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HUMAN:EPS15
Contents |
| Species (Taxon ID) | Homo sapiens (Human). ([1]) | |
| Gene Name(s) | EPS15 (synonyms: AF1P) | |
| Protein Name(s) | Epidermal growth factor receptor substrate 15
Protein Eps15 Protein AF-1p | |
| External Links | ||
| EMBL | U07707 Z29064 AK313396 DQ367924 BX647676 AL671986 AC104170 CH471059 | |
| IPI | IPI00292134 IPI00916208 | |
| PIR | S43074 | |
| RefSeq | NP_001153441.1 NP_001972.1 | |
| UniGene | Hs.83722 | |
| PDB | 1C07 1EH2 1F8H 1FF1 2IV9 2JXC | |
| PDBsum | 1C07 1EH2 1F8H 1FF1 2IV9 2JXC | |
| ProteinModelPortal | P42566 | |
| SMR | P42566 | |
| IntAct | P42566 | |
| MINT | MINT-107223 | |
| STRING | P42566 | |
| PhosphoSite | P42566 | |
| OGP | P42566 | |
| PeptideAtlas | P42566 | |
| PRIDE | P42566 | |
| Ensembl | ENST00000371733 | |
| GeneID | 2060 | |
| KEGG | hsa:2060 | |
| NMPDR | fig|9606.3.peg.1148 | |
| UCSC | uc001csq.1 | |
| CTD | 2060 | |
| GeneCards | GC01M049937 | |
| H-InvDB | HIX0000572 | |
| HGNC | HGNC:3419 | |
| HPA | CAB010164 HPA008451 | |
| MIM | 600051 | |
| neXtProt | NX_P42566 | |
| GeneTree | ENSGT00600000084249 | |
| HOGENOM | HBG714644 | |
| HOVERGEN | HBG005591 | |
| InParanoid | P42566 | |
| OrthoDB | EOG4BRWKB | |
| PhylomeDB | P42566 | |
| Reactome | REACT_9417 | |
| NextBio | 8377 | |
| ArrayExpress | P42566 | |
| Bgee | P42566 | |
| CleanEx | HS_EPS15 | |
| Genevestigator | P42566 | |
| GermOnline | ENSG00000085832 | |
| GO | GO:0005829 GO:0031901 GO:0005509 GO:0017124 GO:0008283 GO:0048268 GO:0032456 GO:0007173 GO:0042059 GO:0015031 | |
| InterPro | IPR011992 IPR018247 IPR018249 IPR002048 IPR000261 IPR003903 | |
| Gene3D | G3DSA:1.10.238.10 | |
| SMART | SM00054 SM00027 SM00726 | |
| PROSITE | PS00018 PS50222 PS50031 PS50330 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005509 |
calcium ion binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005509 |
calcium ion binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0086 |
C |
Seeded From UniProt |
|||
| GO:0005737 |
cytoplasm |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005768 |
endosome |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005829 |
cytosol |
Reactome:REACT_12387 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005829 |
cytosol |
Reactome:REACT_12495 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005829 |
cytosol |
Reactome:REACT_12520 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005829 |
cytosol |
Reactome:REACT_12527 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000099790 |
C |
Seeded From UniProt |
|||
| GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0039 |
C |
Seeded From UniProt |
|||
| GO:0005886 |
plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005905 |
coated pit |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0006810 |
transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0007173 |
epidermal growth factor receptor signaling pathway |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0007173 |
epidermal growth factor receptor signaling pathway |
Reactome:REACT_9417 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0008283 |
cell proliferation |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0015031 |
protein transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016050 |
vesicle organization |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0017124 |
SH3 domain binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0030122 |
AP-2 adaptor complex |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000099790 |
C |
Seeded From UniProt |
|||
| GO:0030136 |
clathrin-coated vesicle |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000099790 |
C |
Seeded From UniProt |
|||
| GO:0031901 |
early endosome membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0093 |
C |
Seeded From UniProt |
|||
| GO:0032456 |
endocytic recycling |
IC: Inferred by Curator |
GO:0048268 |
P |
Seeded From UniProt |
|||
| GO:0042059 |
negative regulation of epidermal growth factor receptor signaling pathway |
Reactome:REACT_12484 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0043231 |
intracellular membrane-bounded organelle |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0048268 |
clathrin coat assembly |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0046718 |
entry of virus into host cell |
IMP: Inferred from Mutant Phenotype |
P |
Fig. 4B and Fig. 4C |
complete | |||
| GO:0019065 |
receptor-mediated endocytosis of virus by host |
IMP: Inferred from Mutant Phenotype |
P |
Fig. 2B Part of the clathrin-mediated endocytosis entry pathway. |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Poupon V et al. (1999) Molecular cloning and characterization of MT-ACT48, a novel mitochondrial acyl-CoA thioesterase. J Biol Chem 274: 19188-94 PubMed GONUTS page
- ↑ Wu C et al. (2007) Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. Proteomics 7: 1775-85 PubMed GONUTS page
- ↑ 3.0 3.1 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page
- ↑ de Melker AA et al. (2004) Ubiquitin ligase activity of c-Cbl guides the epidermal growth factor receptor into clathrin-coated pits by two distinct modes of Eps15 recruitment. J Biol Chem 279: 55465-73 PubMed GONUTS page
- ↑ 5.0 5.1 Lewin DA et al. (1998) Cloning, expression, and localization of a novel gamma-adaptin-like molecule. FEBS Lett 435: 263-8 PubMed GONUTS page
- ↑ 6.0 6.1 Wong WT et al. (1994) The human eps15 gene, encoding a tyrosine kinase substrate, is conserved in evolution and maps to 1p31-p32. Oncogene 9: 1591-7 PubMed GONUTS page
- ↑ 7.0 7.1 Morgan JR et al. (2003) Eps15 homology domain-NPF motif interactions regulate clathrin coat assembly during synaptic vesicle recycling. J Biol Chem 278: 33583-92 PubMed GONUTS page
- ↑ Bhattacharyya S et al. (2010) Ebola virus uses clathrin-mediated endocytosis as an entry pathway. Virology 401: 18-28 PubMed GONUTS page
- ↑ Hunt CL et al. (2011) The Tyro3 receptor kinase Axl enhances macropinocytosis of Zaire ebolavirus. J Virol 85: 334-47 PubMed GONUTS page
