HUMAN:BUB1

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	BUB1 ( synonyms: BUB1L )
Protein Name(s)	Mitotic checkpoint serine/threonine-protein kinase BUB1 hBUB1 BUB1A
External Links
UniProt Identifier	BUB1_HUMAN
UniProt Accessions	O43683, O43430, O43643, O60626,
EMBL	AF046078, AF043294, AF053305, AF047471, AF139363, AF139349, AF139350, AF139351, AF139352, AF139353, AF139354, AF139355, AF139356, AF139357, AF139358, AF139359, AF139360, AF139361, AF139362, BC028201, AF011387,
RefSeq	NP_004327.1,
PDB	2LAH, 3E7E,
IntAct	O43683,
Ensembl	ENST00000302759,
Pfam	PF08311, PF00069,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0000087	M phase of mitotic cell cycle	Reactome:REACT_910	TAS: Traceable Author Statement		P
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0000236	mitotic prometaphase	Reactome:REACT_682	TAS: Traceable Author Statement		P
	GO:0000278	mitotic cell cycle	Reactome:REACT_152	TAS: Traceable Author Statement		P
	GO:0000775	chromosome, centromeric region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0137	C
	GO:0000775	chromosome, centromeric region	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028858	C
	GO:0000776	kinetochore	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0995	C
	GO:0000776	kinetochore	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028858	C
	GO:0000776	kinetochore	PMID:15020684^[1]	IDA: Inferred from Direct Assay		C
	GO:0000776	kinetochore	PMID:16760428^[2]	IDA: Inferred from Direct Assay		C
	GO:0000776	kinetochore	PMID:17227893^[3]	IDA: Inferred from Direct Assay		C
	GO:0000777	condensed chromosome kinetochore	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0149	C
	GO:0000777	condensed chromosome kinetochore	PMID:19465021^[4]	IDA: Inferred from Direct Assay		C
	GO:0000780	condensed nuclear chromosome, centromeric region	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028858	C
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017441	F
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	F
	GO:0004672	protein kinase activity	PMID:10198256^[5]	TAS: Traceable Author Statement		F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008271	F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0723	F
	GO:0005515	protein binding	PMID:10198256^[5]	IPI: Inferred from Physical Interaction	UniProtKB:O43684	F
	GO:0005515	protein binding	PMID:15525512^[6]	IPI: Inferred from Physical Interaction	UniProtKB:O43684	F
	GO:0005515	protein binding	PMID:16760428^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P53350	F
	GO:0005515	protein binding	PMID:17981135^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q8NG31	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017441	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	F
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005694	chromosome	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0158	C
	GO:0005829	cytosol	Reactome:REACT_14798	TAS: Traceable Author Statement		C
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008271	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017441	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	P
	GO:0006915	apoptosis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0053	P
	GO:0006915	apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028858	P
	GO:0007049	cell cycle	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0131	P
	GO:0007059	chromosome segregation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0159	P
	GO:0007063	regulation of sister chromatid cohesion	PMID:15723797^[8]	IDA: Inferred from Direct Assay		P
	GO:0007067	mitosis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0498	P
	GO:0007093	mitotic cell cycle checkpoint	PMID:9521327^[9]	TAS: Traceable Author Statement		P
	GO:0007094	mitotic cell cycle spindle assembly checkpoint	PMID:9790499^[10]	TAS: Traceable Author Statement		P
	GO:0009790	embryo development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028858	P
	GO:0016301	kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	F
	GO:0016310	phosphorylation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	P
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F
	GO:0044419	interspecies interaction between organisms	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0945	P
	GO:0051301	cell division	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0132	P
	GO:0051983	regulation of chromosome segregation	PMID:19487456^[11]	IMP: Inferred from Mutant Phenotype		P
	GO:0071173	spindle assembly checkpoint	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000028858	P
	GO:0071173	spindle assembly checkpoint	PMID:15020684^[1]	IDA: Inferred from Direct Assay		P
	GO:0071173	spindle assembly checkpoint	PMID:15525512^[6]	IDA: Inferred from Direct Assay		P
	GO:0071173	spindle assembly checkpoint	PMID:19487456^[11]	IMP: Inferred from Mutant Phenotype		P
	GO:0000087	M phase of mitotic cell cycle	Reactome:REACT_910	TAS: Traceable Author Statement		P
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0000236	mitotic prometaphase	Reactome:REACT_682	TAS: Traceable Author Statement		P
	GO:0000278	mitotic cell cycle	Reactome:REACT_152	TAS: Traceable Author Statement		P
	GO:0000775	chromosome, centromeric region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0137	C
	GO:0000776	kinetochore	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0995	C
	GO:0000776	kinetochore	PMID:15020684^[1]	IDA: Inferred from Direct Assay		C
	GO:0000776	kinetochore	PMID:16760428^[2]	IDA: Inferred from Direct Assay		C
	GO:0000776	kinetochore	PMID:17227893^[3]	IDA: Inferred from Direct Assay		C
	GO:0000777	condensed chromosome kinetochore	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0149	C
	GO:0000777	condensed chromosome kinetochore	PMID:19465021^[4]	IDA: Inferred from Direct Assay		C
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0004672	protein kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	F
	GO:0004672	protein kinase activity	PMID:10198256^[5]	TAS: Traceable Author Statement		F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008271	F
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0723	F
	GO:0005515	protein binding	PMID:10198256^[5]	IPI: Inferred from Physical Interaction	UniProtKB:O43684	F
	GO:0005515	protein binding	PMID:15525512^[6]	IPI: Inferred from Physical Interaction	UniProtKB:O43684	F
	GO:0005515	protein binding	PMID:16760428^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P53350	F
	GO:0005515	protein binding	PMID:17981135^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q8NG31	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017441	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	F
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005694	chromosome	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0158	C
	GO:0005829	cytosol	Reactome:REACT_14798	TAS: Traceable Author Statement		C
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000719	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008271	P
	GO:0006468	protein phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017442	P
	GO:0006468	protein phosphorylation	PMID:10198256^[5]	TAS: Traceable Author Statement		P
	GO:0006915	apoptosis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0053	P
	GO:0007049	cell cycle	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0131	P
	GO:0007059	chromosome segregation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0159	P
	GO:0007063	regulation of sister chromatid cohesion	PMID:15723797^[8]	IDA: Inferred from Direct Assay		P
	GO:0007067	mitosis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0498	P
	GO:0007093	mitotic cell cycle checkpoint	PMID:9521327^[9]	TAS: Traceable Author Statement		P
	GO:0007094	mitotic cell cycle spindle assembly checkpoint	PMID:9790499^[10]	TAS: Traceable Author Statement		P
	GO:0008283	cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000042114	P
	GO:0016301	kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	F
	GO:0016310	phosphorylation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	P
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F
	GO:0016772	transferase activity, transferring phosphorus-containing groups	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F
	GO:0044419	interspecies interaction between organisms	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0945	P
	GO:0051301	cell division	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0132	P
	GO:0051983	regulation of chromosome segregation	PMID:19487456^[11]	IMP: Inferred from Mutant Phenotype		P
	GO:0071173	spindle assembly checkpoint	PMID:15020684^[1]	IDA: Inferred from Direct Assay		P
	GO:0071173	spindle assembly checkpoint	PMID:15525512^[6]	IDA: Inferred from Direct Assay		P
	GO:0071173	spindle assembly checkpoint	PMID:19487456^[11]	IMP: Inferred from Mutant Phenotype		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Johnson VL et al. (2004) Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression. J Cell Sci 117: 1577-89 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Qi W et al. (2006) Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1. Mol Biol Cell 17: 3705-16 PubMed GONUTS page
↑ ^3.0 ^3.1 Dikovskaya D et al. (2007) Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. J Cell Biol 176: 183-95 PubMed GONUTS page
↑ ^4.0 ^4.1 Gambe AE et al. (2009) A nucleolar protein RRS1 contributes to chromosome congression. FEBS Lett 583: 1951-6 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Seeley TW et al. (1999) Phosphorylation of human MAD1 by the BUB1 kinase in vitro. Biochem Biophys Res Commun 257: 589-95 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Tang Z et al. (2004) Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint. Mol Cell 16: 387-97 PubMed GONUTS page
↑ ^7.0 ^7.1 Kiyomitsu T et al. (2007) Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1. Dev Cell 13: 663-76 PubMed GONUTS page
↑ ^8.0 ^8.1 Kitajima TS et al. (2005) Human Bub1 defines the persistent cohesion site along the mitotic chromosome by affecting Shugoshin localization. Curr Biol 15: 353-9 PubMed GONUTS page
↑ ^9.0 ^9.1 Cahill DP et al. (1998) Mutations of mitotic checkpoint genes in human cancers. Nature 392: 300-3 PubMed GONUTS page
↑ ^10.0 ^10.1 Ouyang B et al. (1998) Human Bub1: a putative spindle checkpoint kinase closely linked to cell proliferation. Cell Growth Differ 9: 877-85 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Klebig C et al. (2009) Bub1 regulates chromosome segregation in a kinetochore-independent manner. J Cell Biol 185: 841-58 PubMed GONUTS page

[PMID:15020684-0] 1.0 ^1.1 ^1.2 ^1.3 Johnson VL et al. (2004) Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression. J Cell Sci 117: 1577-89 PubMed GONUTS page

[PMID:16760428-1] 2.0 ^2.1 ^2.2 ^2.3 Qi W et al. (2006) Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1. Mol Biol Cell 17: 3705-16 PubMed GONUTS page

[PMID:17227893-2] 3.0 ^3.1 Dikovskaya D et al. (2007) Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. J Cell Biol 176: 183-95 PubMed GONUTS page

[PMID:19465021-3] 4.0 ^4.1 Gambe AE et al. (2009) A nucleolar protein RRS1 contributes to chromosome congression. FEBS Lett 583: 1951-6 PubMed GONUTS page

[PMID:10198256-4] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Seeley TW et al. (1999) Phosphorylation of human MAD1 by the BUB1 kinase in vitro. Biochem Biophys Res Commun 257: 589-95 PubMed GONUTS page

[PMID:15525512-5] 6.0 ^6.1 ^6.2 ^6.3 Tang Z et al. (2004) Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint. Mol Cell 16: 387-97 PubMed GONUTS page

[PMID:17981135-6] 7.0 ^7.1 Kiyomitsu T et al. (2007) Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1. Dev Cell 13: 663-76 PubMed GONUTS page

[PMID:15723797-7] 8.0 ^8.1 Kitajima TS et al. (2005) Human Bub1 defines the persistent cohesion site along the mitotic chromosome by affecting Shugoshin localization. Curr Biol 15: 353-9 PubMed GONUTS page

[PMID:9521327-8] 9.0 ^9.1 Cahill DP et al. (1998) Mutations of mitotic checkpoint genes in human cancers. Nature 392: 300-3 PubMed GONUTS page

[PMID:9790499-9] 10.0 ^10.1 Ouyang B et al. (1998) Human Bub1: a putative spindle checkpoint kinase closely linked to cell proliferation. Cell Growth Differ 9: 877-85 PubMed GONUTS page

[PMID:19487456-10] 11.0 ^11.1 ^11.2 ^11.3 Klebig C et al. (2009) Bub1 regulates chromosome segregation in a kinetochore-independent manner. J Cell Biol 185: 841-58 PubMed GONUTS page

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HUMAN:BUB1

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