HUMAN:DICER

From GONUTS

Jump to: navigation, search

Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	DICER1 ( synonyms: DICER, HERNA, KIAA0928 )
Protein Name(s)	Endoribonuclease Dicer Helicase with RNase motif Helicase MOI
External Links
UniProt Identifier	DICER_HUMAN
UniProt Accessions	Q9UPY3, A7E2D3, O95943, Q9UQ02,
EMBL	AB028449, AJ132261, AB023145, AL356017, AL390254, CH471061, BC150287,
RefSeq	NP_085124.2, NP_803187.1,
PDB	2EB1,
IntAct	Q9UPY3,
Ensembl	ENST00000343455, ENST00000393063,
Pfam	PF00270, PF03368, PF00271, PF02170, PF00636,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q8R418	P
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0001525	angiogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	P
	GO:0001942	hair follicle development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	P
	GO:0003676	nucleic acid binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001650	F
	GO:0003676	nucleic acid binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011545	F
	GO:0003723	RNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000999	F
	GO:0003723	RNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014720	F
	GO:0003723	RNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0694	F
	GO:0003725	double-stranded RNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001159	F
	GO:0003725	double-stranded RNA binding	PMID:12411504^[1]	IDA: Inferred from Direct Assay		F
	GO:0004386	helicase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001650	F
	GO:0004386	helicase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0347	F
	GO:0004518	nuclease activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0540	F
	GO:0004519	endonuclease activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0255	F
	GO:0004525	ribonuclease III activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000999	F
	GO:0004525	ribonuclease III activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	F
	GO:0004525	ribonuclease III activity	PMID:12560494^[2]	IDA: Inferred from Direct Assay		F
	GO:0005515	protein binding	PMID:12526743^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q8CJG0	F
	GO:0005515	protein binding	PMID:12526743^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UL18	F
	GO:0005515	protein binding	PMID:14749716^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q96J94	F
	GO:0005515	protein binding	PMID:14749716^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UKV8	F
	GO:0005515	protein binding	PMID:15973356^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q15633	F
	GO:0005515	protein binding	PMID:16142218^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q15633	F
	GO:0005515	protein binding	PMID:17452327^[7]	IPI: Inferred from Physical Interaction	UniProtKB:O75569	F
	GO:0005515	protein binding	PMID:17452327^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q15633	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001650	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011545	F
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001159	C
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR014720	C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005829	cytosol	Reactome:REACT_12438	TAS: Traceable Author Statement		C
	GO:0006396	RNA processing	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000999	P
	GO:0006396	RNA processing	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	P
	GO:0006915	apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	P
	GO:0008026	ATP-dependent helicase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011545	F
	GO:0009791	post-embryonic development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	P
	GO:0010070	zygote asymmetric cell division	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	P
	GO:0010626	negative regulation of Schwann cell proliferation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q4G034	P
	GO:0010628	positive regulation of gene expression	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	P
	GO:0014040	positive regulation of Schwann cell differentiation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q4G034	P
	GO:0014040	positive regulation of Schwann cell differentiation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q8R418	P
	GO:0016442	RNA-induced silencing complex	PMID:15973356^[5]	IDA: Inferred from Direct Assay		C
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F
	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005034	F
	GO:0019827	stem cell maintenance	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	P
	GO:0021675	nerve development	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q8R418	P
	GO:0021889	olfactory bulb interneuron differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	P
	GO:0030324	lung development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	P
	GO:0030326	embryonic limb morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	P
	GO:0030422	production of siRNA involved in RNA interference	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	P
	GO:0030422	production of siRNA involved in RNA interference	PMID:15973356^[5]	IDA: Inferred from Direct Assay		P
	GO:0030422	production of siRNA involved in RNA interference	PMID:17452327^[7]	IDA: Inferred from Direct Assay		P
	GO:0030423	targeting of mRNA for destruction involved in RNA interference	PMID:15973356^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0030423	targeting of mRNA for destruction involved in RNA interference	PMID:17452327^[7]	IMP: Inferred from Mutant Phenotype		P
	GO:0031047	gene silencing by RNA	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0943	P
	GO:0031054	pre-miRNA processing	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	P
	GO:0031054	pre-miRNA processing	PMID:15973356^[5]	IDA: Inferred from Direct Assay		P
	GO:0031069	hair follicle morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	P
	GO:0031643	positive regulation of myelination	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q4G034	P
	GO:0031643	positive regulation of myelination	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q8R418	P
	GO:0032290	peripheral nervous system myelin formation	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q8R418	P
	GO:0035116	embryonic hindlimb morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	P
	GO:0035196	production of miRNAs involved in gene silencing by miRNA	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	P
	GO:0035196	production of miRNAs involved in gene silencing by miRNA	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q4G034	P
	GO:0035198	miRNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	F
	GO:0035264	multicellular organism growth	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	P
	GO:0042487	regulation of odontogenesis of dentine-containing tooth	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	P
	GO:0042981	regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	P
	GO:0043066	negative regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	P
	GO:0045069	regulation of viral genome replication	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	P
	GO:0045595	regulation of cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	P
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0048536	spleen development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	P
	GO:0048565	digestive tract development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	P
	GO:0048730	epidermis morphogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	P
	GO:0048754	branching morphogenesis of a tube	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	P
	GO:0048812	neuron projection morphogenesis	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q8R418	P
	GO:0050767	regulation of neurogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	P
	GO:0051225	spindle assembly	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	P
	GO:0051607	defense response to virus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	P
	GO:0055013	cardiac muscle cell development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	P
	GO:0060576	intestinal epithelial cell development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	P
	GO:0070173	regulation of enamel mineralization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	P
	GO:0071335	hair follicle cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000043676	P
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Provost P et al. (2002) Ribonuclease activity and RNA binding of recombinant human Dicer. EMBO J 21: 5864-74 PubMed GONUTS page
↑ Kawasaki H et al. (2003) siRNAs generated by recombinant human Dicer induce specific and significant but target site-independent gene silencing in human cells. Nucleic Acids Res 31: 981-7 PubMed GONUTS page
↑ ^3.0 ^3.1 Doi N et al. (2003) Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors. Curr Biol 13: 41-6 PubMed GONUTS page
↑ ^4.0 ^4.1 Tahbaz N et al. (2004) Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer. EMBO Rep 5: 189-94 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Chendrimada TP et al. (2005) TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature 436: 740-4 PubMed GONUTS page
↑ Haase AD et al. (2005) TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing. EMBO Rep 6: 961-7 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Kok KH et al. (2007) Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA. J Biol Chem 282: 17649-57 PubMed GONUTS page

[PMID:12411504-0] Provost P et al. (2002) Ribonuclease activity and RNA binding of recombinant human Dicer. EMBO J 21: 5864-74 PubMed GONUTS page

[PMID:12560494-1] Kawasaki H et al. (2003) siRNAs generated by recombinant human Dicer induce specific and significant but target site-independent gene silencing in human cells. Nucleic Acids Res 31: 981-7 PubMed GONUTS page

[PMID:12526743-2] 3.0 ^3.1 Doi N et al. (2003) Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors. Curr Biol 13: 41-6 PubMed GONUTS page

[PMID:14749716-3] 4.0 ^4.1 Tahbaz N et al. (2004) Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer. EMBO Rep 5: 189-94 PubMed GONUTS page

[PMID:15973356-4] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Chendrimada TP et al. (2005) TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature 436: 740-4 PubMed GONUTS page

[PMID:16142218-5] Haase AD et al. (2005) TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing. EMBO Rep 6: 961-7 PubMed GONUTS page

[PMID:17452327-6] 7.0 ^7.1 ^7.2 ^7.3 Kok KH et al. (2007) Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA. J Biol Chem 282: 17649-57 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

HUMAN:DICER

Contents

Annotations

Notes

References

a

b

c

d

e

g

h

h cont.

i

l

m

n

o

p

p cont.

r

s

t

v

z

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Cacao

Journal Clubs

page contributors

Toolbox