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HUMAN:CSKP

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Contents

Species (Taxon ID) Homo sapiens (Human). ([1])
Gene Name(s) CASK (synonyms: LIN2)
Protein Name(s) Peripheral plasma membrane protein CASK

hCASK Calcium/calmodulin-dependent serine protein kinase Protein lin-2 homolog

External Links
EMBL AF032119
AF035582
AB039327
AY705392
AL627402
AL158144
AL353691
AL445239
AL603754
AL627402
AL158144
AL353691
AL445239
AL603754
AL627402
AL158144
AL353691
AL445239
AL603754
AL627402
AL158144
AL353691
AL445239
AL603754
AL445239
AL158144
AL353691
AL603754
AL627402
AL445239
AL158144
AL353691
AL603754
AL627402
AL445239
AL158144
AL353691
AL603754
AL627402
AL445239
AL158144
AL353691
AL603754
AL627402
AL603754
AL158144
AL353691
AL445239
AL627402
AL603754
AL158144
AL353691
AL445239
AL627402
AL603754
AL158144
AL353691
AL445239
AL627402
AL603754
AL158144
AL353691
AL445239
AL627402
AL353691
AL158144
AL445239
AL603754
AL627402
AL353691
AL158144
AL445239
AL603754
AL627402
AL353691
AL158144
AL445239
AL603754
AL627402
AL353691
AL158144
AL445239
AL603754
AL627402
AL158144
AL353691
AL445239
AL603754
AL627402
AL158144
AL353691
AL445239
AL603754
AL627402
AL158144
AL353691
AL445239
AL603754
AL627402
AL158144
AL353691
AL445239
AL603754
AL627402
BC117311
BC143454
AB208859
AF262404
AF262405
IPI IPI00514301
IPI00555605
IPI00641315
IPI00646452
IPI00877929
IPI00937304
RefSeq NP_001119526.1
NP_001119527.1
NP_003679.2
UniGene Hs.495984
PDB 1KGD
1KWA
1ZL8
3C0G
3C0H
3C0I
3MFR
3MFS
3MFT
3MFU
PDBsum 1KGD
1KWA
1ZL8
3C0G
3C0H
3C0I
3MFR
3MFS
3MFT
3MFU
ProteinModelPortal O14936
SMR O14936
IntAct O14936
MINT MINT-102444
STRING O14936
PhosphoSite O14936
PRIDE O14936
Ensembl ENST00000378163
ENST00000442742
GeneID 8573
KEGG hsa:8573
UCSC uc004dfl.2
uc004dfm.2
uc004dfn.2
CTD 8573
GeneCards GC0XM039105
HGNC HGNC:1497
HPA CAB001949
HPA023857
MIM 300172
300422
300749
neXtProt NX_O14936
PharmGKB PA26081
eggNOG prNOG13160
GeneTree ENSGT00560000077048
HOVERGEN HBG001858
OMA AIELVCT
BRENDA 2.7.11.1
Pathway_Interaction_DB syndecan_1_pathway
syndecan_2_pathway
syndecan_3_pathway
Reactome REACT_23853
ArrayExpress O14936
Bgee O14936
CleanEx HS_CASK
Genevestigator O14936
GermOnline ENSG00000147044
GO GO:0015629
GO:0005737
GO:0005634
GO:0005886
GO:0005524
GO:0005516
GO:0004385
GO:0004674
GO:0007155
InterPro IPR008144
IPR008145
IPR020590
IPR011009
IPR004172
IPR014775
IPR001478
IPR000719
IPR017442
IPR002290
IPR011511
IPR001452
Pfam PF00625
PF02828
PF00595
PF00069
PF07653
SMART SM00072
SM00569
SM00228
SM00220
SM00326
SUPFAM SSF56112
SSF50156
SSF50044
PROSITE PS00856
PS50052
PS51022
PS50106
PS00107
PS50011
PS00108
PS50002

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

Seeded From UniProt

GO:0004385

guanylate kinase activity

PMID:9660868[1]

TAS: Traceable Author Statement

F

Seeded From UniProt

GO:0004672

protein kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719

F

Seeded From UniProt

GO:0004672

protein kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017442

F

Seeded From UniProt

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002290

F

Seeded From UniProt

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0723

F

Seeded From UniProt

GO:0005515

protein binding

PMID:11377421[2]

IPI: Inferred from Physical Interaction

UniProtKB:Q9Y2J0

F

Seeded From UniProt

GO:0005515

protein binding

PMID:15694377[3]

IPI: Inferred from Physical Interaction

UniProtKB:P41134

F

Seeded From UniProt

GO:0005515

protein binding

PMID:18423203[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q63373

F

Seeded From UniProt

GO:0005515

protein binding

PMID:9660868[1]

IPI: Inferred from Physical Interaction

UniProtKB:P34741

F

Seeded From UniProt

GO:0005516

calmodulin binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0112

F

Seeded From UniProt

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719

F

Seeded From UniProt

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002290

F

Seeded From UniProt

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017442

F

Seeded From UniProt

GO:0005524

ATP binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0539

C

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0191

C

Seeded From UniProt

GO:0005737

cytoplasm

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded From UniProt

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded From UniProt

GO:0005886

plasma membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

Seeded From UniProt

GO:0005886

plasma membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0039

C

Seeded From UniProt

GO:0005886

plasma membrane

PMID:9660868[1]

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0006468

protein phosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719

P

Seeded From UniProt

GO:0006468

protein phosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002290

P

Seeded From UniProt

GO:0006468

protein phosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017442

P

Seeded From UniProt

GO:0007155

cell adhesion

PMID:9660868[1]

TAS: Traceable Author Statement

P

Seeded From UniProt

GO:0015629

actin cytoskeleton

PMID:9660868[1]

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0016020

membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

Seeded From UniProt

GO:0016301

kinase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0418

F

Seeded From UniProt

GO:0016310

phosphorylation

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0418

P

Seeded From UniProt

GO:0016740

transferase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0808

F

Seeded From UniProt

GO:0016772

transferase activity, transferring phosphorus-containing groups

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011009

F

Seeded From UniProt

GO:0005604

basement membrane

PMID:18664494[5]

IDA: Inferred from Direct Assay

C

Figure 1D immunofluorescence shows in adult human Cask localizes to cell borders of cells of the basal layer of the epidermis. Dashed line indicate basement membrane zone.

complete

GO:0005730

nucleolus

PMID:18664494[5]

IDA: Inferred from Direct Assay

C

Figure 5D, CASK protein retained in nucleoli, from nuclear matrix extraction.

complete

GO:0005652

nuclear lamina

PMID:18664494[5]

IDA: Inferred from Direct Assay

C

Figure 5CD, CASK retained in nuclear lamina, nuclear matrix extraction.

complete

GO:0010839

negative regulation of keratinocyte proliferation

PMID:18664494[5]

IDA: Inferred from Direct Assay

P

Figure 6B, knockout CASK in human keratinocyte cell line HaCaT, showed increase in HaCaT cell number compared to control. Therefore knockout CASK mice increased in growth rate of cells compared to control, figure 6C.

complete

GO:0090288

negative regulation of cellular response to growth factor stimulus

PMID:18664494[5]

IMP: Inferred from Mutant Phenotype

P

Figure 7B, show knockout CASK increased response to growth factors when treated with KGF and TGFalpha compared to control by increase in cell proliferation.

A possible regulation term can be created: ‘regulation of response to growth factor stimulus’ and ‘negative regulation of response to growth factor stimulus’

complete

GO:0061045

negative regulation of wound healing

PMID:18664494[5]

IMP: Inferred from Mutant Phenotype

P

Figure 9B, knockout human CASK protein showed accelerated keratinocyte cell matrix adhesion during wound healing. More spreading of cells and formation focal adhesion sites of attached cells, figure 9C

Another possible new GO term could be: wound healing, cell-matrix adhesion

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Cohen AR et al. (1998) Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells. J Cell Biol 142: 129-38 PubMed GONUTS page
  2. ↑ Zhang Y et al. (2001) The scaffolding protein CASK mediates the interaction between rabphilin3a and beta-neurexins. FEBS Lett 497: 99-102 PubMed GONUTS page
  3. ↑ Qi J et al. (2005) CASK inhibits ECV304 cell growth and interacts with Id1. Biochem Biophys Res Commun 328: 517-21 PubMed GONUTS page
  4. ↑ Mukherjee K et al. (2008) CASK Functions as a Mg2+-independent neurexin kinase. Cell 133: 328-39 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 Ojeh N et al. (2008) The MAGUK-family protein CASK is targeted to nuclei of the basal epidermis and controls keratinocyte proliferation. J Cell Sci 121: 2705-17 PubMed GONUTS page
Retrieved from "http://gowiki.tamu.edu/wiki/index.php/HUMAN:CSKP"
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