HUMAN:CDT1

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	CDT1
Protein Name(s)	DNA replication factor Cdt1 Double parked homolog DUP
External Links
UniProt Identifier	CDT1_HUMAN
UniProt Accessions	Q9H211, Q86XX9, Q96CJ5, Q96GK5, Q96H67, Q96HE6, Q9BWM0,
EMBL	AF321125, AB053172, AC092384, BC000137, BC008676, BC008860, BC009410, BC014202, BC049205, AF070552,
RefSeq	NP_112190.2,
PDB	2WVR,
IntAct	Q9H211,
Ensembl	ENST00000301019,
Pfam	PF08839,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005654	nucleoplasm		EXP: Inferred from Experiment		C	Source: Reactome
	GO:0003677	DNA binding		ISS: Inferred from Sequence or Structural Similarity		F	Source: UniProtKB
	GO:0005515	protein binding		IPI: Inferred from Physical Interaction		F	Source: IntAct
	GO:0007049	cell cycle		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0006260	DNA replication		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0000076	DNA replication checkpoint		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0005730	nucleolus	PMID:11555648^[1]	IDA: Inferred from Direct Assay		C	Figure 2.	complete
	GO:0000076	DNA replication checkpoint	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000006760	P
	GO:0000076	DNA replication checkpoint	PMID:14672932^[2]	IDA: Inferred from Direct Assay		P
	GO:0000082	G1/S transition of mitotic cell cycle	Reactome:REACT_1783	TAS: Traceable Author Statement		P
	GO:0000083	regulation of transcription involved in G1/S phase of mitotic cell cycle	Reactome:REACT_683	TAS: Traceable Author Statement		P
	GO:0000084	S phase of mitotic cell cycle	Reactome:REACT_899	TAS: Traceable Author Statement		P
	GO:0000216	M/G1 transition of mitotic cell cycle	Reactome:REACT_1725	TAS: Traceable Author Statement		P
	GO:0000278	mitotic cell cycle	Reactome:REACT_152	TAS: Traceable Author Statement		P
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003677	DNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000006760	F
	GO:0003677	DNA binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q8R4E9	F
	GO:0005515	protein binding	PMID:11125146^[3]	IPI: Inferred from Physical Interaction	UniProtKB:O75496	F
	GO:0005515	protein binding	PMID:14672932^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q99741	F
	GO:0005515	protein binding	PMID:15232106^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q13415	F
	GO:0005515	protein binding	PMID:15232106^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q13416	F
	GO:0005515	protein binding	PMID:15232106^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q99459	F
	GO:0005515	protein binding	PMID:20202939^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q14566	F
	GO:0005515	protein binding	PMID:20932478^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UFC0	F
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000006760	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:11125146^[3]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:18029348^[7]	IDA: Inferred from Direct Assay		C
	GO:0005654	nucleoplasm	Reactome:REACT_1770	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_1975	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_2111	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_22145	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_541	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_757	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_951	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_1787	TAS: Traceable Author Statement		C
	GO:0006260	DNA replication	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0235	P
	GO:0007049	cell cycle	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0131	P
	GO:0007090	regulation of S phase of mitotic cell cycle	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000006760	P
	GO:0030174	regulation of DNA-dependent DNA replication initiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000006760	P
	GO:0030174	regulation of DNA-dependent DNA replication initiation	PMID:11125146^[3]	IDA: Inferred from Direct Assay		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Nishitani H et al. (2001) The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase. J Biol Chem 276: 44905-11 PubMed GONUTS page
↑ ^2.0 ^2.1 Cook JG et al. (2004) The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells. J Biol Chem 279: 9625-33 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Wohlschlegel JA et al. (2000) Inhibition of eukaryotic DNA replication by geminin binding to Cdt1. Science 290: 2309-12 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Ramachandran N et al. (2004) Self-assembling protein microarrays. Science 305: 86-90 PubMed GONUTS page
↑ Wei Z et al. (2010) Characterization and structure determination of the Cdt1 binding domain of human minichromosome maintenance (Mcm) 6. J Biol Chem 285: 12469-73 PubMed GONUTS page
↑ Shen Z et al. (2010) A WD-repeat protein stabilizes ORC binding to chromatin. Mol Cell 40: 99-111 PubMed GONUTS page
↑ Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page

[PMID:11555648-0] Nishitani H et al. (2001) The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase. J Biol Chem 276: 44905-11 PubMed GONUTS page

[PMID:14672932-1] 2.0 ^2.1 Cook JG et al. (2004) The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells. J Biol Chem 279: 9625-33 PubMed GONUTS page

[PMID:11125146-2] 3.0 ^3.1 ^3.2 Wohlschlegel JA et al. (2000) Inhibition of eukaryotic DNA replication by geminin binding to Cdt1. Science 290: 2309-12 PubMed GONUTS page

[PMID:15232106-3] 4.0 ^4.1 ^4.2 Ramachandran N et al. (2004) Self-assembling protein microarrays. Science 305: 86-90 PubMed GONUTS page

[PMID:20202939-4] Wei Z et al. (2010) Characterization and structure determination of the Cdt1 binding domain of human minichromosome maintenance (Mcm) 6. J Biol Chem 285: 12469-73 PubMed GONUTS page

[PMID:20932478-5] Shen Z et al. (2010) A WD-repeat protein stabilizes ORC binding to chromatin. Mol Cell 40: 99-111 PubMed GONUTS page

[PMID:18029348-6] Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page

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HUMAN:CDT1

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