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HUMAN:BMPR2
Contents |
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | BMPR2 (synonyms: PPH1) | |
| Protein Name(s) | Bone morphogenetic protein receptor type-2
BMP type-2 receptor BMPR-2 Bone morphogenetic protein receptor type II BMP type II receptor BMPR-II | |
| External Links | ||
| UniProt | Q13873 | |
| EMBL | Z48923 D50516 U20165 AC009960 AC073410 AC064836 BC052985 | |
| IPI | IPI00783156 | |
| PIR | I38935 | |
| RefSeq | NP_001195.2 | |
| UniGene | Hs.471119 | |
| PDB | 2HLQ 3G2F | |
| PDBsum | 2HLQ 3G2F | |
| ProteinModelPortal | Q13873 | |
| SMR | Q13873 | |
| DIP | DIP-5794N DIP-5941N DIP-5942N | |
| IntAct | Q13873 | |
| STRING | Q13873 | |
| PhosphoSite | Q13873 | |
| DMDM | 12643724 | |
| PRIDE | Q13873 | |
| Ensembl | ENST00000374574 ENST00000374580 ENST00000445231 | |
| GeneID | 659 | |
| KEGG | hsa:659 | |
| UCSC | uc002uzf.2 | |
| CTD | 659 | |
| GeneCards | GC02P203205 | |
| H-InvDB | HIX0002749 | |
| HGNC | HGNC:1078 | |
| HPA | HPA017385 | |
| MIM | 178600 265450 600799 | |
| neXtProt | NX_Q13873 | |
| Orphanet | 422 31837 | |
| PharmGKB | PA25388 | |
| GeneTree | ENSGT00560000076906 | |
| HOGENOM | HBG447050 | |
| HOVERGEN | HBG050705 | |
| InParanoid | Q13873 | |
| OMA | GPTPVCL | |
| OrthoDB | EOG470TGJ | |
| PhylomeDB | Q13873 | |
| Pathway_Interaction_DB | bmppathway | |
| Reactome | REACT_111102 | |
| NextBio | 2680 | |
| ArrayExpress | Q13873 | |
| Bgee | Q13873 | |
| CleanEx | HS_BMPR2 | |
| Genevestigator | Q13873 | |
| GermOnline | ENSG00000204217 | |
| GO | GO:0005887 GO:0016362 GO:0005524 GO:0046872 GO:0005024 GO:0009952 GO:0030509 GO:0009267 GO:0048286 GO:0001707 GO:0030308 GO:0003085 GO:0045906 GO:0030513 GO:0030501 GO:0010595 GO:0001938 GO:0010634 GO:0045669 GO:0010862 GO:0014916 GO:0006366 GO:0048010 | |
| InterPro | IPR000472 IPR015770 IPR011009 IPR000719 IPR017441 IPR017442 | |
| KO | K04671 | |
| PANTHER | PTHR23255:SF12 | |
| Pfam | PF01064 PF00069 | |
| SUPFAM | SSF56112 | |
| PROSITE | PS00107 PS50011 PS00108 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0001707 |
mesoderm formation |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000084701 |
P |
Seeded From UniProt |
|||
| GO:0001707 |
mesoderm formation |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0001938 |
positive regulation of endothelial cell proliferation |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0003085 |
negative regulation of systemic arterial blood pressure |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0004672 |
protein kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004674 |
protein serine/threonine kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004675 |
transmembrane receptor protein serine/threonine kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0004675 |
transmembrane receptor protein serine/threonine kinase activity |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000037011 |
F |
Seeded From UniProt |
|||
| GO:0004675 |
transmembrane receptor protein serine/threonine kinase activity |
Reactome:REACT_12052 |
TAS: Traceable Author Statement |
|
F |
Seeded From UniProt |
||
| GO:0004872 |
receptor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005024 |
transforming growth factor beta-activated receptor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005737 |
cytoplasm |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000037011 |
C |
Seeded From UniProt |
|||
| GO:0005886 |
plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005886 |
plasma membrane |
Reactome:REACT_115888 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005886 |
plasma membrane |
Reactome:REACT_12009 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005886 |
plasma membrane |
Reactome:REACT_12011 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005886 |
plasma membrane |
Reactome:REACT_12013 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005886 |
plasma membrane |
Reactome:REACT_12052 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005886 |
plasma membrane |
Reactome:REACT_12054 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005886 |
plasma membrane |
Reactome:REACT_12069 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005886 |
plasma membrane |
Reactome:REACT_12070 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005887 |
integral to plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005901 |
caveola |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000037011 |
C |
Seeded From UniProt |
|||
| GO:0006366 |
transcription from RNA polymerase II promoter |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0006468 |
protein phosphorylation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006468 |
protein phosphorylation |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000037011 |
P |
Seeded From UniProt |
|||
| GO:0007178 |
transmembrane receptor protein serine/threonine kinase signaling pathway |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0007420 |
brain development |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000037011 |
P |
Seeded From UniProt |
|||
| GO:0009267 |
cellular response to starvation |
IEP: Inferred from Expression Pattern |
|
P |
Seeded From UniProt |
|||
| GO:0009925 |
basal plasma membrane |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000037011 |
C |
Seeded From UniProt |
|||
| GO:0009952 |
anterior/posterior pattern specification |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000084701 |
P |
Seeded From UniProt |
|||
| GO:0009952 |
anterior/posterior pattern specification |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0009986 |
cell surface |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000084701 |
C |
Seeded From UniProt |
|||
| GO:0010595 |
positive regulation of endothelial cell migration |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0010634 |
positive regulation of epithelial cell migration |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0010862 |
positive regulation of pathway-restricted SMAD protein phosphorylation |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0014916 |
regulation of lung blood pressure |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000084701 |
P |
Seeded From UniProt |
|||
| GO:0014916 |
regulation of lung blood pressure |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0014916 |
regulation of lung blood pressure |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0162 |
C |
Seeded From UniProt |
|||
| GO:0016021 |
integral to membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016301 |
kinase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016310 |
phosphorylation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0016324 |
apical plasma membrane |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000037011 |
C |
Seeded From UniProt |
|||
| GO:0016362 |
activin receptor activity, type II |
Reactome:REACT_12070 |
TAS: Traceable Author Statement |
|
F |
Seeded From UniProt |
||
| GO:0016740 |
transferase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016772 |
transferase activity, transferring phosphorus-containing groups |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0019838 |
growth factor binding |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000037011 |
F |
Seeded From UniProt |
|||
| GO:0030308 |
negative regulation of cell growth |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0030425 |
dendrite |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000037011 |
C |
Seeded From UniProt |
|||
| GO:0030501 |
positive regulation of bone mineralization |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0030509 |
BMP signaling pathway |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000084701 |
P |
Seeded From UniProt |
|||
| GO:0030509 |
BMP signaling pathway |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0030509 |
BMP signaling pathway |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0030509 |
BMP signaling pathway |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0030509 |
BMP signaling pathway |
Reactome:REACT_12034 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0030513 |
positive regulation of BMP signaling pathway |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0042127 |
regulation of cell proliferation |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0043025 |
neuronal cell body |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000037011 |
C |
Seeded From UniProt |
|||
| GO:0045669 |
positive regulation of osteoblast differentiation |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0045906 |
negative regulation of vasoconstriction |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000084701 |
P |
Seeded From UniProt |
|||
| GO:0045906 |
negative regulation of vasoconstriction |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0046872 |
metal ion binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0048010 |
vascular endothelial growth factor receptor signaling pathway |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000084701 |
P |
Seeded From UniProt |
|||
| GO:0048010 |
vascular endothelial growth factor receptor signaling pathway |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0048286 |
lung alveolus development |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000084701 |
P |
Seeded From UniProt |
|||
| GO:0048286 |
lung alveolus development |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0060041 |
retina development in camera-type eye |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000037011 |
P |
Seeded From UniProt |
|||
| GO:0005901 |
caveola |
IMP: Inferred from Mutant Phenotype |
|
C |
Seeded From UniProt |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Southwood M et al. (2008) Regulation of bone morphogenetic protein signalling in human pulmonary vascular development. J Pathol 214: 85-95 PubMed GONUTS page
- ↑ 2.0 2.1 Fu LJ et al. (2008) A novel mutation in the BMPR2 gene in familial pulmonary arterial hypertension. Chin Med J (Engl) 121: 399-404 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Rudarakanchana N et al. (2002) Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertension. Hum Mol Genet 11: 1517-25 PubMed GONUTS page
- ↑ 4.0 4.1 Hassel S et al. (2004) Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry. Proteomics 4: 1346-58 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 Nohe A et al. (2005) Dynamics and interaction of caveolin-1 isoforms with BMP-receptors. J Cell Sci 118: 643-50 PubMed GONUTS page
- ↑ 6.0 6.1 Langenfeld EM et al. (2003) The mature bone morphogenetic protein-2 is aberrantly expressed in non-small cell lung carcinomas and stimulates tumor growth of A549 cells. Carcinogenesis 24: 1445-54 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Lavery K et al. (2008) BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. J Biol Chem 283: 20948-58 PubMed GONUTS page
- ↑ Morrell NW et al. (2001) Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins. Circulation 104: 790-5 PubMed GONUTS page
