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HUMAN:DFFB
Contents |
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | DFFB (synonyms: CAD, DFF2, DFF40) | |
| Protein Name(s) | DNA fragmentation factor subunit beta
Caspase-activated deoxyribonuclease CAD Caspase-activated DNase Caspase-activated nuclease CPAN DNA fragmentation factor 40 kDa subunit DFF-40 | |
| External Links | ||
| UniProt | O76075 | |
| EMBL | AF064019 AB013918 AF039210 AB028911 AB028912 AB028913 AK290877 AL691523 BC048797 | |
| IPI | IPI00008794 IPI00179341 IPI00218518 IPI00883793 | |
| RefSeq | NP_004393.1 | |
| UniGene | Hs.133089 | |
| PDB | 1IBX | |
| PDBsum | 1IBX | |
| ProteinModelPortal | O76075 | |
| SMR | O76075 | |
| STRING | O76075 | |
| PRIDE | O76075 | |
| Ensembl | ENST00000378209 | |
| GeneID | 1677 | |
| KEGG | hsa:1677 | |
| UCSC | uc001alc.1 | |
| CTD | 1677 | |
| GeneCards | GC01P003069 | |
| HGNC | HGNC:2773 | |
| HPA | CAB004328 | |
| MIM | 601883 | |
| neXtProt | NX_O76075 | |
| PharmGKB | PA27255 | |
| eggNOG | prNOG19837 | |
| HOVERGEN | HBG003828 | |
| InParanoid | O76075 | |
| OrthoDB | EOG41RPV9 | |
| PhylomeDB | O76075 | |
| Pathway_Interaction_DB | caspase_pathway faspathway hivnefpathway | |
| Reactome | REACT_578 | |
| NextBio | 6902 | |
| ArrayExpress | O76075 | |
| Bgee | O76075 | |
| CleanEx | HS_CAD HS_DFFB | |
| Genevestigator | O76075 | |
| GermOnline | ENSG00000169598 | |
| GO | GO:0005829 GO:0005654 GO:0004536 GO:0019899 GO:0030263 GO:0006309 GO:0035556 | |
| InterPro | IPR015311 IPR003508 | |
| KO | K02311 | |
| Pfam | PF02017 PF09230 | |
| PROSITE | PS51135 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0003677 |
DNA binding |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000030893 |
F |
Seeded From UniProt |
|||
| GO:0004516 |
nicotinate phosphoribosyltransferase activity |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000030893 |
F |
Seeded From UniProt |
|||
| GO:0004518 |
nuclease activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004536 |
deoxyribonuclease activity |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000034722 |
F |
Seeded From UniProt |
|||
| GO:0004536 |
deoxyribonuclease activity |
TAS: Traceable Author Statement |
|
F |
Seeded From UniProt |
|||
| GO:0005622 |
intracellular |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000034722 |
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0191 |
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_12404 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_12544 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_13514 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_13544 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_13689 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_13702 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005654 |
nucleoplasm |
Reactome:REACT_13708 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0086 |
C |
Seeded From UniProt |
|||
| GO:0005829 |
cytosol |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0005829 |
cytosol |
Reactome:REACT_13544 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005829 |
cytosol |
Reactome:REACT_13679 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005829 |
cytosol |
Reactome:REACT_13756 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0006309 |
DNA fragmentation involved in apoptotic nuclear change |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006309 |
DNA fragmentation involved in apoptotic nuclear change |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000034722 |
P |
Seeded From UniProt |
|||
| GO:0006309 |
DNA fragmentation involved in apoptotic nuclear change |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0006309 |
DNA fragmentation involved in apoptotic nuclear change |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0006309 |
DNA fragmentation involved in apoptotic nuclear change |
Reactome:REACT_1213 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0006915 |
apoptosis |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006915 |
apoptosis |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006915 |
apoptosis |
Reactome:REACT_578 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0006917 |
induction of apoptosis |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000034722 |
P |
Seeded From UniProt |
|||
| GO:0006921 |
cellular component disassembly involved in apoptosis |
Reactome:REACT_995 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0008152 |
metabolic process |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000030893 |
P |
Seeded From UniProt |
|||
| GO:0016787 |
hydrolase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016787 |
hydrolase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0019899 |
enzyme binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0030263 |
apoptotic chromosome condensation |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0035556 |
intracellular signal transduction |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Liu X et al. (1998) The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis. Proc Natl Acad Sci U S A 95: 8461-6 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Durrieu F et al. (2000) DNA topoisomerase IIalpha interacts with CAD nuclease and is involved in chromatin condensation during apoptotic execution. Curr Biol 10: 923-6 PubMed GONUTS page
- ↑ 3.0 3.1 Korn C et al. (2005) Interaction of DNA fragmentation factor (DFF) with DNA reveals an unprecedented mechanism for nuclease inhibition and suggests that DFF can be activated in a DNA-bound state. J Biol Chem 280: 6005-15 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Liu X et al. (1997) DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell 89: 175-84 PubMed GONUTS page
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