HUMAN:DDX6

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	DDX6 (synonyms: HLR2, RCK)
Protein Name(s)	Probable ATP-dependent RNA helicase DDX6 ATP-dependent RNA helicase p54 DEAD box protein 6 Oncogene RCK
External Links
UniProt	P26196
EMBL	Z11685 BC065007 D17532
CCDS	CCDS44751.1
PIR	S22651
RefSeq	NP_001244120.1 NP_004388.2 XP_005271474.1
UniGene	Hs.408461
PDB	1VEC 2WAX 2WAY 4CRW 4CT4 4CT5
PDBsum	1VEC 2WAX 2WAY 4CRW 4CT4 4CT5
ProteinModelPortal	P26196
SMR	P26196
BioGrid	108022
DIP	DIP-29195N
IntAct	P26196
MINT	MINT-5004149
STRING	9606.ENSP00000264018
PhosphoSite	P26196
DMDM	116241327
DOSAC-COBS-2DPAGE	P26196
MaxQB	P26196
PaxDb	P26196
PeptideAtlas	P26196
PRIDE	P26196
DNASU	1656
Ensembl	ENST00000526070 ENST00000534980 ENST00000620157
GeneID	1656
KEGG	hsa:1656
UCSC	uc001pub.2
CTD	1656
GeneCards	GC11M118619
HGNC	HGNC:2747
HPA	CAB004668 HPA024201 HPA026644
MIM	600326
neXtProt	NX_P26196
PharmGKB	PA27229
eggNOG	COG0513
GeneTree	ENSGT00740000115573
HOGENOM	HOG000268797
HOVERGEN	HBG106685
InParanoid	P26196
KO	K12614
OMA	RIYQKVQ
OrthoDB	EOG7D85W7
PhylomeDB	P26196
TreeFam	TF300440
Reactome	REACT_20518
ChiTaRS	DDX6
EvolutionaryTrace	P26196
GeneWiki	DDX6
GenomeRNAi	1656
NextBio	6820
PRO	PR:P26196
Proteomes	UP000005640
Bgee	P26196
CleanEx	HS_DDX6
ExpressionAtlas	P26196
Genevestigator	P26196
GO	GO:0005737 GO:0000932 GO:0010494 GO:0005829 GO:0043231 GO:0016020 GO:0016442 GO:0005524 GO:0008026 GO:0004386 GO:0044822 GO:0003724 GO:0033962 GO:0043928 GO:0010467 GO:0016071 GO:0000288 GO:0016070
Gene3D	3.40.50.300
InterPro	IPR011545 IPR014001 IPR001650 IPR027417 IPR000629 IPR014014
Pfam	PF00270 PF00271
SMART	SM00487 SM00490
SUPFAM	SSF52540
PROSITE	PS00039 PS51192 PS51194 PS51195

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0000932	cytoplasmic mRNA processing body	PMID:22022269^[1]	ECO:0000315			C	Fig. 2AB	complete CACAO 2728
	GO:0019074	viral RNA genome packaging	PMID:22022269^[1]	ECO:0000315			P	Fig. 5BC	complete CACAO 2729
part_of	GO:0010494	cytoplasmic stress granule	PMID:26184334^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:26184334^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:26184334^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000932	P-body	PMID:23125361^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:25468996^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0019074	viral RNA genome packaging	PMID:22022269^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0000932	P-body	PMID:22022269^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:24768540^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:A5YKK6	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22658674^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22681889^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0010494	cytoplasmic stress granule	PMID:17392519^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000932	P-body	PMID:16699599^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000932	P-body	PMID:22915799^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0033962	cytoplasmic mRNA processing body assembly	PMID:20826699^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0016442	RISC complex	PMID:20616046^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000932	P-body	PMID:20826699^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000932	P-body	PMID:20616046^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0036464	cytoplasmic ribonucleoprotein granule	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0097227	sperm annulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZD73 ensembl:ENSRNOP00000073900	C	Seeded From UniProt	complete
part_of	GO:0061830	concave side of sperm head	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZD73 ensembl:ENSRNOP00000073900	C	Seeded From UniProt	complete
involved_in	GO:0048515	spermatid differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZD73 ensembl:ENSRNOP00000073900	P	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZD73 ensembl:ENSRNOP00000073900	C	Seeded From UniProt	complete
part_of	GO:0033391	chromatoid body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZD73 ensembl:ENSRNOP00000073900	C	Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZD73 ensembl:ENSRNOP00000073900	P	Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZD73 ensembl:ENSRNOP00000073900	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZD73 ensembl:ENSRNOP00000073900	C	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZD73 ensembl:ENSRNOP00000073900	C	Seeded From UniProt	complete
part_of	GO:0001520	outer dense fiber	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZD73 ensembl:ENSRNOP00000073900	C	Seeded From UniProt	complete
part_of	GO:0000792	heterochromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZD73 ensembl:ENSRNOP00000073900	C	Seeded From UniProt	complete
involved_in	GO:0045665	negative regulation of neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54823 ensembl:ENSMUSP00000128421	P	Seeded From UniProt	complete
involved_in	GO:0019827	stem cell population maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54823 ensembl:ENSMUSP00000128421	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54823 ensembl:ENSMUSP00000128421	C	Seeded From UniProt	complete
part_of	GO:0000932	P-body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P54823 ensembl:ENSMUSP00000128421	C	Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011545	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011545	F	Seeded From UniProt	complete
enables	GO:0004386	helicase activity	PMID:1394235^[14] PMID:1579499^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003724	RNA helicase activity	PMID:1579499^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0043928	exonucleolytic catabolism of deadenylated mRNA	Reactome:R-HSA-430039	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-429860	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
enables	GO:0004386	helicase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0347	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
part_of	GO:0000932	P-body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0230	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Yu, SF et al. (2011) The DEAD-box RNA helicase DDX6 is required for efficient encapsidation of a retroviral genome. PLoS Pathog. 7 e1002303 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Bish, R et al. (2015) Comprehensive Protein Interactome Analysis of a Key RNA Helicase: Detection of Novel Stress Granule Proteins. Biomolecules 5 1441-66 PubMed GONUTS page
↑ Loedige, I et al. (2013) The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function. Nucleic Acids Res. 41 518-32 PubMed GONUTS page
↑ Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
↑ Chen, Y et al. (2014) A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing. Mol. Cell 54 737-50 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
↑ Nonhoff, U et al. (2007) Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules. Mol. Biol. Cell 18 1385-96 PubMed GONUTS page
↑ Wichroski, MJ et al. (2006) Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. PLoS Pathog. 2 e41 PubMed GONUTS page
↑ Phalora, PK et al. (2012) HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies. J. Virol. 86 11712-24 PubMed GONUTS page
↑ ^12.0 ^12.1 Marnef, A et al. (2010) Distinct functions of maternal and somatic Pat1 protein paralogs. RNA 16 2094-107 PubMed GONUTS page
↑ ^13.0 ^13.1 James, V et al. (2010) LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing. Proc. Natl. Acad. Sci. U.S.A. 107 12499-504 PubMed GONUTS page
↑ Akao, Y et al. (1992) The RCK gene associated with t(11;14) translocation is distinct from the MLL/ALL-1 gene with t(4;11) and t(11;19) translocations. Cancer Res. 52 6083-7 PubMed GONUTS page
↑ ^15.0 ^15.1 Lu, D & Yunis, JJ (1992) Cloning, expression and localization of an RNA helicase gene from a human lymphoid cell line with chromosomal breakpoint 11q23.3. Nucleic Acids Res. 20 1967-72 PubMed GONUTS page

[PMID:22022269-1] 1.0 ^1.1 ^1.2 ^1.3 Yu, SF et al. (2011) The DEAD-box RNA helicase DDX6 is required for efficient encapsidation of a retroviral genome. PLoS Pathog. 7 e1002303 PubMed GONUTS page

[PMID:26184334-2] 2.0 ^2.1 ^2.2 Bish, R et al. (2015) Comprehensive Protein Interactome Analysis of a Key RNA Helicase: Detection of Novel Stress Granule Proteins. Biomolecules 5 1441-66 PubMed GONUTS page

[PMID:23125361-3] Loedige, I et al. (2013) The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function. Nucleic Acids Res. 41 518-32 PubMed GONUTS page

[PMID:25468996-4] Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page

[PMID:24768540-5] Chen, Y et al. (2014) A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing. Mol. Cell 54 737-50 PubMed GONUTS page

[PMID:19946888-6] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:22658674-7] Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page

[PMID:22681889-8] Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page

[PMID:17392519-9] Nonhoff, U et al. (2007) Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules. Mol. Biol. Cell 18 1385-96 PubMed GONUTS page

[PMID:16699599-10] Wichroski, MJ et al. (2006) Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. PLoS Pathog. 2 e41 PubMed GONUTS page

[PMID:22915799-11] Phalora, PK et al. (2012) HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies. J. Virol. 86 11712-24 PubMed GONUTS page

[PMID:20826699-12] 12.0 ^12.1 Marnef, A et al. (2010) Distinct functions of maternal and somatic Pat1 protein paralogs. RNA 16 2094-107 PubMed GONUTS page

[PMID:20616046-13] 13.0 ^13.1 James, V et al. (2010) LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing. Proc. Natl. Acad. Sci. U.S.A. 107 12499-504 PubMed GONUTS page

[PMID:1394235-14] Akao, Y et al. (1992) The RCK gene associated with t(11;14) translocation is distinct from the MLL/ALL-1 gene with t(4;11) and t(11;19) translocations. Cancer Res. 52 6083-7 PubMed GONUTS page

[PMID:1579499-15] 15.0 ^15.1 Lu, D & Yunis, JJ (1992) Cloning, expression and localization of an RNA helicase gene from a human lymphoid cell line with chromosomal breakpoint 11q23.3. Nucleic Acids Res. 20 1967-72 PubMed GONUTS page

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HUMAN:DDX6

Contents

Annotations

Notes

References

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