HUMAN:DOPO

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Species (Taxon ID)	Homo sapiens (Human). ([1])
Gene Name(s)	DBH
Protein Name(s)	Dopamine beta-hydroxylase Dopamine beta-monooxygenase Soluble dopamine beta-hydroxylase
External Links
EMBL	AL365494 Y00096 BC017174 X13255 X13256
IPI	IPI00171678
PIR	S03020
RefSeq	NP_000778.3
UniGene	Hs.591890
ProteinModelPortal	P09172
MINT	MINT-2843963
STRING	P09172
PhosphoSite	P09172
PRIDE	P09172
Ensembl	ENST00000393056
GeneID	1621
KEGG	hsa:1621
UCSC	uc004cel.1
CTD	1621
GeneCards	GC09P106002
H-InvDB	HIX0008510
HGNC	HGNC:2689
HPA	HPA005960
MIM	223360 609312
neXtProt	NX_P09172
Orphanet	230
PharmGKB	PA136
eggNOG	prNOG12129
GeneTree	ENSGT00530000063085
HOGENOM	HBG443534
HOVERGEN	HBG005519
InParanoid	P09172
OMA	LDSQQDY
OrthoDB	EOG4SN1ND
Reactome	REACT_111217
DrugBank	DB00988 DB00126
NextBio	6654
ArrayExpress	P09172
Bgee	P09172
CleanEx	HS_DBH
Genevestigator	P09172
GermOnline	ENSG00000123454
GO	GO:0034466 GO:0042584 GO:0005576 GO:0016021 GO:0005624 GO:0005625 GO:0030658 GO:0004500 GO:0031418 GO:0042446
InterPro	IPR014784 IPR020611 IPR014783 IPR000323 IPR005018 IPR000945 IPR008977
Gene3D	G3DSA:2.60.120.230 G3DSA:2.60.120.310
KO	K00503
PANTHER	PTHR10157
Pfam	PF01082 PF03351
PRINTS	PR00767
SMART	SM00664
SUPFAM	SSF49742
PROSITE	PS00084 PS00085 PS50836

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0001816	cytokine production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000910	P	Seeded From UniProt
	GO:0001974	blood vessel remodeling	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000910	P	Seeded From UniProt
	GO:0001975	response to amphetamine	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000910	P	Seeded From UniProt
	GO:0002443	leukocyte mediated immunity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000910	P	Seeded From UniProt
	GO:0003824	catalytic activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008977	F	Seeded From UniProt
	GO:0003824	catalytic activity	PMID:3443096^[1]	TAS: Traceable Author Statement		F	Seeded From UniProt
	GO:0004497	monooxygenase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000323	F	Seeded From UniProt
	GO:0004497	monooxygenase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0503	F	Seeded From UniProt
	GO:0004500	dopamine beta-monooxygenase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000945	F	Seeded From UniProt
	GO:0004500	dopamine beta-monooxygenase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:1.14.17.1	F	Seeded From UniProt
	GO:0004500	dopamine beta-monooxygenase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000057915	F	Seeded From UniProt
	GO:0004500	dopamine beta-monooxygenase activity	Reactome:REACT_15372	TAS: Traceable Author Statement		F	Seeded From UniProt
	GO:0005507	copper ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000323	F	Seeded From UniProt
	GO:0005507	copper ion binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000057915	F	Seeded From UniProt
	GO:0005576	extracellular region	PMID:14718574^[2]	NAS: Non-traceable Author Statement		C	Seeded From UniProt
	GO:0005624	membrane fraction	PMID:3443096^[1]	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005625	soluble fraction	PMID:3443096^[1]	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000057915	C	Seeded From UniProt
	GO:0005737	cytoplasm	PMID:3443096^[1]	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0006584	catecholamine metabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000945	P	Seeded From UniProt
	GO:0007268	synaptic transmission	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000057915	P	Seeded From UniProt
	GO:0007268	synaptic transmission	PMID:2880016^[3]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0007613	memory	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000910	P	Seeded From UniProt
	GO:0007626	locomotory behavior	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000910	P	Seeded From UniProt
	GO:0008306	associative learning	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000910	P	Seeded From UniProt
	GO:0008542	visual learning	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000910	P	Seeded From UniProt
	GO:0010039	response to iron ion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000057915	P	Seeded From UniProt
	GO:0010193	response to ozone	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000057915	P	Seeded From UniProt
	GO:0010259	multicellular organismal aging	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000057915	P	Seeded From UniProt
	GO:0014070	response to organic cyclic compound	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000057915	P	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C	Seeded From UniProt
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C	Seeded From UniProt
	GO:0016023	cytoplasmic membrane-bounded vesicle	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000057915	C	Seeded From UniProt
	GO:0016023	cytoplasmic membrane-bounded vesicle	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0088	C	Seeded From UniProt
	GO:0016491	oxidoreductase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	F	Seeded From UniProt
	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000323	F	Seeded From UniProt
	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014783	F	Seeded From UniProt
	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014784	F	Seeded From UniProt
	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020611	F	Seeded From UniProt
	GO:0030141	stored secretory granule	Reactome:REACT_15372	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0030424	axon	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000057915	C	Seeded From UniProt
	GO:0030425	dendrite	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000057915	C	Seeded From UniProt
	GO:0030658	transport vesicle membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0245	C	Seeded From UniProt
	GO:0031410	cytoplasmic vesicle	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0968	C	Seeded From UniProt
	GO:0031418	L-ascorbic acid binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0847	F	Seeded From UniProt
	GO:0032355	response to estradiol stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000057915	P	Seeded From UniProt
	GO:0034466	chromaffin granule lumen	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0349	C	Seeded From UniProt
	GO:0034641	cellular nitrogen compound metabolic process	Reactome:REACT_13	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0035176	social behavior	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000057915	P	Seeded From UniProt
	GO:0042127	regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000910	P	Seeded From UniProt
	GO:0042309	homoiothermy	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000910	P	Seeded From UniProt
	GO:0042420	dopamine catabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000910	P	Seeded From UniProt
	GO:0042421	norepinephrine biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000910	P	Seeded From UniProt
	GO:0042421	norepinephrine biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000057915	P	Seeded From UniProt
	GO:0042423	catecholamine biosynthetic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0127	P	Seeded From UniProt
	GO:0042446	hormone biosynthetic process	Reactome:REACT_15314	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0042583	chromaffin granule	GO_REF:0000029	NAS: Non-traceable Author Statement		C	Seeded From UniProt
	GO:0042584	chromaffin granule membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0062	C	Seeded From UniProt
	GO:0042593	glucose homeostasis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000910	P	Seeded From UniProt
	GO:0042593	glucose homeostasis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000057915	P	Seeded From UniProt
	GO:0042596	fear response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000910	P	Seeded From UniProt
	GO:0042711	maternal behavior	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000910	P	Seeded From UniProt
	GO:0042981	regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000910	P	Seeded From UniProt
	GO:0043025	neuronal cell body	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000057915	C	Seeded From UniProt
	GO:0043195	terminal button	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000057915	C	Seeded From UniProt
	GO:0043196	varicosity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000057915	C	Seeded From UniProt
	GO:0043434	response to peptide hormone stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000057915	P	Seeded From UniProt
	GO:0045177	apical part of cell	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000057915	C	Seeded From UniProt
	GO:0045202	synapse	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000057915	C	Seeded From UniProt
	GO:0045471	response to ethanol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000057915	P	Seeded From UniProt
	GO:0045907	positive regulation of vasoconstriction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000910	P	Seeded From UniProt
	GO:0046333	octopamine metabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000057915	P	Seeded From UniProt
	GO:0046688	response to copper ion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000057915	P	Seeded From UniProt
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F	Seeded From UniProt
	GO:0048149	behavioral response to ethanol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000910	P	Seeded From UniProt
	GO:0048265	response to pain	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000910	P	Seeded From UniProt
	GO:0050900	leukocyte migration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000000910	P	Seeded From UniProt
	GO:0050909	sensory perception of taste	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000057915	P	Seeded From UniProt
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000323	P	Seeded From UniProt
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000945	P	Seeded From UniProt
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014783	P	Seeded From UniProt
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014784	P	Seeded From UniProt
	GO:0055114	oxidation-reduction process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020611	P	Seeded From UniProt
	GO:0055114	oxidation-reduction process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	P	Seeded From UniProt
	GO:0060348	bone development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000057915	P	Seeded From UniProt
	GO:0071287	cellular response to manganese ion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000057915	P	Seeded From UniProt
	GO:0071316	cellular response to nicotine	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000057915	P	Seeded From UniProt
	GO:0004500		PMID:15164053^[4]	ISA: Inferred from Sequence Alignment			Figure 4	Missing: with/from
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Lamouroux A et al. (1987) The primary structure of human dopamine-beta-hydroxylase: insights into the relationship between the soluble and the membrane-bound forms of the enzyme. EMBO J 6: 3931-7 PubMed GONUTS page
↑ Anderson NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol Cell Proteomics 3: 311-26 PubMed GONUTS page
↑ Man in 't Veld AJ et al. (1987) Congenital dopamine-beta-hydroxylase deficiency. A novel orthostatic syndrome. Lancet 1: 183-8 PubMed GONUTS page
↑ Humphray SJ et al. (2004) DNA sequence and analysis of human chromosome 9. Nature 429: 369-74 PubMed GONUTS page

[PMID:3443096-0] 1.0 ^1.1 ^1.2 ^1.3 Lamouroux A et al. (1987) The primary structure of human dopamine-beta-hydroxylase: insights into the relationship between the soluble and the membrane-bound forms of the enzyme. EMBO J 6: 3931-7 PubMed GONUTS page

[PMID:14718574-1] Anderson NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol Cell Proteomics 3: 311-26 PubMed GONUTS page

[PMID:2880016-2] Man in 't Veld AJ et al. (1987) Congenital dopamine-beta-hydroxylase deficiency. A novel orthostatic syndrome. Lancet 1: 183-8 PubMed GONUTS page

[PMID:15164053-3] Humphray SJ et al. (2004) DNA sequence and analysis of human chromosome 9. Nature 429: 369-74 PubMed GONUTS page

[1]

[2]

[3]

[4]

HUMAN:DOPO

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