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HUMAN:EZH2
Contents |
| Species (Taxon ID) | Homo sapiens (Human). (taxon:9606) | |
| Gene Name(s) | EZH2 ( synonyms: KMT6 ) | |
| Protein Name(s) |
| |
| External Links | ||
| UniProt Identifier | EZH2_HUMAN | |
| UniProt Accessions | Q15910, B2RAQ1, B3KS30, B7Z1D6, B7Z7L6, Q15755, Q92857, Q96FI6, | |
| EMBL | X95653, U61145, AK302216, AK092676, AK293239, AK314291, AC006323, AC073140, CH471146, CH471146, BC010858, U52965, | |
| PIR | G02838, | |
| RefSeq | NP_001190176.1, NP_001190177.1, NP_001190178.1, NP_004447.2, NP_694543.1, | |
| PDB | 2C6V, | |
| IntAct | Q15910, | |
| Ensembl | ENST00000350995, ENST00000460911, ENST00000476773, ENST00000478654, ENST00000483967, | |
| Pfam | PF11616, PF00856, | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0048387 |
negative regulation of retinoic acid receptor signaling pathway |
IMP: Inferred from Mutant Phenotype |
|
P |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0006351 |
transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0006325 |
chromatin organization |
TAS: Traceable Author Statement |
|
P |
||||
| GO:0035098 |
ESC/E(Z) complex |
IDA: Inferred from Direct Assay |
|
C |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0034968 |
histone lysine methylation |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0016740 |
transferase activity |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0003677 |
DNA binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0003677 |
DNA binding |
TAS: Traceable Author Statement |
|
F |
||||
| GO:0035098 |
ESC/E(Z) complex |
IDA: Inferred from Direct Assay |
|
C |
||||
| GO:0016564 |
transcription repressor activity |
IMP: Inferred from Mutant Phenotype |
|
F |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
TAS: Traceable Author Statement |
|
P |
||||
| GO:0016568 |
chromatin modification |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0191 |
C |
||||
| GO:0034968 |
histone lysine methylation |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0008168 |
methyltransferase activity |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0032259 |
methylation |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0018024 |
histone-lysine N-methyltransferase activity |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0016571 |
histone methylation |
IDA: Inferred from Direct Assay |
|
P |
||||
| GO:0042054 |
histone methyltransferase activity |
IDA: Inferred from Direct Assay |
|
F |
||||
| GO:0003677 |
DNA binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0003677 |
DNA binding |
TAS: Traceable Author Statement |
F |
|||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0191 |
C |
||||
| GO:0006325 |
chromatin organization |
TAS: Traceable Author Statement |
P |
|||||
| GO:0006351 |
transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
TAS: Traceable Author Statement |
P |
|||||
| GO:0008168 |
methyltransferase activity |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0016568 |
chromatin modification |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0016571 |
histone methylation |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0016740 |
transferase activity |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0018024 |
histone-lysine N-methyltransferase activity |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0018024 |
histone-lysine N-methyltransferase activity |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0032259 |
methylation |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0034968 |
histone lysine methylation |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0034968 |
histone lysine methylation |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0035098 |
ESC/E(Z) complex |
IDA: Inferred from Direct Assay |
C |
|||||
| GO:0035098 |
ESC/E(Z) complex |
IDA: Inferred from Direct Assay |
C |
|||||
| GO:0042054 |
histone methyltransferase activity |
IDA: Inferred from Direct Assay |
F |
|||||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
IMP: Inferred from Mutant Phenotype |
P |
|||||
| GO:0048387 |
negative regulation of retinoic acid receptor signaling pathway |
IMP: Inferred from Mutant Phenotype |
P |
| ||||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Epping MT et al. (2005) The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling. Cell 122: 835-47 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Viré E et al. (2006) The Polycomb group protein EZH2 directly controls DNA methylation. Nature 439: 871-4 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Abel KJ et al. (1996) Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1. Genomics 37: 161-71 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Pasini D et al. (2004) Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J 23: 4061-71 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Villa R et al. (2007) Role of the polycomb repressive complex 2 in acute promyelocytic leukemia. Cancer Cell 11: 513-25 PubMed GONUTS page
- ↑ 6.0 6.1 Chen H et al. (1996) Cloning of a human homolog of the Drosophila enhancer of zeste gene (EZH2) that maps to chromosome 21q22.2. Genomics 38: 30-7 PubMed GONUTS page
- ↑ 7.0 7.1 Pasini D et al. (2010) JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Nature 464: 306-10 PubMed GONUTS page
cdeh |
h cont.mn |
n cont.prt |
