HUMAN:BMP1

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	BMP1 ( synonyms: PCOLC )
Protein Name(s)	Bone morphogenetic protein 1 BMP-1 Mammalian tolloid protein mTld Procollagen C-proteinase PCP
External Links
UniProt Identifier	BMP1_HUMAN
UniProt Accessions	P13497, A8K6F5, B2RN46, D3DSR0, Q13292, Q13872, Q14874, Q99421, Q99422, Q99423, Q9UL38,
EMBL	U50330, M22488, Y08723, Y08724, Y08725, L35278, L35279, AK291620, CH471080, CH471080, CH471080, BC136679,
PIR	A37278, A58788, B58788,
RefSeq	NP_001190.1, NP_006120.1,
PDB	3EDG, 3EDH,
IntAct	P13497,
Ensembl	ENST00000306385,
Pfam	PF01400, PF00431, PF07645,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect
	GO:0001501	skeletal system development	PMID:3201241^[1]	TAS: Traceable Author Statement		P
	GO:0001501	skeletal system development	PMID:7798260^[2]	NAS: Non-traceable Author Statement		P
	GO:0001502	cartilage condensation	PMID:3201241^[1]	TAS: Traceable Author Statement		P
	GO:0001503	ossification	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0892	P
	GO:0004222	metalloendopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001506	F
	GO:0004222	metalloendopeptidase activity	Reactome:REACT_13407	TAS: Traceable Author Statement		F
	GO:0005125	cytokine activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0202	F
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001881	F
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018097	F
	GO:0005576	extracellular region	Reactome:REACT_13407	TAS: Traceable Author Statement		C
	GO:0005615	extracellular space	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0202	C
	GO:0005615	extracellular space	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000040287	C
	GO:0006508	proteolysis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001506	P
	GO:0006508	proteolysis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006026	P
	GO:0006508	proteolysis	PMID:16824737^[3]	IDA: Inferred from Direct Assay		P
	GO:0006629	lipid metabolic process	Reactome:REACT_602	TAS: Traceable Author Statement		P
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P
	GO:0007275	multicellular organismal development	PMID:7798260^[2]	TAS: Traceable Author Statement		P
	GO:0008083	growth factor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0339	F
	GO:0008233	peptidase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0645	F
	GO:0008233	peptidase activity	PMID:12393877^[4]	IDA: Inferred from Direct Assay		F
	GO:0008233	peptidase activity	PMID:16824737^[3]	IDA: Inferred from Direct Assay		F
	GO:0008233	peptidase activity	PMID:8553073^[5]	TAS: Traceable Author Statement		F
	GO:0008237	metallopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006026	F
	GO:0008237	metallopeptidase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0482	F
	GO:0008237	metallopeptidase activity	PMID:7798260^[2]	NAS: Non-traceable Author Statement		F
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006026	F
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F
	GO:0030154	cell differentiation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0221	P
	GO:0031988	membrane-bounded vesicle	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000040287	C
	GO:0042157	lipoprotein metabolic process	Reactome:REACT_13621	TAS: Traceable Author Statement		P
	GO:0042157	lipoprotein metabolic process	Reactome:REACT_6823	TAS: Traceable Author Statement		P
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0051216	cartilage development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0891	P
	GO:0061036	positive regulation of cartilage development	PMID:3201241^[1]	IDA: Inferred from Direct Assay		P
	GO:0001501	skeletal system development	PMID:3201241^[1]	TAS: Traceable Author Statement		P
	GO:0001501	skeletal system development	PMID:7798260^[2]	NAS: Non-traceable Author Statement		P
	GO:0001502	cartilage condensation	PMID:3201241^[1]	TAS: Traceable Author Statement		P
	GO:0001503	ossification	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0892	P
	GO:0004222	metalloendopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001506	F
	GO:0004222	metalloendopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015446	F
	GO:0004222	metalloendopeptidase activity	Reactome:REACT_13407	TAS: Traceable Author Statement		F
	GO:0005125	cytokine activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0202	F
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001881	F
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018097	F
	GO:0005576	extracellular region	Reactome:REACT_13407	TAS: Traceable Author Statement		C
	GO:0005615	extracellular space	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0202	C
	GO:0006508	proteolysis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001506	P
	GO:0006508	proteolysis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006026	P
	GO:0006508	proteolysis	PMID:16824737^[3]	IDA: Inferred from Direct Assay		P
	GO:0006629	lipid metabolic process	Reactome:REACT_602	TAS: Traceable Author Statement		P
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P
	GO:0007275	multicellular organismal development	PMID:7798260^[2]	TAS: Traceable Author Statement		P
	GO:0008083	growth factor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0339	F
	GO:0008233	peptidase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0645	F
	GO:0008233	peptidase activity	PMID:12393877^[4]	IDA: Inferred from Direct Assay		F
	GO:0008233	peptidase activity	PMID:16824737^[3]	IDA: Inferred from Direct Assay		F
	GO:0008233	peptidase activity	PMID:8553073^[5]	TAS: Traceable Author Statement		F
	GO:0008237	metallopeptidase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006026	F
	GO:0008237	metallopeptidase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0482	F
	GO:0008237	metallopeptidase activity	PMID:7798260^[2]	NAS: Non-traceable Author Statement		F
	GO:0008270	zinc ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006026	F
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F
	GO:0030154	cell differentiation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0221	P
	GO:0042157	lipoprotein metabolic process	Reactome:REACT_13621	TAS: Traceable Author Statement		P
	GO:0042157	lipoprotein metabolic process	Reactome:REACT_6823	TAS: Traceable Author Statement		P
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0051216	cartilage development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0891	P
	GO:0061036	positive regulation of cartilage development	PMID:3201241^[1]	IDA: Inferred from Direct Assay		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Wozney JM et al. (1988) Novel regulators of bone formation: molecular clones and activities. Science 242: 1528-34 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Takahara K et al. (1994) Bone morphogenetic protein-1 and a mammalian tolloid homologue (mTld) are encoded by alternatively spliced transcripts which are differentially expressed in some tissues. J Biol Chem 269: 32572-8 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Jasuja R et al. (2006) bmp1 and mini fin are functionally redundant in regulating formation of the zebrafish dorsoventral axis. Mech Dev 123: 548-58 PubMed GONUTS page
↑ ^4.0 ^4.1 Steiglitz BM et al. (2002) PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1. J Biol Chem 277: 49820-30 PubMed GONUTS page
↑ ^5.0 ^5.1 Kessler E et al. (1996) Bone morphogenetic protein-1: the type I procollagen C-proteinase. Science 271: 360-2 PubMed GONUTS page

[PMID:3201241-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Wozney JM et al. (1988) Novel regulators of bone formation: molecular clones and activities. Science 242: 1528-34 PubMed GONUTS page

[PMID:7798260-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Takahara K et al. (1994) Bone morphogenetic protein-1 and a mammalian tolloid homologue (mTld) are encoded by alternatively spliced transcripts which are differentially expressed in some tissues. J Biol Chem 269: 32572-8 PubMed GONUTS page

[PMID:16824737-2] 3.0 ^3.1 ^3.2 ^3.3 Jasuja R et al. (2006) bmp1 and mini fin are functionally redundant in regulating formation of the zebrafish dorsoventral axis. Mech Dev 123: 548-58 PubMed GONUTS page

[PMID:12393877-3] 4.0 ^4.1 Steiglitz BM et al. (2002) PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1. J Biol Chem 277: 49820-30 PubMed GONUTS page

[PMID:8553073-4] 5.0 ^5.1 Kessler E et al. (1996) Bone morphogenetic protein-1: the type I procollagen C-proteinase. Science 271: 360-2 PubMed GONUTS page

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HUMAN:BMP1

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