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HUMAN:DEDD2
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | DEDD2 (synonyms: FLAME3) | |
| Protein Name(s) | DNA-binding death effector domain-containing protein 2
DED-containing protein FLAME-3 FADD-like anti-apoptotic molecule 3 | |
| External Links | ||
| UniProt | Q8WXF8 | |
| EMBL | AF443591 AF457575 AY125488 AK075328 BC013372 BC027930 | |
| CCDS | CCDS12597.1 CCDS59391.1 | |
| RefSeq | NP_001257543.1 NP_001257544.1 NP_579874.1 | |
| UniGene | Hs.515432 Hs.741580 | |
| ProteinModelPortal | Q8WXF8 | |
| SMR | Q8WXF8 | |
| BioGrid | 127838 | |
| IntAct | Q8WXF8 | |
| STRING | 9606.ENSP00000336972 | |
| PhosphoSite | Q8WXF8 | |
| DMDM | 47116024 | |
| PaxDb | Q8WXF8 | |
| PRIDE | Q8WXF8 | |
| Ensembl | ENST00000336034 ENST00000595337 ENST00000596251 | |
| GeneID | 162989 | |
| KEGG | hsa:162989 | |
| UCSC | uc002osu.2 uc002osw.2 | |
| CTD | 162989 | |
| GeneCards | GC19M042702 | |
| HGNC | HGNC:24450 | |
| HPA | HPA043419 HPA043554 | |
| neXtProt | NX_Q8WXF8 | |
| PharmGKB | PA134912744 | |
| eggNOG | NOG42334 | |
| GeneTree | ENSGT00390000008714 | |
| HOGENOM | HOG000049120 | |
| HOVERGEN | HBG007220 | |
| InParanoid | Q8WXF8 | |
| OMA | SPERYNY | |
| PhylomeDB | Q8WXF8 | |
| TreeFam | TF331807 | |
| ChiTaRS | DEDD2 | |
| GenomeRNAi | 162989 | |
| NextBio | 88251 | |
| PRO | PR:Q8WXF8 | |
| Proteomes | UP000005640 | |
| Bgee | Q8WXF8 | |
| CleanEx | HS_DEDD2 | |
| ExpressionAtlas | Q8WXF8 | |
| Genevestigator | Q8WXF8 | |
| GO | GO:0005730 GO:0003677 GO:0030159 GO:0030262 GO:0019725 GO:0008625 GO:0035556 GO:0045892 GO:2001238 GO:0006396 GO:0016075 GO:0006351 | |
| Gene3D | 1.10.533.10 | |
| InterPro | IPR011029 IPR001875 | |
| Pfam | PF01335 | |
| SMART | SM00031 | |
| SUPFAM | SSF47986 | |
| PROSITE | PS50168 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0006915 |
apoptotic process |
ECO:0000316 |
P |
Fig 4 shows that DEDD2 is able to induce apoptosis |
Missing: with/from | |||||
|
involved_in |
GO:2001238 |
positive regulation of extrinsic apoptotic signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035556 |
intracellular signal transduction |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030262 |
apoptotic nuclear changes |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030159 |
receptor signaling complex adaptor activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019725 |
cellular homeostasis |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016075 |
rRNA catabolic process |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008625 |
extrinsic apoptotic signaling pathway via death domain receptors |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006396 |
RNA processing |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008625 |
extrinsic apoptotic signaling pathway via death domain receptors |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1333874 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1333874 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1333874 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042981 |
regulation of apoptotic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 Roth, W et al. (2002) Identification and characterization of DEDD2, a death effector domain-containing protein. J. Biol. Chem. 277 7501-8 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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