HUMAN:FGF1

From GONUTS

Jump to: navigation, search

Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	FGF1 ( synonyms: FGFA )
Protein Name(s)	Heparin-binding growth factor 1 HBGF-1 Acidic fibroblast growth factor aFGF Beta-endothelial cell growth factor ECGF-beta
External Links
UniProt Identifier	FGF1_HUMAN
UniProt Accessions	P05230, B2R5T0, D3DQF2, P07502, Q16588,
EMBL	M13361, M30492, M30490, M30491, M23087, M23086, X51943, X65778, S67291, S67292, AY601819, AC005370, AK312301, CH471062, CH471062, CH471062, BC032697, M60515, M60516,
PIR	A33665, JH0708,
RefSeq	NP_000791.1, NP_001138364.1, NP_001138406.1, NP_001138407.1, NP_149127.1, NP_149128.1,
PDB	1AXM, 1DJS, 1DZC, 1DZD, 1E0O, 1EVT, 1HKN, 1JQZ, 1JT3, 1JT4, 1JT5, 1JT7, 1JTC, 1JY0, 1K5U, 1K5V, 1M16, 1NZK, 1P63, 1PZZ, 1Q03, 1Q04, 1QCT, 1RG8, 1RML, 1RY7, 1YTO, 1Z2V, 1Z4S, 2AFG, 2AQZ, 2AXM, 2ERM, 2HW9, 2HWA, 2HWM, 2HZ9, 2K43, 2K4A, 2K8R, 2KI4, 2KI6, 2NTD, 2Q9X, 2RQ9, 3B9U, 3BA4, 3BA5, 3BA7, 3BAD, 3BAG, 3BAH, 3BAO, 3BAQ, 3BAU, 3BAV, 3BB2, 3CQA, 3CRG, 3CRH, 3CRI, 3CU1, 3FGM, 3FJ8, 3FJ9, 3FJA, 3FJB, 3FJC, 3FJD, 3FJE, 3FJF, 3FJH, 3FJI, 3FJJ, 3FJK, 3HOM, 3JUT, 3K1X, 3O3Q,
IntAct	P05230,
Ensembl	ENST00000337706, ENST00000359370, ENST00000378046, ENST00000403113, ENST00000419524, ENST00000441680,
Pfam	PF00167,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005829	cytosol		IDA: Inferred from Direct Assay		C	Source: UniProtKB
	GO:0005104	fibroblast growth factor receptor binding		IPI: Inferred from Physical Interaction		F	Source: MGI
	GO:0008083	growth factor activity		TAS: Traceable Author Statement		F	Source: ProtInc
	GO:0008201	heparin binding		IEA: Inferred from Electronic Annotation		F	Source: UniProtKB-KW
	GO:0048155	S100 alpha binding		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0001525	angiogenesis		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0034605	cellular response to heat		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0008543	fibroblast growth factor receptor signaling...		IGI: Inferred from Genetic Interaction		P	Source: MGI
	GO:0010552	positive regulation of gene-specific transcription from RNA polymerase II promoter	PMID:19229075^[1]	IDA: Inferred from Direct Assay		P	Figure 1A: FGF-1 increases the expression of LXRα mRNA Figure 1A: FGF-1 increases the expression of apoE mRNA Figure 1B: FGF-1 increases the expression of ABCA1 mRNA Figure 4B: the luciferase assay shows that FGF-1 activates the apoE gene. Also figure 4C shows that responses of the reporter gene to FGF-1 disappear when a mutation is introduced on the promoter sequence Figure 5: Chip assay demonstrated that FGF-1 activates LXR to enhance expression of the apoE gene through its interaction with the LXRE of the endogenous apoE promoter NOTE: From the company's website the only recombinant FGF-1 protein they have at the moment is human, so I’m assuming it is human based on the current Sigma-Aldrich catalogue.	complete
	GO:0051781	positive regulation of cell division		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0045542	positive regulation of cholesterol biosynthetic process	PMID:19229075^[1]	IDA: Inferred from Direct Assay		P	Figure 6A: this shows that cholesterol biosynthesis is increased by FGF-1 Figure 6D: this shows an increase of cholesterol 25-hydroxylase mRNA by FGF-1 Figure 6F: this shows an increase of 25-hydroxycholesterol (a ligand of LXR) by FGF-1 Figure 6B: this shows that IGF-1 increases the expression of HMG-CoA reductase gene NOTE 1: From the company's website the only recombinant FGF-1 protein they have at the moment is human, so I’m assuming it is human based on the current Sigma-Aldrich catalogue. NOTE 2: a more specific term could be used if it was available "regulation of cellular cholesterol metabolic process by positive regulation of transcription from an RNA polymerase II promoter"	complete
	GO:0009306	protein secretion	PMID:19229075^[1]	IDA: Inferred from Direct Assay		P	Figure 2 and 3: The presence of FGF-1 resulted in an increase in the levels of secreted apoE protein NOTE 1: From the company's website the only recombinant FGF-1 protein they have at the moment is human, so I’m assuming it is human based on the current Sigma-Aldrich catalogue. NOTE 2: a more specific term could be used if it was available “apolipoprotein secretion”	complete
	GO:0001525	angiogenesis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0037	P
	GO:0001759	organ induction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000045710	P
	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000045710	P
	GO:0004713	protein tyrosine kinase activity	Reactome:REACT_9419	TAS: Traceable Author Statement		F
	GO:0004713	protein tyrosine kinase activity	Reactome:REACT_9474	TAS: Traceable Author Statement		F
	GO:0004713	protein tyrosine kinase activity	Reactome:REACT_9498	TAS: Traceable Author Statement		F
	GO:0004713	protein tyrosine kinase activity	Reactome:REACT_9519	TAS: Traceable Author Statement		F
	GO:0005104	fibroblast growth factor receptor binding	PMID:10830168^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P11362	F
	GO:0005104	fibroblast growth factor receptor binding	PMID:12815063^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P22607-1	F
	GO:0005104	fibroblast growth factor receptor binding	PMID:12815063^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P22607-2	F
	GO:0005515	protein binding	PMID:10618369^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P21802	F
	GO:0005515	protein binding	PMID:10830168^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P11362	F
	GO:0005515	protein binding	PMID:14732692^[5]	IPI: Inferred from Physical Interaction	UniProtKB:P22607	F
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005576	extracellular region	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000045710	C
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C
	GO:0005576	extracellular region	PMID:12746488^[6]	IDA: Inferred from Direct Assay		C
	GO:0005576	extracellular region	Reactome:REACT_21248	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_21258	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_21307	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_21329	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_21333	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_21339	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_21344	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_21357	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_21365	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_21372	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_21398	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_21411	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_244	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_9419	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_9432	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_9447	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_9459	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_9460	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_9462	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_9474	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_9476	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_9477	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_9489	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_9493	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_9498	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_9519	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_9523	TAS: Traceable Author Statement		C
	GO:0005578	proteinaceous extracellular matrix	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000045710	C
	GO:0005615	extracellular space	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000045710	C
	GO:0005615	extracellular space	PMID:18400376^[7]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000018577	C
	GO:0005730	nucleolus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000018577	C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000018577	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005829	cytosol	PMID:12746488^[6]	IDA: Inferred from Direct Assay		C
	GO:0005938	cell cortex	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0138	C
	GO:0007165	signal transduction	PMID:3778488^[8]	NAS: Non-traceable Author Statement		P
	GO:0007243	intracellular protein kinase cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000018577	P
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P
	GO:0007275	multicellular organismal development	PMID:10903182^[9]	TAS: Traceable Author Statement		P
	GO:0007399	nervous system development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000018577	P
	GO:0008083	growth factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002209	F
	GO:0008083	growth factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002348	F
	GO:0008083	growth factor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0339	F
	GO:0008083	growth factor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000018577	F
	GO:0008083	growth factor activity	PMID:1693186^[10]	TAS: Traceable Author Statement		F
	GO:0008083	growth factor activity	PMID:20145243^[11]	IDA: Inferred from Direct Assay		F
	GO:0008201	heparin binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0358	F
	GO:0008201	heparin binding	PMID:20145243^[11]	IDA: Inferred from Direct Assay		F
	GO:0008284	positive regulation of cell proliferation	PMID:18187602^[12]	IGI: Inferred from Genetic Interaction	UniProtKB:P16092	P
	GO:0008284	positive regulation of cell proliferation	PMID:18187602^[12]	IGI: Inferred from Genetic Interaction	UniProtKB:P21803	P
	GO:0008284	positive regulation of cell proliferation	PMID:18187602^[12]	IGI: Inferred from Genetic Interaction	UniProtKB:Q03142	P
	GO:0008284	positive regulation of cell proliferation	PMID:18187602^[12]	IGI: Inferred from Genetic Interaction	UniProtKB:Q61851	P
	GO:0008284	positive regulation of cell proliferation	PMID:8663044^[13]	IGI: Inferred from Genetic Interaction	UniProtKB:P11362	P
	GO:0008284	positive regulation of cell proliferation	PMID:8663044^[13]	IGI: Inferred from Genetic Interaction	UniProtKB:P21802	P
	GO:0008286	insulin receptor signaling pathway	Reactome:REACT_498	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:10830168^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P11362	P
	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:18187602^[12]	IGI: Inferred from Genetic Interaction	UniProtKB:P16092	P
	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:18187602^[12]	IGI: Inferred from Genetic Interaction	UniProtKB:P21803	P
	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:18187602^[12]	IGI: Inferred from Genetic Interaction	UniProtKB:Q03142	P
	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:18187602^[12]	IGI: Inferred from Genetic Interaction	UniProtKB:Q61851	P
	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:20145243^[11]	IDA: Inferred from Direct Assay		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[13]	IGI: Inferred from Genetic Interaction	UniProtKB:P11362	P
	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[13]	IGI: Inferred from Genetic Interaction	UniProtKB:P21802	P
	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[13]	IGI: Inferred from Genetic Interaction	UniProtKB:P22607	P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9390	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9396	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9400	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9413	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9416	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9439	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9452	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9470	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9483	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9508	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9510	TAS: Traceable Author Statement		P
	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:REACT_9515	TAS: Traceable Author Statement		P
	GO:0009653	anatomical structure morphogenesis	PMID:1693186^[10]	TAS: Traceable Author Statement		P
	GO:0010740	positive regulation of intracellular protein kinase cascade	PMID:19229075^[1]	IDA: Inferred from Direct Assay		P
	GO:0030154	cell differentiation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0221	P
	GO:0030324	lung development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000045710	P
	GO:0030335	positive regulation of cell migration	PMID:20145243^[11]	IDA: Inferred from Direct Assay		P
	GO:0034605	cellular response to heat	PMID:12746488^[6]	IDA: Inferred from Direct Assay		P
	GO:0045542	positive regulation of cholesterol biosynthetic process	PMID:19229075^[1]	IDA: Inferred from Direct Assay		P
	GO:0045766	positive regulation of angiogenesis	PMID:20145243^[11]	IDA: Inferred from Direct Assay		P
	GO:0045785	positive regulation of cell adhesion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000018577	P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:19229075^[1]	IDA: Inferred from Direct Assay		P
	GO:0048155	S100 alpha binding	PMID:11432880^[14]	IPI: Inferred from Physical Interaction	UniProtKB:Q99584	F
	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000045710	P
	GO:0051781	positive regulation of cell division	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0497	P
	GO:0051781	positive regulation of cell division	PMID:20145243^[11]	IDA: Inferred from Direct Assay		P
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Lu R et al. (2009) FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes. J Lipid Res 50: 1156-64 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Plotnikov AN et al. (2000) Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. Cell 101: 413-24 PubMed GONUTS page
↑ ^3.0 ^3.1 Olsen SK et al. (2003) Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs. J Biol Chem 278: 34226-36 PubMed GONUTS page
↑ Stauber DJ et al. (2000) Structural interactions of fibroblast growth factor receptor with its ligands. Proc Natl Acad Sci U S A 97: 49-54 PubMed GONUTS page
↑ Olsen SK et al. (2004) Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity. Proc Natl Acad Sci U S A 101: 935-40 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Mandinova A et al. (2003) S100A13 mediates the copper-dependent stress-induced release of IL-1alpha from both human U937 and murine NIH 3T3 cells. J Cell Sci 116: 2687-96 PubMed GONUTS page
↑ Di Serio C et al. (2008) The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol 3-kinase/Akt intracellular signaling pathway. Cancer Lett 267: 67-74 PubMed GONUTS page
↑ Gautschi-Sova P et al. (1986) Amino acid sequence of human acidic fibroblast growth factor. Biochem Biophys Res Commun 140: 874-80 PubMed GONUTS page
↑ Nguyen M & Arnheiter H (2000) Signaling and transcriptional regulation in early mammalian eye development: a link between FGF and MITF. Development 127: 3581-91 PubMed GONUTS page
↑ ^10.0 ^10.1 Chiu IM et al. (1990) Alternative splicing generates two forms of mRNA coding for human heparin-binding growth factor 1. Oncogene 5: 755-62 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Fernández IS et al. (2010) Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors. J Biol Chem 285: 11714-29 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 Suzuki M et al. (2008) betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c. Mol Endocrinol 22: 1006-14 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 Ornitz DM et al. (1996) Receptor specificity of the fibroblast growth factor family. J Biol Chem 271: 15292-7 PubMed GONUTS page
↑ Landriscina M et al. (2001) Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress. J Biol Chem 276: 25549-57 PubMed GONUTS page

[PMID:19229075-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Lu R et al. (2009) FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes. J Lipid Res 50: 1156-64 PubMed GONUTS page

[PMID:10830168-1] 2.0 ^2.1 ^2.2 Plotnikov AN et al. (2000) Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. Cell 101: 413-24 PubMed GONUTS page

[PMID:12815063-2] 3.0 ^3.1 Olsen SK et al. (2003) Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs. J Biol Chem 278: 34226-36 PubMed GONUTS page

[PMID:10618369-3] Stauber DJ et al. (2000) Structural interactions of fibroblast growth factor receptor with its ligands. Proc Natl Acad Sci U S A 97: 49-54 PubMed GONUTS page

[PMID:14732692-4] Olsen SK et al. (2004) Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity. Proc Natl Acad Sci U S A 101: 935-40 PubMed GONUTS page

[PMID:12746488-5] 6.0 ^6.1 ^6.2 Mandinova A et al. (2003) S100A13 mediates the copper-dependent stress-induced release of IL-1alpha from both human U937 and murine NIH 3T3 cells. J Cell Sci 116: 2687-96 PubMed GONUTS page

[PMID:18400376-6] Di Serio C et al. (2008) The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol 3-kinase/Akt intracellular signaling pathway. Cancer Lett 267: 67-74 PubMed GONUTS page

[PMID:3778488-7] Gautschi-Sova P et al. (1986) Amino acid sequence of human acidic fibroblast growth factor. Biochem Biophys Res Commun 140: 874-80 PubMed GONUTS page

[PMID:10903182-8] Nguyen M & Arnheiter H (2000) Signaling and transcriptional regulation in early mammalian eye development: a link between FGF and MITF. Development 127: 3581-91 PubMed GONUTS page

[PMID:1693186-9] 10.0 ^10.1 Chiu IM et al. (1990) Alternative splicing generates two forms of mRNA coding for human heparin-binding growth factor 1. Oncogene 5: 755-62 PubMed GONUTS page

[PMID:20145243-10] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Fernández IS et al. (2010) Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors. J Biol Chem 285: 11714-29 PubMed GONUTS page

[PMID:18187602-11] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 Suzuki M et al. (2008) betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c. Mol Endocrinol 22: 1006-14 PubMed GONUTS page

[PMID:8663044-12] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 Ornitz DM et al. (1996) Receptor specificity of the fibroblast growth factor family. J Biol Chem 271: 15292-7 PubMed GONUTS page

[PMID:11432880-13] Landriscina M et al. (2001) Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress. J Biol Chem 276: 25549-57 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

HUMAN:FGF1

Contents

Annotations

Notes

References

a

c

e

f

g

h

i

l

m

n

o

p

p cont.

s

v

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Cacao

Journal Clubs

page contributors

Toolbox