HUMAN:CBX5

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	CBX5 ( synonyms: HP1A )
Protein Name(s)	Chromobox protein homolog 5 Antigen p25 Heterochromatin protein 1 homolog alpha HP1 alpha
External Links
UniProt Identifier	CBX5_HUMAN
UniProt Accessions	P45973, B2R8T9,
EMBL	S62077, L07515, AK313506, CH471054, BC006821, U26311,
PIR	G01808,
RefSeq	NP_001120793.1, NP_001120794.1, NP_036249.1,
PDB	3FDT, 3I3C,
IntAct	P45973,
Ensembl	ENST00000209875, ENST00000439541, ENST00000454593,
Pfam	PF00385, PF01393,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000118	histone deacetylase complex		ISS: Inferred from Sequence or Structural Similarity		C	Source: BHF-UCL
	GO:0035097	histone methyltransferase complex		ISS: Inferred from Sequence or Structural Similarity		C	Source: BHF-UCL
	GO:0031618	nuclear centromeric heterochromatin		NAS: Non-traceable Author Statement		C	Source: BHF-UCL
	GO:0005635	nuclear envelope		TAS: Traceable Author Statement		C	Source: ProtInc
	GO:0005730	nucleolus		IDA: Inferred from Direct Assay		C	Source: BHF-UCL
	GO:0017053	transcriptional repressor complex		ISS: Inferred from Sequence or Structural Similarity		C	Source: BHF-UCL
	GO:0016565	general transcriptional repressor activity		IMP: Inferred from Mutant Phenotype		F	Source: BHF-UCL
	GO:0035064	methylated histone residue binding		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0030674	protein binding, bridging		ISS: Inferred from Sequence or Structural Similarity		F	Source: BHF-UCL
	GO:0070491	transcription repressor binding		ISS: Inferred from Sequence or Structural Similarity		F	Source: BHF-UCL
	GO:0006333	chromatin assembly or disassembly		IEA: Inferred from Electronic Annotation		P	Source: InterPro
	GO:0000118	histone deacetylase complex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113157	C
	GO:0000118	histone deacetylase complex	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q61686	C
	GO:0000775	chromosome, centromeric region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0137	C
	GO:0000775	chromosome, centromeric region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0047	C
	GO:0000776	kinetochore	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113157	C
	GO:0000792	heterochromatin	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113157	C
	GO:0003682	chromatin binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113157	F
	GO:0005515	protein binding	PMID:10330177^[1]	IPI: Inferred from Physical Interaction	UniProtKB:Q13263	F
	GO:0005515	protein binding	PMID:12711603^[2]	IPI: Inferred from Physical Interaction	UniProtKB:O43463	F
	GO:0005515	protein binding	PMID:12711603^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UIS9	F
	GO:0005515	protein binding	PMID:15502821^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q9H081	F
	GO:0005515	protein binding	PMID:15882967^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P23497	F
	GO:0005515	protein binding	PMID:15882967^[4]	IPI: Inferred from Physical Interaction	UniProtKB:P46100	F
	GO:0005515	protein binding	PMID:15882967^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q13111	F
	GO:0005515	protein binding	PMID:15882967^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q13263	F
	GO:0005515	protein binding	PMID:15882967^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q14739	F
	GO:0005515	protein binding	PMID:15882967^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q6KC79	F
	GO:0005515	protein binding	PMID:19666599^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q8TBE0	F
	GO:0005515	protein binding	PMID:20850016^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q7Z3K3	F
	GO:0005515	protein binding	PMID:20850016^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q96JM3	F
	GO:0005515	protein binding	PMID:8663349^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q14739	F
	GO:0005515	protein binding	PMID:9636146^[8]	IPI: Inferred from Physical Interaction	UniProtKB:O35892	F
	GO:0005515	protein binding	PMID:9636146^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P23497-1	F
	GO:0005515	protein binding	PMID:9636146^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P23497-2	F
	GO:0005515	protein binding	PMID:9636147^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P23497	F
	GO:0005515	protein binding	PMID:9636147^[9]	IPI: Inferred from Physical Interaction	UniProtKB:P23497-3	F
	GO:0005515	protein binding	PMID:9864353^[10]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NQS7	F
	GO:0005515	protein binding	PMID:9864353^[10]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NQS7	F
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000953	C
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008251	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113157	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:18029348^[11]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:19783980^[12]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:9636146^[8]	IDA: Inferred from Direct Assay		C
	GO:0005635	nuclear envelope	PMID:8663349^[7]	TAS: Traceable Author Statement		C
	GO:0005654	nucleoplasm	Reactome:REACT_25059	TAS: Traceable Author Statement		C
	GO:0005694	chromosome	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0158	C
	GO:0005694	chromosome	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0468	C
	GO:0005720	nuclear heterochromatin	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113157	C
	GO:0005720	nuclear heterochromatin	PMID:8663349^[7]	TAS: Traceable Author Statement		C
	GO:0005730	nucleolus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113157	C
	GO:0005730	nucleolus	PMID:9636146^[8]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	PMID:18029348^[11]	IDA: Inferred from Direct Assay		C
	GO:0007596	blood coagulation	Reactome:REACT_604	TAS: Traceable Author Statement		P
	GO:0010369	chromocenter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113157	C
	GO:0017053	transcriptional repressor complex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113157	C
	GO:0017053	transcriptional repressor complex	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q61686	C
	GO:0019899	enzyme binding	PMID:19486527^[13]	IPI: Inferred from Physical Interaction	UniProtKB:Q86Y97	F
	GO:0030674	protein binding, bridging	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113157	F
	GO:0030674	protein binding, bridging	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q61686	F
	GO:0031618	nuclear centromeric heterochromatin	PMID:16177824^[14]	NAS: Non-traceable Author Statement		C
	GO:0035064	methylated histone residue binding	PMID:19783980^[12]	IDA: Inferred from Direct Assay		F
	GO:0035064	methylated histone residue binding	PMID:21029866^[15]	IDA: Inferred from Direct Assay		F
	GO:0035097	histone methyltransferase complex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113157	C
	GO:0035097	histone methyltransferase complex	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q61686	C
	GO:0042826	histone deacetylase binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113157	F
	GO:0044419	interspecies interaction between organisms	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0945	P
	GO:0045892	negative regulation of transcription, DNA-dependent	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113157	P
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:9636146^[8]	IMP: Inferred from Mutant Phenotype		P
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:9636147^[9]	IDA: Inferred from Direct Assay		P
	GO:0045892	negative regulation of transcription, DNA-dependent	PMID:9636147^[9]	IMP: Inferred from Mutant Phenotype		P
	GO:0070491	repressing transcription factor binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113157	F
	GO:0070491	repressing transcription factor binding	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q61686	F
colocalizes_with	GO:0016605	PML body	PMID:9636146^[8]	IMP: Inferred from Mutant Phenotype		C
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Ryan RF et al. (1999) KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Krüppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing. Mol Cell Biol 19: 4366-78 PubMed GONUTS page
↑ ^2.0 ^2.1 Fujita N et al. (2003) Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression. J Biol Chem 278: 24132-8 PubMed GONUTS page
↑ Obuse C et al. (2004) A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. Nat Cell Biol 6: 1135-41 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Lechner MS et al. (2005) The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain. Biochem Biophys Res Commun 331: 929-37 PubMed GONUTS page
↑ Bierne H et al. (2009) Human BAHD1 promotes heterochromatic gene silencing. Proc Natl Acad Sci U S A 106: 13826-31 PubMed GONUTS page
↑ ^6.0 ^6.1 Vermeulen M et al. (2010) Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. Cell 142: 967-80 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Ye Q & Worman HJ (1996) Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1. J Biol Chem 271: 14653-6 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Seeler JS et al. (1998) Interaction of SP100 with HP1 proteins: a link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment. Proc Natl Acad Sci U S A 95: 7316-21 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Lehming N et al. (1998) Chromatin components as part of a putative transcriptional repressing complex. Proc Natl Acad Sci U S A 95: 7322-6 PubMed GONUTS page
↑ ^10.0 ^10.1 Ainsztein AM et al. (1998) INCENP centromere and spindle targeting: identification of essential conserved motifs and involvement of heterochromatin protein HP1. J Cell Biol 143: 1763-74 PubMed GONUTS page
↑ ^11.0 ^11.1 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page
↑ ^12.0 ^12.1 Dawson MA et al. (2009) JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature 461: 819-22 PubMed GONUTS page
↑ Souza PP et al. (2009) The histone methyltransferase SUV420H2 and Heterochromatin Proteins HP1 interact but show different dynamic behaviours. BMC Cell Biol 10: 41 PubMed GONUTS page
↑ Ling PD et al. (2005) Mediation of Epstein-Barr virus EBNA-LP transcriptional coactivation by Sp100. EMBO J 24: 3565-75 PubMed GONUTS page
↑ Bartke T et al. (2010) Nucleosome-interacting proteins regulated by DNA and histone methylation. Cell 143: 470-84 PubMed GONUTS page

[PMID:10330177-0] Ryan RF et al. (1999) KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Krüppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing. Mol Cell Biol 19: 4366-78 PubMed GONUTS page

[PMID:12711603-1] 2.0 ^2.1 Fujita N et al. (2003) Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression. J Biol Chem 278: 24132-8 PubMed GONUTS page

[PMID:15502821-2] Obuse C et al. (2004) A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. Nat Cell Biol 6: 1135-41 PubMed GONUTS page

[PMID:15882967-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Lechner MS et al. (2005) The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain. Biochem Biophys Res Commun 331: 929-37 PubMed GONUTS page

[PMID:19666599-4] Bierne H et al. (2009) Human BAHD1 promotes heterochromatic gene silencing. Proc Natl Acad Sci U S A 106: 13826-31 PubMed GONUTS page

[PMID:20850016-5] 6.0 ^6.1 Vermeulen M et al. (2010) Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. Cell 142: 967-80 PubMed GONUTS page

[PMID:8663349-6] 7.0 ^7.1 ^7.2 Ye Q & Worman HJ (1996) Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1. J Biol Chem 271: 14653-6 PubMed GONUTS page

[PMID:9636146-7] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Seeler JS et al. (1998) Interaction of SP100 with HP1 proteins: a link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment. Proc Natl Acad Sci U S A 95: 7316-21 PubMed GONUTS page

[PMID:9636147-8] 9.0 ^9.1 ^9.2 ^9.3 Lehming N et al. (1998) Chromatin components as part of a putative transcriptional repressing complex. Proc Natl Acad Sci U S A 95: 7322-6 PubMed GONUTS page

[PMID:9864353-9] 10.0 ^10.1 Ainsztein AM et al. (1998) INCENP centromere and spindle targeting: identification of essential conserved motifs and involvement of heterochromatin protein HP1. J Cell Biol 143: 1763-74 PubMed GONUTS page

[PMID:18029348-10] 11.0 ^11.1 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page

[PMID:19783980-11] 12.0 ^12.1 Dawson MA et al. (2009) JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature 461: 819-22 PubMed GONUTS page

[PMID:19486527-12] Souza PP et al. (2009) The histone methyltransferase SUV420H2 and Heterochromatin Proteins HP1 interact but show different dynamic behaviours. BMC Cell Biol 10: 41 PubMed GONUTS page

[PMID:16177824-13] Ling PD et al. (2005) Mediation of Epstein-Barr virus EBNA-LP transcriptional coactivation by Sp100. EMBO J 24: 3565-75 PubMed GONUTS page

[PMID:21029866-14] Bartke T et al. (2010) Nucleosome-interacting proteins regulated by DNA and histone methylation. Cell 143: 470-84 PubMed GONUTS page

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HUMAN:CBX5

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