HUMAN:EGF

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Species (Taxon ID)	Homo sapiens (Human). ([1])
Gene Name(s)	EGF
Protein Name(s)	Pro-epidermal growth factor EGF Epidermal growth factor Urogastrone
External Links
EMBL	X04571 AY506357 AK299306 AC004050 AC005509 BC093731 BC113461
IPI	IPI00000073
PIR	A25531
RefSeq	NP_001171602.1 NP_001954.2
UniGene	Hs.419815
PDB	1IVO 1JL9 1NQL 1P9J 2KV4 3NJP
PDBsum	1IVO 1JL9 1NQL 1P9J 2KV4 3NJP
ProteinModelPortal	P01133
SMR	P01133
DIP	DIP-5767N
IntAct	P01133
MINT	MINT-260489
STRING	P01133
PhosphoSite	P01133
PRIDE	P01133
Ensembl	ENST00000265171 ENST00000509793
GeneID	1950
KEGG	hsa:1950
UCSC	uc003hzy.2
CTD	1950
GeneCards	GC04P106566
H-InvDB	HIX0031420
HGNC	HGNC:3229
HPA	CAB017843
MIM	131530 611718
neXtProt	NX_P01133
Orphanet	34527
PharmGKB	PA27664
eggNOG	prNOG06050
HOGENOM	HBG279909
HOVERGEN	HBG003858
InParanoid	P01133
OMA	DHDPVEN
Pathway_Interaction_DB	a6b1_a6b4_integrin_pathway arf6cyclingpathway ceramidepathway endothelinpathway telomerasepathway ptp1bpathway txa2pathway
Reactome	REACT_604 REACT_9417
DrugBank	DB00605
NextBio	7903
PMAP-CutDB	P01133
ArrayExpress	P01133
Bgee	P01133
CleanEx	HS_EGF
Genevestigator	P01133
GO	GO:0016021 GO:0005886 GO:0031093 GO:0005509 GO:0005154 GO:0008083 GO:0030297 GO:0001525 GO:0006260 GO:0007173 GO:0042059 GO:0051048 GO:0030168 GO:0002576 GO:0035413 GO:0045741 GO:0043406 GO:0045840 GO:0090279 GO:2000008
InterPro	IPR011042 IPR006209 IPR006210 IPR001881 IPR013032 IPR000152 IPR000742 IPR018097 IPR000033 IPR016317
Gene3D	G3DSA:2.120.10.30
Pfam	PF00008 PF07645 PF00058
PIRSF	PIRSF001778
SMART	SM00181 SM00179 SM00135
PROSITE	PS00010 PS00022 PS01186 PS50026 PS01187 PS51120

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000186	activation of MAPKK activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000029653	P	Seeded From UniProt
	GO:0001525	angiogenesis	PMID:15611079^[1]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0002576	platelet degranulation	Reactome:REACT_318	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0005154	epidermal growth factor receptor binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000029653	F	Seeded From UniProt
	GO:0005154	epidermal growth factor receptor binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000040920	F	Seeded From UniProt
	GO:0005154	epidermal growth factor receptor binding	PMID:15611079^[1]	TAS: Traceable Author Statement		F	Seeded From UniProt
	GO:0005154	epidermal growth factor receptor binding	PMID:9712850^[2]	TAS: Traceable Author Statement		F	Seeded From UniProt
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001881	F	Seeded From UniProt
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018097	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:12620237^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P00533	F	Seeded From UniProt
	GO:0005576	extracellular region	PMID:9712850^[2]	IC: Inferred by Curator	GO:0005154	C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12381	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12386	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12387	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12390	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12392	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12401	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12402	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12407	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12412	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12423	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12424	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12425	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12432	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12451	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12466	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12490	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12491	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12495	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12501	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12514	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12515	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12520	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12521	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12527	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12534	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12562	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12569	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12580	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12592	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12601	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12605	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12626	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12629	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12632	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_12636	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_21351	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_9388	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_9397	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_9401	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005576	extracellular region	Reactome:REACT_9481	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005615	extracellular space	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000029653	C	Seeded From UniProt
	GO:0005625	soluble fraction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000040920	C	Seeded From UniProt
	GO:0005886	plasma membrane	PMID:3491360^[4]	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0006260	DNA replication	PMID:9482941^[5]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0007165	signal transduction	Reactome:REACT_12478	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0007173	epidermal growth factor receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000029653	P	Seeded From UniProt
	GO:0007173	epidermal growth factor receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000040920	P	Seeded From UniProt
	GO:0007173	epidermal growth factor receptor signaling pathway	Reactome:REACT_9417	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0007262	STAT protein import into nucleus	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P01132	P	Seeded From UniProt
	GO:0007596	blood coagulation	Reactome:REACT_604	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0008083	growth factor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0339	F	Seeded From UniProt
	GO:0008083	growth factor activity	PMID:15611079^[1]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0008083	growth factor activity	PMID:7736574^[6]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0008284	positive regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000029653	P	Seeded From UniProt
	GO:0008284	positive regulation of cell proliferation	PMID:15611079^[1]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0008284	positive regulation of cell proliferation	PMID:20388803^[7]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0008284	positive regulation of cell proliferation	PMID:7736574^[6]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0162	C	Seeded From UniProt
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C	Seeded From UniProt
	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000029653	P	Seeded From UniProt
	GO:0021940	positive regulation of cerebellar granule cell precursor proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000029653	P	Seeded From UniProt
	GO:0030168	platelet activation	Reactome:REACT_798	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	PMID:9712850^[2]	TAS: Traceable Author Statement		F	Seeded From UniProt
	GO:0031093	platelet alpha granule lumen	Reactome:REACT_21351	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0035413	positive regulation of catenin import into nucleus	PMID:20302655^[8]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	Reactome:REACT_12484	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0042327	positive regulation of phosphorylation	PMID:15611079^[1]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0043388	positive regulation of DNA binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P01132	P	Seeded From UniProt
	GO:0043406	positive regulation of MAP kinase activity	PMID:15611079^[1]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	PMID:15611079^[1]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	PMID:9712850^[2]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0045840	positive regulation of mitosis	PMID:15611079^[1]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0048754	branching morphogenesis of a tube	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000029653	P	Seeded From UniProt
	GO:0050708	regulation of protein secretion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000040920	P	Seeded From UniProt
	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000029653	P	Seeded From UniProt
	GO:0051048	negative regulation of secretion	PMID:10559227^[9]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0051223	regulation of protein transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000040920	P	Seeded From UniProt
	GO:0090279	regulation of calcium ion import	PMID:19996314^[10]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:2000008	regulation of protein localization at cell surface	PMID:19996314^[10]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0032320	positive regulation of Ras GTPase activity	PMID:21968647^[11]	IDA: Inferred from Direct Assay		P	EGF was able to increase the amount of GTP-bound Ras. (Fig 4B)	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Kochupurakkal BS et al. (2005) Epigen, the last ligand of ErbB receptors, reveals intricate relationships between affinity and mitogenicity. J Biol Chem 280: 8503-12 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Lee NH & Malek RL (1998) Nerve growth factor regulation of m4 muscarinic receptor mRNA stability but not gene transcription requires mitogen-activated protein kinase activity. J Biol Chem 273: 22317-25 PubMed GONUTS page
↑ Ferguson KM et al. (2003) EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization. Mol Cell 11: 507-17 PubMed GONUTS page
↑ Bell GI et al. (1986) Human epidermal growth factor precursor: cDNA sequence, expression in vitro and gene organization. Nucleic Acids Res 14: 8427-46 PubMed GONUTS page
↑ Chen J et al. (1998) Expression of Q227L-galphas in MCF-7 human breast cancer cells inhibits tumorigenesis. Proc Natl Acad Sci U S A 95: 2648-52 PubMed GONUTS page
↑ ^6.0 ^6.1 Miyazaki T et al. (1995) Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. Cell 81: 223-31 PubMed GONUTS page
↑ Hattermann K et al. (2010) The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates antiapoptotic effects. Cancer Res 70: 3299-308 PubMed GONUTS page
↑ Lee CH et al. (2010) Epidermal growth factor receptor regulates beta-catenin location, stability, and transcriptional activity in oral cancer. Mol Cancer 9: 64 PubMed GONUTS page
↑ Keely SJ & Barrett KE (1999) ErbB2 and ErbB3 receptors mediate inhibition of calcium-dependent chloride secretion in colonic epithelial cells. J Biol Chem 274: 33449-54 PubMed GONUTS page
↑ ^10.0 ^10.1 Graziani A et al. (2010) Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction. J Biol Chem 285: 4213-23 PubMed GONUTS page
↑ Jin T et al. (2012) PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus. Cell Res 22: 661-76 PubMed GONUTS page

[PMID:15611079-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Kochupurakkal BS et al. (2005) Epigen, the last ligand of ErbB receptors, reveals intricate relationships between affinity and mitogenicity. J Biol Chem 280: 8503-12 PubMed GONUTS page

[PMID:9712850-1] 2.0 ^2.1 ^2.2 ^2.3 Lee NH & Malek RL (1998) Nerve growth factor regulation of m4 muscarinic receptor mRNA stability but not gene transcription requires mitogen-activated protein kinase activity. J Biol Chem 273: 22317-25 PubMed GONUTS page

[PMID:12620237-2] Ferguson KM et al. (2003) EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization. Mol Cell 11: 507-17 PubMed GONUTS page

[PMID:3491360-3] Bell GI et al. (1986) Human epidermal growth factor precursor: cDNA sequence, expression in vitro and gene organization. Nucleic Acids Res 14: 8427-46 PubMed GONUTS page

[PMID:9482941-4] Chen J et al. (1998) Expression of Q227L-galphas in MCF-7 human breast cancer cells inhibits tumorigenesis. Proc Natl Acad Sci U S A 95: 2648-52 PubMed GONUTS page

[PMID:7736574-5] 6.0 ^6.1 Miyazaki T et al. (1995) Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. Cell 81: 223-31 PubMed GONUTS page

[PMID:20388803-6] Hattermann K et al. (2010) The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates antiapoptotic effects. Cancer Res 70: 3299-308 PubMed GONUTS page

[PMID:20302655-7] Lee CH et al. (2010) Epidermal growth factor receptor regulates beta-catenin location, stability, and transcriptional activity in oral cancer. Mol Cancer 9: 64 PubMed GONUTS page

[PMID:10559227-8] Keely SJ & Barrett KE (1999) ErbB2 and ErbB3 receptors mediate inhibition of calcium-dependent chloride secretion in colonic epithelial cells. J Biol Chem 274: 33449-54 PubMed GONUTS page

[PMID:19996314-9] 10.0 ^10.1 Graziani A et al. (2010) Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction. J Biol Chem 285: 4213-23 PubMed GONUTS page

[PMID:21968647-10] Jin T et al. (2012) PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus. Cell Res 22: 661-76 PubMed GONUTS page

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HUMAN:EGF

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