HUMAN:CSK21

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Species (Taxon ID)	Homo sapiens (Human). ([1])
Gene Name(s)	CSNK2A1 (synonyms: CK2A1)
Protein Name(s)	Casein kinase II subunit alpha CK II alpha
External Links
EMBL	J02853 M55265 X70251 S53149 BT019792 AB451279 AL049761 CH471133 CH471133 CH471133 CH471133 BC011668 BC053532 BC071167
IPI	IPI00744507
PIR	A30319
RefSeq	NP_001886.1 NP_808227.1 NP_808228.1
UniGene	Hs.644056 Hs.654675
PDB	1JWH 1NA7 1PJK 2PVR 2ZJW 3BQC 3C13 3FWQ 3H30 3JUH 3MB6 3MB7 3NGA 3NSZ 3OWJ 3OWK 3OWL 3PE4 3RP0 3RPS
PDBsum	1JWH 1NA7 1PJK 2PVR 2ZJW 3BQC 3C13 3FWQ 3H30 3JUH 3MB6 3MB7 3NGA 3NSZ 3OWJ 3OWK 3OWL 3PE4 3RP0 3RPS
ProteinModelPortal	P68400
SMR	P68400
DIP	DIP-32682N
IntAct	P68400
MINT	MINT-142347
STRING	P68400
PhosphoSite	P68400
PRIDE	P68400
Ensembl	ENST00000217244 ENST00000349736
GeneID	1457
KEGG	hsa:1457
UCSC	uc002wdw.1
CTD	1457
H-InvDB	HIX0015555
HGNC	HGNC:2457
HPA	CAB020680
MIM	115440
neXtProt	NX_P68400
eggNOG	prNOG12460
HOVERGEN	HBG107282
OrthoDB	EOG4J118H
PhylomeDB	P68400
Pathway_Interaction_DB	alphasynuclein_pathway nfkappabatypicalpathway bcr_5pathway wnt_canonical_pathway lis1pathway pdgfrapathway ps1pathway nfat_3pathway p38alphabetadownstreampathway
Reactome	REACT_18266
NextBio	5989
ArrayExpress	P68400
Bgee	P68400
CleanEx	HS_CSNK2A1
Genevestigator	P68400
GermOnline	ENSG00000101266
GO	GO:0005829 GO:0016581 GO:0005886 GO:0016580 GO:0005524 GO:0047485 GO:0004674 GO:0007411 GO:0016055
InterPro	IPR011009 IPR000719 IPR017441 IPR017442 IPR008271 IPR002290
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F	Seeded From UniProt
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F	Seeded From UniProt
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	F	Seeded From UniProt
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	F	Seeded From UniProt
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008271	F	Seeded From UniProt
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0723	F	Seeded From UniProt
	GO:0004674	protein serine/threonine kinase activity	PMID:2174700^[1]	TAS: Traceable Author Statement		F	Seeded From UniProt
	GO:0005515	protein binding	PMID:14667819^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P67870	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:16873060^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P29590	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:19011756^[4]	IPI: Inferred from Physical Interaction	UniProtKB:O60282	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:19011756^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P19784	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017441	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F	Seeded From UniProt
	GO:0005634	nucleus	PMID:10799509^[5]	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005634	nucleus	PMID:21282530^[6]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005829	cytosol	Reactome:REACT_22378	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005886	plasma membrane	PMID:10799509^[5]	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008271	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096829	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	PMID:2174700^[1]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0007165	signal transduction	PMID:2174700^[1]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0007411	axon guidance	Reactome:REACT_18266	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0008013	beta-catenin binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096829	F	Seeded From UniProt
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0879	P	Seeded From UniProt
	GO:0016301	kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	F	Seeded From UniProt
	GO:0016301	kinase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096829	F	Seeded From UniProt
	GO:0016310	phosphorylation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	P	Seeded From UniProt
	GO:0016580	Sin3 complex	PMID:17827154^[7]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0016581	NuRD complex	PMID:17827154^[7]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F	Seeded From UniProt
	GO:0016772	transferase activity, transferring phosphorus-containing groups	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F	Seeded From UniProt
	GO:0019888	protein phosphatase regulator activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096829	F	Seeded From UniProt
	GO:0046777	protein autophosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000096829	P	Seeded From UniProt
	GO:0047485	protein N-terminus binding	PMID:11972058^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P25054	F	Seeded From UniProt
	GO:0031519	PcG protein complex	PMID:21282530^[6]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0004674	protein serine/threonine kinase activity	PMID:11035045^[9]	IMP: Inferred from Mutant Phenotype		F	Figure three shows CK2 phosphorylates the C terminus of PTEN.	complete
	GO:0004672	protein kinase activity	PMID:22318540^[10]	IDA: Inferred from Direct Assay		F	Fig 1c&d CK2 decrease cell viability in glioma cells	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Lozeman FJ et al. (1990) Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II. Biochemistry 29: 8436-47 PubMed GONUTS page
↑ Lehner B et al. (2004) Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. Genomics 83: 153-67 PubMed GONUTS page
↑ Scaglioni PP et al. (2006) A CK2-dependent mechanism for degradation of the PML tumor suppressor. Cell 126: 269-83 PubMed GONUTS page
↑ ^4.0 ^4.1 Schäfer B et al. (2009) KIF5C: a new binding partner for protein kinase CK2 with a preference for the CK2alpha' subunit. Cell Mol Life Sci 66: 339-49 PubMed GONUTS page
↑ ^5.0 ^5.1 Bosc DG et al. (2000) Identification and characterization of CKIP-1, a novel pleckstrin homology domain-containing protein that interacts with protein kinase CK2. J Biol Chem 275: 14295-306 PubMed GONUTS page
↑ ^6.0 ^6.1 Vandamme J et al. (2011) Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells. Mol Cell Proteomics 10: M110.002642 PubMed GONUTS page
↑ ^7.0 ^7.1 Sun JM et al. (2007) Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin. J Biol Chem 282: 33227-36 PubMed GONUTS page
↑ Homma MK et al. (2002) Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein. Proc Natl Acad Sci U S A 99: 5959-64 PubMed GONUTS page
↑ Torres J & Pulido R (2001) The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation. J Biol Chem 276: 993-8 PubMed GONUTS page
↑ Dixit D et al. (2012) Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNFα)-induced apoptosis through SIRT1 inhibition. Cell Death Dis 3: e271 PubMed GONUTS page

[PMID:2174700-0] 1.0 ^1.1 ^1.2 Lozeman FJ et al. (1990) Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II. Biochemistry 29: 8436-47 PubMed GONUTS page

[PMID:14667819-1] Lehner B et al. (2004) Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. Genomics 83: 153-67 PubMed GONUTS page

[PMID:16873060-2] Scaglioni PP et al. (2006) A CK2-dependent mechanism for degradation of the PML tumor suppressor. Cell 126: 269-83 PubMed GONUTS page

[PMID:19011756-3] 4.0 ^4.1 Schäfer B et al. (2009) KIF5C: a new binding partner for protein kinase CK2 with a preference for the CK2alpha' subunit. Cell Mol Life Sci 66: 339-49 PubMed GONUTS page

[PMID:10799509-4] 5.0 ^5.1 Bosc DG et al. (2000) Identification and characterization of CKIP-1, a novel pleckstrin homology domain-containing protein that interacts with protein kinase CK2. J Biol Chem 275: 14295-306 PubMed GONUTS page

[PMID:21282530-5] 6.0 ^6.1 Vandamme J et al. (2011) Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells. Mol Cell Proteomics 10: M110.002642 PubMed GONUTS page

[PMID:17827154-6] 7.0 ^7.1 Sun JM et al. (2007) Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin. J Biol Chem 282: 33227-36 PubMed GONUTS page

[PMID:11972058-7] Homma MK et al. (2002) Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein. Proc Natl Acad Sci U S A 99: 5959-64 PubMed GONUTS page

[PMID:11035045-8] Torres J & Pulido R (2001) The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation. J Biol Chem 276: 993-8 PubMed GONUTS page

[PMID:22318540-9] Dixit D et al. (2012) Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNFα)-induced apoptosis through SIRT1 inhibition. Cell Death Dis 3: e271 PubMed GONUTS page

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HUMAN:CSK21

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