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HUMAN:CETP
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | CETP (ECO:0000312 with HGNC:HGNC:1869) | |
Protein Name(s) | Cholesteryl ester transfer protein (ECO:0000303 with PMID:3600759[1])
Lipid transfer protein I (ECO:0000312 with MIM:118470) | |
External Links | ||
UniProt | P11597 | |
EMBL | M30185 M32998 M32992 M32993 M32994 M32995 M32996 M32997 AY422211 BC025739 U71187 AF027656 M83573 | |
CCDS | CCDS10772.1 CCDS67032.1 | |
PIR | A26941 | |
RefSeq | NP_000069.2 | |
UniGene | Hs.89538 | |
PDB | 2OBD 4EWS 4F2A | |
PDBsum | 2OBD 4EWS 4F2A | |
ProteinModelPortal | P11597 | |
SMR | P11597 | |
BioGrid | 107498 | |
IntAct | P11597 | |
STRING | 9606.ENSP00000200676 | |
BindingDB | P11597 | |
ChEMBL | CHEMBL3572 | |
PhosphoSite | P11597 | |
BioMuta | CETP | |
DMDM | 71153497 | |
PaxDb | P11597 | |
PeptideAtlas | P11597 | |
PRIDE | P11597 | |
DNASU | 1071 | |
Ensembl | ENST00000200676 ENST00000379780 | |
GeneID | 1071 | |
KEGG | hsa:1071 | |
UCSC | uc002eki.2 uc002ekj.2 | |
CTD | 1071 | |
GeneCards | GC16P056996 | |
HGNC | HGNC:1869 | |
MIM | 118470 143470 | |
neXtProt | NX_P11597 | |
Orphanet | 79506 | |
PharmGKB | PA108 | |
eggNOG | NOG252260 | |
GeneTree | ENSGT00390000008226 | |
HOGENOM | HOG000111553 | |
HOVERGEN | HBG005310 | |
InParanoid | P11597 | |
KO | K16835 | |
OMA | PKISCQN | |
OrthoDB | EOG783MV4 | |
PhylomeDB | P11597 | |
TreeFam | TF333484 | |
Reactome | REACT_13621 REACT_6934 | |
EvolutionaryTrace | P11597 | |
GeneWiki | Cholesterylester_transfer_protein | |
GenomeRNAi | 1071 | |
NextBio | 4472 | |
PRO | PR:P11597 | |
Proteomes | UP000005640 | |
Bgee | P11597 | |
CleanEx | HS_CETP | |
ExpressionAtlas | P11597 | |
Genevisible | P11597 | |
GO | GO:0070062 GO:0005576 GO:0005615 GO:0034364 GO:0031982 GO:0015485 GO:0017127 GO:0008289 GO:0005319 GO:0031210 GO:0005548 GO:0017129 GO:0042632 GO:0008203 GO:0030301 GO:0034375 GO:0055088 GO:0006869 GO:0042157 GO:0034374 GO:0010745 GO:0046470 GO:0055091 GO:0015914 GO:0006898 GO:0010874 GO:0043691 GO:0044281 GO:0070328 GO:0006641 GO:0034197 GO:0034372 | |
InterPro | IPR017943 IPR017130 IPR001124 IPR017954 IPR017942 | |
PANTHER | PTHR10504:SF12 | |
Pfam | PF01273 PF02886 | |
PIRSF | PIRSF037185 | |
SMART | SM00328 SM00329 | |
SUPFAM | SSF55394 | |
PROSITE | PS00400 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034197 |
triglyceride transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030301 |
cholesterol transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0017127 |
cholesterol transporter activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034375 |
high-density lipoprotein particle remodeling |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034372 |
very-low-density lipoprotein particle remodeling |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0070328 |
triglyceride homeostasis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0055091 |
phospholipid homeostasis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0055088 |
lipid homeostasis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0046470 |
phosphatidylcholine metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043691 |
reverse cholesterol transport |
ECO:0000305 |
curator inference used in manual assertion |
GO:0034375 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042632 |
cholesterol homeostasis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034375 |
high-density lipoprotein particle remodeling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034374 |
low-density lipoprotein particle remodeling |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034372 |
very-low-density lipoprotein particle remodeling |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0034364 |
high-density lipoprotein particle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0031982 |
vesicle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0031210 |
phosphatidylcholine binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030301 |
cholesterol transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0017129 |
triglyceride binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0017127 |
cholesterol transporter activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0017127 |
cholesterol transporter activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0015914 |
phospholipid transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0015485 |
cholesterol binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010874 |
regulation of cholesterol efflux |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010745 |
negative regulation of macrophage derived foam cell differentiation |
ECO:0000305 |
curator inference used in manual assertion |
GO:0010874 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0008289 |
lipid binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008203 |
cholesterol metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008203 |
cholesterol metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006869 |
lipid transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006641 |
triglyceride metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005548 |
phospholipid transporter activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005319 |
lipid transporter activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0070328 |
triglyceride homeostasis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002935167 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0055091 |
phospholipid homeostasis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002935167 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0046470 |
phosphatidylcholine metabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002935167 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042632 |
cholesterol homeostasis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002935167 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034375 |
high-density lipoprotein particle remodeling |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002935167 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034374 |
low-density lipoprotein particle remodeling |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002935167 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034372 |
very-low-density lipoprotein particle remodeling |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002935167 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0034364 |
high-density lipoprotein particle |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002935167 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034197 |
triglyceride transport |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002935167 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0031210 |
phosphatidylcholine binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002935167 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0017129 |
triglyceride binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002935167 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0017127 |
cholesterol transporter activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002935167 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0015485 |
cholesterol binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002935167 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0008203 |
cholesterol metabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002935167 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006641 |
triglyceride metabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002935167 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0005548 |
phospholipid transporter activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002935167 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0008289 |
lipid binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001124 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0017127 |
cholesterol transporter activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0034364 |
high-density lipoprotein particle |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043691 |
reverse cholesterol transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034375 |
high-density lipoprotein particle remodeling |
Reactome:R-HSA-8964058 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034374 |
low-density lipoprotein particle remodeling |
Reactome:R-HSA-8964041 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-349404 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
involved_in |
GO:0006869 |
lipid transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008202 |
steroid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008203 |
cholesterol metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005615 |
extracellular space |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Drayna, D et al. () Cloning and sequencing of human cholesteryl ester transfer protein cDNA. Nature 327 632-4 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Morton, RE & Izem, L (2014) Cholesteryl ester transfer proteins from different species do not have equivalent activities. J. Lipid Res. 55 258-65 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
- ↑ 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 5.12 5.13 5.14 5.15 Swenson, TL et al. (1988) Plasma cholesteryl ester transfer protein has binding sites for neutral lipids and phospholipids. J. Biol. Chem. 263 5150-7 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Hesler, CB et al. (1987) Purification and characterization of a human plasma cholesteryl ester transfer protein. J. Biol. Chem. 262 2275-82 PubMed GONUTS page
- ↑ Murakami, T et al. (1995) Triglycerides are major determinants of cholesterol esterification/transfer and HDL remodeling in human plasma. Arterioscler. Thromb. Vasc. Biol. 15 1819-28 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Brown, ML et al. (1989) Molecular basis of lipid transfer protein deficiency in a family with increased high-density lipoproteins. Nature 342 448-51 PubMed GONUTS page
- ↑ 9.0 9.1 Cheung, MC et al. (1986) Distribution and localization of lecithin:cholesterol acyltransferase and cholesteryl ester transfer activity in A-I-containing lipoproteins. J. Lipid Res. 27 1135-44 PubMed GONUTS page
- ↑ 10.0 10.1 Matsuura, F et al. (2006) HDL from CETP-deficient subjects shows enhanced ability to promote cholesterol efflux from macrophages in an apoE- and ABCG1-dependent pathway. J. Clin. Invest. 116 1435-42 PubMed GONUTS page
- ↑ 11.00 11.01 11.02 11.03 11.04 11.05 11.06 11.07 11.08 11.09 11.10 11.11 11.12 11.13 11.14 11.15 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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