HUMAN:FA9

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	F9
Protein Name(s)	Coagulation factor IX Christmas factor Plasma thromboplastin component PTC Coagulation factor IXa light chain Coagulation factor IXa heavy chain
External Links
UniProt Identifier	FA9_HUMAN
UniProt Accessions	P00740, A8K9N4, Q5JYJ8,
EMBL	J00136, J00137, K02053, K02048, K02049, K02051, K02052, K02402, M11309, AL033403, AF536327, AK292749, CH471150, BC109214, BC109215, S68634, M35672, M19063, S66752,
PIR	A00922,
RefSeq	NP_000124.1,
PDB	1CFH, 1CFI, 1EDM, 1IXA, 1MGX, 1NL0, 1RFN, 2WPH, 2WPI, 2WPJ, 2WPK, 2WPL, 2WPM, 3KCG, 3LC3, 3LC5,
Ensembl	ENST00000218099, ENST00000394090,
Pfam	PF00008, PF00594, PF00089,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0003824	catalytic activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009003	F
	GO:0004252	serine-type endopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001254	F
	GO:0004252	serine-type endopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001314	F
	GO:0004252	serine-type endopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012224	F
	GO:0004252	serine-type endopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018114	F
	GO:0004252	serine-type endopeptidase activity	PMID:2472424^[1]	TAS: Traceable Author Statement		F
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000294	F
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001881	F
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012224	F
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018097	F
	GO:0005576	extracellular region	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000294	C
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C
	GO:0005576	extracellular region	PMID:14718574^[2]	NAS: Non-traceable Author Statement		C
	GO:0005576	extracellular region	PMID:8626656^[3]	EXP: Inferred from Experiment		C
	GO:0005576	extracellular region	Reactome:REACT_158	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_2073	TAS: Traceable Author Statement		C
	GO:0005788	endoplasmic reticulum lumen	Reactome:REACT_2045	TAS: Traceable Author Statement		C
	GO:0005788	endoplasmic reticulum lumen	Reactome:REACT_618	TAS: Traceable Author Statement		C
	GO:0005796	Golgi lumen	Reactome:REACT_420	TAS: Traceable Author Statement		C
	GO:0005796	Golgi lumen	Reactome:REACT_618	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	PMID:2110473^[4]	EXP: Inferred from Experiment		C
	GO:0005886	plasma membrane	PMID:8626656^[3]	EXP: Inferred from Experiment		C
	GO:0006508	proteolysis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001254	P
	GO:0006508	proteolysis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001314	P
	GO:0006508	proteolysis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018114	P
	GO:0006508	proteolysis	Reactome:REACT_733	TAS: Traceable Author Statement		P
	GO:0007596	blood coagulation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012224	P
	GO:0007596	blood coagulation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0094	P
	GO:0007596	blood coagulation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033477	P
	GO:0007596	blood coagulation	PMID:2472424^[1]	TAS: Traceable Author Statement		P
	GO:0007596	blood coagulation	Reactome:REACT_2051	TAS: Traceable Author Statement		P
	GO:0007596	blood coagulation	Reactome:REACT_604	TAS: Traceable Author Statement		P
	GO:0007597	blood coagulation, intrinsic pathway	Reactome:REACT_326	TAS: Traceable Author Statement		P
	GO:0007598	blood coagulation, extrinsic pathway	PMID:7598447^[5]	EXP: Inferred from Experiment		P
	GO:0008233	peptidase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0645	F
	GO:0008233	peptidase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033477	F
	GO:0008236	serine-type peptidase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0720	F
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F
	GO:0017187	peptidyl-glutamic acid carboxylation	Reactome:REACT_1050	TAS: Traceable Author Statement		P
	GO:0017187	peptidyl-glutamic acid carboxylation	Reactome:REACT_1132	TAS: Traceable Author Statement		P
	GO:0043687	post-translational protein modification	Reactome:REACT_1069	TAS: Traceable Author Statement		P
	GO:0043687	post-translational protein modification	Reactome:REACT_22161	TAS: Traceable Author Statement		P
	GO:0044267	cellular protein metabolic process	Reactome:REACT_17015	TAS: Traceable Author Statement		P
	GO:0003824	catalytic activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009003	F
	GO:0004252	serine-type endopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001254	F
	GO:0004252	serine-type endopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001314	F
	GO:0004252	serine-type endopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012224	F
	GO:0004252	serine-type endopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018114	F
	GO:0004252	serine-type endopeptidase activity	PMID:2472424^[1]	TAS: Traceable Author Statement		F
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000294	F
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001881	F
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012224	F
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018097	F
	GO:0005576	extracellular region	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000294	C
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C
	GO:0005576	extracellular region	PMID:14718574^[2]	NAS: Non-traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_112	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_158	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_2073	TAS: Traceable Author Statement		C
	GO:0005788	endoplasmic reticulum lumen	Reactome:REACT_2045	TAS: Traceable Author Statement		C
	GO:0005788	endoplasmic reticulum lumen	Reactome:REACT_618	TAS: Traceable Author Statement		C
	GO:0005796	Golgi lumen	Reactome:REACT_420	TAS: Traceable Author Statement		C
	GO:0005796	Golgi lumen	Reactome:REACT_618	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_112	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_1668	TAS: Traceable Author Statement		C
	GO:0006508	proteolysis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001254	P
	GO:0006508	proteolysis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001314	P
	GO:0006508	proteolysis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018114	P
	GO:0006508	proteolysis	Reactome:REACT_733	TAS: Traceable Author Statement		P
	GO:0007596	blood coagulation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012224	P
	GO:0007596	blood coagulation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0094	P
	GO:0007596	blood coagulation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033477	P
	GO:0007596	blood coagulation	PMID:2472424^[1]	TAS: Traceable Author Statement		P
	GO:0007596	blood coagulation	Reactome:REACT_2051	TAS: Traceable Author Statement		P
	GO:0007596	blood coagulation	Reactome:REACT_604	TAS: Traceable Author Statement		P
	GO:0007597	blood coagulation, intrinsic pathway	Reactome:REACT_326	TAS: Traceable Author Statement		P
	GO:0007598	blood coagulation, extrinsic pathway	Reactome:REACT_1573	TAS: Traceable Author Statement		P
	GO:0008233	peptidase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0645	F
	GO:0008233	peptidase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000033477	F
	GO:0008236	serine-type peptidase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0720	F
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F
	GO:0017187	peptidyl-glutamic acid carboxylation	Reactome:REACT_1050	TAS: Traceable Author Statement		P
	GO:0017187	peptidyl-glutamic acid carboxylation	Reactome:REACT_1132	TAS: Traceable Author Statement		P
	GO:0043687	post-translational protein modification	Reactome:REACT_1069	TAS: Traceable Author Statement		P
	GO:0043687	post-translational protein modification	Reactome:REACT_22161	TAS: Traceable Author Statement		P
	GO:0044267	cellular protein metabolic process	Reactome:REACT_17015	TAS: Traceable Author Statement		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Chen SH et al. (1989) Three point mutations in the factor IX genes of five hemophilia B patients. Identification strategy using localization by altered epitopes in their hemophilic proteins. J Clin Invest 84: 113-8 PubMed GONUTS page
↑ ^2.0 ^2.1 Anderson NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol Cell Proteomics 3: 311-26 PubMed GONUTS page
↑ ^3.0 ^3.1 Gilbert GE & Arena AA (1996) Activation of the factor VIIIa-factor IXa enzyme complex of blood coagulation by membranes containing phosphatidyl-L-serine. J Biol Chem 271: 11120-5 PubMed GONUTS page
↑ Rawala-Sheikh R et al. (1990) Kinetics of coagulation factor X activation by platelet-bound factor IXa. Biochemistry 29: 2606-11 PubMed GONUTS page
↑ Broze GJ Jr (1995) Tissue factor pathway inhibitor and the revised theory of coagulation. Annu Rev Med 46: 103-12 PubMed GONUTS page

[PMID:2472424-0] 1.0 ^1.1 ^1.2 ^1.3 Chen SH et al. (1989) Three point mutations in the factor IX genes of five hemophilia B patients. Identification strategy using localization by altered epitopes in their hemophilic proteins. J Clin Invest 84: 113-8 PubMed GONUTS page

[PMID:14718574-1] 2.0 ^2.1 Anderson NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol Cell Proteomics 3: 311-26 PubMed GONUTS page

[PMID:8626656-2] 3.0 ^3.1 Gilbert GE & Arena AA (1996) Activation of the factor VIIIa-factor IXa enzyme complex of blood coagulation by membranes containing phosphatidyl-L-serine. J Biol Chem 271: 11120-5 PubMed GONUTS page

[PMID:2110473-3] Rawala-Sheikh R et al. (1990) Kinetics of coagulation factor X activation by platelet-bound factor IXa. Biochemistry 29: 2606-11 PubMed GONUTS page

[PMID:7598447-4] Broze GJ Jr (1995) Tissue factor pathway inhibitor and the revised theory of coagulation. Annu Rev Med 46: 103-12 PubMed GONUTS page

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HUMAN:FA9

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