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HUMAN:DVL1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) DVL1
Protein Name(s) Segment polarity protein dishevelled homolog DVL-1

Dishevelled-1 DSH homolog 1

External Links
UniProt O14640
EMBL AF006011
AL139287
AL139287
CCDS CCDS22.1
RefSeq NP_004412.2
XP_005244788.1
UniGene Hs.731450
ProteinModelPortal O14640
SMR O14640
BioGrid 108188
DIP DIP-40773N
IntAct O14640
MINT MINT-100885
STRING 9606.ENSP00000368169
BindingDB O14640
ChEMBL CHEMBL6027
PhosphoSite O14640
MaxQB O14640
PRIDE O14640
Ensembl ENST00000378888
ENST00000378891
GeneID 1855
KEGG hsa:1855
UCSC uc001aer.4
uc002quu.3
CTD 1855
GeneCards GC01M001262
HGNC HGNC:3084
HPA CAB011538
MIM 601365
neXtProt NX_O14640
PharmGKB PA27540
GeneTree ENSGT00390000013552
HOGENOM HOG000017084
HOVERGEN HBG005542
InParanoid O14640
KO K02353
OMA YPRYGMS
OrthoDB EOG7BP82N
PhylomeDB O14640
TreeFam TF318198
Reactome REACT_172581
REACT_200610
REACT_200668
REACT_200777
REACT_200841
REACT_228242
SignaLink O14640
GeneWiki DVL1
GenomeRNAi 1855
NextBio 7599
PRO PR:O14640
Proteomes UP000005640
Bgee O14640
CleanEx HS_DVL1
ExpressionAtlas O14640
Genevestigator O14640
GO GO:0030424
GO:0005938
GO:0030136
GO:0016023
GO:0031410
GO:0005829
GO:0030425
GO:0030426
GO:0005874
GO:0043025
GO:0005886
GO:0045202
GO:0019899
GO:0005109
GO:0042802
GO:0019901
GO:0048365
GO:0048675
GO:0007411
GO:0060070
GO:0090103
GO:0048668
GO:0060026
GO:0022007
GO:0031122
GO:0048813
GO:0035556
GO:0032091
GO:0006469
GO:0021915
GO:0007528
GO:0007269
GO:0090179
GO:0090263
GO:0010976
GO:0032436
GO:0045893
GO:0030177
GO:0060134
GO:0035372
GO:0034504
GO:0043113
GO:0001505
GO:0071340
GO:0035176
GO:0050808
GO:0006366
GO:0060071
Gene3D 1.10.10.10
2.30.42.10
InterPro IPR000591
IPR024580
IPR008339
IPR003351
IPR001158
IPR015506
IPR008340
IPR001478
IPR029071
IPR011991
PANTHER PTHR10878
PTHR10878:SF5
Pfam PF00610
PF02377
PF00778
PF12316
PF00595
PRINTS PR01760
SMART SM00021
SM00049
SM00228
SUPFAM SSF50156
SSF54236
PROSITE PS50186
PS50841
PS50106

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0019900

kinase binding

19643732

IPI: Inferred from Physical Interaction

UniProtKB:Q6P3W7


F

Fig 1C. Immunoprecipitation analysis: positive signal of Dvl in anti-CVAK104 precipitates, but not with control rabbit IgG.

Missing: reference

GO:0001505

regulation of neurotransmitter levels

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P51141

P

complete

GO:0004871

signal transducer activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001158

F

complete

GO:0004871

signal transducer activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003351

F

complete

GO:0004871

signal transducer activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008339

F

complete

GO:0004871

signal transducer activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008340

F

complete

GO:0005109

frizzled binding

PMID:19388021[1]

IPI: Inferred from Physical Interaction

UniProtKB:O75084

F

complete

GO:0005109

frizzled binding

PMID:19388021[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q14332

F

complete

GO:0005109

frizzled binding

PMID:19388021[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q9NPG1

F

complete

GO:0005109

frizzled binding

PMID:19388021[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q9ULV1

F

complete

GO:0005109

frizzled binding

PMID:19388021[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q9UP38

F

complete

GO:0005515

protein binding

PMID:10330181[2]

IPI: Inferred from Physical Interaction

UniProtKB:D4ADV8

F

complete

GO:0005515

protein binding

PMID:10330181[2]

IPI: Inferred from Physical Interaction

UniProtKB:O14640

F

complete

GO:0005515

protein binding

PMID:10330181[2]

IPI: Inferred from Physical Interaction

UniProtKB:Q92997

F

complete

GO:0005515

protein binding

PMID:10644691[3]

IPI: Inferred from Physical Interaction

UniProtKB:O75369

F

complete

GO:0005515

protein binding

PMID:10644691[3]

IPI: Inferred from Physical Interaction

UniProtKB:P35813

F

complete

GO:0005515

protein binding

PMID:10644691[3]

IPI: Inferred from Physical Interaction

UniProtKB:P63172

F

complete

GO:0005515

protein binding

PMID:11113207[4]

IPI: Inferred from Physical Interaction

UniProtKB:O70239

F

complete

GO:0005515

protein binding

PMID:11113207[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q9EQC9

F

complete

GO:0005515

protein binding

PMID:11113207[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q9H2H0

F

complete

GO:0005515

protein binding

PMID:11742073[5]

IPI: Inferred from Physical Interaction

UniProtKB:P29066

F

complete

GO:0005515

protein binding

PMID:14750955[6]

IPI: Inferred from Physical Interaction

UniProtKB:Q6VGS5

F

complete

GO:0005515

protein binding

PMID:19465938[7]

IPI: Inferred from Physical Interaction

UniProtKB:Q9NZC7

F

complete

GO:0005515

protein binding

PMID:20412773[8]

IPI: Inferred from Physical Interaction

UniProtKB:Q9GZV5

F

complete

GO:0005622

intracellular

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001158

C

complete

GO:0005737

cytoplasm

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

complete

GO:0005829

cytosol

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0091

C

complete

GO:0005874

microtubule

GO_REF:0000033

PANTHER:PTHR10878_AN57

C

Missing: evidence

GO:0005886

plasma membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

complete

GO:0005886

plasma membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0039

C

complete

GO:0005938

cell cortex

GO_REF:0000033

PANTHER:PTHR10878_AN0

C

Missing: evidence

GO:0006366

transcription from RNA polymerase II promoter

PMID:11742073[5]

IDA: Inferred from Direct Assay

P

complete

GO:0006469

negative regulation of protein kinase activity

PMID:10330181[2]

IDA: Inferred from Direct Assay

P

complete

GO:0007269

neurotransmitter secretion

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P51141

P

complete

GO:0007275

multicellular organismal development

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001158

P

complete

GO:0007275

multicellular organismal development

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003351

P

complete

GO:0007275

multicellular organismal development

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008339

P

complete

GO:0007275

multicellular organismal development

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008340

P

complete

GO:0007275

multicellular organismal development

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0217

P

complete

GO:0007411

axon guidance

GO_REF:0000033

PANTHER:PTHR10878_AN57

P

Missing: evidence

GO:0007528

neuromuscular junction development

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P51141

P

complete

GO:0016020

membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

complete

GO:0016023

cytoplasmic membrane-bounded vesicle

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0088

C

complete

GO:0016023

cytoplasmic membrane-bounded vesicle

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P51141

C

complete

GO:0016055

Wnt receptor signaling pathway

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0879

P

complete

GO:0019717

synaptosome

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P51141

C

complete

GO:0019899

enzyme binding

PMID:15454084[9]

IPI: Inferred from Physical Interaction

UniProtKB:P34925

F

complete

GO:0019899

enzyme binding

PMID:19643732[10]

IPI: Inferred from Physical Interaction

UniProtKB:P97346

F

complete

GO:0019901

protein kinase binding

PMID:19643732[10]

IPI: Inferred from Physical Interaction

UniProtKB:Q6P3W7

F

complete

GO:0019901

protein kinase binding

PMID:19643732[10]

IPI: Inferred from Physical Interaction

UniProtKB:Q8CFE4

F

complete

GO:0021915

neural tube development

PMID:8817329[11]

IEP: Inferred from Expression Pattern

P

complete

GO:0030136

clathrin-coated vesicle

GO_REF:0000033

PANTHER:PTHR10878_AN57

C

Missing: evidence

GO:0030177

positive regulation of Wnt receptor signaling pathway

PMID:11113207[4]

IDA: Inferred from Direct Assay

P

complete

GO:0030424

axon

GO_REF:0000033

PANTHER:PTHR10878_AN57

C

Missing: evidence

GO:0030425

dendrite

GO_REF:0000033

PANTHER:PTHR10878_AN57

C

Missing: evidence

GO:0030426

growth cone

GO_REF:0000033

PANTHER:PTHR10878_AN57

C

Missing: evidence

GO:0031410

cytoplasmic vesicle

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0968

C

complete

GO:0031410

cytoplasmic vesicle

PMID:11113207[4]

IDA: Inferred from Direct Assay

C

complete

GO:0032091

negative regulation of protein binding

PMID:19643732[10]

IDA: Inferred from Direct Assay

P

complete

GO:0034504

protein localization to nucleus

PMID:10330181[2]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0035556

intracellular signal transduction

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000591

P

complete

GO:0042802

identical protein binding

PMID:10330181[2]

IPI: Inferred from Physical Interaction

UniProtKB:O14640

F

complete

GO:0043025

neuronal cell body

GO_REF:0000033

PANTHER:PTHR10878_AN57

C

Missing: evidence

GO:0043113

receptor clustering

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P51141

P

complete

GO:0045202

synapse

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P51141

C

complete

GO:0045202

synapse

GO_REF:0000033

PANTHER:PTHR10878_AN57

C

Missing: evidence

GO:0045893

positive regulation of transcription, DNA-dependent

PMID:12805222[12]

IDA: Inferred from Direct Assay

P

complete

GO:0045893

positive regulation of transcription, DNA-dependent

PMID:17593335[13]

IDA: Inferred from Direct Assay

P

complete

GO:0048365

Rac GTPase binding

GO_REF:0000033

PANTHER:PTHR10878_AN57

F

Missing: evidence

GO:0048668

collateral sprouting

GO_REF:0000033

PANTHER:PTHR10878_AN57

P

Missing: evidence

GO:0048675

axon extension

GO_REF:0000033

PANTHER:PTHR10878_AN57

P

Missing: evidence

GO:0048813

dendrite morphogenesis

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P51141

P

complete

GO:0048813

dendrite morphogenesis

GO_REF:0000033

PANTHER:PTHR10878_AN57

P

Missing: evidence

GO:0050808

synapse organization

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P51141

P

complete

GO:0060026

convergent extension

GO_REF:0000033

PANTHER:PTHR10878_AN35

P

Missing: evidence

GO:0060070

canonical Wnt receptor signaling pathway

PMID:11113207[4]

IDA: Inferred from Direct Assay

P

complete

GO:0060070

canonical Wnt receptor signaling pathway

PMID:14747478[14]

IDA: Inferred from Direct Assay

P

complete

GO:0060070

canonical Wnt receptor signaling pathway

PMID:17593335[13]

IDA: Inferred from Direct Assay

P

complete

GO:0060071

Wnt receptor signaling pathway, planar cell polarity pathway

PMID:12805222[12]

IDA: Inferred from Direct Assay

P

complete

GO:0071340

skeletal muscle nicotinic acetylcholine receptor clustering

GO_REF:0000033

PANTHER:PTHR10878_AN57

P

Missing: evidence

GO:0090103

cochlea morphogenesis

GO_REF:0000033

PANTHER:PTHR10878_AN35

P

Missing: evidence

GO:0090179

planar cell polarity pathway involved in neural tube closure

GO_REF:0000033

PANTHER:PTHR10878_AN34

P

Missing: evidence

GO:0001505

regulation of neurotransmitter levels

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000030948

P

Seeded From UniProt

complete

GO:0001505

regulation of neurotransmitter levels

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P51141

P

Seeded From UniProt

complete

GO:0001932

regulation of protein phosphorylation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000030948

P

Seeded From UniProt

complete

GO:0001933

negative regulation of protein phosphorylation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000030948

P

Seeded From UniProt

complete

GO:0001934

positive regulation of protein phosphorylation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000030948

P

Seeded From UniProt

complete

GO:0005109

frizzled binding

PMID:19388021[1]

IPI: Inferred from Physical Interaction

UniProtKB:O75084

F

Seeded From UniProt

complete

GO:0005109

frizzled binding

PMID:19388021[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q14332

F

Seeded From UniProt

complete

GO:0005109

frizzled binding

PMID:19388021[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q9NPG1

F

Seeded From UniProt

complete

GO:0005109

frizzled binding

PMID:19388021[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q9ULV1

F

Seeded From UniProt

complete

GO:0005109

frizzled binding

PMID:19388021[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q9UP38

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:10330181[2]

IPI: Inferred from Physical Interaction

UniProtKB:D4ADV8

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:10330181[2]

IPI: Inferred from Physical Interaction

UniProtKB:O14640

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:10330181[2]

IPI: Inferred from Physical Interaction

UniProtKB:O70239

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:10330181[2]

IPI: Inferred from Physical Interaction

UniProtKB:Q92997

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:10330181[2]

IPI: Inferred from Physical Interaction

UniProtKB:Q92997

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:10644691[3]

IPI: Inferred from Physical Interaction

UniProtKB:O75369

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:10644691[3]

IPI: Inferred from Physical Interaction

UniProtKB:P35813

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:10644691[3]

IPI: Inferred from Physical Interaction

UniProtKB:P63172

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11113207[4]

IPI: Inferred from Physical Interaction

UniProtKB:O70239

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11113207[4]

IPI: Inferred from Physical Interaction

UniProtKB:O70239

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11113207[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q9EQC9

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11113207[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q9EQC9

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11113207[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q9H2H0

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11425858[15]

IPI: Inferred from Physical Interaction

UniProtKB:O70239

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11425858[15]

IPI: Inferred from Physical Interaction

UniProtKB:P25054

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11425858[15]

IPI: Inferred from Physical Interaction

UniProtKB:P49674

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11742073[5]

IPI: Inferred from Physical Interaction

UniProtKB:P29066

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:14750955[6]

IPI: Inferred from Physical Interaction

UniProtKB:Q6VGS5

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:19465938[7]

IPI: Inferred from Physical Interaction

UniProtKB:Q9NZC7

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:19625296[16]

IPI: Inferred from Physical Interaction

UniProtKB:Q5S007

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:19643732[10]

IPI: Inferred from Physical Interaction

UniProtKB:Q6P3W7

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:20177058[17]

IPI: Inferred from Physical Interaction

UniProtKB:Q969F2

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:20224554[18]

IPI: Inferred from Physical Interaction

UniProtKB:P25054

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:20412773[8]

IPI: Inferred from Physical Interaction

UniProtKB:Q9GZV5

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:20412773[8]

IPI: Inferred from Physical Interaction

UniProtKB:Q9GZV5

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:22773187[19]

IPI: Inferred from Physical Interaction

UniProtKB:Q14186

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:25557784[20]

IPI: Inferred from Physical Interaction

UniProtKB:Q9UHG0

F

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

GO:0005829

cytosol

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000093945

C

Seeded From UniProt

complete

GO:0005829

cytosol

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0091

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_263855

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_263925

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_263993

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_264193

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_264423

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_264452

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_264481

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_264559

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_264564

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_264574

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005874

microtubule

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000026439

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-1003

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

GO:0006366

transcription from RNA polymerase II promoter

PMID:11742073[5]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0006469

negative regulation of protein kinase activity

PMID:10330181[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0007269

neurotransmitter secretion

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000030948

P

Seeded From UniProt

complete

GO:0007269

neurotransmitter secretion

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P51141

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0007409

axonogenesis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000030948

P

Seeded From UniProt

complete

GO:0007411

axon guidance

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000030948

P

Seeded From UniProt

complete

GO:0007528

neuromuscular junction development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000030948

P

Seeded From UniProt

complete

GO:0007528

neuromuscular junction development

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P51141

P

Seeded From UniProt

complete

GO:0010976

positive regulation of neuron projection development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000030948

P

Seeded From UniProt

complete

GO:0015630

microtubule cytoskeleton

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000030948

C

Seeded From UniProt

complete

GO:0015630

microtubule cytoskeleton

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000026439

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016023

cytoplasmic membrane-bounded vesicle

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000030948

C

Seeded From UniProt

complete

GO:0016023

cytoplasmic membrane-bounded vesicle

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P51141

C

Seeded From UniProt

complete

GO:0016023

cytoplasmic membrane-bounded vesicle

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0088

C

Seeded From UniProt

complete

GO:0016055

Wnt signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008339
InterPro:IPR008340
InterPro:IPR015506

P

Seeded From UniProt

complete

GO:0016055

Wnt signaling pathway

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0879

P

Seeded From UniProt

complete

GO:0019899

enzyme binding

PMID:15454084[9]

IPI: Inferred from Physical Interaction

UniProtKB:P34925

F

Seeded From UniProt

complete

GO:0019899

enzyme binding

PMID:19643732[10]

IPI: Inferred from Physical Interaction

UniProtKB:P97346

F

Seeded From UniProt

complete

GO:0019901

protein kinase binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000026439

F

Seeded From UniProt

complete

GO:0019901

protein kinase binding

PMID:19643732[10]

IPI: Inferred from Physical Interaction

UniProtKB:Q6P3W7

F

Seeded From UniProt

complete

GO:0019901

protein kinase binding

PMID:19643732[10]

IPI: Inferred from Physical Interaction

UniProtKB:Q8CFE4

F

Seeded From UniProt

complete

GO:0021915

neural tube development

PMID:8817329[11]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0022007

convergent extension involved in neural plate elongation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000030948

P

Seeded From UniProt

complete

GO:0030136

clathrin-coated vesicle

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000030948

C

Seeded From UniProt

complete

GO:0030177

positive regulation of Wnt signaling pathway

PMID:11113207[4]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0030424

axon

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000030948

C

Seeded From UniProt

complete

GO:0030424

axon

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000026439

C

Seeded From UniProt

complete

GO:0030425

dendrite

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000026439

C

Seeded From UniProt

complete

GO:0030426

growth cone

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000026439

C

Seeded From UniProt

complete

GO:0031122

cytoplasmic microtubule organization

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000030948

P

Seeded From UniProt

complete

GO:0031410

cytoplasmic vesicle

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0968

C

Seeded From UniProt

complete

GO:0031410

cytoplasmic vesicle

PMID:11113207[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0032091

negative regulation of protein binding

PMID:19643732[10]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

PMID:20177058[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0034504

protein localization to nucleus

PMID:10330181[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035176

social behavior

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000030948

P

Seeded From UniProt

complete

GO:0035372

protein localization to microtubule

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000030948

P

Seeded From UniProt

complete

GO:0035556

intracellular signal transduction

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000591

P

Seeded From UniProt

complete

GO:0042802

identical protein binding

PMID:10330181[2]

IPI: Inferred from Physical Interaction

UniProtKB:O14640

F

Seeded From UniProt

complete

GO:0042802

identical protein binding

PMID:10330181[2]

IPI: Inferred from Physical Interaction

UniProtKB:O14640

F

Seeded From UniProt

complete

GO:0043025

neuronal cell body

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000026439

C

Seeded From UniProt

complete

GO:0043113

receptor clustering

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000030948

P

Seeded From UniProt

complete

GO:0043113

receptor clustering

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P51141

P

Seeded From UniProt

complete

GO:0045202

synapse

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000030948

C

Seeded From UniProt

complete

GO:0045202

synapse

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P51141

C

Seeded From UniProt

complete

GO:0045893

positive regulation of transcription, DNA-templated

PMID:12805222[12]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0045893

positive regulation of transcription, DNA-templated

PMID:17593335[13]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0048365

Rac GTPase binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000026439

F

Seeded From UniProt

complete

GO:0048668

collateral sprouting

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000030948

P

Seeded From UniProt

complete

GO:0048675

axon extension

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000030948

P

Seeded From UniProt

complete

GO:0048813

dendrite morphogenesis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000030948

P

Seeded From UniProt

complete

GO:0048813

dendrite morphogenesis

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P51141

P

Seeded From UniProt

complete

GO:0050808

synapse organization

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000030948

P

Seeded From UniProt

complete

GO:0050808

synapse organization

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P51141

P

Seeded From UniProt

complete

GO:0060029

convergent extension involved in organogenesis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000030948

P

Seeded From UniProt

complete

GO:0060070

canonical Wnt signaling pathway

PMID:11113207[4]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0060070

canonical Wnt signaling pathway

PMID:14747478[14]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0060070

canonical Wnt signaling pathway

PMID:17593335[13]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0060071

Wnt signaling pathway, planar cell polarity pathway

PMID:12805222[12]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0060134

prepulse inhibition

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000030948

P

Seeded From UniProt

complete

GO:0071340

skeletal muscle acetylcholine-gated channel clustering

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000030948

P

Seeded From UniProt

complete

GO:0090090

negative regulation of canonical Wnt signaling pathway

Reactome:REACT_264438

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0090103

cochlea morphogenesis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000030948

P

Seeded From UniProt

complete

GO:0090179

planar cell polarity pathway involved in neural tube closure

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000030948

P

Seeded From UniProt

complete

GO:0090179

planar cell polarity pathway involved in neural tube closure

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000093866

P

Seeded From UniProt

complete

GO:0090263

positive regulation of canonical Wnt signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000030948

P

Seeded From UniProt

complete

GO:0090263

positive regulation of canonical Wnt signaling pathway

Reactome:REACT_264034

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

colocalizes_with

GO:0016328

lateral plasma membrane

PMID:20177058[17]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Punchihewa, C et al. (2009) Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins. Protein Sci. 18 994-1002 PubMed GONUTS page
  2. 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 2.14 Kishida, S et al. (1999) DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability. Mol. Cell. Biol. 19 4414-22 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 Strovel, ET et al. (2000) Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription. J. Biol. Chem. 275 2399-403 PubMed GONUTS page
  4. 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 4.13 Hino, S et al. (2001) Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. Mol. Cell. Biol. 21 330-42 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Chen, W et al. (2001) beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins. Proc. Natl. Acad. Sci. U.S.A. 98 14889-94 PubMed GONUTS page
  6. 6.0 6.1 Oshita, A et al. (2003) Identification and characterization of a novel Dvl-binding protein that suppresses Wnt signalling pathway. Genes Cells 8 1005-17 PubMed GONUTS page
  7. 7.0 7.1 Bouteille, N et al. (2009) Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein. Oncogene 28 2569-80 PubMed GONUTS page
  8. 8.0 8.1 8.2 Varelas, X et al. (2010) The Hippo pathway regulates Wnt/beta-catenin signaling. Dev. Cell 18 579-91 PubMed GONUTS page
  9. 9.0 9.1 Lu, W et al. (2004) Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell 119 97-108 PubMed GONUTS page
  10. 10.0 10.1 10.2 10.3 10.4 10.5 10.6 10.7 10.8 Terabayashi, T et al. (2009) A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5). J. Biol. Chem. 284 26716-24 PubMed GONUTS page
  11. 11.0 11.1 Pizzuti, A et al. (1996) cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene. Hum. Mol. Genet. 5 953-8 PubMed GONUTS page
  12. 12.0 12.1 12.2 12.3 Hocevar, BA et al. (2003) Regulation of the Wnt signaling pathway by disabled-2 (Dab2). EMBO J. 22 3084-94 PubMed GONUTS page
  13. 13.0 13.1 13.2 13.3 Ding, VW et al. (2007) Activation of p53 by Dishevelled independent of Wnt or planar polarity pathways. J. Mol. Med. 85 1281-9 PubMed GONUTS page
  14. 14.0 14.1 Golan, T et al. (2004) The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade. J. Biol. Chem. 279 14879-88 PubMed GONUTS page
  15. 15.0 15.1 15.2 Kishida, M et al. (2001) Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase Iepsilon. J. Biol. Chem. 276 33147-55 PubMed GONUTS page
  16. Sancho, RM et al. (2009) Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways. Hum. Mol. Genet. 18 3955-68 PubMed GONUTS page
  17. 17.0 17.1 17.2 Hu, T et al. (2010) Myristoylated Naked2 antagonizes Wnt-beta-catenin activity by degrading Dishevelled-1 at the plasma membrane. J. Biol. Chem. 285 13561-8 PubMed GONUTS page
  18. Matsumoto, S et al. (2010) Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells. EMBO J. 29 1192-204 PubMed GONUTS page
  19. Kim, WT et al. (2012) Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning. EMBO J. 31 3384-97 PubMed GONUTS page
  20. Schueler, M et al. (2015) DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling. Am. J. Hum. Genet. 96 81-92 PubMed GONUTS page