694-700 PubMed GONUTS page
↑ Dionne CA et al. (1990) Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors. EMBO J 9: 2685-92 PubMed GONUTS page
↑ Kanai M et al. (1997) Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein. J Biol Chem 272: 6621-8 PubMed GONUTS page
↑ Mohammadi M et al. (1997) Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Science 276: 955-60 PubMed GONUTS page
↑ ^14.00 ^14.01 ^14.02 ^14.03 ^14.04 ^14.05 ^14.06 ^14.07 ^14.08 ^14.09 ^14.10 ^14.11 Ghosh AK et al. (1996) Molecular cloning and characterization of human FGF8 alternative messenger RNA forms. Cell Growth Differ 7: 1425-34 PubMed GONUTS page
↑ ^15.0 ^15.1 Payson RA et al. (1996) The human FGF-8 gene localizes on chromosome 10q24 and is subjected to induction by androgen in breast cancer cells. Oncogene 13: 47-53 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Potula HH et al. (2008) Transient expression, purification and characterization of bioactive human fibroblast growth factor 8b in tobacco plants. Transgenic Res 17: 19-32 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 Falardeau J et al. (2008) Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice. J Clin Invest 118: 2822-31 PubMed GONUTS page
↑ Moffa AB & Ethier SP (2007) Differential signal transduction of alternatively spliced FGFR2 variants expressed in human mammary epithelial cells. J Cell Physiol 210: 720-31 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 Ornitz DM et al. (1996) Receptor specificity of the fibroblast growth factor family. J Biol Chem 271: 15292-7 PubMed GONUTS page
↑ ^20.0 ^20.1 White RA et al. (1995) Assignment of FGF8 to human chromosome 10q25-q26: mutations in FGF8 may be responsible for some types of acrocephalosyndactyly linked to this region. Genomics 30: 109-11 PubMed GONUTS page
↑ ^21.0 ^21.1 Lin D et al. (2007) Expression survey of genes critical for tooth development in the human embryonic tooth germ. Dev Dyn 236: 1307-12 PubMed GONUTS page
↑ ^22.0 ^22.1 Schneider BL et al. (2007) Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation. Hum Mol Genet 16: 651-66 PubMed GONUTS page
↑ ^23.0 ^23.1 Wang X et al. (2004) Forskolin cooperating with growth factor on generation of dopaminergic neurons from human fetal mesencephalic neural progenitor cells. Neurosci Lett 362: 117-21 PubMed GONUTS page
↑ Tirosh-Finkel L et al. (2010) BMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors. Development 137: 2989-3000 PubMed GONUTS page

[PMID:18437684-0] 1.0 ^1.1 ^1.2 ^1.3 Carev D et al. (2008) Involvement of FGF and BMP family proteins and VEGF in early human kidney development. Histol Histopathol 23: 853-62 PubMed GONUTS page

[PMID:16384934-1] 2.0 ^2.1 ^2.2 ^2.3 Olsen SK et al. (2006) Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain. Genes Dev 20: 185-98 PubMed GONUTS page

[PMID:10579907-2] Carpenter G & Ji Q (1999) Phospholipase C-gamma as a signal-transducing element. Exp Cell Res 253: 15-24 PubMed GONUTS page

[PMID:10629055-3] Ong SH et al. (2000) FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors. Mol Cell Biol 20: 979-89 PubMed GONUTS page

[PMID:10652257-4] Cross MJ et al. (2000) Tyrosine 766 in the fibroblast growth factor receptor-1 is required for FGF-stimulation of phospholipase C, phospholipase D, phospholipase A(2), phosphoinositide 3-kinase and cytoskeletal reorganisation in porcine aortic endothelial cells. J Cell Sci 113 ( Pt 4): 643-51 PubMed GONUTS page

[PMID:11294897-5] Hart KC et al. (2001) Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation. Mol Biol Cell 12: 931-42 PubMed GONUTS page

[PMID:11353842-6] Ong SH et al. (2001) Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins. Proc Natl Acad Sci U S A 98: 6074-9 PubMed GONUTS page

[PMID:12660731-7] Koyasu S (2003) The role of PI3K in immune cells. Nat Immunol 4: 313-9 PubMed GONUTS page

[PMID:14534538-8] Agazie YM et al. (2003) The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3. Oncogene 22: 6909-18 PubMed GONUTS page

[PMID:16597617-9] Zhang X et al. (2006) Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. J Biol Chem 281: 15694-700 PubMed GONUTS page

[PMID:1697263-10] Dionne CA et al. (1990) Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors. EMBO J 9: 2685-92 PubMed GONUTS page

[PMID:9045692-11] Kanai M et al. (1997) Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein. J Biol Chem 272: 6621-8 PubMed GONUTS page

[PMID:9139660-12] Mohammadi M et al. (1997) Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Science 276: 955-60 PubMed GONUTS page

[PMID:8891346-13] 14.00 ^14.01 ^14.02 ^14.03 ^14.04 ^14.05 ^14.06 ^14.07 ^14.08 ^14.09 ^14.10 ^14.11 Ghosh AK et al. (1996) Molecular cloning and characterization of human FGF8 alternative messenger RNA forms. Cell Growth Differ 7: 1425-34 PubMed GONUTS page

[PMID:8700553-14] 15.0 ^15.1 Payson RA et al. (1996) The human FGF-8 gene localizes on chromosome 10q24 and is subjected to induction by androgen in breast cancer cells. Oncogene 13: 47-53 PubMed GONUTS page

[PMID:17265164-15] 16.0 ^16.1 ^16.2 ^16.3 Potula HH et al. (2008) Transient expression, purification and characterization of bioactive human fibroblast growth factor 8b in tobacco plants. Transgenic Res 17: 19-32 PubMed GONUTS page

[PMID:18596921-16] 17.0 ^17.1 ^17.2 ^17.3 Falardeau J et al. (2008) Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice. J Clin Invest 118: 2822-31 PubMed GONUTS page

[PMID:17133345-17] Moffa AB & Ethier SP (2007) Differential signal transduction of alternatively spliced FGFR2 variants expressed in human mammary epithelial cells. J Cell Physiol 210: 720-31 PubMed GONUTS page

[PMID:8663044-18] 19.0 ^19.1 ^19.2 ^19.3 Ornitz DM et al. (1996) Receptor specificity of the fibroblast growth factor family. J Biol Chem 271: 15292-7 PubMed GONUTS page

[PMID:8595889-19] 20.0 ^20.1 White RA et al. (1995) Assignment of FGF8 to human chromosome 10q25-q26: mutations in FGF8 may be responsible for some types of acrocephalosyndactyly linked to this region. Genomics 30: 109-11 PubMed GONUTS page

[PMID:17394220-20] 21.0 ^21.1 Lin D et al. (2007) Expression survey of genes critical for tooth development in the human embryonic tooth germ. Dev Dyn 236: 1307-12 PubMed GONUTS page

[PMID:17309880-21] 22.0 ^22.1 Schneider BL et al. (2007) Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation. Hum Mol Genet 16: 651-66 PubMed GONUTS page

[PMID:15193767-22] 23.0 ^23.1 Wang X et al. (2004) Forskolin cooperating with growth factor on generation of dopaminergic neurons from human fetal mesencephalic neural progenitor cells. Neurosci Lett 362: 117-21 PubMed GONUTS page

[PMID:20702560-23] Tirosh-Finkel L et al. (2010) BMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors. Development 137: 2989-3000 PubMed GONUTS page

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HUMAN:FGF8

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