HUMAN:CTGF

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	CTGF ( synonyms: CCN2, HCS24, IGFBP8 )
Protein Name(s)	Connective tissue growth factor CCN family member 2 Hypertrophic chondrocyte-specific protein 24 Insulin-like growth factor-binding protein 8 IBP-8 IGF-binding protein 8 IGFBP-8
External Links
UniProt Identifier	CTGF_HUMAN
UniProt Accessions	P29279, E1P578, Q6LCY0, Q96A79, Q96QX2, Q9UDL6,
EMBL	M92934, X78947, AY395801, AY550024, BT019794, BT019795, CR541759, AL354866, X92511, CH471051, CH471051, AF316366, AF316367, AF316368, U14750,
PIR	A40551,
RefSeq	NP_001892.1,
IntAct	P29279,
Ensembl	ENST00000367976,
Pfam	PF00007, PF00219, PF00090, PF00093,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0001502	cartilage condensation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000020171	P
	GO:0001503	ossification	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000020171	P
	GO:0001525	angiogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000020171	P
	GO:0001558	regulation of cell growth	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000867	P
	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0001968	fibronectin binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	F
	GO:0005178	integrin binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000020171	F
	GO:0005520	insulin-like growth factor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000867	F
	GO:0005520	insulin-like growth factor binding	PMID:9371786^[1]	TAS: Traceable Author Statement		F
	GO:0005576	extracellular region	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000867	C
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005576	extracellular region	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000020171	C
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C
	GO:0005578	proteinaceous extracellular matrix	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0272	C
	GO:0005578	proteinaceous extracellular matrix	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000020171	C
	GO:0005578	proteinaceous extracellular matrix	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0111	C
	GO:0005578	proteinaceous extracellular matrix	PMID:10809757^[2]	TAS: Traceable Author Statement		C
	GO:0005615	extracellular space	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	C
	GO:0005801	cis-Golgi network	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	C
	GO:0005829	cytosol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	C
	GO:0005886	plasma membrane	PMID:10809757^[2]	TAS: Traceable Author Statement		C
	GO:0005938	cell cortex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	C
	GO:0006260	DNA replication	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0237	P
	GO:0007155	cell adhesion	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0130	P
	GO:0007160	cell-matrix adhesion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000020171	P
	GO:0007229	integrin-mediated signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000020171	P
	GO:0008083	growth factor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	F
	GO:0008201	heparin binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0358	F
	GO:0008201	heparin binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000020171	F
	GO:0008284	positive regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0008543	fibroblast growth factor receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000020171	P
	GO:0008544	epidermis development	PMID:10809757^[2]	TAS: Traceable Author Statement		P
	GO:0009611	response to wounding	PMID:10809757^[2]	TAS: Traceable Author Statement		P
	GO:0009749	response to glucose stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0010260	organ senescence	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0010628	positive regulation of gene expression	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0010942	positive regulation of cell death	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0014070	response to organic cyclic compound	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0016477	cell migration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000020171	P
	GO:0030154	cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000020171	P
	GO:0030324	lung development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000020171	P
	GO:0030324	lung development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0032355	response to estradiol stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0032967	positive regulation of collagen biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0034059	response to anoxia	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0043200	response to amino acid stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0043280	positive regulation of caspase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0043434	response to peptide hormone stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0044255	cellular lipid metabolic process	Reactome:REACT_22279	TAS: Traceable Author Statement		P
	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	C
	GO:0050867	positive regulation of cell activation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0051385	response to mineralocorticoid stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0060401	cytosolic calcium ion transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0060452	positive regulation of cardiac muscle contraction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0070278	extracellular matrix constituent secretion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0070318	positive regulation of G0 to G1 transition	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0070542	response to fatty acid	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0001558	regulation of cell growth	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000867	P
	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0001968	fibronectin binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	F
	GO:0005520	insulin-like growth factor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000867	F
	GO:0005520	insulin-like growth factor binding	PMID:9371786^[1]	TAS: Traceable Author Statement		F
	GO:0005576	extracellular region	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000867	C
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C
	GO:0005576	extracellular region	Reactome:REACT_22360	TAS: Traceable Author Statement		C
	GO:0005578	proteinaceous extracellular matrix	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0272	C
	GO:0005578	proteinaceous extracellular matrix	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0111	C
	GO:0005578	proteinaceous extracellular matrix	PMID:10809757^[2]	TAS: Traceable Author Statement		C
	GO:0005615	extracellular space	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	C
	GO:0005801	cis-Golgi network	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	C
	GO:0005829	cytosol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	C
	GO:0005886	plasma membrane	PMID:10809757^[2]	TAS: Traceable Author Statement		C
	GO:0005938	cell cortex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	C
	GO:0006260	DNA replication	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0237	P
	GO:0007155	cell adhesion	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0130	P
	GO:0008083	growth factor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	F
	GO:0008201	heparin binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0358	F
	GO:0008284	positive regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0008544	epidermis development	PMID:10809757^[2]	TAS: Traceable Author Statement		P
	GO:0009611	response to wounding	PMID:10809757^[2]	TAS: Traceable Author Statement		P
	GO:0009749	response to glucose stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0010260	organ senescence	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0010628	positive regulation of gene expression	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0010942	positive regulation of cell death	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0014070	response to organic cyclic compound	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0030324	lung development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0032355	response to estradiol stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0032967	positive regulation of collagen biosynthetic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0034059	response to anoxia	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0035556	intracellular signal transduction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0043200	response to amino acid stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0043280	positive regulation of caspase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0043434	response to peptide hormone stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0044255	cellular lipid metabolic process	Reactome:REACT_22279	TAS: Traceable Author Statement		P
	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	C
	GO:0050867	positive regulation of cell activation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0051385	response to mineralocorticoid stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0060401	cytosolic calcium ion transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0060452	positive regulation of cardiac muscle contraction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0070278	extracellular matrix constituent secretion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0070318	positive regulation of G0 to G1 transition	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
	GO:0070542	response to fatty acid	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000020528	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Kim HS et al. (1997) Identification of a family of low-affinity insulin-like growth factor binding proteins (IGFBPs): characterization of connective tissue growth factor as a member of the IGFBP superfamily. Proc Natl Acad Sci U S A 94: 12981-6 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Abraham DJ et al. (2000) Tumor necrosis factor alpha suppresses the induction of connective tissue growth factor by transforming growth factor-beta in normal and scleroderma fibroblasts. J Biol Chem 275: 15220-5 PubMed GONUTS page

[PMID:9371786-0] 1.0 ^1.1 Kim HS et al. (1997) Identification of a family of low-affinity insulin-like growth factor binding proteins (IGFBPs): characterization of connective tissue growth factor as a member of the IGFBP superfamily. Proc Natl Acad Sci U S A 94: 12981-6 PubMed GONUTS page

[PMID:10809757-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Abraham DJ et al. (2000) Tumor necrosis factor alpha suppresses the induction of connective tissue growth factor by transforming growth factor-beta in normal and scleroderma fibroblasts. J Biol Chem 275: 15220-5 PubMed GONUTS page

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HUMAN:CTGF

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