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HUMAN:BMI1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) BMI1 (synonyms: PCGF4, RNF51)
Protein Name(s) Polycomb complex protein BMI-1

Polycomb group RING finger protein 4 RING finger protein 51

External Links
UniProt P35226
EMBL L13689
AK313235
AL158211
CH471072
CH471072
CH471072
CH471072
BC011652
AH004292
CCDS CCDS7138.1
PIR I54339
RefSeq NP_001190991.1
NP_005171.4
UniGene Hs.380403
Hs.731287
PDB 2H0D
3RPG
4R8P
PDBsum 2H0D
3RPG
4R8P
ProteinModelPortal P35226
SMR P35226
BioGrid 107116
1529410
DIP DIP-41879N
IntAct P35226
MINT MINT-158260
STRING 9606.ENSP00000365851
PhosphoSite P35226
DMDM 22258801
MaxQB P35226
PaxDb P35226
PRIDE P35226
DNASU 648
Ensembl ENST00000376663
GeneID 100532731
648
KEGG hsa:100532731
hsa:648
UCSC uc001irh.3
CTD 100532731
648
GeneCards GC10P022611
HGNC HGNC:1066
HPA CAB011120
HPA030472
MIM 164831
neXtProt NX_P35226
PharmGKB PA25376
eggNOG NOG304672
GeneTree ENSGT00550000074463
HOGENOM HOG000231945
HOVERGEN HBG052826
InParanoid P35226
KO K11459
PhylomeDB P35226
TreeFam TF324206
Reactome REACT_169436
EvolutionaryTrace P35226
GeneWiki BMI1
NextBio 2628
PRO PR:P35226
Proteomes UP000005640
Bgee P35226
CleanEx HS_BMI1
ExpressionAtlas P35226
Genevestigator P35226
GO GO:0005737
GO:0005654
GO:0005634
GO:0031519
GO:0035102
GO:0000151
GO:0071535
GO:0008270
GO:0016568
GO:0030097
GO:0000122
GO:0048146
GO:0051443
GO:0010468
GO:0007379
GO:0006351
Gene3D 3.30.40.10
InterPro IPR018957
IPR001841
IPR013083
IPR017907
Pfam PF00097
SMART SM00184
PROSITE PS00518
PS50089

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0043526

neuroprotection

PMID:22384090[1]

ECO:0000315

P

Figure 3. Loss of BM1 due to aging results in loss of neurons

complete
CACAO 3901

part_of

GO:0031519

PcG protein complex

PMID:26151332[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0036353

histone H2A-K119 monoubiquitination

PMID:26151332[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:1990841

promoter-specific chromatin binding

PMID:24623306[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045814

negative regulation of gene expression, epigenetic

PMID:24623306[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048146

positive regulation of fibroblast proliferation

PMID:17420273[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010468

regulation of gene expression

PMID:17420273[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0071535

RING-like zinc finger domain binding

PMID:16714294[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q99496

F

Seeded From UniProt

complete

involved_in

GO:0051443

positive regulation of ubiquitin-protein transferase activity

PMID:16714294[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0035102

PRC1 complex

PMID:19636380[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0035102

PRC1 complex

PMID:12167701[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0031519

PcG protein complex

PMID:21282530[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030097

hemopoiesis

PMID:15334543[9]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

PMID:16714294[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21282530[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:10445843[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000151

ubiquitin ligase complex

PMID:16714294[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:19636380[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:1990841

promoter-specific chromatin binding

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88174
PANTHER:PTN000850589
UniProtKB:P35226

F

Seeded From UniProt

complete

involved_in

GO:0036353

histone H2A-K119 monoubiquitination

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000850589
UniProtKB:P35226
UniProtKB:P35227
UniProtKB:Q9BSM1

P

Seeded From UniProt

complete

part_of

GO:0035102

PRC1 complex

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000850589
UniProtKB:P35226
UniProtKB:P35227
UniProtKB:P35820

C

Seeded From UniProt

complete

involved_in

GO:0006342

chromatin silencing

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0265623
PANTHER:PTN000850589
UniProtKB:P35820

P

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88174
MGI:MGI:99161
PANTHER:PTN000850589
UniProtKB:P35226
UniProtKB:P35227

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:9367786[12]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016604

nuclear body

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007379

segment specification

PMID:7715727[13]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070317

negative regulation of G0 to G1 transition

Reactome:R-HSA-8953750

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-8954082
Reactome:R-HSA-4570499
Reactome:R-HSA-4570463
Reactome:R-HSA-4551727
Reactome:R-HSA-4551655
Reactome:R-HSA-3927824
Reactome:R-HSA-3229102
Reactome:R-HSA-3229089
Reactome:R-HSA-3108209
Reactome:R-HSA-3108203

ECO:0000304

author statement supported by traceable reference used in manual assertion










C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0006325

chromatin organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0156

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Abdouh, M et al. (2012) Bmi1 is down-regulated in the aging brain and displays antioxidant and protective activities in neurons. PLoS ONE 7 e31870 PubMed GONUTS page
  2. ↑ 2.0 2.1 Taherbhoy, AM et al. (2015) BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase. Nat Commun 6 7621 PubMed GONUTS page
  3. ↑ 3.0 3.1 Serra, RW et al. (2014) A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. Elife 3 e02313 PubMed GONUTS page
  4. ↑ 4.0 4.1 Ruas, M et al. (2007) CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms. Mol. Cell. Biol. 27 4273-82 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Li, Z et al. (2006) Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex. J. Biol. Chem. 281 20643-9 PubMed GONUTS page
  6. ↑ 6.0 6.1 Maertens, GN et al. (2009) Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. PLoS ONE 4 e6380 PubMed GONUTS page
  7. ↑ Levine, SS et al. (2002) The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. Mol. Cell. Biol. 22 6070-8 PubMed GONUTS page
  8. ↑ 8.0 8.1 Vandamme, J et al. (2011) Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells. Mol. Cell Proteomics 10 M110.002642 PubMed GONUTS page
  9. ↑ MacGrogan, D et al. (2004) Structural integrity and expression of the L3MBTL gene in normal and malignant hematopoietic cells. Genes Chromosomes Cancer 41 203-13 PubMed GONUTS page
  10. ↑ Koga, H et al. (1999) A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes. Oncogene 18 3799-809 PubMed GONUTS page
  11. ↑ 11.0 11.1 11.2 11.3 11.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  12. ↑ Alkema, MJ et al. (1997) MPc2, a new murine homolog of the Drosophila polycomb protein is a member of the mouse polycomb transcriptional repressor complex. J. Mol. Biol. 273 993-1003 PubMed GONUTS page
  13. ↑ Alkema, MJ et al. (1995) Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice. Nature 374 724-7 PubMed GONUTS page
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