HUMAN:DNM3B

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	DNMT3B
Protein Name(s)	DNA (cytosine-5)-methyltransferase 3B Dnmt3b DNA methyltransferase HsaIIIB DNA MTase HsaIIIB M.HsaIIIB
External Links
UniProt	Q9UBC3
EMBL	AF156487 AF156488 AF176228 AF331857 AK299821 AK299915 AL035071 AL035071 AL035071 AL035071 CH471077 CH471077 CH471077 CH471077 CH471077 AF129267 AF129268 AF129269
CCDS	CCDS13204.1 CCDS13205.1 CCDS13206.1 CCDS13207.1 CCDS56183.1 CCDS56184.1
RefSeq	NP_001193984.1 NP_001193985.1 NP_008823.1 NP_787044.1 NP_787045.1 NP_787046.1
UniGene	Hs.643024 Hs.713611
PDB	3FLG 3QKJ
PDBsum	3FLG 3QKJ
ProteinModelPortal	Q9UBC3
SMR	Q9UBC3
BioGrid	108126
DIP	DIP-30000N
IntAct	Q9UBC3
MINT	MINT-2820816
STRING	9606.ENSP00000328547
BindingDB	Q9UBC3
ChEMBL	CHEMBL6095
REBASE	4120
PhosphoSite	Q9UBC3
DMDM	17375667
MaxQB	Q9UBC3
PaxDb	Q9UBC3
PRIDE	Q9UBC3
DNASU	1789
Ensembl	ENST00000201963 ENST00000328111 ENST00000348286 ENST00000353855 ENST00000443239 ENST00000456297
GeneID	1789
KEGG	hsa:1789
UCSC	uc002wyc.3 uc002wyd.3 uc002wye.3 uc002wyf.3
CTD	1789
GeneCards	GC20P031350
HGNC	HGNC:2979
HPA	HPA001595
MIM	242860 602900
neXtProt	NX_Q9UBC3
Orphanet	2268
PharmGKB	PA27446
eggNOG	NOG70699
GeneTree	ENSGT00390000008341
HOVERGEN	HBG051381
InParanoid	Q9UBC3
KO	K17399
OMA	RRKDWNV
OrthoDB	EOG7MWGW6
PhylomeDB	Q9UBC3
TreeFam	TF329039
Reactome	REACT_200808 REACT_200856 REACT_267652
ChiTaRS	DNMT3B
EvolutionaryTrace	Q9UBC3
GeneWiki	DNMT3B
GenomeRNAi	1789
NextBio	7289
PRO	PR:Q9UBC3
Proteomes	UP000005640
Bgee	Q9UBC3
CleanEx	HS_DNMT3B
Genevestigator	Q9UBC3
GO	GO:0000775 GO:0005737 GO:0043231 GO:0005720 GO:0005654 GO:0005634 GO:0003886 GO:0051718 GO:0009008 GO:0046872 GO:0003714 GO:0045322 GO:0090116 GO:0071230 GO:0006306 GO:0043045 GO:0010424 GO:0006346 GO:0051573 GO:0000122 GO:0010628 GO:0051571 GO:0045666 GO:0031503 GO:0006349 GO:0042493 GO:0010212 GO:0046498 GO:0046499
Gene3D	3.40.50.150
InterPro	IPR025766 IPR018117 IPR001525 IPR000313 IPR029063 IPR011011
Pfam	PF00855
SMART	SM00293
SUPFAM	SSF53335 SSF57903
PROSITE	PS51533 PS00094 PS50812 PS51679

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0042127	regulation of cell proliferation	PMID:21572997^[1]	ECO:0000314			P	FIg. 2B shows that inhibition of DNMTs decreases the proliferation rate in a dose-dependent manner. Fig. 2E shows that inhibition of DNMTs arrests most cells in the G1 phase.	complete CACAO 10768
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:P17679	F	Seeded From UniProt	complete
involved_in	GO:0051573	negative regulation of histone H3-K9 methylation	PMID:18413740^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051571	positive regulation of histone H3-K4 methylation	PMID:18413740^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:18413740^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0009008	DNA-methyltransferase activity	PMID:11102980^[3]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0009008	DNA-methyltransferase activity	PMID:10555141^[4]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0009008	DNA-methyltransferase activity	PMID:10325416^[5]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006306	DNA methylation	PMID:10555141^[4]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006306	DNA methylation	PMID:11102980^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17303076^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	PMID:10647011^[7]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:18567530^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:17303076^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:17303076^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	PMID:16543361^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0090116	C-5 methylation of cytosine	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003886	P	Seeded From UniProt	complete
involved_in	GO:0090116	C-5 methylation of cytosine	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003886	P	Seeded From UniProt	complete
involved_in	GO:0090116	C-5 methylation of cytosine	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003886	P	Seeded From UniProt	complete
involved_in	GO:0090116	C-5 methylation of cytosine	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003886	P	Seeded From UniProt	complete
involved_in	GO:0071549	cellular response to dexamethasone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ51 ensembl:ENSRNOP00000015482	P	Seeded From UniProt	complete
involved_in	GO:0071455	cellular response to hyperoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ51 ensembl:ENSRNOP00000015482	P	Seeded From UniProt	complete
involved_in	GO:0045666	positive regulation of neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ51 ensembl:ENSRNOP00000015482	P	Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ51 ensembl:ENSRNOP00000015482	F	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ51 ensembl:ENSRNOP00000015482	P	Seeded From UniProt	complete
involved_in	GO:0042220	response to cocaine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ51 ensembl:ENSRNOP00000015482	P	Seeded From UniProt	complete
involved_in	GO:0033189	response to vitamin A	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ51 ensembl:ENSRNOP00000015482	P	Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ51 ensembl:ENSRNOP00000015482	P	Seeded From UniProt	complete
involved_in	GO:0031000	response to caffeine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ51 ensembl:ENSRNOP00000015482	P	Seeded From UniProt	complete
involved_in	GO:0014823	response to activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ51 ensembl:ENSRNOP00000015482	P	Seeded From UniProt	complete
involved_in	GO:0010212	response to ionizing radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ51 ensembl:ENSRNOP00000015482	P	Seeded From UniProt	complete
involved_in	GO:0009636	response to toxic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ51 ensembl:ENSRNOP00000015482	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ51 ensembl:ENSRNOP00000015482	C	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ51 ensembl:ENSRNOP00000015482	F	Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1LZ51 ensembl:ENSRNOP00000015482	P	Seeded From UniProt	complete
involved_in	GO:0006306	DNA methylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030488	P	Seeded From UniProt	complete
enables	GO:0008168	methyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001525	F	Seeded From UniProt	complete
enables	GO:0009008	DNA-methyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030488	F	Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030488	P	Seeded From UniProt	complete
enables	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.1.1.37	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10433969^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006306	DNA methylation	PMID:10433969^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003886	DNA (cytosine-5-)-methyltransferase activity	PMID:10433969^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045814	negative regulation of gene expression, epigenetic	Reactome:R-HSA-212300	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0009008	DNA-methyltransferase activity	Reactome:R-HSA-212269	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-4655374 Reactome:R-HSA-212269 Reactome:R-HSA-212222	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0032259	methylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	P	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
enables	GO:0008168	methyltransferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0489	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ So, AY et al. (2011) DNA methyltransferase controls stem cell aging by regulating BMI1 and EZH2 through microRNAs. PLoS ONE 6 e19503 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Sun, L et al. (2008) DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation. Cancer Res. 68 2726-35 PubMed GONUTS page
↑ ^3.0 ^3.1 Wijmenga, C et al. (2000) Genetic variation in ICF syndrome: evidence for genetic heterogeneity. Hum. Mutat. 16 509-17 PubMed GONUTS page
↑ ^4.0 ^4.1 Okano, M et al. (1999) DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99 247-57 PubMed GONUTS page
↑ Robertson, KD et al. (1999) The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. Nucleic Acids Res. 27 2291-8 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Kim, SH et al. (2007) Zinc-fingers and homeoboxes 1 (ZHX1) binds DNA methyltransferase (DNMT) 3B to enhance DNMT3B-mediated transcriptional repression. Biochem. Biophys. Res. Commun. 355 318-23 PubMed GONUTS page
↑ Xu, GL et al. (1999) Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. Nature 402 187-91 PubMed GONUTS page
↑ Kim, SH et al. (2008) DNA methyltransferase 3B acts as a co-repressor of the human polycomb protein hPc2 to repress fibroblast growth factor receptor 3 transcription. Int. J. Biochem. Cell Biol. 40 2462-71 PubMed GONUTS page
↑ Xie, ZH et al. (2006) Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect its regulation by DNMT3L. Hum. Mol. Genet. 15 1375-85 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Xie, S et al. (1999) Cloning, expression and chromosome locations of the human DNMT3 gene family. Gene 236 87-95 PubMed GONUTS page

[PMID:21572997-1] So, AY et al. (2011) DNA methyltransferase controls stem cell aging by regulating BMI1 and EZH2 through microRNAs. PLoS ONE 6 e19503 PubMed GONUTS page

[PMID:18413740-2] 2.0 ^2.1 ^2.2 Sun, L et al. (2008) DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation. Cancer Res. 68 2726-35 PubMed GONUTS page

[PMID:11102980-3] 3.0 ^3.1 Wijmenga, C et al. (2000) Genetic variation in ICF syndrome: evidence for genetic heterogeneity. Hum. Mutat. 16 509-17 PubMed GONUTS page

[PMID:10555141-4] 4.0 ^4.1 Okano, M et al. (1999) DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99 247-57 PubMed GONUTS page

[PMID:10325416-5] Robertson, KD et al. (1999) The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. Nucleic Acids Res. 27 2291-8 PubMed GONUTS page

[PMID:17303076-6] 6.0 ^6.1 ^6.2 Kim, SH et al. (2007) Zinc-fingers and homeoboxes 1 (ZHX1) binds DNA methyltransferase (DNMT) 3B to enhance DNMT3B-mediated transcriptional repression. Biochem. Biophys. Res. Commun. 355 318-23 PubMed GONUTS page

[PMID:10647011-7] Xu, GL et al. (1999) Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. Nature 402 187-91 PubMed GONUTS page

[PMID:18567530-8] Kim, SH et al. (2008) DNA methyltransferase 3B acts as a co-repressor of the human polycomb protein hPc2 to repress fibroblast growth factor receptor 3 transcription. Int. J. Biochem. Cell Biol. 40 2462-71 PubMed GONUTS page

[PMID:16543361-9] Xie, ZH et al. (2006) Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect its regulation by DNMT3L. Hum. Mol. Genet. 15 1375-85 PubMed GONUTS page

[PMID:10433969-10] 10.0 ^10.1 ^10.2 Xie, S et al. (1999) Cloning, expression and chromosome locations of the human DNMT3 gene family. Gene 236 87-95 PubMed GONUTS page

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HUMAN:DNM3B

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