HUMAN:CHK2

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Species (Taxon ID)	Homo sapiens (Human). ([1])
Gene Name(s)	CHEK2 (synonyms: CDS1, CHK2, RAD53)
Protein Name(s)	Serine/threonine-protein kinase Chk2 CHK2 checkpoint homolog Cds1 homolog Hucds1 hCds1 Checkpoint kinase 2
External Links
EMBL	AF086904 AJ131197 AF096279 AY551295 AY551296 AY551297 AY551298 AY551299 AY551300 AY551301 AY551302 AY551303 AY551304 AY551305 CR456418 AF174135 AB040105 AK290754 AY800241 AL121825 AL117330 AL117330 AL121825 AL121825 AL117330 AL121825 AL117330 AL121825 AL117330 AL117330 AL121825 AL117330 AL121825 AL117330 AL121825 CH471095 BC004207
IPI	IPI00014072 IPI00030746 IPI00423146 IPI00423149 IPI00423156 IPI00423157 IPI00607619 IPI00607680 IPI00607709 IPI00607739 IPI00607753 IPI00607851
RefSeq	NP_001005735.1 NP_009125.1 NP_665861.1
UniGene	Hs.291363 Hs.505297
PDB	1GXC 2CN5 2CN8 2W0J 2W7X 2WTC 2WTD 2WTI 2WTJ 2XBJ 2XM8 2XM9 2YIQ 2YIR 2YIT 3I6U 3I6W
PDBsum	1GXC 2CN5 2CN8 2W0J 2W7X 2WTC 2WTD 2WTI 2WTJ 2XBJ 2XM8 2XM9 2YIQ 2YIR 2YIT 3I6U 3I6W
ProteinModelPortal	O96017
SMR	O96017
DIP	DIP-24270N
IntAct	O96017
MINT	MINT-124588
STRING	O96017
PhosphoSite	O96017
PRIDE	O96017
Ensembl	ENST00000328354 ENST00000404276 ENST00000405598
GeneID	11200
KEGG	hsa:11200
UCSC	uc003adu.1 uc003adv.1 uc003ady.1
CTD	11200
GeneCards	GC22M012048
HGNC	HGNC:16627
HPA	CAB002030 HPA001878
MIM	114480 176807 259500 604373 609265
neXtProt	NX_O96017
Orphanet	1331 145 524 668
PharmGKB	PA404
eggNOG	prNOG16187
HOVERGEN	HBG108055
OMA	PKARFTT
OrthoDB	EOG4M0F1R
PhylomeDB	O96017
BRENDA	2.7.11.1
Pathway_Interaction_DB	foxm1pathway
Reactome	REACT_1538
NextBio	42629
ArrayExpress	O96017
Bgee	O96017
Genevestigator	O96017
GermOnline	ENSG00000183765
GO	GO:0016605 GO:0005524 GO:0046872 GO:0042803 GO:0004674 GO:0007049 GO:0000077 GO:0008630 GO:0046777 GO:0090399
InterPro	IPR000253 IPR011009 IPR000719 IPR017442 IPR008271 IPR002290 IPR008984
Gene3D	G3DSA:2.60.200.20
KO	K06641
Pfam	PF00498 PF00069
SMART	SM00240 SM00220
SUPFAM	SSF56112 SSF49879
PROSITE	PS50006 PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000075	cell cycle checkpoint	Reactome:REACT_1538	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0000077	DNA damage checkpoint	PMID:10617473^[1]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0000077	DNA damage checkpoint	PMID:9889122^[2]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0000086	G2/M transition of mitotic cell cycle	PMID:16481012^[3]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F	Seeded From UniProt
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F	Seeded From UniProt
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	F	Seeded From UniProt
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	F	Seeded From UniProt
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008271	F	Seeded From UniProt
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0723	F	Seeded From UniProt
	GO:0004674	protein serine/threonine kinase activity	PMID:16794575^[4]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0004674	protein serine/threonine kinase activity	PMID:9836640^[5]	TAS: Traceable Author Statement		F	Seeded From UniProt
	GO:0005515	protein binding	PMID:11298456^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P30304	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:12402044^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P29590-5	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:12493754^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P53350	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:15380617^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q13362-1	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:15380617^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q13362-2	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:15380617^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q13362-3	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:15380617^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q15172	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:15380617^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q15173	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:15380617^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q16537	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:17157788^[10]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NY61	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:17525332^[11]	IPI: Inferred from Physical Interaction	UniProtKB:P55072	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:17525332^[11]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y248	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:18644861^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q13616	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C	Seeded From UniProt
	GO:0005654	nucleoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0190	C	Seeded From UniProt
	GO:0005654	nucleoplasm	Reactome:REACT_1603	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005654	nucleoplasm	Reactome:REACT_43	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0006281	DNA repair	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0234	P	Seeded From UniProt
	GO:0006302	double-strand break repair	PMID:18317453^[13]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P	Seeded From UniProt
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P	Seeded From UniProt
	GO:0006355	regulation of transcription, DNA-dependent	PMID:12717439^[14]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002290	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008271	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	P	Seeded From UniProt
	GO:0006915	apoptosis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0053	P	Seeded From UniProt
	GO:0006974	response to DNA damage stimulus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0227	P	Seeded From UniProt
	GO:0006974	response to DNA damage stimulus	PMID:16481012^[3]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0006974	response to DNA damage stimulus	PMID:9836640^[5]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0006974	response to DNA damage stimulus	PMID:9889122^[2]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0006975	DNA damage induced protein phosphorylation	PMID:11298456^[6]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0007049	cell cycle	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0131	P	Seeded From UniProt
	GO:0007067	mitosis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0498	P	Seeded From UniProt
	GO:0008630	DNA damage response, signal transduction resulting in induction of apoptosis	PMID:12402044^[7]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0008630	DNA damage response, signal transduction resulting in induction of apoptosis	PMID:12717439^[14]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0008630	DNA damage response, signal transduction resulting in induction of apoptosis	PMID:18644861^[12]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0016301	kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	F	Seeded From UniProt
	GO:0016310	phosphorylation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	P	Seeded From UniProt
	GO:0016605	PML body	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0465	C	Seeded From UniProt
	GO:0016605	PML body	PMID:12402044^[7]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F	Seeded From UniProt
	GO:0016772	transferase activity, transferring phosphorus-containing groups	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F	Seeded From UniProt
	GO:0019901	protein kinase binding	PMID:16481012^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q9H4B4	F	Seeded From UniProt
	GO:0042176	regulation of protein catabolic process	PMID:17101782^[15]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0042770	signal transduction in response to DNA damage	PMID:14744935^[16]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0042803	protein homodimerization activity	PMID:16794575^[4]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0044257	cellular protein catabolic process	PMID:11298456^[6]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:17101782^[15]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0046777	protein autophosphorylation	PMID:16794575^[4]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0046777	protein autophosphorylation	PMID:18644861^[12]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F	Seeded From UniProt
	GO:0051301	cell division	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0132	P	Seeded From UniProt
	GO:0072428	signal transduction involved in intra-S DNA damage checkpoint	PMID:11298456^[6]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0090307	spindle assembly involved in mitosis	PMID:20364141^[17]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0090399	replicative senescence	PMID:15149599^[18]	NAS: Non-traceable Author Statement		P	Seeded From UniProt
	GO:0000781	chromosome, telomeric region	PMID:15149599^[18]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Bell DW et al. (1999) Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome. Science 286: 2528-31 PubMed GONUTS page
↑ ^2.0 ^2.1 Blasina A et al. (1999) A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase. Curr Biol 9: 1-10 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Bahassi el M et al. (2006) Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage. Mutat Res 596: 166-76 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Oliver AW et al. (2006) Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange. EMBO J 25: 3179-90 PubMed GONUTS page
↑ ^5.0 ^5.1 Matsuoka S et al. (1998) Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 282: 1893-7 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Falck J et al. (2001) The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 410: 842-7 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Yang S et al. (2002) PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2. Nat Cell Biol 4: 865-70 PubMed GONUTS page
↑ Tsvetkov L et al. (2003) Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody. J Biol Chem 278: 8468-75 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Dozier C et al. (2004) Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit. Biol Cell 96: 509-17 PubMed GONUTS page
↑ Bruno T et al. (2006) Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint. Cancer Cell 10: 473-86 PubMed GONUTS page
↑ ^11.0 ^11.1 Matsuoka S et al. (2007) ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316: 1160-6 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Lovly CM et al. (2008) Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379. Mol Cell Biol 28: 5874-85 PubMed GONUTS page
↑ Bahassi EM et al. (2008) The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage. Oncogene 27: 3977-85 PubMed GONUTS page
↑ ^14.0 ^14.1 Stevens C et al. (2003) Chk2 activates E2F-1 in response to DNA damage. Nat Cell Biol 5: 401-9 PubMed GONUTS page
↑ ^15.0 ^15.1 Tan Y et al. (2007) Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes. Mol Cell Biol 27: 1007-16 PubMed GONUTS page
↑ Qu L et al. (2004) Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. Genes Dev 18: 261-77 PubMed GONUTS page
↑ Stolz A et al. (2010) The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells. Nat Cell Biol 12: 492-9 PubMed GONUTS page
↑ ^18.0 ^18.1 Herbig U et al. (2004) Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell 14: 501-13 PubMed GONUTS page

[PMID:10617473-0] Bell DW et al. (1999) Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome. Science 286: 2528-31 PubMed GONUTS page

[PMID:9889122-1] 2.0 ^2.1 Blasina A et al. (1999) A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase. Curr Biol 9: 1-10 PubMed GONUTS page

[PMID:16481012-2] 3.0 ^3.1 ^3.2 Bahassi el M et al. (2006) Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage. Mutat Res 596: 166-76 PubMed GONUTS page

[PMID:16794575-3] 4.0 ^4.1 ^4.2 Oliver AW et al. (2006) Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange. EMBO J 25: 3179-90 PubMed GONUTS page

[PMID:9836640-4] 5.0 ^5.1 Matsuoka S et al. (1998) Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 282: 1893-7 PubMed GONUTS page

[PMID:11298456-5] 6.0 ^6.1 ^6.2 ^6.3 Falck J et al. (2001) The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 410: 842-7 PubMed GONUTS page

[PMID:12402044-6] 7.0 ^7.1 ^7.2 Yang S et al. (2002) PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2. Nat Cell Biol 4: 865-70 PubMed GONUTS page

[PMID:12493754-7] Tsvetkov L et al. (2003) Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody. J Biol Chem 278: 8468-75 PubMed GONUTS page

[PMID:15380617-8] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Dozier C et al. (2004) Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit. Biol Cell 96: 509-17 PubMed GONUTS page

[PMID:17157788-9] Bruno T et al. (2006) Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint. Cancer Cell 10: 473-86 PubMed GONUTS page

[PMID:17525332-10] 11.0 ^11.1 Matsuoka S et al. (2007) ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316: 1160-6 PubMed GONUTS page

[PMID:18644861-11] 12.0 ^12.1 ^12.2 Lovly CM et al. (2008) Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379. Mol Cell Biol 28: 5874-85 PubMed GONUTS page

[PMID:18317453-12] Bahassi EM et al. (2008) The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage. Oncogene 27: 3977-85 PubMed GONUTS page

[PMID:12717439-13] 14.0 ^14.1 Stevens C et al. (2003) Chk2 activates E2F-1 in response to DNA damage. Nat Cell Biol 5: 401-9 PubMed GONUTS page

[PMID:17101782-14] 15.0 ^15.1 Tan Y et al. (2007) Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes. Mol Cell Biol 27: 1007-16 PubMed GONUTS page

[PMID:14744935-15] Qu L et al. (2004) Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. Genes Dev 18: 261-77 PubMed GONUTS page

[PMID:20364141-16] Stolz A et al. (2010) The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells. Nat Cell Biol 12: 492-9 PubMed GONUTS page

[PMID:15149599-17] 18.0 ^18.1 Herbig U et al. (2004) Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell 14: 501-13 PubMed GONUTS page

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HUMAN:CHK2

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