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HUMAN:CAPR2
Contents |
| Species (Taxon ID) | Homo sapiens (Human). (taxon:9606) | |
| Gene Name(s) | CAPRIN2 ( synonyms: C1QDC1, EEG1, KIAA1873, RNG140 ) | |
| Protein Name(s) |
| |
| External Links | ||
| UniProt Identifier | CAPR2_HUMAN | |
| UniProt Accessions | Q6IMN6, Q149P7, Q6IMN5, Q7Z371, Q8TE70, Q8TE71, Q96RN6, Q9H667, Q9HAL4, | |
| EMBL | AY074490, AY074491, AC010198, BC066295, BC111007, BC117672, AK021453, AK026222, AF326778, BX538080, BK001102, BK001103, | |
| RefSeq | NP_001002259.1, NP_076414.2, NP_115532.3, | |
| Ensembl | ENST00000251071, | |
| Pfam | PF00386, PF12287, | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005739 |
mitochondrion |
IDA: Inferred from Direct Assay |
C |
Source: UniProtKB |
||||
| GO:0030308 |
negative regulation of cell growth |
IDA: Inferred from Direct Assay |
P |
Source: UniProtKB |
||||
| GO:0030169 |
low-density lipoprotein binding |
IPI: Inferred from Physical Interaction |
|
F |
Figure 1A: Co-immunoprecipitation assay confirmed that caprin-2 interacts with LRP5 and not caprin-1 |
complete | ||
| GO:0030169 |
low-density lipoprotein binding |
IPI: Inferred from Physical Interaction |
|
F |
Figure 1B: Co-immunoprecipitation showed that LRP6 was coimmunoprecipitated with Caprin-2. Caprin-2 interacts with LRP6. |
complete | ||
| GO:0030177 |
positive regulation of Wnt receptor signaling pathway |
IDA: Inferred from Direct Assay |
P |
Figure 2A: Capin-2 overexpression enhanced the accumulation of cytoplasmic beta catenin leading to the activation of Wnt signalling. |
complete | |||
| GO:0090090 |
negative regulation of canonical Wnt receptor signaling pathway |
IMP: Inferred from Mutant Phenotype |
P |
Figure 2C:Knockdown of caprin-2 decreased Wnt3a-stimulated LEF-1 dependent reporter activity and diminished Wnt induced accummulation of beta catenin. |
complete | |||
| GO:0042327 |
positive regulation of phosphorylation |
IMP: Inferred from Mutant Phenotype |
P |
Figure 5D: Knockdown of caprin 2 showed that although caprin 2 interacts with LRP6 phosphorylation, caprin 2 overxpression and Wnt3a stimulation lead to the increased phosphorylation of LRP6. |
complete | |||
| GO:0032403 |
protein complex binding |
IPI: Inferred from Physical Interaction |
UniProtKB:O75197 UniProtKB:O15169
|
F |
Figure 5B: Co-iummunoprecipitation showed that caprin 2 enhanced the interaction between Axin and LRP5. |
complete | ||
| GO:0019901 |
protein kinase binding |
IPI: Inferred from Physical Interaction |
|
F |
Figure 5B: Caprin-2 enhanced interaction between Axin and LRP5 but the interaction was notable elevated when caprin 2 cotransfected with GSK3beta |
complete | ||
| GO:0003723 |
RNA binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0005102 |
receptor binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005102 |
receptor binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0086 |
C |
||||
| GO:0005737 |
cytoplasm |
IDA: Inferred from Direct Assay |
C |
|||||
| GO:0005737 |
cytoplasm |
IDA: Inferred from Direct Assay |
C |
|||||
| GO:0005739 |
mitochondrion |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0005739 |
mitochondrion |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0173 |
C |
||||
| GO:0005739 |
mitochondrion |
IDA: Inferred from Direct Assay |
C |
|||||
| GO:0005739 |
mitochondrion |
IDA: Inferred from Direct Assay |
C |
|||||
| GO:0017148 |
negative regulation of translation |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0030154 |
cell differentiation |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0030308 |
negative regulation of cell growth |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0032092 |
positive regulation of protein binding |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0040008 |
regulation of growth |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0043235 |
receptor complex |
IDA: Inferred from Direct Assay |
C |
|||||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0050775 |
positive regulation of dendrite morphogenesis |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000107195 |
P |
||||
| GO:0050775 |
positive regulation of dendrite morphogenesis |
ISS: Inferred from Sequence or Structural Similarity |
P |
|||||
| GO:0061003 |
positive regulation of dendritic spine morphogenesis |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000107195 |
P |
||||
| GO:0061003 |
positive regulation of dendritic spine morphogenesis |
ISS: Inferred from Sequence or Structural Similarity |
P |
|||||
| GO:0090263 |
positive regulation of canonical Wnt receptor signaling pathway |
IDA: Inferred from Direct Assay |
P |
| ||||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 Ding Y et al. (2008) Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation. J Cell Biol 182: 865-72 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Aerbajinai W et al. (2004) Cloning and characterization of a gene expressed during terminal differentiation that encodes a novel inhibitor of growth. J Biol Chem 279: 1916-21 PubMed GONUTS page
