HUMAN:DDC

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	DDC ( synonyms: AADC )
Protein Name(s)	Aromatic-L-amino-acid decarboxylase AADC DOPA decarboxylase DDC
External Links
UniProt Identifier	DDC_HUMAN
UniProt Accessions	P20711, Q16723, Q75MJ6,
EMBL	M76180, M88700, M84592, M84600, M84593, M84594, M84596, M84597, M84595, M84598, M84599, M84588, M84589, M84590, M84591, AY526322, AC018705, BC000485, BC008366, L05075, S46516,
PIR	A33663,
RefSeq	NP_000781.1, NP_001076440.1,
IntAct	P20711,
Ensembl	ENST00000357936, ENST00000444124,
Pfam	PF00282,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0004058	aromatic-L-amino-acid decarboxylase activity	PMID:13201577^[1]	IDA: Inferred from Direct Assay		F	Source: UniProtKB	complete
	GO:0005515	protein binding	PMID:13201577^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P48775	F	Source: IntAct	complete
	GO:0006587	serotonin biosynthetic process from tryptophan	PMID:13295286^[2]	IDA: Inferred from Direct Assay		P	Table 2	complete
	GO:0003824	catalytic activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015421	F
	GO:0003824	catalytic activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015422	F
	GO:0004058	aromatic-L-amino-acid decarboxylase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:4.1.1.28	F
	GO:0004058	aromatic-L-amino-acid decarboxylase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000005851	F
	GO:0004058	aromatic-L-amino-acid decarboxylase activity	PMID:16338639^[3]	IDA: Inferred from Direct Assay		F
	GO:0004058	aromatic-L-amino-acid decarboxylase activity	PMID:7567987^[4]	TAS: Traceable Author Statement		F
	GO:0004058	aromatic-L-amino-acid decarboxylase activity	Reactome:REACT_15382	TAS: Traceable Author Statement		F
	GO:0004058	aromatic-L-amino-acid decarboxylase activity	Reactome:REACT_15546	TAS: Traceable Author Statement		F
	GO:0005515	protein binding	PMID:12864730^[5]	IPI: Inferred from Physical Interaction	UniProtKB:P10275	F
	GO:0005515	protein binding	PMID:12864730^[5]	IPI: Inferred from Physical Interaction	UniProtKB:P15207	F
	GO:0005625	soluble fraction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000005851	C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000005851	C
	GO:0005829	cytosol	Reactome:REACT_15382	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_15546	TAS: Traceable Author Statement		C
	GO:0006520	cellular amino acid metabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR010977	P
	GO:0007268	synaptic transmission	Reactome:REACT_13477	TAS: Traceable Author Statement		P
	GO:0007268	synaptic transmission	Reactome:REACT_13685	TAS: Traceable Author Statement		P
	GO:0007269	neurotransmitter secretion	Reactome:REACT_13723	TAS: Traceable Author Statement		P
	GO:0007623	circadian rhythm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000005851	P
	GO:0008021	synaptic vesicle	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000005851	C
	GO:0009636	response to toxin	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000068525	P
	GO:0010259	multicellular organismal aging	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000005851	P
	GO:0015842	synaptic vesicle amine transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000005851	P
	GO:0016597	amino acid binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000005851	F
	GO:0016829	lyase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0456	F
	GO:0016831	carboxy-lyase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002129	F
	GO:0016831	carboxy-lyase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR010977	F
	GO:0016831	carboxy-lyase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR021115	F
	GO:0016831	carboxy-lyase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0210	F
	GO:0019752	carboxylic acid metabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002129	P
	GO:0019904	protein domain specific binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000005851	F
	GO:0030170	pyridoxal phosphate binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002129	F
	GO:0030170	pyridoxal phosphate binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015421	F
	GO:0030170	pyridoxal phosphate binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015422	F
	GO:0030170	pyridoxal phosphate binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000005851	F
	GO:0030424	axon	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000005851	C
	GO:0033076	isoquinoline alkaloid metabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000005851	P
	GO:0034641	cellular nitrogen compound metabolic process	Reactome:REACT_13	TAS: Traceable Author Statement		P
	GO:0035690	cellular response to drug	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000005851	P
	GO:0042416	dopamine biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000005851	P
	GO:0042423	catecholamine biosynthetic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0127	P
	GO:0042427	serotonin biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000005851	P
	GO:0042446	hormone biosynthetic process	Reactome:REACT_15314	TAS: Traceable Author Statement		P
	GO:0043025	neuronal cell body	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000005851	C
	GO:0046684	response to pyrethroid	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000005851	P
	GO:0052314	phytoalexin metabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000005851	P
	GO:0071312	cellular response to alkaloid	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000005851	P
	GO:0071363	cellular response to growth factor stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000005851	P
	GO:0071445	cellular response to protein stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000005851	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 CLARK CT et al. (1954) 5-Hydroxytryptophan decarboxylase: preparation and properties. J Biol Chem 210: 139-48 PubMed GONUTS page
↑ UDENFRIEND S et al. (1956) Biogenesis and metabolism of 5-hydroxyindole compounds. J Biol Chem 219: 335-44 PubMed GONUTS page
↑ Duan CL et al. (2005) The assays of activities and function of TH, AADC, and GCH1 and their potential use in ex vivo gene therapy of PD. Brain Res Brain Res Protoc 16: 37-43 PubMed GONUTS page
↑ Rorsman F et al. (1995) Aromatic-L-amino-acid decarboxylase, a pyridoxal phosphate-dependent enzyme, is a beta-cell autoantigen. Proc Natl Acad Sci U S A 92: 8626-9 PubMed GONUTS page
↑ ^5.0 ^5.1 Wafa LA et al. (2003) Isolation and identification of L-dopa decarboxylase as a protein that binds to and enhances transcriptional activity of the androgen receptor using the repressed transactivator yeast two-hybrid system. Biochem J 375: 373-83 PubMed GONUTS page

[PMID:13201577-0] 1.0 ^1.1 CLARK CT et al. (1954) 5-Hydroxytryptophan decarboxylase: preparation and properties. J Biol Chem 210: 139-48 PubMed GONUTS page

[PMID:13295286-1] UDENFRIEND S et al. (1956) Biogenesis and metabolism of 5-hydroxyindole compounds. J Biol Chem 219: 335-44 PubMed GONUTS page

[PMID:16338639-2] Duan CL et al. (2005) The assays of activities and function of TH, AADC, and GCH1 and their potential use in ex vivo gene therapy of PD. Brain Res Brain Res Protoc 16: 37-43 PubMed GONUTS page

[PMID:7567987-3] Rorsman F et al. (1995) Aromatic-L-amino-acid decarboxylase, a pyridoxal phosphate-dependent enzyme, is a beta-cell autoantigen. Proc Natl Acad Sci U S A 92: 8626-9 PubMed GONUTS page

[PMID:12864730-4] 5.0 ^5.1 Wafa LA et al. (2003) Isolation and identification of L-dopa decarboxylase as a protein that binds to and enhances transcriptional activity of the androgen receptor using the repressed transactivator yeast two-hybrid system. Biochem J 375: 373-83 PubMed GONUTS page

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HUMAN:DDC

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