HUMAN:BCL10

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	BCL10 ( synonyms: CIPER, CLAP )
Protein Name(s)	B-cell lymphoma/leukemia 10 B-cell CLL/lymphoma 10 Bcl-10 CARD-containing molecule enhancing NF-kappa-B CARD-like apoptotic protein hCLAP CED-3/ICH-1 prodomain homologous E10-like regulator CIPER Cellular homolog of vCARMEN cCARMEN Cellular-E10 c-E10 Mammalian CARD-containing adapter molecule E10 mE10
External Links
UniProt Identifier	BCL10_HUMAN
UniProt Accessions	O95999,
EMBL	AJ006288, AF057700, AF100338, AF127386, AF134395, AF105066, AF082283, AF097732, BC053617,
RefSeq	NP_003912.1,
IntAct	O95999,
Ensembl	ENST00000271015, ENST00000370580, ENST00000394761,
Pfam	PF00619,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0032449	CBM complex		NAS: Non-traceable Author Statement		C	Source: UniProtKB
	GO:0005829	cytosol		IDA: Inferred from Direct Assay		C	Source: UniProtKB
	GO:0005764	lysosome		IDA: Inferred from Direct Assay		C	Source: UniProtKB
	GO:0045121	membrane raft		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-SubCell
	GO:0005634	nucleus		IDA: Inferred from Direct Assay		C	Source: UniProtKB
	GO:0048471	perinuclear region of cytoplasm		IDA: Inferred from Direct Assay		C	Source: UniProtKB
	GO:0051059	NF-kappaB binding		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0008022	protein C-terminus binding		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0043621	protein self-association		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0003713	transcription coactivator activity		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0043130	ubiquitin binding		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0031625	ubiquitin protein ligase binding		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0006915	apoptosis		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0045087	innate immune response		IEP: Inferred from Expression Pattern		P	Source: UniProtKB
	GO:0042226	interleukin-6 biosynthetic process		NAS: Non-traceable Author Statement		P	Source: UniProtKB
	GO:0042109	lymphotoxin A biosynthetic process		NAS: Non-traceable Author Statement		P	Source: UniProtKB
	GO:0002906	negative regulation of mature B cell apoptosis		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0001843	neural tube closure		ISS: Inferred from Sequence or Structural Similarity		P	Source: UniProtKB
	GO:0043123	positive regulation of I-kappaB kinase/NF-k...		IEP: Inferred from Expression Pattern		P	Source: UniProtKB
	GO:0045416	positive regulation of interleukin-8 biosyn...		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB
	GO:0032765	positive regulation of mast cell cytokine p...		NAS: Non-traceable Author Statement		P	Source: UniProtKB
	GO:0051092	positive regulation of NF-kappaB transcript...		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0042327	positive regulation of phosphorylation		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0031398	positive regulation of protein ubiquitination		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0045893	positive regulation of transcription, DNA-d...		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0051260	protein homooligomerization		TAS: Traceable Author Statement		P	Source: UniProtKB
	GO:0002237	response to molecule of bacterial origin		IEP: Inferred from Expression Pattern		P	Source: UniProtKB
	GO:0050852	T cell receptor signaling pathway		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0002224	toll-like receptor signaling pathway		IC: Inferred by Curator		P	Source: UniProtKB
	GO:0001772	immunological synapse	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000029842	C
	GO:0001843	neural tube closure	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000029842	P
	GO:0001843	neural tube closure	PMID:11163238^[1]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9Z0H7	P
	GO:0002020	protease binding	PMID:18223652^[2]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UDY8	F
	GO:0002224	toll-like receptor signaling pathway	PMID:16831874^[3]	IC: Inferred by Curator	GO:0046696	P
	GO:0002237	response to molecule of bacterial origin	PMID:16831874^[3]	IEP: Inferred from Expression Pattern		P
	GO:0002250	adaptive immune response	PMID:16831874^[3]	TAS: Traceable Author Statement		P
	GO:0002906	negative regulation of mature B cell apoptosis	PMID:15878976^[4]	IDA: Inferred from Direct Assay		P
	GO:0003713	transcription coactivator activity	PMID:15207693^[5]	IDA: Inferred from Direct Assay		F
	GO:0005515	protein binding	PMID:1040062^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q15628	F
	GO:0005515	protein binding	PMID:11259443^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q9BWT7	F
	GO:0005515	protein binding	PMID:11278692^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q9BXL6	F
	GO:0005515	protein binding	PMID:11278692^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q9BXL7	F
	GO:0005515	protein binding	PMID:11466612^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q12933	F
	GO:0005515	protein binding	PMID:11472070^[10]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NPP4	F
	GO:0005515	protein binding	PMID:14695475^[11]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UDY8	F
	GO:0005515	protein binding	PMID:16280327^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P20749	F
	GO:0005515	protein binding	PMID:16280327^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P20749	F
	GO:0005515	protein binding	PMID:16280327^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P31749	F
	GO:0005515	protein binding	PMID:16809782^[13]	IPI: Inferred from Physical Interaction	UniProtKB:Q9BXL7	F
	GO:0005515	protein binding	PMID:17353931^[14]	IPI: Inferred from Physical Interaction	UniProtKB:P62807	F
	GO:0005515	protein binding	PMID:17353931^[14]	IPI: Inferred from Physical Interaction	UniProtKB:Q14525	F
	GO:0005622	intracellular	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001315	C
	GO:0005634	nucleus	PMID:16280327^[12]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000029842	C
	GO:0005737	cytoplasm	PMID:11021819^[15]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	PMID:11053425^[16]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	PMID:11278692^[8]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	PMID:15082780^[17]	IDA: Inferred from Direct Assay		C
	GO:0005764	lysosome	PMID:15082780^[17]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000029842	C
	GO:0005829	cytosol	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000019911	C
	GO:0005829	cytosol	PMID:12154360^[18]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	Reactome:REACT_12448	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_12518	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_12553	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_12563	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_12574	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_12581	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_12595	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_12619	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_12639	TAS: Traceable Author Statement		C
	GO:0006915	apoptosis	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0053	P
	GO:0006915	apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000029842	P
	GO:0006915	apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000019911	P
	GO:0006915	apoptosis	PMID:11466612^[9]	IDA: Inferred from Direct Assay		P
	GO:0006917	induction of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000019911	P
	GO:0006968	cellular defense response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000029842	P
	GO:0007249	I-kappaB kinase/NF-kappaB cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000029842	P
	GO:0008022	protein C-terminus binding	PMID:11053425^[16]	IPI: Inferred from Physical Interaction	UniProtKB:Q9H257	F
	GO:0008134	transcription factor binding	PMID:15207693^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q00403	F
	GO:0008219	cell death	PMID:1040062^[6]5	IDA: Inferred from Direct Assay		P
	GO:0009620	response to fungus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000029842	P
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016064	immunoglobulin mediated immune response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000029842	P
	GO:0019899	enzyme binding	PMID:14695475^[11]	IPI: Inferred from Physical Interaction	UniProtKB:P61088	F
	GO:0019900	kinase binding	PMID:16831874^[3]	IPI: Inferred from Physical Interaction	UniProtKB:P51617-1	F
	GO:0019900	kinase binding	PMID:17052756^[19]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UQM7	F
	GO:0019901	protein kinase binding	PMID:17052756^[19]	IDA: Inferred from Direct Assay		F
	GO:0031398	positive regulation of protein ubiquitination	PMID:14695475^[11]	IDA: Inferred from Direct Assay		P
	GO:0031625	ubiquitin protein ligase binding	PMID:16395405^[20]	IPI: Inferred from Physical Interaction	UniProtKB:Q13489	F
	GO:0032449	CBM complex	PMID:15125833^[21]	NAS: Non-traceable Author Statement		C
	GO:0032765	positive regulation of mast cell cytokine production	PMID:16647297^[22]	NAS: Non-traceable Author Statement		P
	GO:0042109	lymphotoxin A biosynthetic process	PMID:16647297^[22]	NAS: Non-traceable Author Statement		P
	GO:0042221	response to chemical stimulus	PMID:17095757^[23]	IDA: Inferred from Direct Assay		P
	GO:0042226	interleukin-6 biosynthetic process	PMID:16647297^[22]	NAS: Non-traceable Author Statement		P
	GO:0042327	positive regulation of phosphorylation	PMID:15125833^[21]	IDA: Inferred from Direct Assay		P
	GO:0042981	regulation of apoptosis	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001315	P
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	PMID:12761501^[24]	IEP: Inferred from Expression Pattern		P
	GO:0043130	ubiquitin binding	PMID:15082780^[17]	IDA: Inferred from Direct Assay		F
	GO:0043234	protein complex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000019911	C
	GO:0043234	protein complex	PMID:14695475^[11]	IDA: Inferred from Direct Assay		C
	GO:0043234	protein complex	PMID:16280327^[12]	IDA: Inferred from Direct Assay		C
	GO:0043422	protein kinase B binding	PMID:16280327^[12]	IPI: Inferred from Physical Interaction	UniProtKB:P31749	F
	GO:0043621	protein self-association	PMID:15125833^[21]	IPI: Inferred from Physical Interaction	UniProtKB:O95999	F
	GO:0045087	innate immune response	PMID:16831874^[3]	IEP: Inferred from Expression Pattern		P
	GO:0045121	membrane raft	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000029842	C
	GO:0045121	membrane raft	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0370	C
	GO:0045416	positive regulation of interleukin-8 biosynthetic process	PMID:17095757^[23]	IMP: Inferred from Mutant Phenotype		P
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:15207693^[5]	IDA: Inferred from Direct Assay		P
	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0198	C
	GO:0048471	perinuclear region of cytoplasm	PMID:16127295^[25]	IDA: Inferred from Direct Assay		C
	GO:0050852	T cell receptor signaling pathway	PMID:15125833^[21]	IDA: Inferred from Direct Assay		P
	GO:0050852	T cell receptor signaling pathway	Reactome:REACT_12526	TAS: Traceable Author Statement		P
	GO:0050856	regulation of T cell receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000029842	P
	GO:0050870	positive regulation of T cell activation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000029842	P
	GO:0051059	NF-kappaB binding	PMID:16280327^[12]	IDA: Inferred from Direct Assay		F
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000029842	P
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:1040062^[6]5	IDA: Inferred from Direct Assay		P
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:14695475^[11]	IDA: Inferred from Direct Assay		P
	GO:0051259	protein oligomerization	PMID:14695475^[11]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UDY8	P
	GO:0051260	protein homooligomerization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000029842	P
	GO:0051260	protein homooligomerization	PMID:16831874^[3]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9Z0H7	P
	GO:0051260	protein homooligomerization	PMID:16831874^[3]	TAS: Traceable Author Statement		P
	GO:0071260	cellular response to mechanical stimulus	PMID:19593445^[26]	IEP: Inferred from Expression Pattern		P
colocalizes_with	GO:0042101	T cell receptor complex	PMID:12154360^[18]	IDA: Inferred from Direct Assay		C
colocalizes_with	GO:0046696	lipopolysaccharide receptor complex	PMID:16831874^[3]	IDA: Inferred from Direct Assay		C
contributes_to	GO:0019209	kinase activator activity	PMID:15125833^[21]	IDA: Inferred from Direct Assay		F
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Ruland J et al. (2001) Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure. Cell 104: 33-42 PubMed GONUTS page
↑ Coornaert B et al. (2008) T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20. Nat Immunol 9: 263-71 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Dong W et al. (2006) The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4. J Biol Chem 281: 26029-40 PubMed GONUTS page
↑ Tian MT et al. (2005) Bcl10 can promote survival of antigen-stimulated B lymphocytes. Blood 106: 2105-12 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Liu Y et al. (2004) Characterization of Bcl10 as a potential transcriptional activator that interacts with general transcription factor TFIIB. Biochem Biophys Res Commun 320: 1-6 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Hasegawa H (1975) [Nurses replies to expectations of the nursing profession]. Kango 27: 66-80 PubMed GONUTS page
↑ Wang L et al. (2001) Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B. J Biol Chem 276: 21405-9 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Bertin J et al. (2001) CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B. J Biol Chem 276: 11877-82 PubMed GONUTS page
↑ ^9.0 ^9.1 Yui D et al. (2001) Interchangeable binding of Bcl10 to TRAF2 and cIAPs regulates apoptosis signaling. Oncogene 20: 4317-23 PubMed GONUTS page
↑ Damiano JS et al. (2001) CLAN, a novel human CED-4-like gene. Genomics 75: 77-83 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Zhou H et al. (2004) Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO. Nature 427: 167-71 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 Yeh PY et al. (2006) A pathway for tumor necrosis factor-alpha-induced Bcl10 nuclear translocation. Bcl10 is up-regulated by NF-kappaB and phosphorylated by Akt1 and then complexes with Bcl3 to enter the nucleus. J Biol Chem 281: 167-75 PubMed GONUTS page
↑ Ishiguro K et al. (2006) Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-kappaB activation. Mol Cell Biol 26: 5497-508 PubMed GONUTS page
↑ ^14.0 ^14.1 Ewing RM et al. (2007) Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol 3: 89 PubMed GONUTS page
↑ Ye H et al. (2000) BCL10 expression in normal and neoplastic lymphoid tissue. Nuclear localization in MALT lymphoma. Am J Pathol 157: 1147-54 PubMed GONUTS page
↑ ^16.0 ^16.1 Bertin J et al. (2000) CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B. J Biol Chem 275: 41082-6 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Scharschmidt E et al. (2004) Degradation of Bcl10 induced by T-cell activation negatively regulates NF-kappa B signaling. Mol Cell Biol 24: 3860-73 PubMed GONUTS page
↑ ^18.0 ^18.1 Gaide O et al. (2002) CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation. Nat Immunol 3: 836-43 PubMed GONUTS page
↑ ^19.0 ^19.1 Ishiguro K et al. (2007) Bcl10 is phosphorylated on Ser138 by Ca2+/calmodulin-dependent protein kinase II. Mol Immunol 44: 2095-100 PubMed GONUTS page
↑ Hu S et al. (2006) cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas. J Clin Invest 116: 174-81 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 ^21.4 Sun L et al. (2004) The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol Cell 14: 289-301 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 Rivera J (2006) Adaptors discriminate mast-cell cytokine production from eicosanoid production and degranulation. Trends Immunol 27: 251-3 PubMed GONUTS page
↑ ^23.0 ^23.1 Borthakur A et al. (2007) Carrageenan induces interleukin-8 production through distinct Bcl10 pathway in normal human colonic epithelial cells. Am J Physiol Gastrointest Liver Physiol 292: G829-38 PubMed GONUTS page
↑ Matsuda A et al. (2003) Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 22: 3307-18 PubMed GONUTS page
↑ Nakamura K et al. (2005) Accumulation of BCL10 at the perinuclear region is required for the BCL10-mediated nuclear factor-kappa B activation. Pathobiology 72: 191-202 PubMed GONUTS page
↑ Smith AJ et al. (2009) Expression of the Bcl-2 protein BAD promotes prostate cancer growth. PLoS One 4: e6224 PubMed GONUTS page

[PMID:11163238-0] Ruland J et al. (2001) Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure. Cell 104: 33-42 PubMed GONUTS page

[PMID:18223652-1] Coornaert B et al. (2008) T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20. Nat Immunol 9: 263-71 PubMed GONUTS page

[PMID:16831874-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Dong W et al. (2006) The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4. J Biol Chem 281: 26029-40 PubMed GONUTS page

[PMID:15878976-3] Tian MT et al. (2005) Bcl10 can promote survival of antigen-stimulated B lymphocytes. Blood 106: 2105-12 PubMed GONUTS page

[PMID:15207693-4] 5.0 ^5.1 ^5.2 Liu Y et al. (2004) Characterization of Bcl10 as a potential transcriptional activator that interacts with general transcription factor TFIIB. Biochem Biophys Res Commun 320: 1-6 PubMed GONUTS page

[PMID:1040062-5] 6.0 ^6.1 ^6.2 Hasegawa H (1975) [Nurses replies to expectations of the nursing profession]. Kango 27: 66-80 PubMed GONUTS page

[PMID:11259443-6] Wang L et al. (2001) Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B. J Biol Chem 276: 21405-9 PubMed GONUTS page

[PMID:11278692-7] 8.0 ^8.1 ^8.2 Bertin J et al. (2001) CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B. J Biol Chem 276: 11877-82 PubMed GONUTS page

[PMID:11466612-8] 9.0 ^9.1 Yui D et al. (2001) Interchangeable binding of Bcl10 to TRAF2 and cIAPs regulates apoptosis signaling. Oncogene 20: 4317-23 PubMed GONUTS page

[PMID:11472070-9] Damiano JS et al. (2001) CLAN, a novel human CED-4-like gene. Genomics 75: 77-83 PubMed GONUTS page

[PMID:14695475-10] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Zhou H et al. (2004) Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO. Nature 427: 167-71 PubMed GONUTS page

[PMID:16280327-11] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 Yeh PY et al. (2006) A pathway for tumor necrosis factor-alpha-induced Bcl10 nuclear translocation. Bcl10 is up-regulated by NF-kappaB and phosphorylated by Akt1 and then complexes with Bcl3 to enter the nucleus. J Biol Chem 281: 167-75 PubMed GONUTS page

[PMID:16809782-12] Ishiguro K et al. (2006) Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-kappaB activation. Mol Cell Biol 26: 5497-508 PubMed GONUTS page

[PMID:17353931-13] 14.0 ^14.1 Ewing RM et al. (2007) Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol 3: 89 PubMed GONUTS page

[PMID:11021819-14] Ye H et al. (2000) BCL10 expression in normal and neoplastic lymphoid tissue. Nuclear localization in MALT lymphoma. Am J Pathol 157: 1147-54 PubMed GONUTS page

[PMID:11053425-15] 16.0 ^16.1 Bertin J et al. (2000) CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B. J Biol Chem 275: 41082-6 PubMed GONUTS page

[PMID:15082780-16] 17.0 ^17.1 ^17.2 Scharschmidt E et al. (2004) Degradation of Bcl10 induced by T-cell activation negatively regulates NF-kappa B signaling. Mol Cell Biol 24: 3860-73 PubMed GONUTS page

[PMID:12154360-17] 18.0 ^18.1 Gaide O et al. (2002) CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation. Nat Immunol 3: 836-43 PubMed GONUTS page

[PMID:17052756-18] 19.0 ^19.1 Ishiguro K et al. (2007) Bcl10 is phosphorylated on Ser138 by Ca2+/calmodulin-dependent protein kinase II. Mol Immunol 44: 2095-100 PubMed GONUTS page

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