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HUMAN:CD38
Contents |
| Species (Taxon ID) | Homo sapiens (Human). ([1]) | |
| Gene Name(s) | CD38 | |
| Protein Name(s) | ADP-ribosyl cyclase 1
Cyclic ADP-ribose hydrolase 1 cADPr hydrolase 1 T10 | |
| External Links | ||
| EMBL | M34461 D84276 D84277 D84284 BC007964 | |
| IPI | IPI00006071 IPI00395006 | |
| PIR | A43521 | |
| RefSeq | NP_001766.2 | |
| UniGene | Hs.479214 | |
| PDB | 1YH3 1ZVM 2EF1 2HCT 2I65 2I66 2I67 2O3Q 2O3R 2O3S 2O3T 2O3U 2PGJ 2PGL 3DZF 3DZG 3DZH 3DZI 3DZJ 3DZK 3F6Y 3I9M 3I9N 3OFS 3RAJ | |
| PDBsum | 1YH3 1ZVM 2EF1 2HCT 2I65 2I66 2I67 2O3Q 2O3R 2O3S 2O3T 2O3U 2PGJ 2PGL 3DZF 3DZG 3DZH 3DZI 3DZJ 3DZK 3F6Y 3I9M 3I9N 3OFS 3RAJ | |
| ProteinModelPortal | P28907 | |
| SMR | P28907 | |
| STRING | P28907 | |
| PeptideAtlas | P28907 | |
| PRIDE | P28907 | |
| Ensembl | ENST00000226279 | |
| GeneID | 952 | |
| KEGG | hsa:952 | |
| NMPDR | fig|9606.3.peg.23952 | |
| UCSC | uc003goj.1 uc003gol.1 | |
| CTD | 952 | |
| GeneCards | GC04P015130 | |
| H-InvDB | HIX0004113 | |
| HGNC | HGNC:1667 | |
| HPA | CAB002493 CAB025255 HPA022132 | |
| MIM | 107270 | |
| neXtProt | NX_P28907 | |
| PharmGKB | PA26214 | |
| eggNOG | prNOG18655 | |
| HOGENOM | HBG715775 | |
| HOVERGEN | HBG005277 | |
| InParanoid | P28907 | |
| OMA | SCPDWRK | |
| PhylomeDB | P28907 | |
| NextBio | 3962 | |
| ArrayExpress | P28907 | |
| Bgee | P28907 | |
| CleanEx | HS_CD38 | |
| Genevestigator | P28907 | |
| GermOnline | ENSG00000004468 | |
| GO | GO:0016021 GO:0005886 GO:0005488 GO:0003953 GO:0004872 GO:0050853 GO:0008624 GO:0043066 GO:0045892 GO:0030890 GO:0045893 GO:0042493 | |
| InterPro | IPR003193 IPR016040 | |
| Gene3D | G3DSA:3.40.50.720 | |
| KO | K01242 | |
| PANTHER | PTHR10912 | |
| Pfam | PF02267 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0001666 |
response to hypoxia |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000004121 |
P |
Seeded From UniProt |
|||
| GO:0003953 |
NAD+ nucleosidase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003953 |
NAD+ nucleosidase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003953 |
NAD+ nucleosidase activity |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000004121 |
F |
Seeded From UniProt |
|||
| GO:0004872 |
receptor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005624 |
membrane fraction |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000030964 |
C |
Seeded From UniProt |
|||
| GO:0005624 |
membrane fraction |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000004121 |
C |
Seeded From UniProt |
|||
| GO:0005792 |
microsome |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000004121 |
C |
Seeded From UniProt |
|||
| GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000004121 |
C |
Seeded From UniProt |
|||
| GO:0005886 |
plasma membrane |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0007165 |
signal transduction |
NAS: Non-traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0007204 |
elevation of cytosolic calcium ion concentration |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000004121 |
P |
Seeded From UniProt |
|||
| GO:0007565 |
female pregnancy |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000004121 |
P |
Seeded From UniProt |
|||
| GO:0008624 |
induction of apoptosis by extracellular signals |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0009725 |
response to hormone stimulus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000004121 |
P |
Seeded From UniProt |
|||
| GO:0009986 |
cell surface |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000030964 |
C |
Seeded From UniProt |
|||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0162 |
C |
Seeded From UniProt |
|||
| GO:0016021 |
integral to membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016787 |
hydrolase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016798 |
hydrolase activity, acting on glycosyl bonds |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000030964 |
F |
Seeded From UniProt |
|||
| GO:0016849 |
phosphorus-oxygen lyase activity |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000030964 |
F |
Seeded From UniProt |
|||
| GO:0030307 |
positive regulation of cell growth |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000004121 |
P |
Seeded From UniProt |
|||
| GO:0030890 |
positive regulation of B cell proliferation |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000030964 |
P |
Seeded From UniProt |
|||
| GO:0030890 |
positive regulation of B cell proliferation |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0032024 |
positive regulation of insulin secretion |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000004121 |
P |
Seeded From UniProt |
|||
| GO:0032355 |
response to estradiol stimulus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000004121 |
P |
Seeded From UniProt |
|||
| GO:0032526 |
response to retinoic acid |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000004121 |
P |
Seeded From UniProt |
|||
| GO:0032570 |
response to progesterone stimulus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000004121 |
P |
Seeded From UniProt |
|||
| GO:0033194 |
response to hydroperoxide |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000004121 |
P |
Seeded From UniProt |
|||
| GO:0034097 |
response to cytokine stimulus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000004121 |
P |
Seeded From UniProt |
|||
| GO:0042493 |
response to drug |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0043066 |
negative regulation of apoptosis |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0045779 |
negative regulation of bone resorption |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000004121 |
P |
Seeded From UniProt |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0045907 |
positive regulation of vasoconstriction |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000004121 |
P |
Seeded From UniProt |
|||
| GO:0050853 |
B cell receptor signaling pathway |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0060292 |
long term synaptic depression |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000004121 |
P |
Seeded From UniProt |
|||
| GO:0070555 |
response to interleukin-1 |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000004121 |
P |
Seeded From UniProt |
|||
| GO:0003953 |
NAD+ nucleosidase activity |
IMP: Inferred from Mutant Phenotype |
F |
Fig. 5D |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Takasawa S et al. (1993) Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 and inhibition of the hydrolysis by ATP. J Biol Chem 268: 26052-4 PubMed GONUTS page
- ↑ Han MK et al. (2000) Interaction of two classes of ADP-ribose transfer reactions in immune signaling. J Biol Chem 275: 20799-805 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Joshi AD et al. (2007) ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia. Clin Cancer Res 13: 5295-304 PubMed GONUTS page
- ↑ Mamik MK et al. (2011) HIV-1 and IL-1β regulate astrocytic CD38 through mitogen-activated protein kinases and nuclear factor-κB signaling mechanisms. J Neuroinflammation 8: 145 PubMed GONUTS page
