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HUMAN:ATPA
Contents |
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | ATP5A1 (synonyms: ATP5A, ATP5AL2, ATPM) | |
| Protein Name(s) | ATP synthase subunit alpha, mitochondrial | |
| External Links | ||
| UniProt | P25705 | |
| EMBL | X59066 X65460 D14710 D28126 BT007209 BC003119 BC007299 BC008028 BC011384 BC016046 BC019310 BC039135 BC064562 BC067385 | |
| IPI | IPI00440493 | |
| PIR | S17193 | |
| RefSeq | NP_001001937.1 NP_004037.1 | |
| UniGene | Hs.298280 | |
| ProteinModelPortal | P25705 | |
| SMR | P25705 | |
| IntAct | P25705 | |
| MINT | MINT-1163289 | |
| STRING | P25705 | |
| PhosphoSite | P25705 | |
| DMDM | 114517 | |
| OGP | P25705 | |
| REPRODUCTION-2DPAGE | P25705 | |
| UCD-2DPAGE | P25705 | |
| PRIDE | P25705 | |
| Ensembl | ENST00000282050 ENST00000398752 | |
| GeneID | 498 | |
| KEGG | hsa:498 | |
| UCSC | uc002lbr.1 | |
| CTD | 498 | |
| GeneCards | GC18M043664 | |
| H-InvDB | HIX0014426 | |
| HGNC | HGNC:823 | |
| HPA | CAB013067 | |
| MIM | 164360 | |
| neXtProt | NX_P25705 | |
| PharmGKB | PA25115 | |
| eggNOG | prNOG10055 | |
| GeneTree | ENSGT00550000074846 | |
| HOVERGEN | HBG001536 | |
| InParanoid | P25705 | |
| OMA | QKRWNNG | |
| OrthoDB | EOG4ZCT48 | |
| PhylomeDB | P25705 | |
| Reactome | REACT_111217 | |
| NextBio | 2089 | |
| PMAP-CutDB | P25705 | |
| ArrayExpress | P25705 | |
| Bgee | P25705 | |
| CleanEx | HS_ATP5A1 | |
| Genevestigator | P25705 | |
| GermOnline | ENSG00000152234 | |
| GO | GO:0005759 GO:0005886 GO:0005524 GO:0043499 GO:0046933 GO:0042288 GO:0046961 GO:0015991 GO:0009790 GO:0006629 GO:0042776 GO:0001937 GO:0022904 | |
| InterPro | IPR020003 IPR005294 IPR018118 IPR023366 IPR000793 IPR004100 IPR000194 | |
| Gene3D | G3DSA:2.40.30.20 | |
| KO | K02132 | |
| Pfam | PF00006 PF00306 PF02874 | |
| SUPFAM | SSF47917 SSF50615 | |
| TIGRFAMs | TIGR00962 | |
| PROSITE | PS00152 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0000275 |
mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000022892 |
C |
Seeded From UniProt |
|||
| GO:0001937 |
negative regulation of endothelial cell proliferation |
IMP: Inferred from Mutant Phenotype |
|
P |
Seeded From UniProt |
|||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000026495 |
F |
Seeded From UniProt |
|||
| GO:0005524 |
ATP binding |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000022892 |
F |
Seeded From UniProt |
|||
| GO:0005524 |
ATP binding |
ISS: Inferred from Sequence or Structural Similarity |
F |
Seeded From UniProt |
||||
| GO:0005739 |
mitochondrion |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005739 |
mitochondrion |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000026495 |
C |
Seeded From UniProt |
|||
| GO:0005739 |
mitochondrion |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000022892 |
C |
Seeded From UniProt |
|||
| GO:0005739 |
mitochondrion |
IC: Inferred by Curator |
GO:0005753 |
C |
Seeded From UniProt |
|||
| GO:0005739 |
mitochondrion |
NAS: Non-traceable Author Statement |
|
C |
Seeded From UniProt |
|||
| GO:0005743 |
mitochondrial inner membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005743 |
mitochondrial inner membrane |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000026495 |
C |
Seeded From UniProt |
|||
| GO:0005743 |
mitochondrial inner membrane |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000022892 |
C |
Seeded From UniProt |
|||
| GO:0005743 |
mitochondrial inner membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0168 |
C |
Seeded From UniProt |
|||
| GO:0005743 |
mitochondrial inner membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005753 |
mitochondrial proton-transporting ATP synthase complex |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0005759 |
mitochondrial matrix |
Reactome:REACT_190 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005759 |
mitochondrial matrix |
Reactome:REACT_1985 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005759 |
mitochondrial matrix |
Reactome:REACT_991 |
TAS: Traceable Author Statement |
|
C |
Seeded From UniProt |
||
| GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005886 |
plasma membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0039 |
C |
Seeded From UniProt |
|||
| GO:0005886 |
plasma membrane |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0006172 |
ADP biosynthetic process |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000022892 |
P |
Seeded From UniProt |
|||
| GO:0006200 |
ATP catabolic process |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000022892 |
P |
Seeded From UniProt |
|||
| GO:0006200 |
ATP catabolic process |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0006629 |
lipid metabolic process |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000026495 |
P |
Seeded From UniProt |
|||
| GO:0006629 |
lipid metabolic process |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0006754 |
ATP biosynthetic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006754 |
ATP biosynthetic process |
IC: Inferred by Curator |
GO:0016887 |
P |
Seeded From UniProt |
|||
| GO:0006754 |
ATP biosynthetic process |
NAS: Non-traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0006810 |
transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006811 |
ion transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0009790 |
embryo development |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000026495 |
P |
Seeded From UniProt |
|||
| GO:0009790 |
embryo development |
ISS: Inferred from Sequence or Structural Similarity |
P |
Seeded From UniProt |
||||
| GO:0015986 |
ATP synthesis coupled proton transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0015991 |
ATP hydrolysis coupled proton transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0015992 |
proton transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0015992 |
proton transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0015992 |
proton transport |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016469 |
proton-transporting two-sector ATPase complex |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016469 |
proton-transporting two-sector ATPase complex |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0016820 |
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016887 |
ATPase activity |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000022892 |
F |
Seeded From UniProt |
|||
| GO:0022857 |
transmembrane transporter activity |
IC: Inferred by Curator |
GO:0005753 |
F |
Seeded From UniProt |
|||
| GO:0022904 |
respiratory electron transport chain |
Reactome:REACT_6305 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0033178 |
proton-transporting two-sector ATPase complex, catalytic domain |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0034220 |
ion transmembrane transport |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000026495 |
P |
Seeded From UniProt |
|||
| GO:0042288 |
MHC class I protein binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0042776 |
mitochondrial ATP synthesis coupled proton transport |
IC: Inferred by Curator |
GO:0005753 |
P |
Seeded From UniProt |
|||
| GO:0042776 |
mitochondrial ATP synthesis coupled proton transport |
Reactome:REACT_6759 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0043499 |
eukaryotic cell surface binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0043531 |
ADP binding |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000022892 |
F |
Seeded From UniProt |
|||
| GO:0044281 |
small molecule metabolic process |
Reactome:REACT_111217 |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
||
| GO:0045261 |
proton-transporting ATP synthase complex, catalytic core F(1) |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0045261 |
proton-transporting ATP synthase complex, catalytic core F(1) |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0045261 |
proton-transporting ATP synthase complex, catalytic core F(1) |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000022892 |
C |
Seeded From UniProt |
|||
| GO:0046034 |
ATP metabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0046034 |
ATP metabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0046034 |
ATP metabolic process |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000022892 |
P |
Seeded From UniProt |
|||
| GO:0046933 |
hydrogen ion transporting ATP synthase activity, rotational mechanism |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0046933 |
hydrogen ion transporting ATP synthase activity, rotational mechanism |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0046933 |
hydrogen ion transporting ATP synthase activity, rotational mechanism |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0046933 |
hydrogen ion transporting ATP synthase activity, rotational mechanism |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSMUSP00000026495 |
F |
Seeded From UniProt |
|||
| GO:0046933 |
hydrogen ion transporting ATP synthase activity, rotational mechanism |
ISS: Inferred from Sequence or Structural Similarity |
F |
Seeded From UniProt |
||||
| GO:0046961 |
proton-transporting ATPase activity, rotational mechanism |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0046961 |
proton-transporting ATPase activity, rotational mechanism |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0046961 |
proton-transporting ATPase activity, rotational mechanism |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0008180 |
signalosome |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0016887 |
ATPase activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:2001169 |
regulation of ATP biosynthetic process |
IDA: Inferred from Direct Assay |
P |
Table 2 shows that the anti-proliferative effect of angiostatin is reversed by an anti-α subunit ATP antibody. |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Moser TL et al. (1999) Angiostatin binds ATP synthase on the surface of human endothelial cells. Proc Natl Acad Sci U S A 96: 2811-6 PubMed GONUTS page
- ↑ Wang ZG et al. (2001) Atp11p and Atp12p are assembly factors for the F(1)-ATPase in human mitochondria. J Biol Chem 276: 30773-8 PubMed GONUTS page
- ↑ Ohta T et al. (2009) High affinity interaction between histidine-rich glycoprotein and the cell surface type ATP synthase on T-cells. Biochim Biophys Acta 1788: 1099-107 PubMed GONUTS page
- ↑ Law IK et al. (2009) Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins. Proteomics 9: 2444-56 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 Aggeler R et al. (2002) A functionally active human F1F0 ATPase can be purified by immunocapture from heart tissue and fibroblast cell lines. Subunit structure and activity studies. J Biol Chem 277: 33906-12 PubMed GONUTS page
- ↑ 6.0 6.1 Kataoka H & Biswas C (1991) Nucleotide sequence of a cDNA for the alpha subunit of human mitochondrial ATP synthase. Biochim Biophys Acta 1089: 393-5 PubMed GONUTS page
- ↑ Kim DW et al. (2008) Identification of mitochondrial F(1)F(0)-ATP synthase interacting with galectin-3 in colon cancer cells. Cancer Sci 99: 1884-91 PubMed GONUTS page
- ↑ Vantourout P et al. (2008) Ecto-F1-ATPase and MHC-class I close association on cell membranes. Mol Immunol 45: 485-92 PubMed GONUTS page
- ↑ Fang L et al. (2008) Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. J Proteome Res 7: 4914-25 PubMed GONUTS page
