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HUMAN:CETP

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CETP (ECO:0000312 with HGNC:HGNC:1869)
Protein Name(s) Cholesteryl ester transfer protein (ECO:0000303 with PMID:3600759[1])

Lipid transfer protein I (ECO:0000312 with MIM:118470)

External Links
UniProt P11597
EMBL M30185
M32998
M32992
M32993
M32994
M32995
M32996
M32997
AY422211
BC025739
U71187
AF027656
M83573
CCDS CCDS10772.1
CCDS67032.1
PIR A26941
RefSeq NP_000069.2
UniGene Hs.89538
PDB 2OBD
4EWS
4F2A
PDBsum 2OBD
4EWS
4F2A
ProteinModelPortal P11597
SMR P11597
BioGrid 107498
IntAct P11597
STRING 9606.ENSP00000200676
BindingDB P11597
ChEMBL CHEMBL3572
PhosphoSite P11597
BioMuta CETP
DMDM 71153497
PaxDb P11597
PeptideAtlas P11597
PRIDE P11597
DNASU 1071
Ensembl ENST00000200676
ENST00000379780
GeneID 1071
KEGG hsa:1071
UCSC uc002eki.2
uc002ekj.2
CTD 1071
GeneCards GC16P056996
HGNC HGNC:1869
MIM 118470
143470
neXtProt NX_P11597
Orphanet 79506
PharmGKB PA108
eggNOG NOG252260
GeneTree ENSGT00390000008226
HOGENOM HOG000111553
HOVERGEN HBG005310
InParanoid P11597
KO K16835
OMA PKISCQN
OrthoDB EOG783MV4
PhylomeDB P11597
TreeFam TF333484
Reactome REACT_13621
REACT_6934
EvolutionaryTrace P11597
GeneWiki Cholesterylester_transfer_protein
GenomeRNAi 1071
NextBio 4472
PRO PR:P11597
Proteomes UP000005640
Bgee P11597
CleanEx HS_CETP
ExpressionAtlas P11597
Genevisible P11597
GO GO:0070062
GO:0005576
GO:0005615
GO:0034364
GO:0031982
GO:0015485
GO:0017127
GO:0008289
GO:0005319
GO:0031210
GO:0005548
GO:0017129
GO:0042632
GO:0008203
GO:0030301
GO:0034375
GO:0055088
GO:0006869
GO:0042157
GO:0034374
GO:0010745
GO:0046470
GO:0055091
GO:0015914
GO:0006898
GO:0010874
GO:0043691
GO:0044281
GO:0070328
GO:0006641
GO:0034197
GO:0034372
InterPro IPR017943
IPR017130
IPR001124
IPR017954
IPR017942
PANTHER PTHR10504:SF12
Pfam PF01273
PF02886
PIRSF PIRSF037185
SMART SM00328
SM00329
SUPFAM SSF55394
PROSITE PS00400

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005615

extracellular space

PMID:24293641[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0034197

triglyceride transport

PMID:24293641[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030301

cholesterol transport

PMID:24293641[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0017127

cholesterol transporter activity

PMID:24293641[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0034375

high-density lipoprotein particle remodeling

PMID:24293641[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034372

very-low-density lipoprotein particle remodeling

PMID:24293641[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:23533145[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

involved_in

GO:0070328

triglyceride homeostasis

PMID:2833496[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0055091

phospholipid homeostasis

PMID:2833496[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0055088

lipid homeostasis

PMID:3818596[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046470

phosphatidylcholine metabolic process

PMID:2833496[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043691

reverse cholesterol transport

PMID:7583561[7]

ECO:0000305

curator inference used in manual assertion

GO:0034375

P

Seeded From UniProt

complete

involved_in

GO:0042632

cholesterol homeostasis

PMID:2586614[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034375

high-density lipoprotein particle remodeling

PMID:2586614[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034374

low-density lipoprotein particle remodeling

PMID:2833496[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034372

very-low-density lipoprotein particle remodeling

PMID:2833496[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0034364

high-density lipoprotein particle

PMID:3104518[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0031982

vesicle

PMID:2833496[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0031210

phosphatidylcholine binding

PMID:2833496[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0030301

cholesterol transport

PMID:2833496[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0017129

triglyceride binding

PMID:2833496[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0017127

cholesterol transporter activity

PMID:2833496[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0017127

cholesterol transporter activity

PMID:3600759[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0015914

phospholipid transport

PMID:2833496[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0015485

cholesterol binding

PMID:2833496[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0010874

regulation of cholesterol efflux

PMID:16670775[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010745

negative regulation of macrophage derived foam cell differentiation

PMID:16670775[10]

ECO:0000305

curator inference used in manual assertion

GO:0010874

P

Seeded From UniProt

complete

enables

GO:0008289

lipid binding

PMID:3818596[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0008203

cholesterol metabolic process

PMID:2586614[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008203

cholesterol metabolic process

PMID:2833496[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006869

lipid transport

PMID:3818596[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006641

triglyceride metabolic process

PMID:2833496[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:3104518[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005548

phospholipid transporter activity

PMID:2833496[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005319

lipid transporter activity

PMID:2833496[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0070328

triglyceride homeostasis

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002935167
UniProtKB:P11597

P

Seeded From UniProt

complete

involved_in

GO:0055091

phospholipid homeostasis

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002935167
UniProtKB:P11597

P

Seeded From UniProt

complete

involved_in

GO:0046470

phosphatidylcholine metabolic process

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002935167
UniProtKB:P11597

P

Seeded From UniProt

complete

involved_in

GO:0042632

cholesterol homeostasis

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002935167
UniProtKB:P11597

P

Seeded From UniProt

complete

involved_in

GO:0034375

high-density lipoprotein particle remodeling

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002935167
UniProtKB:P11597

P

Seeded From UniProt

complete

involved_in

GO:0034374

low-density lipoprotein particle remodeling

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002935167
UniProtKB:P11597

P

Seeded From UniProt

complete

involved_in

GO:0034372

very-low-density lipoprotein particle remodeling

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002935167
UniProtKB:P11597

P

Seeded From UniProt

complete

part_of

GO:0034364

high-density lipoprotein particle

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002935167
UniProtKB:P11597

C

Seeded From UniProt

complete

involved_in

GO:0034197

triglyceride transport

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002935167
UniProtKB:P11597

P

Seeded From UniProt

complete

enables

GO:0031210

phosphatidylcholine binding

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002935167
UniProtKB:P11597

F

Seeded From UniProt

complete

enables

GO:0017129

triglyceride binding

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002935167
UniProtKB:P11597

F

Seeded From UniProt

complete

enables

GO:0017127

cholesterol transporter activity

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002935167
UniProtKB:P11597

F

Seeded From UniProt

complete

enables

GO:0015485

cholesterol binding

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002935167
UniProtKB:P11597

F

Seeded From UniProt

complete

involved_in

GO:0008203

cholesterol metabolic process

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002935167
UniProtKB:P11597

P

Seeded From UniProt

complete

involved_in

GO:0006641

triglyceride metabolic process

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002935167
UniProtKB:P11597

P

Seeded From UniProt

complete

enables

GO:0005548

phospholipid transporter activity

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002935167
UniProtKB:P11597

F

Seeded From UniProt

complete

enables

GO:0008289

lipid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001124
InterPro:IPR017942
InterPro:IPR017943
InterPro:IPR017954

F

Seeded From UniProt

complete

enables

GO:0017127

cholesterol transporter activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017130

F

Seeded From UniProt

complete

part_of

GO:0034364

high-density lipoprotein particle

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017130

C

Seeded From UniProt

complete

involved_in

GO:0043691

reverse cholesterol transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017130

P

Seeded From UniProt

complete

involved_in

GO:0034375

high-density lipoprotein particle remodeling

Reactome:R-HSA-8964058

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034374

low-density lipoprotein particle remodeling

Reactome:R-HSA-8964041

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-349404
Reactome:R-HSA-266350
Reactome:R-HSA-266328

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

involved_in

GO:0006869

lipid transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0445

P

Seeded From UniProt

complete

involved_in

GO:0008202

steroid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0753

P

Seeded From UniProt

complete

involved_in

GO:0008203

cholesterol metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0153

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964

C

Seeded From UniProt

complete

involved_in

GO:0006629

lipid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0443

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0112

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Drayna, D et al. () Cloning and sequencing of human cholesteryl ester transfer protein cDNA. Nature 327 632-4 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Morton, RE & Izem, L (2014) Cholesteryl ester transfer proteins from different species do not have equivalent activities. J. Lipid Res. 55 258-65 PubMed GONUTS page
  3. Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  4. Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  5. 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 5.12 5.13 5.14 5.15 Swenson, TL et al. (1988) Plasma cholesteryl ester transfer protein has binding sites for neutral lipids and phospholipids. J. Biol. Chem. 263 5150-7 PubMed GONUTS page
  6. 6.0 6.1 6.2 Hesler, CB et al. (1987) Purification and characterization of a human plasma cholesteryl ester transfer protein. J. Biol. Chem. 262 2275-82 PubMed GONUTS page
  7. Murakami, T et al. (1995) Triglycerides are major determinants of cholesterol esterification/transfer and HDL remodeling in human plasma. Arterioscler. Thromb. Vasc. Biol. 15 1819-28 PubMed GONUTS page
  8. 8.0 8.1 8.2 Brown, ML et al. (1989) Molecular basis of lipid transfer protein deficiency in a family with increased high-density lipoproteins. Nature 342 448-51 PubMed GONUTS page
  9. 9.0 9.1 Cheung, MC et al. (1986) Distribution and localization of lecithin:cholesterol acyltransferase and cholesteryl ester transfer activity in A-I-containing lipoproteins. J. Lipid Res. 27 1135-44 PubMed GONUTS page
  10. 10.0 10.1 Matsuura, F et al. (2006) HDL from CETP-deficient subjects shows enhanced ability to promote cholesterol efflux from macrophages in an apoE- and ABCG1-dependent pathway. J. Clin. Invest. 116 1435-42 PubMed GONUTS page
  11. 11.00 11.01 11.02 11.03 11.04 11.05 11.06 11.07 11.08 11.09 11.10 11.11 11.12 11.13 11.14 11.15 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page