HUMAN:ATM

From GONUTS

Jump to: navigation, search

Species (Taxon ID)	Homo sapiens (Human). ([1])
Gene Name(s)	ATM
Protein Name(s)	Serine-protein kinase ATM Ataxia telangiectasia mutated A-T mutated
External Links
EMBL	U33841 U55757 U55704 U55705 U55707 U55708 U55709 U55710 U55711 U55712 U55713 U55714 U55715 U55716 U55717 U55718 U55719 U55720 U55721 U55722 U55723 U55724 U55725 U55726 U55727 U55728 U55729 U55730 U55731 U55732 U55733 U55734 U55735 U55736 U55737 U55738 U55739 U55740 U55741 U55742 U55743 U55744 U55745 U55746 U55747 U55748 U55749 U55750 U55751 U55752 U55753 U55754 U55755 U55756 U55757 U55726 U55727 U55728 U55729 U55730 U55731 U55732 U55733 U55734 U55735 U55736 U55737 U55738 U55739 U55740 U55741 U55742 U55743 U55744 U55745 U55746 U55747 U55748 U55749 U55750 U55751 U55752 U55753 U55754 U55755 U55756 U82828 AP001925 AP005718 CH471065 X91196 U67092 AY220758 U26455 BC137169
IPI	IPI00298306
PIR	A43100
RefSeq	NP_000042.3
UniGene	Hs.367437
ProteinModelPortal	Q13315
DIP	DIP-182N
IntAct	Q13315
MINT	MINT-194471
STRING	Q13315
PhosphoSite	Q13315
PRIDE	Q13315
Ensembl	ENST00000278616
GeneID	472
KEGG	hsa:472
CTD	472
GeneCards	GC11P104019
H-InvDB	HIX0010089
HGNC	HGNC:795
HPA	CAB000102
MIM	208900 607585
neXtProt	NX_Q13315
Orphanet	100 67038 52416
PharmGKB	PA61
eggNOG	prNOG08080
HOVERGEN	HBG004304
InParanoid	Q13315
OrthoDB	EOG4X97G7
Pathway_Interaction_DB	bard1pathway nfkappabcanonicalpathway p38_mkk3_6pathway telomerasepathway
Reactome	REACT_1538 REACT_216 REACT_27271
NextBio	1949
ArrayExpress	Q13315
Bgee	Q13315
CleanEx	HS_ATM
Genevestigator	Q13315
GermOnline	ENSG00000149311
GO	GO:0016023 GO:0005654 GO:0016303 GO:0005524 GO:0003677 GO:0004677 GO:0042802 GO:0032403 GO:0046983 GO:0047485 GO:0007050 GO:0071480 GO:0006975 GO:0006977 GO:0000724 GO:0031572 GO:0071044 GO:0007094 GO:0030889 GO:0018105 GO:0043517 GO:0002331 GO:0046777 GO:0007131 GO:0090399
InterPro	IPR016024 IPR015519 IPR003152 IPR011009 IPR000403 IPR018936 IPR003151 IPR014009 IPR021668
Gene3D	G3DSA:1.10.1070.11
PANTHER	PTHR11139:SF3
Pfam	PF02259 PF02260 PF00454 PF11640
SMART	SM00146
SUPFAM	SSF48371 SSF56112
PROSITE	PS51189 PS51190 PS00915 PS00916 PS50290

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000075	cell cycle checkpoint	Reactome:REACT_1538	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0000077	DNA damage checkpoint	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113388	P	Seeded From UniProt
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F	Seeded From UniProt
	GO:0000724	double-strand break repair via homologous recombination	Reactome:REACT_1874	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0001666	response to hypoxia	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000045529	P	Seeded From UniProt
	GO:0001756	somitogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113388	P	Seeded From UniProt
	GO:0002331	pre-B cell allelic exclusion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113388	P	Seeded From UniProt
	GO:0002331	pre-B cell allelic exclusion	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q62388	P	Seeded From UniProt
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F	Seeded From UniProt
	GO:0004672	protein kinase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113388	F	Seeded From UniProt
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR015519	F	Seeded From UniProt
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR021668	F	Seeded From UniProt
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0723	F	Seeded From UniProt
	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000045529	F	Seeded From UniProt
	GO:0004674	protein serine/threonine kinase activity	PMID:11375976^[1]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0004674	protein serine/threonine kinase activity	PMID:20096447^[2]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0004674	protein serine/threonine kinase activity	PMID:9733515^[3]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0004677	DNA-dependent protein kinase activity	PMID:15790808^[4]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0005488	binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016024	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:11375976^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P54274	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:11375976^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P54274	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:11375976^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P54274-1	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:11375976^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P54274-2	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:11375976^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P54274-2	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:12607005^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q14676	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:16452482^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q6PJG6	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:17157788^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NY61	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:18160036^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Y4R8	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:18449195^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q9BQ15	F	Seeded From UniProt
	GO:0005515	protein binding	PMID:18710941^[10]	IPI: Inferred from Physical Interaction	UniProtKB:Q92499	F	Seeded From UniProt
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000045529	C	Seeded From UniProt
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C	Seeded From UniProt
	GO:0005654	nucleoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113388	C	Seeded From UniProt
	GO:0005654	nucleoplasm	Reactome:REACT_1116	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005654	nucleoplasm	Reactome:REACT_1167	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005654	nucleoplasm	Reactome:REACT_1304	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005654	nucleoplasm	Reactome:REACT_1517	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005654	nucleoplasm	Reactome:REACT_1603	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005654	nucleoplasm	Reactome:REACT_1756	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005654	nucleoplasm	Reactome:REACT_1782	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005654	nucleoplasm	Reactome:REACT_18293	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005654	nucleoplasm	Reactome:REACT_18335	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005654	nucleoplasm	Reactome:REACT_2009	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005654	nucleoplasm	Reactome:REACT_20543	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005654	nucleoplasm	Reactome:REACT_937	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005654	nucleoplasm	Reactome:REACT_988	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000045529	C	Seeded From UniProt
	GO:0005819	spindle	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113388	C	Seeded From UniProt
	GO:0006281	DNA repair	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0234	P	Seeded From UniProt
	GO:0006281	DNA repair	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113388	P	Seeded From UniProt
	GO:0006281	DNA repair	Reactome:REACT_216	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0006302	double-strand break repair	Reactome:REACT_2054	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0006468	protein phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113388	P	Seeded From UniProt
	GO:0006915	apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000045529	P	Seeded From UniProt
	GO:0006974	response to DNA damage stimulus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0227	P	Seeded From UniProt
	GO:0006974	response to DNA damage stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000045529	P	Seeded From UniProt
	GO:0006974	response to DNA damage stimulus	PMID:15790808^[4]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0006974	response to DNA damage stimulus	PMID:17875758^[11]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0006975	DNA damage induced protein phosphorylation	PMID:9733515^[3]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	Reactome:REACT_1625	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0007049	cell cycle	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0131	P	Seeded From UniProt
	GO:0007050	cell cycle arrest	PMID:15149599^[12]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0007094	mitotic cell cycle spindle assembly checkpoint	PMID:11943150^[13]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0007131	reciprocal meiotic recombination	PMID:7792600^[14]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0007165	signal transduction	PMID:7792600^[14]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0007292	female gamete generation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113388	P	Seeded From UniProt
	GO:0007420	brain development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113388	P	Seeded From UniProt
	GO:0007507	heart development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113388	P	Seeded From UniProt
	GO:0008219	cell death	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0523	P	Seeded From UniProt
	GO:0008630	DNA damage response, signal transduction resulting in induction of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113388	P	Seeded From UniProt
	GO:0010212	response to ionizing radiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113388	P	Seeded From UniProt
	GO:0010212	response to ionizing radiation	PMID:11375976^[1]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0010212	response to ionizing radiation	PMID:9733515^[3]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0016023	cytoplasmic membrane-bounded vesicle	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0088	C	Seeded From UniProt
	GO:0016301	kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	F	Seeded From UniProt
	GO:0016301	kinase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113388	F	Seeded From UniProt
	GO:0016303	1-phosphatidylinositol-3-kinase activity	PMID:11375976^[1]	IMP: Inferred from Mutant Phenotype		F	Seeded From UniProt
	GO:0016310	phosphorylation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	P	Seeded From UniProt
	GO:0016310	phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113388	P	Seeded From UniProt
	GO:0016572	histone phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000045529	P	Seeded From UniProt
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F	Seeded From UniProt
	GO:0016772	transferase activity, transferring phosphorus-containing groups	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F	Seeded From UniProt
	GO:0016773	phosphotransferase activity, alcohol group as acceptor	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000403	F	Seeded From UniProt
	GO:0016773	phosphotransferase activity, alcohol group as acceptor	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018936	F	Seeded From UniProt
	GO:0018105	peptidyl-serine phosphorylation	PMID:9733515^[3]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0030889	negative regulation of B cell proliferation	PMID:17875758^[11]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0031410	cytoplasmic vesicle	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0968	C	Seeded From UniProt
	GO:0031572	G2/M transition DNA damage checkpoint	PMID:15149599^[12]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0032403	protein complex binding	PMID:15790808^[4]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0035174	histone serine kinase activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000045529	F	Seeded From UniProt
	GO:0035404	histone-serine phosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000045529	P	Seeded From UniProt
	GO:0042159	lipoprotein catabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113388	P	Seeded From UniProt
	GO:0043065	positive regulation of apoptosis	PMID:17875758^[11]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0043066	negative regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113388	P	Seeded From UniProt
	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	PMID:9733515^[3]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0043525	positive regulation of neuron apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113388	P	Seeded From UniProt
	GO:0046777	protein autophosphorylation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000045529	P	Seeded From UniProt
	GO:0046777	protein autophosphorylation	PMID:15790808^[4]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0046777	protein autophosphorylation	PMID:9733515^[3]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0046983	protein dimerization activity	PMID:15790808^[4]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0047485	protein N-terminus binding	PMID:11375976^[1]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0051402	neuron apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000113388	P	Seeded From UniProt
	GO:0051726	regulation of cell cycle	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000045529	P	Seeded From UniProt
	GO:0071044	histone mRNA catabolic process	PMID:16086026^[15]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0071480	cellular response to gamma radiation	PMID:9925639^[16]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0090399	replicative senescence	PMID:15149599^[12]	IMP: Inferred from Mutant Phenotype		P	Seeded From UniProt
	GO:0000781	chromosome, telomeric region	PMID:15149599^[12]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0045860	positive regulation of protein kinase activity	PMID:10973490^[17]	IMP: Inferred from Mutant Phenotype		P	Figure 6: Mutation of all seven SQ/TQ motifs significantly reduced phosphorylation and activation of Chk2 protein kinase in response to DNA damage by Ionizing Radiation.	complete
	GO:0004674	protein serine/threonine kinase activity	PMID:22266654^[18]	IDA: Inferred from Direct Assay		F	ATM phosphorylates TRF1 at serine367: Figure 1.	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Kishi S et al. (2001) Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks. J Biol Chem 276: 29282-91 PubMed GONUTS page
↑ Yuan J et al. (2010) USP10 regulates p53 localization and stability by deubiquitinating p53. Cell 140: 384-96 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Canman CE et al. (1998) Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281: 1677-9 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Lee JH & Paull TT (2005) ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science 308: 551-4 PubMed GONUTS page
↑ Stewart GS et al. (2003) MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature 421: 961-6 PubMed GONUTS page
↑ Aglipay JA et al. (2006) ATM activation by ionizing radiation requires BRCA1-associated BAAT1. J Biol Chem 281: 9710-8 PubMed GONUTS page
↑ Bruno T et al. (2006) Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint. Cancer Cell 10: 473-86 PubMed GONUTS page
↑ Takai H et al. (2007) Tel2 regulates the stability of PI3K-related protein kinases. Cell 131: 1248-59 PubMed GONUTS page
↑ Richard DJ et al. (2008) Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature 453: 677-81 PubMed GONUTS page
↑ Li L et al. (2008) A role for DEAD box 1 at DNA double-strand breaks. Mol Cell Biol 28: 6413-25 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Joshi AD et al. (2007) ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia. Clin Cancer Res 13: 5295-304 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Herbig U et al. (2004) Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell 14: 501-13 PubMed GONUTS page
↑ Nakamura M et al. (2002) Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle. FEBS Lett 514: 193-8 PubMed GONUTS page
↑ ^14.0 ^14.1 Savitsky K et al. (1995) A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 268: 1749-53 PubMed GONUTS page
↑ Kaygun H & Marzluff WF (2005) Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1. Nat Struct Mol Biol 12: 794-800 PubMed GONUTS page
↑ Tibbetts RS et al. (1999) A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev 13: 152-7 PubMed GONUTS page
↑ Matsuoka S et al. (2000) Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proc Natl Acad Sci U S A 97: 10389-94 PubMed GONUTS page
↑ McKerlie M et al. (2012) ATM regulates proteasome-dependent subnuclear localization of TRF1, which is important for telomere maintenance. Nucleic Acids Res 40: 3975-89 PubMed GONUTS page

[PMID:11375976-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Kishi S et al. (2001) Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks. J Biol Chem 276: 29282-91 PubMed GONUTS page

[PMID:20096447-1] Yuan J et al. (2010) USP10 regulates p53 localization and stability by deubiquitinating p53. Cell 140: 384-96 PubMed GONUTS page

[PMID:9733515-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Canman CE et al. (1998) Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281: 1677-9 PubMed GONUTS page

[PMID:15790808-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Lee JH & Paull TT (2005) ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science 308: 551-4 PubMed GONUTS page

[PMID:12607005-4] Stewart GS et al. (2003) MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature 421: 961-6 PubMed GONUTS page

[PMID:16452482-5] Aglipay JA et al. (2006) ATM activation by ionizing radiation requires BRCA1-associated BAAT1. J Biol Chem 281: 9710-8 PubMed GONUTS page

[PMID:17157788-6] Bruno T et al. (2006) Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint. Cancer Cell 10: 473-86 PubMed GONUTS page

[PMID:18160036-7] Takai H et al. (2007) Tel2 regulates the stability of PI3K-related protein kinases. Cell 131: 1248-59 PubMed GONUTS page

[PMID:18449195-8] Richard DJ et al. (2008) Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature 453: 677-81 PubMed GONUTS page

[PMID:18710941-9] Li L et al. (2008) A role for DEAD box 1 at DNA double-strand breaks. Mol Cell Biol 28: 6413-25 PubMed GONUTS page

[PMID:17875758-10] 11.0 ^11.1 ^11.2 Joshi AD et al. (2007) ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia. Clin Cancer Res 13: 5295-304 PubMed GONUTS page

[PMID:15149599-11] 12.0 ^12.1 ^12.2 ^12.3 Herbig U et al. (2004) Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell 14: 501-13 PubMed GONUTS page

[PMID:11943150-12] Nakamura M et al. (2002) Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle. FEBS Lett 514: 193-8 PubMed GONUTS page

[PMID:7792600-13] 14.0 ^14.1 Savitsky K et al. (1995) A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 268: 1749-53 PubMed GONUTS page

[PMID:16086026-14] Kaygun H & Marzluff WF (2005) Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1. Nat Struct Mol Biol 12: 794-800 PubMed GONUTS page

[PMID:9925639-15] Tibbetts RS et al. (1999) A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev 13: 152-7 PubMed GONUTS page

[PMID:10973490-16] Matsuoka S et al. (2000) Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proc Natl Acad Sci U S A 97: 10389-94 PubMed GONUTS page

[PMID:22266654-17] McKerlie M et al. (2012) ATM regulates proteasome-dependent subnuclear localization of TRF1, which is important for telomere maintenance. Nucleic Acids Res 40: 3975-89 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

HUMAN:ATM

Contents

Annotations

Notes

References

1

a

b

c

d

d cont.

f

g

h

k

l

m

n

p

p cont.

r

s

t

Personal tools

Namespaces

Variants

Views

Actions

Search

Navigation

Cacao

Journal Clubs

page contributors

Toolbox