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HUMAN:FGF19
Contents |
| Species (Taxon ID) | Homo sapiens (Human). ([1]) | |
| Gene Name(s) | FGF19 | |
| Protein Name(s) | Fibroblast growth factor 19
FGF-19 | |
| External Links | ||
| EMBL | AB018122 AF110400 AY358302 BT006729 BC017664 | |
| IPI | IPI00032908 | |
| RefSeq | NP_005108.1 | |
| UniGene | Hs.249200 | |
| PDB | 1PWA 2P23 | |
| PDBsum | 1PWA 2P23 | |
| ProteinModelPortal | O95750 | |
| SMR | O95750 | |
| DIP | DIP-6039N | |
| STRING | O95750 | |
| PRIDE | O95750 | |
| Ensembl | ENST00000294312 | |
| GeneID | 9965 | |
| KEGG | hsa:9965 | |
| UCSC | uc001opf.1 | |
| CTD | 9965 | |
| GeneCards | GC11M065805 | |
| H-InvDB | HIX0009891 | |
| HGNC | HGNC:3675 | |
| HPA | HPA036082 | |
| MIM | 603891 | |
| neXtProt | NX_O95750 | |
| PharmGKB | PA28114 | |
| eggNOG | prNOG09705 | |
| GeneTree | ENSGT00530000063469 | |
| HOGENOM | HBG446834 | |
| HOVERGEN | HBG051611 | |
| InParanoid | O95750 | |
| OMA | DGYNVYR | |
| OrthoDB | EOG45X7X5 | |
| PhylomeDB | O95750 | |
| Pathway_Interaction_DB | fgf_pathway | |
| Reactome | REACT_111102 | |
| NextBio | 37606 | |
| ArrayExpress | O95750 | |
| Bgee | O95750 | |
| CleanEx | HS_FGF19 | |
| Genevestigator | O95750 | |
| GermOnline | ENSG00000162344 | |
| GO | GO:0005576 GO:0005104 GO:0008083 GO:0004713 GO:0008543 GO:0008286 GO:0070858 GO:0007399 GO:0008284 GO:0070374 GO:0046326 GO:0046330 | |
| InterPro | IPR008996 IPR017338 IPR002209 IPR002348 | |
| KO | K04358 | |
| PANTHER | PTHR11486 | |
| Pfam | PF00167 | |
| PIRSF | PIRSF037961 | |
| PRINTS | PR00263 PR00262 | |
| SMART | SM00442 | |
| SUPFAM | SSF50353 | |
| PROSITE | PS00247 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001755 |
neural crest cell migration |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000033389 |
P |
Seeded From UniProt |
|||
| GO:0004713 |
protein tyrosine kinase activity |
Reactome:REACT_9474 |
TAS: Traceable Author Statement |
|
F |
Seeded From UniProt |
||
| GO:0005104 |
fibroblast growth factor receptor binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005104 |
fibroblast growth factor receptor binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005576 |
extracellular region |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005576 |
extracellular region |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0243 |
C |
Seeded From UniProt |
|||
| GO:0005576 |
extracellular region |
Reactome:REACT_21248 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005576 |
extracellular region |
Reactome:REACT_21258 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005576 |
extracellular region |
Reactome:REACT_21307 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005576 |
extracellular region |
Reactome:REACT_21329 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005576 |
extracellular region |
Reactome:REACT_21339 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005576 |
extracellular region |
Reactome:REACT_21365 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005576 |
extracellular region |
Reactome:REACT_21372 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005576 |
extracellular region |
Reactome:REACT_21398 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005576 |
extracellular region |
Reactome:REACT_21411 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005576 |
extracellular region |
Reactome:REACT_244 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005576 |
extracellular region |
Reactome:REACT_9447 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005576 |
extracellular region |
Reactome:REACT_9474 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0007399 |
nervous system development |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0007507 |
heart development |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000033389 |
P |
Seeded From UniProt |
|||
| GO:0008083 |
growth factor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0008083 |
growth factor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0008083 |
growth factor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0008284 |
positive regulation of cell proliferation |
IGI: Inferred from Genetic Interaction |
P |
Seeded From UniProt |
||||
| GO:0008284 |
positive regulation of cell proliferation |
IGI: Inferred from Genetic Interaction |
P |
Seeded From UniProt |
||||
| GO:0008284 |
positive regulation of cell proliferation |
IGI: Inferred from Genetic Interaction |
P |
Seeded From UniProt |
||||
| GO:0008284 |
positive regulation of cell proliferation |
IGI: Inferred from Genetic Interaction |
P |
Seeded From UniProt |
||||
| GO:0008286 |
insulin receptor signaling pathway |
Reactome:REACT_498 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0008543 |
fibroblast growth factor receptor signaling pathway |
IPI: Inferred from Physical Interaction |
P |
Seeded From UniProt |
||||
| GO:0008543 |
fibroblast growth factor receptor signaling pathway |
IGI: Inferred from Genetic Interaction |
P |
Seeded From UniProt |
||||
| GO:0008543 |
fibroblast growth factor receptor signaling pathway |
IGI: Inferred from Genetic Interaction |
P |
Seeded From UniProt |
||||
| GO:0008543 |
fibroblast growth factor receptor signaling pathway |
IGI: Inferred from Genetic Interaction |
P |
Seeded From UniProt |
||||
| GO:0008543 |
fibroblast growth factor receptor signaling pathway |
IGI: Inferred from Genetic Interaction |
P |
Seeded From UniProt |
||||
| GO:0008543 |
fibroblast growth factor receptor signaling pathway |
Reactome:REACT_9396 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0008543 |
fibroblast growth factor receptor signaling pathway |
Reactome:REACT_9452 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0008543 |
fibroblast growth factor receptor signaling pathway |
Reactome:REACT_9470 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0046326 |
positive regulation of glucose import |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0046330 |
positive regulation of JNK cascade |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0070858 |
negative regulation of bile acid biosynthetic process |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0070858 |
IDA: Inferred from Direct Assay |
Figure 1 and Figure 2 |
complete | |||||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Xie MH et al. (1999) FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4. Cytokine 11: 729-35 PubMed GONUTS page
- ↑ 2.0 2.1 Wu X et al. (2008) C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors. J Biol Chem 283: 33304-9 PubMed GONUTS page
- ↑ Nishimura T et al. (1999) Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain. Biochim Biophys Acta 1444: 148-51 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 Suzuki M et al. (2008) betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c. Mol Endocrinol 22: 1006-14 PubMed GONUTS page
- ↑ 5.0 5.1 Kurosu H et al. (2007) Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. J Biol Chem 282: 26687-95 PubMed GONUTS page
- ↑ 6.0 6.1 Holt JA et al. (2003) Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. Genes Dev 17: 1581-91 PubMed GONUTS page
- ↑ Song KH et al. (2009) Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression. Hepatology 49: 297-305 PubMed GONUTS page
