HUMAN:ATR

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Species (Taxon ID)	Homo sapiens (Human). ([1])
Gene Name(s)	ATR (synonyms: FRP1)
Protein Name(s)	Serine/threonine-protein kinase ATR Ataxia telangiectasia and Rad3-related protein FRAP-related protein 1
External Links
EMBL	Y09077 U76308 U49844 AF325699 AB208847
IPI	IPI00412298 IPI00554573 IPI00926461
RefSeq	NP_001175.2
UniGene	Hs.271791
ProteinModelPortal	Q13535
SMR	Q13535
DIP	DIP-35308N
IntAct	Q13535
MINT	MINT-194575
STRING	Q13535
PhosphoSite	Q13535
PRIDE	Q13535
Ensembl	ENST00000350721
GeneID	545
KEGG	hsa:545
UCSC	uc003eux.2
CTD	545
GeneCards	GC03M139541
H-InvDB	HIX0030886
HGNC	HGNC:882
HPA	HPA028264
MIM	210600 601215
neXtProt	NX_Q13535
Orphanet	808
PharmGKB	PA74
eggNOG	prNOG12605
GeneTree	ENSGT00550000074948
HOGENOM	HBG356517
HOVERGEN	HBG050619
InParanoid	Q13535
OMA	VLLGCNQ
OrthoDB	EOG48GW2C
PhylomeDB	Q13535
Pathway_Interaction_DB	bard1pathway circadianpathway
Reactome	REACT_1538 REACT_216
NextBio	2253
ArrayExpress	Q13535
Bgee	Q13535
CleanEx	HS_ATR
Genevestigator	Q13535
GermOnline	ENSG00000175054
GO	GO:0016605 GO:0005524 GO:0003677 GO:0032405 GO:0032407 GO:0004674 GO:0007049 GO:0071480 GO:0034644 GO:0000077 GO:0006281 GO:0006260 GO:0007275 GO:0008156 GO:0018105 GO:0043517 GO:0046777 GO:0090399
InterPro	IPR011989 IPR016024 IPR003152 IPR021133 IPR011009 IPR000403 IPR018936 IPR003151 IPR014009 IPR011990 IPR012993
Gene3D	G3DSA:1.25.10.10 G3DSA:1.10.1070.11 G3DSA:1.25.40.10
Pfam	PF02259 PF02260 PF00454 PF08064
SMART	SM00146 SM00802
SUPFAM	SSF48371 SSF56112
PROSITE	PS51189 PS51190 PS50077 PS00915 PS00916 PS50290

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000075	cell cycle checkpoint	Reactome:REACT_1538	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0000077	DNA damage checkpoint	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034980	P	Seeded From UniProt
	GO:0000077	DNA damage checkpoint	PMID:14657349^[1]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F	Seeded From UniProt
	GO:0001741	XY body	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034980	C	Seeded From UniProt
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F	Seeded From UniProt
	GO:0004672	protein kinase activity	PMID:14657349^[1]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0004672	protein kinase activity	PMID:8610130^[2]	TAS: Traceable Author Statement		F	Seeded From UniProt
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012993	F	Seeded From UniProt
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0723	F	Seeded From UniProt
	GO:0004674	protein serine/threonine kinase activity	PMID:9733515^[3]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0004674	protein serine/threonine kinase activity	PMID:9925639^[4]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0005488	binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011989	F	Seeded From UniProt
	GO:0005488	binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011990	F	Seeded From UniProt
	GO:0005488	binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016024	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:14657349^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P43246	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C	Seeded From UniProt
	GO:0005654	nucleoplasm	Reactome:REACT_18293	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005654	nucleoplasm	Reactome:REACT_18335	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005654	nucleoplasm	Reactome:REACT_6750	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005654	nucleoplasm	Reactome:REACT_6869	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005654	nucleoplasm	Reactome:REACT_6939	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0006260	DNA replication	Reactome:REACT_6769	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0006281	DNA repair	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0234	P	Seeded From UniProt
	GO:0006281	DNA repair	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034980	P	Seeded From UniProt
	GO:0006281	DNA repair	PMID:8610130^[2]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0006281	DNA repair	Reactome:REACT_216	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034980	P	Seeded From UniProt
	GO:0006468	protein phosphorylation	PMID:8610130^[2]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0006974	response to DNA damage stimulus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0227	P	Seeded From UniProt
	GO:0006974	response to DNA damage stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034980	P	Seeded From UniProt
	GO:0006974	response to DNA damage stimulus	PMID:15538388^[5]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0007049	cell cycle	PMID:9590286^[6]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0007275	multicellular organismal development	PMID:9590286^[6]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0008156	negative regulation of DNA replication	PMID:14657349^[1]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0016301	kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	F	Seeded From UniProt
	GO:0016310	phosphorylation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	P	Seeded From UniProt
	GO:0016605	PML body	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0465	C	Seeded From UniProt
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F	Seeded From UniProt
	GO:0016772	transferase activity, transferring phosphorus-containing groups	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F	Seeded From UniProt
	GO:0016773	phosphotransferase activity, alcohol group as acceptor	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000403	F	Seeded From UniProt
	GO:0016773	phosphotransferase activity, alcohol group as acceptor	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018936	F	Seeded From UniProt
	GO:0018105	peptidyl-serine phosphorylation	PMID:9733515^[3]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0032405	MutLalpha complex binding	PMID:16713580^[7]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0032407	MutSalpha complex binding	PMID:16713580^[7]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0034644	cellular response to UV	PMID:9925639^[4]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0043393	regulation of protein binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034980	P	Seeded From UniProt
	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	PMID:9925639^[4]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0046777	protein autophosphorylation	PMID:9733515^[3]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0071480	cellular response to gamma radiation	PMID:9925639^[4]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0090399	replicative senescence	PMID:15149599^[8]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Wang Y & Qin J (2003) MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation. Proc Natl Acad Sci U S A 100: 15387-92 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Cimprich KA et al. (1996) cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein. Proc Natl Acad Sci U S A 93: 2850-5 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Canman CE et al. (1998) Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281: 1677-9 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Tibbetts RS et al. (1999) A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev 13: 152-7 PubMed GONUTS page
↑ Tsao CC et al. (2004) Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. EMBO J 23: 4660-9 PubMed GONUTS page
↑ ^6.0 ^6.1 Smith L et al. (1998) Duplication of ATR inhibits MyoD, induces aneuploidy and eliminates radiation-induced G1 arrest. Nat Genet 19: 39-46 PubMed GONUTS page
↑ ^7.0 ^7.1 Yoshioka K et al. (2006) ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. Mol Cell 22: 501-10 PubMed GONUTS page
↑ Herbig U et al. (2004) Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell 14: 501-13 PubMed GONUTS page

[PMID:14657349-0] 1.0 ^1.1 ^1.2 ^1.3 Wang Y & Qin J (2003) MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation. Proc Natl Acad Sci U S A 100: 15387-92 PubMed GONUTS page

[PMID:8610130-1] 2.0 ^2.1 ^2.2 Cimprich KA et al. (1996) cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein. Proc Natl Acad Sci U S A 93: 2850-5 PubMed GONUTS page

[PMID:9733515-2] 3.0 ^3.1 ^3.2 Canman CE et al. (1998) Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281: 1677-9 PubMed GONUTS page

[PMID:9925639-3] 4.0 ^4.1 ^4.2 ^4.3 Tibbetts RS et al. (1999) A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev 13: 152-7 PubMed GONUTS page

[PMID:15538388-4] Tsao CC et al. (2004) Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling. EMBO J 23: 4660-9 PubMed GONUTS page

[PMID:9590286-5] 6.0 ^6.1 Smith L et al. (1998) Duplication of ATR inhibits MyoD, induces aneuploidy and eliminates radiation-induced G1 arrest. Nat Genet 19: 39-46 PubMed GONUTS page

[PMID:16713580-6] 7.0 ^7.1 Yoshioka K et al. (2006) ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. Mol Cell 22: 501-10 PubMed GONUTS page

[PMID:15149599-7] Herbig U et al. (2004) Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell 14: 501-13 PubMed GONUTS page

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HUMAN:ATR

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