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HUMAN:CRCM
Contents |
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | MCC | |
| Protein Name(s) | Colorectal mutant cancer protein
Protein MCC | |
| External Links | ||
| UniProt | P23508 | |
| EMBL | M62397 AC008536 AC010431 AC079465 AC093208 AC106750 AC126917 CH471086 CH471086 BC009279 BC018919 AK128596 | |
| IPI | IPI00011957 IPI00443415 | |
| PIR | A38434 | |
| RefSeq | NP_001078846.1 NP_002378.1 | |
| UniGene | Hs.593171 | |
| ProteinModelPortal | P23508 | |
| DIP | DIP-27599N | |
| IntAct | P23508 | |
| MINT | MINT-1161194 | |
| STRING | P23508 | |
| PhosphoSite | P23508 | |
| DMDM | 117424 | |
| PRIDE | P23508 | |
| Ensembl | ENST00000302475 | |
| GeneID | 4163 | |
| KEGG | hsa:4163 | |
| UCSC | uc003kqj.2 | |
| CTD | 4163 | |
| GeneCards | GC05M112388 | |
| H-InvDB | HIX0020315 | |
| HGNC | HGNC:6935 | |
| HPA | HPA037391 | |
| MIM | 159350 | |
| neXtProt | NX_P23508 | |
| PharmGKB | PA30679 | |
| eggNOG | prNOG15810 | |
| HOGENOM | HBG357807 | |
| HOVERGEN | HBG004762 | |
| OMA | CADAASP | |
| OrthoDB | EOG4ZS92H | |
| NextBio | 16402 | |
| ArrayExpress | P23508 | |
| Bgee | P23508 | |
| CleanEx | HS_MCC | |
| Genevestigator | P23508 | |
| GermOnline | ENSG00000171444 | |
| GO | GO:0005737 GO:0005634 GO:0005886 GO:0005515 GO:0004872 GO:0090090 GO:0010633 GO:0050680 GO:0016055 | |
| InterPro | IPR019536 | |
| Pfam | PF10506 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0004872 |
receptor activity |
TAS: Traceable Author Statement |
|
F |
Seeded From UniProt |
|||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0191 |
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0086 |
C |
Seeded From UniProt |
|||
| GO:0005737 |
cytoplasm |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005737 |
cytoplasm |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0039 |
C |
Seeded From UniProt |
|||
| GO:0005886 |
plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0007165 |
signal transduction |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0010633 |
negative regulation of epithelial cell migration |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016055 |
Wnt receptor signaling pathway |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0050680 |
negative regulation of epithelial cell proliferation |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0090090 |
negative regulation of canonical Wnt receptor signaling pathway |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0005737 |
cytoplasm |
IDA: Inferred from Direct Assay |
C |
Figure 1c showed Western Blot Analysis was used to confirm localization of the MCC protein to the cytoplasm. |
complete | |||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
C |
Figure 1c showed the use of Western Blot Analysis to confirm MCC protein localization in the nucleus of cells. |
complete | |||
| GO:0051726 |
regulation of cell cycle |
IDA: Inferred from Direct Assay |
P |
Figure 4C and 4D shows that MCC regulates the cell cycle by suppressing the DNA-binding activity of β-catenin/TCF/LEF in the nucleus through Western Blot Analysis. This is also confirmed in the section of the text "MCC interacts with β-catenin, blocks β-catenin/TCF/LEF DNA binding, and can affect endogenous β-catenin localization/levels". |
complete | |||
| GO:0045184 |
establishment of protein localization |
IDA: Inferred from Direct Assay |
P |
The section of the text "MCC interacts with β-catenin, blocks β-catenin/TCF/LEF DNA binding, and can affect endogenous β-catenin localization/levels" confirms that MCC relocalizes the β-catenin to the cytoplasm. The results are further confirmed through Western Blot Analysis in Figure 4. |
complete | |||
| GO:0030308 |
negative regulation of cell growth |
IDA: Inferred from Direct Assay |
P |
Immunofluorescence was used and confirmed in Figure 6A/B to show that MCC is responsible for the suppression of basal cell growth. |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Kinzler KW et al. (1991) Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. Science 251: 1366-70 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 Fukuyama R et al. (2008) Mutated in colorectal cancer, a putative tumor suppressor for serrated colorectal cancer, selectively represses beta-catenin-dependent transcription. Oncogene 27: 6044-55 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Arnaud C et al. (2009) MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells. FEBS Lett 583: 2326-32 PubMed GONUTS page
- ↑ Wang J et al. (2011) Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol 7: 536 PubMed GONUTS page
- ↑ Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page
