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HUMAN:DRD2

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Contents

Species (Taxon ID) Homo sapiens (Human). (taxon:9606)
Gene Name(s) DRD2
Protein Name(s)
  • D(2) dopamine receptor
  • Dopamine D2 receptor
External Links
UniProt Identifier DRD2_HUMAN
UniProt Accessions P14416, Q9NZR3, Q9UPA9,
EMBL M30625, X51645, X51646, X51362, M29066, S62137, S69899, S58589, S58577, S58584, S58586, S58588, AF176812, AB065860, AF050737, BC021195,
PIR S08417,
RefSeq NP_000786.1, NP_057658.2,
PDB 1I15, 2HLB,
IntAct P14416,
Ensembl ENST00000362072,
Pfam PF00001,

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001591

dopamine receptor activity, coupled via Gi/Go

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

F

GO:0001591

dopamine receptor activity, coupled via Gi/Go

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

F

GO:0001591

dopamine receptor activity, coupled via Gi/Go

PMID:2531656[1]

IDA: Inferred from Direct Assay

F

GO:0001591

dopamine receptor activity, coupled via Gi/Go

PMID:2531656[1]

IDA: Inferred from Direct Assay

F

GO:0001659

temperature homeostasis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0001659

temperature homeostasis

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0001666

response to hypoxia

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0001669

acrosomal vesicle

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

C

GO:0001670

dopamine D2 receptor activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

F

GO:0001670

dopamine D2 receptor activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

F

GO:0001670

dopamine D2 receptor activity

PMID:8301582[2]

IDA: Inferred from Direct Assay

F

GO:0001963

synaptic transmission, dopaminergic

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0001964

startle response

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0001975

response to amphetamine

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0001975

response to amphetamine

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0001975

response to amphetamine

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0001976

neurological system process involved in regulation of systemic arterial blood pressure

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0001976

neurological system process involved in regulation of systemic arterial blood pressure

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0002027

regulation of heart rate

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0002027

regulation of heart rate

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0002028

regulation of sodium ion transport

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0002028

regulation of sodium ion transport

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0002031

G-protein coupled receptor internalization

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0002052

positive regulation of neuroblast proliferation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0002052

positive regulation of neuroblast proliferation

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0002092

positive regulation of receptor internalization

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0004871

signal transducer activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0807

F

GO:0004872

receptor activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0675

F

GO:0004930

G-protein coupled receptor activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0297

F

GO:0004930

G-protein coupled receptor activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

F

GO:0004952

dopamine receptor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000929

F

GO:0004952

dopamine receptor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001922

F

GO:0004952

dopamine receptor activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

F

GO:0004952

dopamine receptor activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

F

GO:0005102

receptor binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

F

GO:0005515

protein binding

PMID:10692483[3]

IPI: Inferred from Physical Interaction

UniProtKB:P21333

F

GO:0005515

protein binding

PMID:12297500[4]

IPI: Inferred from Physical Interaction

UniProtKB:P48051

F

GO:0005515

protein binding

PMID:12297500[4]

IPI: Inferred from Physical Interaction

UniProtKB:P48544

F

GO:0005515

protein binding

PMID:12297500[4]

IPI: Inferred from Physical Interaction

UniProtKB:P48549

F

GO:0005515

protein binding

PMID:12297500[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q92806

F

GO:0005515

protein binding

PMID:19632986[5]

IPI: Inferred from Physical Interaction

UniProtKB:P29274

F

GO:0005515

protein binding

PMID:19632986[5]

IPI: Inferred from Physical Interaction

UniProtKB:P62158

F

GO:0005625

soluble fraction

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

C

GO:0005886

plasma membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

GO:0005886

plasma membrane

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

C

GO:0005886

plasma membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0039

C

GO:0005886

plasma membrane

PMID:18577758[6]

EXP: Inferred from Experiment

C

GO:0005886

plasma membrane

PMID:2834384[7]

EXP: Inferred from Experiment

C

GO:0005886

plasma membrane

Reactome:REACT_15538

TAS: Traceable Author Statement

C

GO:0005886

plasma membrane

Reactome:REACT_16959

TAS: Traceable Author Statement

C

GO:0005887

integral to plasma membrane

PMID:2531656[1]

IC: Inferred by Curator

GO:0001591

C

GO:0005887

integral to plasma membrane

PMID:2531656[1]

IC: Inferred by Curator

GO:0001591

C

GO:0005887

integral to plasma membrane

PMID:8413587[8]

IDA: Inferred from Direct Assay

C

GO:0006874

cellular calcium ion homeostasis

PMID:7921596[9]

IC: Inferred by Curator

GO:0051927

P

GO:0007165

signal transduction

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0807

P

GO:0007186

G-protein coupled receptor protein signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000276

P

GO:0007186

G-protein coupled receptor protein signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000929

P

GO:0007186

G-protein coupled receptor protein signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001922

P

GO:0007186

G-protein coupled receptor protein signaling pathway

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0297

P

GO:0007186

G-protein coupled receptor protein signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0007188

G-protein signaling, coupled to cAMP nucleotide second messenger

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0007194

negative regulation of adenylate cyclase activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0007194

negative regulation of adenylate cyclase activity

PMID:2531656[1]

IDA: Inferred from Direct Assay

P

GO:0007194

negative regulation of adenylate cyclase activity

PMID:2531656[1]

IDA: Inferred from Direct Assay

P

GO:0007195

inhibition of adenylate cyclase activity by dopamine receptor signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0007195

inhibition of adenylate cyclase activity by dopamine receptor signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0007195

inhibition of adenylate cyclase activity by dopamine receptor signaling pathway

PMID:1331329[10]

IDA: Inferred from Direct Assay

P

GO:0007195

inhibition of adenylate cyclase activity by dopamine receptor signaling pathway

PMID:1331329[10]

IDA: Inferred from Direct Assay

P

GO:0007195

inhibition of adenylate cyclase activity by dopamine receptor signaling pathway

PMID:2531656[1]

IDA: Inferred from Direct Assay

P

GO:0007195

inhibition of adenylate cyclase activity by dopamine receptor signaling pathway

PMID:2531656[1]

IDA: Inferred from Direct Assay

P

GO:0007212

dopamine receptor signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0007212

dopamine receptor signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0007243

intracellular protein kinase cascade

PMID:1331329[10]

IDA: Inferred from Direct Assay

P

GO:0007243

intracellular protein kinase cascade

PMID:1331329[10]

IDA: Inferred from Direct Assay

P

GO:0007270

nerve-nerve synaptic transmission

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0007270

nerve-nerve synaptic transmission

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0007409

axonogenesis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0007409

axonogenesis

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0007416

synapse assembly

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0007416

synapse assembly

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61169

P

GO:0007608

sensory perception of smell

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0007608

sensory perception of smell

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0007616

long-term memory

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0007625

grooming behavior

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0007626

locomotory behavior

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0007626

locomotory behavior

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0007626

locomotory behavior

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0007628

adult walking behavior

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0007628

adult walking behavior

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0007631

feeding behavior

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0008104

protein localization

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0008104

protein localization

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0008144

drug binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

F

GO:0008144

drug binding

PMID:8413587[8]

IDA: Inferred from Direct Assay

F

GO:0008285

negative regulation of cell proliferation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0008285

negative regulation of cell proliferation

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0008306

associative learning

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0008306

associative learning

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0008542

visual learning

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0008542

visual learning

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0009416

response to light stimulus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0009416

response to light stimulus

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0009636

response to toxin

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0010039

response to iron ion

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0014059

regulation of dopamine secretion

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0014069

postsynaptic density

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

C

GO:0015459

potassium channel regulator activity

PMID:12297500[4]

NAS: Non-traceable Author Statement

F

GO:0016020

membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

GO:0016020

membrane

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

C

GO:0016020

membrane

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

C

GO:0016021

integral to membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000276

C

GO:0016021

integral to membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000929

C

GO:0016021

integral to membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001922

C

GO:0016021

integral to membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

GO:0016055

Wnt receptor signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0016328

lateral plasma membrane

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

C

GO:0019861

flagellum

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

C

GO:0021853

cerebral cortex GABAergic interneuron migration

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0021853

cerebral cortex GABAergic interneuron migration

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0021984

adenohypophysis development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0021984

adenohypophysis development

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0030139

endocytic vesicle

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

C

GO:0030146

diuresis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0030146

diuresis

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0030147

natriuresis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0030147

natriuresis

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0030336

negative regulation of cell migration

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0030336

negative regulation of cell migration

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0030424

axon

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

C

GO:0030424

axon

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

C

GO:0030424

axon

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

C

GO:0030425

dendrite

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

C

GO:0030425

dendrite

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

C

GO:0030425

dendrite

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

C

GO:0030432

peristalsis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0030432

peristalsis

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0030534

adult behavior

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0030672

synaptic vesicle membrane

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

C

GO:0030814

regulation of cAMP metabolic process

PMID:8666994[11]

IDA: Inferred from Direct Assay

P

GO:0030900

forebrain development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0031223

auditory behavior

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0031410

cytoplasmic vesicle

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

C

GO:0032147

activation of protein kinase activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0032228

regulation of synaptic transmission, GABAergic

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0032228

regulation of synaptic transmission, GABAergic

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0032922

circadian regulation of gene expression

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0032922

circadian regulation of gene expression

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0034776

response to histamine

PMID:16839358[12]

IDA: Inferred from Direct Assay

P

GO:0035094

response to nicotine

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0035240

dopamine binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

F

GO:0035240

dopamine binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

F

GO:0035255

ionotropic glutamate receptor binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

F

GO:0040018

positive regulation of multicellular organism growth

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0042220

response to cocaine

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0042220

response to cocaine

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0042321

negative regulation of circadian sleep/wake cycle, sleep

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0042417

dopamine metabolic process

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0042417

dopamine metabolic process

PMID:8301582[2]

IC: Inferred by Curator

GO:0001670

P

GO:0042493

response to drug

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0042493

response to drug

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0042493

response to drug

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61169

P

GO:0043197

dendritic spine

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

C

GO:0043204

perikaryon

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

C

GO:0043266

regulation of potassium ion transport

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0043266

regulation of potassium ion transport

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0043266

regulation of potassium ion transport

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61169

P

GO:0043278

response to morphine

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0043278

response to morphine

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0043408

regulation of MAPKKK cascade

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0043473

pigmentation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0043666

regulation of phosphoprotein phosphatase activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0043679

axon terminus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

C

GO:0045471

response to ethanol

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0045745

positive regulation of G-protein coupled receptor protein signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0045776

negative regulation of blood pressure

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0045776

negative regulation of blood pressure

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0046488

phosphatidylinositol metabolic process

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61169

P

GO:0046676

negative regulation of insulin secretion

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0046717

acid secretion

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0048148

behavioral response to cocaine

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0048148

behavioral response to cocaine

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0048149

behavioral response to ethanol

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0048149

behavioral response to ethanol

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0048169

regulation of long-term neuronal synaptic plasticity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0048169

regulation of long-term neuronal synaptic plasticity

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0048678

response to axon injury

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0048755

branching morphogenesis of a nerve

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0048755

branching morphogenesis of a nerve

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0050482

arachidonic acid secretion

PMID:8301582[2]

IDA: Inferred from Direct Assay

P

GO:0050709

negative regulation of protein secretion

PMID:16839358[12]

IDA: Inferred from Direct Assay

P

GO:0050804

regulation of synaptic transmission

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0050804

regulation of synaptic transmission

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0051209

release of sequestered calcium ion into cytosol

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0051209

release of sequestered calcium ion into cytosol

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61169-2

P

GO:0051481

reduction of cytosolic calcium ion concentration

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0051482

elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger

PMID:1331329[10]

IDA: Inferred from Direct Assay

P

GO:0051482

elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger

PMID:1331329[10]

IDA: Inferred from Direct Assay

P

GO:0051584

regulation of dopamine uptake

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0051584

regulation of dopamine uptake

PMID:8301582[2]

IC: Inferred by Curator

GO:0001670

P

GO:0051586

positive regulation of dopamine uptake

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0051586

positive regulation of dopamine uptake

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0051898

negative regulation of protein kinase B signaling cascade

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0051898

negative regulation of protein kinase B signaling cascade

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0051927

negative regulation of calcium ion transport via voltage-gated calcium channel activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0051927

negative regulation of calcium ion transport via voltage-gated calcium channel activity

PMID:7921596[9]

IDA: Inferred from Direct Assay

P

GO:0051967

negative regulation of synaptic transmission, glutamatergic

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0051967

negative regulation of synaptic transmission, glutamatergic

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0060124

positive regulation of growth hormone secretion

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0060124

positive regulation of growth hormone secretion

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0060134

prepulse inhibition

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0060134

prepulse inhibition

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0060158

activation of phospholipase C activity by dopamine receptor signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0060158

activation of phospholipase C activity by dopamine receptor signaling pathway

PMID:17194762[13]

IGI: Inferred from Genetic Interaction

UniProtKB:P21728

P

GO:0060160

negative regulation of dopamine receptor signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0060160

negative regulation of dopamine receptor signaling pathway

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0070374

positive regulation of ERK1 and ERK2 cascade

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0001591

dopamine receptor activity, coupled via Gi/Go

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

F

GO:0001591

dopamine receptor activity, coupled via Gi/Go

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

F

GO:0001591

dopamine receptor activity, coupled via Gi/Go

PMID:2531656[1]

IDA: Inferred from Direct Assay

F

GO:0001591

dopamine receptor activity, coupled via Gi/Go

PMID:2531656[1]

IDA: Inferred from Direct Assay

F

GO:0001659

temperature homeostasis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0001659

temperature homeostasis

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0001666

response to hypoxia

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0001669

acrosomal vesicle

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

C

GO:0001670

dopamine D2 receptor activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

F

GO:0001670

dopamine D2 receptor activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

F

GO:0001670

dopamine D2 receptor activity

PMID:8301582[2]

IDA: Inferred from Direct Assay

F

GO:0001963

synaptic transmission, dopaminergic

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0001964

startle response

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0001975

response to amphetamine

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0001975

response to amphetamine

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0001975

response to amphetamine

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0001976

neurological system process involved in regulation of systemic arterial blood pressure

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0001976

neurological system process involved in regulation of systemic arterial blood pressure

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0002027

regulation of heart rate

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0002027

regulation of heart rate

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0002028

regulation of sodium ion transport

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0002028

regulation of sodium ion transport

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0002031

G-protein coupled receptor internalization

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0002052

positive regulation of neuroblast proliferation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0002052

positive regulation of neuroblast proliferation

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0002092

positive regulation of receptor internalization

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0004871

signal transducer activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0807

F

GO:0004872

receptor activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0675

F

GO:0004930

G-protein coupled receptor activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0297

F

GO:0004930

G-protein coupled receptor activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

F

GO:0004952

dopamine receptor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000929

F

GO:0004952

dopamine receptor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001922

F

GO:0004952

dopamine receptor activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

F

GO:0004952

dopamine receptor activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

F

GO:0005102

receptor binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

F

GO:0005515

protein binding

PMID:10692483[3]

IPI: Inferred from Physical Interaction

UniProtKB:P21333

F

GO:0005515

protein binding

PMID:12297500[4]

IPI: Inferred from Physical Interaction

UniProtKB:P48051

F

GO:0005515

protein binding

PMID:12297500[4]

IPI: Inferred from Physical Interaction

UniProtKB:P48544

F

GO:0005515

protein binding

PMID:12297500[4]

IPI: Inferred from Physical Interaction

UniProtKB:P48549

F

GO:0005515

protein binding

PMID:12297500[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q92806

F

GO:0005515

protein binding

PMID:19632986[5]

IPI: Inferred from Physical Interaction

UniProtKB:P29274

F

GO:0005515

protein binding

PMID:19632986[5]

IPI: Inferred from Physical Interaction

UniProtKB:P62158

F

GO:0005625

soluble fraction

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

C

GO:0005886

plasma membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

GO:0005886

plasma membrane

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

C

GO:0005886

plasma membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0039

C

GO:0005886

plasma membrane

Reactome:REACT_15538

TAS: Traceable Author Statement

C

GO:0005886

plasma membrane

Reactome:REACT_16959

TAS: Traceable Author Statement

C

GO:0005886

plasma membrane

Reactome:REACT_22239

TAS: Traceable Author Statement

C

GO:0005886

plasma membrane

Reactome:REACT_22289

TAS: Traceable Author Statement

C

GO:0005887

integral to plasma membrane

PMID:2531656[1]

IC: Inferred by Curator

GO:0001591

C

GO:0005887

integral to plasma membrane

PMID:2531656[1]

IC: Inferred by Curator

GO:0001591

C

GO:0005887

integral to plasma membrane

PMID:8413587[8]

IDA: Inferred from Direct Assay

C

GO:0006874

cellular calcium ion homeostasis

PMID:7921596[9]

IC: Inferred by Curator

GO:0051927

P

GO:0007165

signal transduction

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0807

P

GO:0007186

G-protein coupled receptor protein signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000276

P

GO:0007186

G-protein coupled receptor protein signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000929

P

GO:0007186

G-protein coupled receptor protein signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001922

P

GO:0007186

G-protein coupled receptor protein signaling pathway

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0297

P

GO:0007186

G-protein coupled receptor protein signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0007188

G-protein signaling, coupled to cAMP nucleotide second messenger

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0007194

negative regulation of adenylate cyclase activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0007194

negative regulation of adenylate cyclase activity

PMID:2531656[1]

IDA: Inferred from Direct Assay

P

GO:0007194

negative regulation of adenylate cyclase activity

PMID:2531656[1]

IDA: Inferred from Direct Assay

P

GO:0007195

inhibition of adenylate cyclase activity by dopamine receptor signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0007195

inhibition of adenylate cyclase activity by dopamine receptor signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0007195

inhibition of adenylate cyclase activity by dopamine receptor signaling pathway

PMID:1331329[10]

IDA: Inferred from Direct Assay

P

GO:0007195

inhibition of adenylate cyclase activity by dopamine receptor signaling pathway

PMID:1331329[10]

IDA: Inferred from Direct Assay

P

GO:0007195

inhibition of adenylate cyclase activity by dopamine receptor signaling pathway

PMID:2531656[1]

IDA: Inferred from Direct Assay

P

GO:0007195

inhibition of adenylate cyclase activity by dopamine receptor signaling pathway

PMID:2531656[1]

IDA: Inferred from Direct Assay

P

GO:0007212

dopamine receptor signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0007212

dopamine receptor signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0007243

intracellular protein kinase cascade

PMID:1331329[10]

IDA: Inferred from Direct Assay

P

GO:0007243

intracellular protein kinase cascade

PMID:1331329[10]

IDA: Inferred from Direct Assay

P

GO:0007270

neuron-neuron synaptic transmission

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0007270

neuron-neuron synaptic transmission

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0007409

axonogenesis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0007409

axonogenesis

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0007416

synapse assembly

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0007416

synapse assembly

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61169

P

GO:0007608

sensory perception of smell

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0007608

sensory perception of smell

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0007616

long-term memory

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0007625

grooming behavior

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0007626

locomotory behavior

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0007626

locomotory behavior

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0007626

locomotory behavior

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0007628

adult walking behavior

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0007628

adult walking behavior

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0007631

feeding behavior

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0008104

protein localization

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0008104

protein localization

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0008144

drug binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

F

GO:0008144

drug binding

PMID:8413587[8]

IDA: Inferred from Direct Assay

F

GO:0008285

negative regulation of cell proliferation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0008285

negative regulation of cell proliferation

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0008306

associative learning

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0008306

associative learning

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0008542

visual learning

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0008542

visual learning

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0009416

response to light stimulus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0009416

response to light stimulus

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0009636

response to toxin

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0010039

response to iron ion

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0014059

regulation of dopamine secretion

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0014069

postsynaptic density

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

C

GO:0015459

potassium channel regulator activity

PMID:12297500[4]

NAS: Non-traceable Author Statement

F

GO:0016020

membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

GO:0016020

membrane

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

C

GO:0016020

membrane

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

C

GO:0016021

integral to membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000276

C

GO:0016021

integral to membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000929

C

GO:0016021

integral to membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001922

C

GO:0016021

integral to membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

GO:0016055

Wnt receptor signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0016328

lateral plasma membrane

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

C

GO:0019861

flagellum

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

C

GO:0021853

cerebral cortex GABAergic interneuron migration

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0021853

cerebral cortex GABAergic interneuron migration

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0021984

adenohypophysis development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0021984

adenohypophysis development

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0030139

endocytic vesicle

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

C

GO:0030336

negative regulation of cell migration

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0030336

negative regulation of cell migration

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0030424

axon

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

C

GO:0030424

axon

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

C

GO:0030424

axon

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

C

GO:0030425

dendrite

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

C

GO:0030425

dendrite

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

C

GO:0030425

dendrite

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

C

GO:0030432

peristalsis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0030432

peristalsis

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0030534

adult behavior

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0030672

synaptic vesicle membrane

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

C

GO:0030814

regulation of cAMP metabolic process

PMID:8666994[11]

IDA: Inferred from Direct Assay

P

GO:0030900

forebrain development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0031223

auditory behavior

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0031410

cytoplasmic vesicle

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

C

GO:0032147

activation of protein kinase activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0032228

regulation of synaptic transmission, GABAergic

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0032228

regulation of synaptic transmission, GABAergic

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0032922

circadian regulation of gene expression

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0032922

circadian regulation of gene expression

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0034776

response to histamine

PMID:16839358[12]

IDA: Inferred from Direct Assay

P

GO:0035094

response to nicotine

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0035240

dopamine binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

F

GO:0035240

dopamine binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

F

GO:0035255

ionotropic glutamate receptor binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

F

GO:0035810

positive regulation of urine volume

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0035815

positive regulation of renal sodium excretion

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0040018

positive regulation of multicellular organism growth

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0042220

response to cocaine

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0042220

response to cocaine

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0042321

negative regulation of circadian sleep/wake cycle, sleep

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0042417

dopamine metabolic process

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0042417

dopamine metabolic process

PMID:8301582[2]

IC: Inferred by Curator

GO:0001670

P

GO:0042493

response to drug

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0042493

response to drug

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0042493

response to drug

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61169

P

GO:0043197

dendritic spine

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

C

GO:0043204

perikaryon

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

C

GO:0043266

regulation of potassium ion transport

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0043266

regulation of potassium ion transport

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0043266

regulation of potassium ion transport

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61169

P

GO:0043278

response to morphine

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0043278

response to morphine

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0043408

regulation of MAPKKK cascade

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0043473

pigmentation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0043666

regulation of phosphoprotein phosphatase activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0043679

axon terminus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

C

GO:0045471

response to ethanol

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0045745

positive regulation of G-protein coupled receptor protein signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0045776

negative regulation of blood pressure

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0045776

negative regulation of blood pressure

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0046488

phosphatidylinositol metabolic process

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0046488

phosphatidylinositol metabolic process

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61169

P

GO:0046676

negative regulation of insulin secretion

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0046717

acid secretion

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0048148

behavioral response to cocaine

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0048148

behavioral response to cocaine

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0048149

behavioral response to ethanol

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0048149

behavioral response to ethanol

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0048169

regulation of long-term neuronal synaptic plasticity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0048169

regulation of long-term neuronal synaptic plasticity

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0048678

response to axon injury

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0048755

branching morphogenesis of a nerve

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0048755

branching morphogenesis of a nerve

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0050482

arachidonic acid secretion

PMID:8301582[2]

IDA: Inferred from Direct Assay

P

GO:0050709

negative regulation of protein secretion

PMID:16839358[12]

IDA: Inferred from Direct Assay

P

GO:0050804

regulation of synaptic transmission

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0050804

regulation of synaptic transmission

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0051209

release of sequestered calcium ion into cytosol

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0051209

release of sequestered calcium ion into cytosol

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61169-2

P

GO:0051481

reduction of cytosolic calcium ion concentration

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0051482

elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger

PMID:1331329[10]

IDA: Inferred from Direct Assay

P

GO:0051482

elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger

PMID:1331329[10]

IDA: Inferred from Direct Assay

P

GO:0051584

regulation of dopamine uptake

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0051584

regulation of dopamine uptake

PMID:8301582[2]

IC: Inferred by Curator

GO:0001670

P

GO:0051586

positive regulation of dopamine uptake

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0051586

positive regulation of dopamine uptake

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0051898

negative regulation of protein kinase B signaling cascade

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0051927

negative regulation of calcium ion transport via voltage-gated calcium channel activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P

GO:0051927

negative regulation of calcium ion transport via voltage-gated calcium channel activity

PMID:7921596[9]

IDA: Inferred from Direct Assay

P

GO:0051967

negative regulation of synaptic transmission, glutamatergic

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0051967

negative regulation of synaptic transmission, glutamatergic

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0060124

positive regulation of growth hormone secretion

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0060124

positive regulation of growth hormone secretion

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0060134

prepulse inhibition

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0060134

prepulse inhibition

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0060158

activation of phospholipase C activity by dopamine receptor signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0060158

activation of phospholipase C activity by dopamine receptor signaling pathway

PMID:17194762[13]

IGI: Inferred from Genetic Interaction

UniProtKB:P21728

P

GO:0060160

negative regulation of dopamine receptor signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000075170

P

GO:0060160

negative regulation of dopamine receptor signaling pathway

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P61168

P

GO:0070374

positive regulation of ERK1 and ERK2 cascade

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063750

P


Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 Dal Toso R et al. (1989) The dopamine D2 receptor: two molecular forms generated by alternative splicing. EMBO J 8: 4025-34 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Freedman SB et al. (1994) Expression and pharmacological characterization of the human D3 dopamine receptor. J Pharmacol Exp Ther 268: 417-26 PubMed GONUTS page
  3. ↑ 3.0 3.1 Li M et al. (2000) Modulation of dopamine D(2) receptor signaling by actin-binding protein (ABP-280). Mol Pharmacol 57: 446-52 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 4.9 Lavine N et al. (2002) G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase. J Biol Chem 277: 46010-9 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Navarro G et al. (2009) Interactions between calmodulin, adenosine A2A, and dopamine D2 receptors. J Biol Chem 284: 28058-68 PubMed GONUTS page
  6. ↑ Lambert NA (2008) Dissociation of heterotrimeric g proteins in cells. Sci Signal 1: re5 PubMed GONUTS page
  7. ↑ Itoh H et al. (1988) Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs. J Biol Chem 263: 6656-64 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 8.3 Seeman P et al. (1993) Dopamine D4 receptors elevated in schizophrenia. Nature 365: 441-5 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 9.3 Seabrook GR et al. (1994) Pharmacology of high-threshold calcium currents in GH4C1 pituitary cells and their regulation by activation of human D2 and D4 dopamine receptors. Br J Pharmacol 112: 728-34 PubMed GONUTS page
  10. ↑ 10.00 10.01 10.02 10.03 10.04 10.05 10.06 10.07 10.08 10.09 10.10 10.11 Liu YF et al. (1992) Differential sensitivity of the short and long human dopamine D2 receptor subtypes to protein kinase C. J Neurochem 59: 2311-7 PubMed GONUTS page
  11. ↑ 11.0 11.1 Robinson SW & Caron MG (1996) Chimeric D2/D3 dopamine receptors efficiently inhibit adenylyl cyclase in HEK 293 cells. J Neurochem 67: 212-9 PubMed GONUTS page
  12. ↑ 12.0 12.1 12.2 12.3 Zarei S et al. (2006) Dopamine modulates von Willebrand factor secretion in endothelial cells via D2-D4 receptors. J Thromb Haemost 4: 1588-95 PubMed GONUTS page
  13. ↑ 13.0 13.1 Rashid AJ et al. (2007) D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum. Proc Natl Acad Sci U S A 104: 654-9 PubMed GONUTS page
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