HUMAN:CD4

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	CD4
Protein Name(s)	T-cell surface glycoprotein CD4 T-cell surface antigen T4/Leu-3
External Links
UniProt Identifier	CD4_HUMAN
UniProt Accessions	P01730, B2R737, D3DUS5, Q4ZGK2, Q5U066, Q9UDE5,
EMBL	M12807, U47924, M35160, BT019791, BT019811, DQ012936, AK312828, CH471116, CH471116, BC025782,
PIR	A90872,
RefSeq	NP_000607.1,
PDB	1CDH, 1CDI, 1CDJ, 1CDU, 1CDY, 1G9M, 1G9N, 1GC1, 1JL4, 1OPN, 1OPT, 1OPW, 1Q68, 1RZJ, 1RZK, 1WBR, 1WIO, 1WIP, 1WIQ, 2B4C, 2JKR, 2JKT, 2KLU, 2NXY, 2NXZ, 2NY0, 2NY1, 2NY2, 2NY3, 2NY4, 2NY5, 2NY6, 2QAD, 3B71, 3CD4, 3JWD, 3JWO, 3LQA, 3O2D,
IntAct	P01730,
Ensembl	ENST00000011653,
Pfam	PF05790, PF09191, PF12104, PF07686,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0001816	cytokine production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	P
	GO:0001948	glycoprotein binding	PMID:10922058^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P03375	F
	GO:0004872	receptor activity	PMID:10413516^[2]	TAS: Traceable Author Statement		F
	GO:0004888	transmembrane receptor activity	PMID:10358157^[3]	TAS: Traceable Author Statement		F
	GO:0005201	extracellular matrix structural constituent	PMID:12444132^[4]	NAS: Non-traceable Author Statement		F
	GO:0005515	protein binding	PMID:11113139^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NZD8	F
	GO:0005515	protein binding	PMID:7831289^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P03406	F
	GO:0005769	early endosome	PMID:15202998^[7]	EXP: Inferred from Experiment		C
	GO:0005769	early endosome	PMID:2014052^[8]	EXP: Inferred from Experiment		C
	GO:0005788	endoplasmic reticulum lumen	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	C
	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	C
	GO:0005789	endoplasmic reticulum membrane	PMID:9660940^[9]	EXP: Inferred from Experiment		C
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	C
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0005886	plasma membrane	PMID:11048639^[10]	EXP: Inferred from Experiment		C
	GO:0005886	plasma membrane	PMID:11390434^[11]	IDA: Inferred from Direct Assay		C
	GO:0005886	plasma membrane	PMID:11827988^[12]	EXP: Inferred from Experiment		C
	GO:0005886	plasma membrane	PMID:15202998^[7]	EXP: Inferred from Experiment		C
	GO:0005886	plasma membrane	PMID:15489916^[13]	EXP: Inferred from Experiment		C
	GO:0005886	plasma membrane	PMID:17652306^[14]	EXP: Inferred from Experiment		C
	GO:0005886	plasma membrane	PMID:2014052^[8]	EXP: Inferred from Experiment		C
	GO:0005886	plasma membrane	PMID:8124721^[15]	IDA: Inferred from Direct Assay		C
	GO:0005886	plasma membrane	Reactome:REACT_12394	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_12421	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_12538	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_12566	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_12633	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_12640	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_12642	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_19146	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_7953	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_7962	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_8003	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_8009	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_8010	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_8020	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_8023	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_8032	TAS: Traceable Author Statement		C
	GO:0006948	induction by virus of host cell-cell fusion	PMID:9166430^[16]	IDA: Inferred from Direct Assay		P
	GO:0006955	immune response	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000973	P
	GO:0006955	immune response	PMID:8512039^[17]	NAS: Non-traceable Author Statement		P
	GO:0007155	cell adhesion	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008424	P
	GO:0007165	signal transduction	PMID:10358157^[3]	TAS: Traceable Author Statement		P
	GO:0007165	signal transduction	PMID:9558100^[18]	TAS: Traceable Author Statement		P
	GO:0007166	cell surface receptor linked signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	P
	GO:0007166	cell surface receptor linked signaling pathway	PMID:9780207^[19]	TAS: Traceable Author Statement		P
	GO:0007167	enzyme linked receptor protein signaling pathway	PMID:10358157^[3]	TAS: Traceable Author Statement		P
	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:8512039^[17]	NAS: Non-traceable Author Statement		P
	GO:0008270	zinc ion binding	PMID:9668045^[20]	IDA: Inferred from Direct Assay		F
	GO:0009897	external side of plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	C
	GO:0009986	cell surface	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	C
	GO:0015026	coreceptor activity	PMID:8512039^[17]	NAS: Non-traceable Author Statement		F
	GO:0015026	coreceptor activity	PMID:8674120^[21]	TAS: Traceable Author Statement		F
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000973	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008424	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0016032	viral reproduction	Reactome:REACT_6185	TAS: Traceable Author Statement		P
	GO:0016032	viral reproduction	Reactome:REACT_6256	TAS: Traceable Author Statement		P
	GO:0019059	initiation of viral infection	PMID:12091904^[22]	EXP: Inferred from Experiment		P
	GO:0019901	protein kinase binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000021915	F
	GO:0019901	protein kinase binding	PMID:7486703^[23]	IPI: Inferred from Physical Interaction	UniProtKB:P06239	F
	GO:0030217	T cell differentiation	PMID:1533274^[24]	IDA: Inferred from Direct Assay		P
	GO:0030260	entry into host cell	Reactome:REACT_6903	TAS: Traceable Author Statement		P
	GO:0031295	T cell costimulation	Reactome:REACT_19344	TAS: Traceable Author Statement		P
	GO:0032507	maintenance of protein location in cell	PMID:15128768^[25]	IDA: Inferred from Direct Assay		P
	GO:0042101	T cell receptor complex	PMID:8512039^[17]	NAS: Non-traceable Author Statement		C
	GO:0042110	T cell activation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000021915	P
	GO:0042289	MHC class II protein binding	PMID:8512039^[17]	NAS: Non-traceable Author Statement		F
	GO:0042803	protein homodimerization activity	PMID:12444132^[4]	IDA: Inferred from Direct Assay		F
	GO:0044419	interspecies interaction between organisms	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0945	P
	GO:0045058	T cell selection	PMID:9551897^[26]	IDA: Inferred from Direct Assay		P
	GO:0045086	positive regulation of interleukin-2 biosynthetic process	PMID:1901411^[27]	NAS: Non-traceable Author Statement		P
	GO:0045121	membrane raft	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	C
	GO:0045234	protein palmitoleylation	PMID:15128768^[25]	IDA: Inferred from Direct Assay		P
	GO:0045860	positive regulation of protein kinase activity	PMID:2118992^[28]	IDA: Inferred from Direct Assay		P
	GO:0050690	regulation of defense response to virus by virus	Reactome:REACT_11149	TAS: Traceable Author Statement		P
	GO:0050690	regulation of defense response to virus by virus	Reactome:REACT_11166	TAS: Traceable Author Statement		P
	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	P
	GO:0050850	positive regulation of calcium-mediated signaling	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	P
	GO:0050852	T cell receptor signaling pathway	Reactome:REACT_12526	TAS: Traceable Author Statement		P
	GO:0050863	regulation of T cell activation	PMID:1533274^[24]	IDA: Inferred from Direct Assay		P
	GO:0050870	positive regulation of T cell activation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	P
	GO:0051789	response to protein stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	P
	GO:0001816	cytokine production	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	P
	GO:0001948	glycoprotein binding	PMID:10922058^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P03375	F
	GO:0004872	receptor activity	PMID:10413516^[2]	TAS: Traceable Author Statement		F
	GO:0004888	transmembrane signaling receptor activity	PMID:10358157^[3]	TAS: Traceable Author Statement		F
	GO:0005201	extracellular matrix structural constituent	PMID:12444132^[4]	NAS: Non-traceable Author Statement		F
	GO:0005515	protein binding	PMID:11113139^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NZD8	F
	GO:0005515	protein binding	PMID:7831289^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P03406	F
	GO:0005769	early endosome	Reactome:REACT_11160	TAS: Traceable Author Statement		C
	GO:0005769	early endosome	Reactome:REACT_11177	TAS: Traceable Author Statement		C
	GO:0005769	early endosome	Reactome:REACT_11227	TAS: Traceable Author Statement		C
	GO:0005788	endoplasmic reticulum lumen	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	C
	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	C
	GO:0005789	endoplasmic reticulum membrane	Reactome:REACT_9009	TAS: Traceable Author Statement		C
	GO:0005789	endoplasmic reticulum membrane	Reactome:REACT_9018	TAS: Traceable Author Statement		C
	GO:0005789	endoplasmic reticulum membrane	Reactome:REACT_9024	TAS: Traceable Author Statement		C
	GO:0005789	endoplasmic reticulum membrane	Reactome:REACT_9063	TAS: Traceable Author Statement		C
	GO:0005789	endoplasmic reticulum membrane	Reactome:REACT_9071	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	C
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0005886	plasma membrane	PMID:11390434^[11]	IDA: Inferred from Direct Assay		C
	GO:0005886	plasma membrane	PMID:8124721^[15]	IDA: Inferred from Direct Assay		C
	GO:0005886	plasma membrane	Reactome:REACT_11091	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_11148	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_11160	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_11227	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_12394	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_12421	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_12446	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_12467	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_12498	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_12538	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_12566	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_12615	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_12633	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_12640	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_12642	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_19146	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_7953	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_7962	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_8003	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_8009	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_8010	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_8020	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_8023	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_8032	TAS: Traceable Author Statement		C
	GO:0006948	induction by virus of host cell-cell fusion	PMID:9166430^[16]	IDA: Inferred from Direct Assay		P
	GO:0006955	immune response	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000973	P
	GO:0006955	immune response	PMID:8512039^[17]	NAS: Non-traceable Author Statement		P
	GO:0007155	cell adhesion	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008424	P
	GO:0007165	signal transduction	PMID:10358157^[3]	TAS: Traceable Author Statement		P
	GO:0007165	signal transduction	PMID:9558100^[18]	TAS: Traceable Author Statement		P
	GO:0007166	cell surface receptor linked signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	P
	GO:0007166	cell surface receptor linked signaling pathway	PMID:9780207^[19]	TAS: Traceable Author Statement		P
	GO:0007167	enzyme linked receptor protein signaling pathway	PMID:10358157^[3]	TAS: Traceable Author Statement		P
	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:8512039^[17]	NAS: Non-traceable Author Statement		P
	GO:0008270	zinc ion binding	PMID:9668045^[20]	IDA: Inferred from Direct Assay		F
	GO:0009897	external side of plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	C
	GO:0009986	cell surface	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	C
	GO:0015026	coreceptor activity	PMID:8512039^[17]	NAS: Non-traceable Author Statement		F
	GO:0015026	coreceptor activity	PMID:8674120^[21]	TAS: Traceable Author Statement		F
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000973	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008424	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0016032	viral reproduction	Reactome:REACT_6185	TAS: Traceable Author Statement		P
	GO:0016032	viral reproduction	Reactome:REACT_6256	TAS: Traceable Author Statement		P
	GO:0019059	initiation of viral infection	Reactome:REACT_6266	TAS: Traceable Author Statement		P
	GO:0019901	protein kinase binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000021915	F
	GO:0019901	protein kinase binding	PMID:7486703^[23]	IPI: Inferred from Physical Interaction	UniProtKB:P06239	F
	GO:0030217	T cell differentiation	PMID:1533274^[24]	IDA: Inferred from Direct Assay		P
	GO:0030260	entry into host cell	Reactome:REACT_6903	TAS: Traceable Author Statement		P
	GO:0031295	T cell costimulation	Reactome:REACT_19344	TAS: Traceable Author Statement		P
	GO:0032507	maintenance of protein location in cell	PMID:15128768^[25]	IDA: Inferred from Direct Assay		P
	GO:0042101	T cell receptor complex	PMID:8512039^[17]	NAS: Non-traceable Author Statement		C
	GO:0042110	T cell activation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000021915	P
	GO:0042289	MHC class II protein binding	PMID:8512039^[17]	NAS: Non-traceable Author Statement		F
	GO:0042803	protein homodimerization activity	PMID:12444132^[4]	IDA: Inferred from Direct Assay		F
	GO:0044419	interspecies interaction between organisms	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0945	P
	GO:0045058	T cell selection	PMID:9551897^[26]	IDA: Inferred from Direct Assay		P
	GO:0045086	positive regulation of interleukin-2 biosynthetic process	PMID:1901411^[27]	NAS: Non-traceable Author Statement		P
	GO:0045121	membrane raft	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	C
	GO:0045234	protein palmitoleylation	PMID:15128768^[25]	IDA: Inferred from Direct Assay		P
	GO:0045860	positive regulation of protein kinase activity	PMID:2118992^[28]	IDA: Inferred from Direct Assay		P
	GO:0050690	regulation of defense response to virus by virus	Reactome:REACT_11149	TAS: Traceable Author Statement		P
	GO:0050690	regulation of defense response to virus by virus	Reactome:REACT_11166	TAS: Traceable Author Statement		P
	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	P
	GO:0050850	positive regulation of calcium-mediated signaling	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	P
	GO:0050852	T cell receptor signaling pathway	Reactome:REACT_12526	TAS: Traceable Author Statement		P
	GO:0050863	regulation of T cell activation	PMID:1533274^[24]	IDA: Inferred from Direct Assay		P
	GO:0050870	positive regulation of T cell activation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	P
	GO:0051789	response to protein stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000024044	P
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Myszka DG et al. (2000) Energetics of the HIV gp120-CD4 binding reaction. Proc Natl Acad Sci U S A 97: 9026-31 PubMed GONUTS page
↑ ^2.0 ^2.1 Zhang W et al. (1999) Conformational changes of gp120 in epitopes near the CCR5 binding site are induced by CD4 and a CD4 miniprotein mimetic. Biochemistry 38: 9405-16 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Su SB et al. (1999) Inhibition of tyrosine kinase activation blocks the down-regulation of CXC chemokine receptor 4 by HIV-1 gp120 in CD4+ T cells. J Immunol 162: 7128-32 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Moldovan MC et al. (2002) CD4 dimers constitute the functional component required for T cell activation. J Immunol 169: 6261-8 PubMed GONUTS page
↑ ^5.0 ^5.1 Zeitlmann L et al. (2001) Cloning of ACP33 as a novel intracellular ligand of CD4. J Biol Chem 276: 9123-32 PubMed GONUTS page
↑ ^6.0 ^6.1 Salghetti S et al. (1995) Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail. Proc Natl Acad Sci U S A 92: 349-53 PubMed GONUTS page
↑ ^7.0 ^7.1 Fauré J et al. (2004) ARF1 regulates Nef-induced CD4 degradation. Curr Biol 14: 1056-64 PubMed GONUTS page
↑ ^8.0 ^8.1 Garcia JV & Miller AD (1991) Serine phosphorylation-independent downregulation of cell-surface CD4 by nef. Nature 350: 508-11 PubMed GONUTS page
↑ Margottin F et al. (1998) A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif. Mol Cell 1: 565-74 PubMed GONUTS page
↑ Kim MJ et al. (2000) The mechanism of phospholipase C-gamma1 regulation. Exp Mol Med 32: 101-9 PubMed GONUTS page
↑ ^11.0 ^11.1 Kirchgessner H et al. (2001) The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain. J Exp Med 193: 1269-84 PubMed GONUTS page
↑ Leo A et al. (2002) Adapters in lymphocyte signaling. J Clin Invest 109: 301-9 PubMed GONUTS page
↑ Palacios EH & Weiss A (2004) Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation. Oncogene 23: 7990-8000 PubMed GONUTS page
↑ Qi Q & August A (2007) Keeping the (kinase) party going: SLP-76 and ITK dance to the beat. Sci STKE 2007: pe39 PubMed GONUTS page
↑ ^15.0 ^15.1 Aiken C et al. (1994) Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain. Cell 76: 853-64 PubMed GONUTS page
↑ ^16.0 ^16.1 Liao F et al. (1997) STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1. J Exp Med 185: 2015-23 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 ^17.7 ^17.8 ^17.9 Miceli MC & Parnes JR (1993) Role of CD4 and CD8 in T cell activation and differentiation. Adv Immunol 53: 59-122 PubMed GONUTS page
↑ ^18.0 ^18.1 Rubbert A et al. (1998) Dendritic cells express multiple chemokine receptors used as coreceptors for HIV entry. J Immunol 160: 3933-41 PubMed GONUTS page
↑ ^19.0 ^19.1 Wang JM et al. (1998) HIV-1 envelope gp120 inhibits the monocyte response to chemokines through CD4 signal-dependent chemokine receptor down-regulation. J Immunol 161: 4309-17 PubMed GONUTS page
↑ ^20.0 ^20.1 Huse M et al. (1998) A Zn2+ ion links the cytoplasmic tail of CD4 and the N-terminal region of Lck. J Biol Chem 273: 18729-33 PubMed GONUTS page
↑ ^21.0 ^21.1 Doranz BJ et al. (1996) A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell 85: 1149-58 PubMed GONUTS page
↑ Greene WC & Peterlin BM (2002) Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy. Nat Med 8: 673-80 PubMed GONUTS page
↑ ^23.0 ^23.1 Campbell KS et al. (1995) Interaction of p56lck with CD4 in the yeast two-hybrid system. Ann N Y Acad Sci 766: 89-92 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 ^24.3 Seong RH et al. (1992) Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail. Nature 356: 718-20 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 ^25.3 Balamuth F et al. (2004) CD4 raft association and signaling regulate molecular clustering at the immunological synapse site. J Immunol 172: 5887-92 PubMed GONUTS page
↑ ^26.0 ^26.1 Frank GD & Parnes JR (1998) The level of CD4 surface protein influences T cell selection in the thymus. J Immunol 160: 634-42 PubMed GONUTS page
↑ ^27.0 ^27.1 Miceli MC et al. (1991) Adhesion versus coreceptor function of CD4 and CD8: role of the cytoplasmic tail in coreceptor activity. Proc Natl Acad Sci U S A 88: 2623-7 PubMed GONUTS page
↑ ^28.0 ^28.1 Luo KX & Sefton BM (1990) Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site. Mol Cell Biol 10: 5305-13 PubMed GONUTS page

[PMID:10922058-0] 1.0 ^1.1 Myszka DG et al. (2000) Energetics of the HIV gp120-CD4 binding reaction. Proc Natl Acad Sci U S A 97: 9026-31 PubMed GONUTS page

[PMID:10413516-1] 2.0 ^2.1 Zhang W et al. (1999) Conformational changes of gp120 in epitopes near the CCR5 binding site are induced by CD4 and a CD4 miniprotein mimetic. Biochemistry 38: 9405-16 PubMed GONUTS page

[PMID:10358157-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Su SB et al. (1999) Inhibition of tyrosine kinase activation blocks the down-regulation of CXC chemokine receptor 4 by HIV-1 gp120 in CD4+ T cells. J Immunol 162: 7128-32 PubMed GONUTS page

[PMID:12444132-3] 4.0 ^4.1 ^4.2 ^4.3 Moldovan MC et al. (2002) CD4 dimers constitute the functional component required for T cell activation. J Immunol 169: 6261-8 PubMed GONUTS page

[PMID:11113139-4] 5.0 ^5.1 Zeitlmann L et al. (2001) Cloning of ACP33 as a novel intracellular ligand of CD4. J Biol Chem 276: 9123-32 PubMed GONUTS page

[PMID:7831289-5] 6.0 ^6.1 Salghetti S et al. (1995) Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail. Proc Natl Acad Sci U S A 92: 349-53 PubMed GONUTS page

[PMID:15202998-6] 7.0 ^7.1 Fauré J et al. (2004) ARF1 regulates Nef-induced CD4 degradation. Curr Biol 14: 1056-64 PubMed GONUTS page

[PMID:2014052-7] 8.0 ^8.1 Garcia JV & Miller AD (1991) Serine phosphorylation-independent downregulation of cell-surface CD4 by nef. Nature 350: 508-11 PubMed GONUTS page

[PMID:9660940-8] Margottin F et al. (1998) A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif. Mol Cell 1: 565-74 PubMed GONUTS page

[PMID:11048639-9] Kim MJ et al. (2000) The mechanism of phospholipase C-gamma1 regulation. Exp Mol Med 32: 101-9 PubMed GONUTS page

[PMID:11390434-10] 11.0 ^11.1 Kirchgessner H et al. (2001) The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain. J Exp Med 193: 1269-84 PubMed GONUTS page

[PMID:11827988-11] Leo A et al. (2002) Adapters in lymphocyte signaling. J Clin Invest 109: 301-9 PubMed GONUTS page

[PMID:15489916-12] Palacios EH & Weiss A (2004) Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation. Oncogene 23: 7990-8000 PubMed GONUTS page

[PMID:17652306-13] Qi Q & August A (2007) Keeping the (kinase) party going: SLP-76 and ITK dance to the beat. Sci STKE 2007: pe39 PubMed GONUTS page

[PMID:8124721-14] 15.0 ^15.1 Aiken C et al. (1994) Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain. Cell 76: 853-64 PubMed GONUTS page

[PMID:9166430-15] 16.0 ^16.1 Liao F et al. (1997) STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1. J Exp Med 185: 2015-23 PubMed GONUTS page

[PMID:8512039-16] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 ^17.7 ^17.8 ^17.9 Miceli MC & Parnes JR (1993) Role of CD4 and CD8 in T cell activation and differentiation. Adv Immunol 53: 59-122 PubMed GONUTS page

[PMID:9558100-17] 18.0 ^18.1 Rubbert A et al. (1998) Dendritic cells express multiple chemokine receptors used as coreceptors for HIV entry. J Immunol 160: 3933-41 PubMed GONUTS page

[PMID:9780207-18] 19.0 ^19.1 Wang JM et al. (1998) HIV-1 envelope gp120 inhibits the monocyte response to chemokines through CD4 signal-dependent chemokine receptor down-regulation. J Immunol 161: 4309-17 PubMed GONUTS page

[PMID:9668045-19] 20.0 ^20.1 Huse M et al. (1998) A Zn2+ ion links the cytoplasmic tail of CD4 and the N-terminal region of Lck. J Biol Chem 273: 18729-33 PubMed GONUTS page

[PMID:8674120-20] 21.0 ^21.1 Doranz BJ et al. (1996) A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell 85: 1149-58 PubMed GONUTS page

[PMID:12091904-21] Greene WC & Peterlin BM (2002) Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy. Nat Med 8: 673-80 PubMed GONUTS page

[PMID:7486703-22] 23.0 ^23.1 Campbell KS et al. (1995) Interaction of p56lck with CD4 in the yeast two-hybrid system. Ann N Y Acad Sci 766: 89-92 PubMed GONUTS page

[PMID:1533274-23] 24.0 ^24.1 ^24.2 ^24.3 Seong RH et al. (1992) Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail. Nature 356: 718-20 PubMed GONUTS page

[PMID:15128768-24] 25.0 ^25.1 ^25.2 ^25.3 Balamuth F et al. (2004) CD4 raft association and signaling regulate molecular clustering at the immunological synapse site. J Immunol 172: 5887-92 PubMed GONUTS page

[PMID:9551897-25] 26.0 ^26.1 Frank GD & Parnes JR (1998) The level of CD4 surface protein influences T cell selection in the thymus. J Immunol 160: 634-42 PubMed GONUTS page

[PMID:1901411-26] 27.0 ^27.1 Miceli MC et al. (1991) Adhesion versus coreceptor function of CD4 and CD8: role of the cytoplasmic tail in coreceptor activity. Proc Natl Acad Sci U S A 88: 2623-7 PubMed GONUTS page

[PMID:2118992-27] 28.0 ^28.1 Luo KX & Sefton BM (1990) Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site. Mol Cell Biol 10: 5305-13 PubMed GONUTS page

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