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HUMAN:BACH1
Contents |
| Species (Taxon ID) | Homo sapiens (Human). ([1]) | |
| Gene Name(s) | BACH1 | |
| Protein Name(s) | Transcription regulator protein BACH1
BTB and CNC homolog 1 HA2303 | |
| External Links | ||
| EMBL | AF026199 AF026200 AB002803 AF124731 AL163249 AP001705 BC063307 | |
| IPI | IPI00024235 | |
| PIR | T00023 | |
| RefSeq | NP_001177.1 NP_996749.1 | |
| UniGene | Hs.154276 | |
| PDB | 2IHC | |
| PDBsum | 2IHC | |
| ProteinModelPortal | O14867 | |
| SMR | O14867 | |
| DIP | DIP-24223N | |
| IntAct | O14867 | |
| STRING | O14867 | |
| PhosphoSite | O14867 | |
| PRIDE | O14867 | |
| Ensembl | ENST00000286800 ENST00000399921 | |
| GeneID | 571 | |
| KEGG | hsa:571 | |
| UCSC | uc002ynj.1 | |
| CTD | 571 | |
| GeneCards | GC21P016079 | |
| H-InvDB | HIX0040836 | |
| HGNC | HGNC:935 | |
| HPA | HPA003175 | |
| MIM | 602751 | |
| neXtProt | NX_O14867 | |
| PharmGKB | PA25234 | |
| eggNOG | prNOG14589 | |
| HOGENOM | HBG715857 | |
| HOVERGEN | HBG099852 | |
| InParanoid | O14867 | |
| OMA | VQPNETS | |
| OrthoDB | EOG4CJVH8 | |
| PhylomeDB | O14867 | |
| NextBio | 2323 | |
| ArrayExpress | O14867 | |
| Bgee | O14867 | |
| CleanEx | HS_BACH1 | |
| Genevestigator | O14867 | |
| GermOnline | ENSG00000156273 | |
| GO | GO:0005634 GO:0046983 GO:0043565 GO:0003700 | |
| InterPro | IPR000210 IPR011333 IPR013069 IPR011616 IPR008917 IPR004827 | |
| Gene3D | G3DSA:3.30.710.10 G3DSA:1.10.880.10 | |
| Pfam | PF00651 PF00170 | |
| SMART | SM00338 SM00225 | |
| SUPFAM | SSF54695 SSF47454 | |
| PROSITE | PS50097 PS50217 PS00036 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000083 |
regulation of transcription involved in G1/S phase of mitotic cell cycle |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0000117 |
regulation of transcription involved in G2/M-phase of mitotic cell cycle |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0001078 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0001078 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription |
IMP: Inferred from Mutant Phenotype |
|
F |
Seeded From UniProt |
|||
| GO:0003677 |
DNA binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003677 |
DNA binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003677 |
DNA binding |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000026703 |
F |
Seeded From UniProt |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000026703 |
F |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000026703 |
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0191 |
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0006351 |
transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006351 |
transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000026703 |
P |
Seeded From UniProt |
|||
| GO:0006355 |
regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000026703 |
P |
Seeded From UniProt |
|||
| GO:0020037 |
heme binding |
NAS: Non-traceable Author Statement |
|
F |
Seeded From UniProt |
|||
| GO:0043565 |
sequence-specific DNA binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0043565 |
sequence-specific DNA binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0043618 |
regulation of transcription from RNA polymerase II promoter in response to stress |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0046983 |
protein dimerization activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005730 |
nucleolus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005829 |
cytosol |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0006281 |
DNA repair |
IMP: Inferred from Mutant Phenotype |
P |
Fig. 5 shows that the mutant interferes with BACH1 ability to timely repair double-strand breaks that BRCA1 usually makes. |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Warnatz HJ et al. (2011) The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle. J Biol Chem 286: 23521-32 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Kitamuro T et al. (2003) Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells. J Biol Chem 278: 9125-33 PubMed GONUTS page
- ↑ 3.0 3.1 Barbe L et al. (2008) Toward a confocal subcellular atlas of the human proteome. Mol Cell Proteomics 7: 499-508 PubMed GONUTS page
- ↑ 4.0 4.1 Hu YH et al. (2006) Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. BMC Genomics 7: 155 PubMed GONUTS page
- ↑ Cantor SB et al. (2001) BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function. Cell 105: 149-60 PubMed GONUTS page
