GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
HUMAN:DGCR8
Contents |
| Species (Taxon ID) | Homo sapiens (Human). (taxon:9606) | |
| Gene Name(s) | DGCR8 ( synonyms: C22orf12, DGCRK6 ) | |
| Protein Name(s) |
| |
| External Links | ||
| UniProt Identifier | DGCR8_HUMAN | |
| UniProt Accessions | Q8WYQ5, B2R8G1, Q6DCB2, Q6MZE9, Q6Y2L0, Q96G39, Q96GP8, Q9H6L8, Q9H6T7, Q9NRW2, | |
| EMBL | AB050770, CR456356, AK025539, AK025780, AK313357, AC006547, BC009323, BC009984, BC078147, AF165527, BX649187, AY189282, | |
| RefSeq | NP_001177255.1, NP_073557.3, | |
| PDB | 1X47, 2YT4, 3LE4, | |
| IntAct | Q8WYQ5, | |
| Ensembl | ENST00000351989, | |
| Pfam | PF00035, | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0003723 |
RNA binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0003723 |
RNA binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0003725 |
double-stranded RNA binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0003725 |
double-stranded RNA binding |
IDA: Inferred from Direct Assay |
|
F |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005622 |
intracellular |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0005622 |
intracellular |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0191 |
C |
||||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
||||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
||||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_12414 |
TAS: Traceable Author Statement |
|
C |
|||
| GO:0005730 |
nucleolus |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0188 |
C |
||||
| GO:0005737 |
cytoplasm |
IDA: Inferred from Direct Assay |
|
C |
||||
| GO:0005737 |
cytoplasm |
IDA: Inferred from Direct Assay |
|
C |
||||
| GO:0015630 |
microtubule cytoskeleton |
IDA: Inferred from Direct Assay |
|
C |
||||
| GO:0031053 |
primary microRNA processing |
IDA: Inferred from Direct Assay |
|
P |
||||
| GO:0031053 |
primary microRNA processing |
IDA: Inferred from Direct Assay |
|
P |
||||
| GO:0046872 |
metal ion binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0005730 |
nucleolus |
IDA: Inferred from Direct Assay |
|
C |
||||
| GO:0003723 |
RNA binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0003723 |
RNA binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0003725 |
double-stranded RNA binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0003725 |
double-stranded RNA binding |
IDA: Inferred from Direct Assay |
F |
|||||
| GO:0004525 |
ribonuclease III activity |
Reactome:REACT_12414 |
TAS: Traceable Author Statement |
F |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005622 |
intracellular |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0005622 |
intracellular |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0191 |
C |
||||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
C |
|||||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
C |
|||||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_12414 |
TAS: Traceable Author Statement |
C |
||||
| GO:0005730 |
nucleolus |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0188 |
C |
||||
| GO:0005737 |
cytoplasm |
IDA: Inferred from Direct Assay |
C |
|||||
| GO:0005737 |
cytoplasm |
IDA: Inferred from Direct Assay |
C |
|||||
| GO:0015630 |
microtubule cytoskeleton |
IDA: Inferred from Direct Assay |
C |
|||||
| GO:0031053 |
primary miRNA processing |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0031053 |
primary miRNA processing |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0046872 |
metal ion binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
|
NOT |
GO:0005730 |
nucleolus |
IDA: Inferred from Direct Assay |
C |
| |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Sohn SY et al. (2007) Crystal structure of human DGCR8 core. Nat Struct Mol Biol 14: 847-53 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Han J et al. (2004) The Drosha-DGCR8 complex in primary microRNA processing. Genes Dev 18: 3016-27 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page
- ↑ 4.0 4.1 Simpson JC et al. (2000) Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. EMBO Rep 1: 287-92 PubMed GONUTS page
- ↑ 5.0 5.1 Gregory RI et al. (2004) The Microprocessor complex mediates the genesis of microRNAs. Nature 432: 235-40 PubMed GONUTS page
cdim |
m cont.n |
pr |
