HUMAN:ATF1

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	ATF1
Protein Name(s)	Cyclic AMP-dependent transcription factor ATF-1 cAMP-dependent transcription factor ATF-1 Activating transcription factor 1 Protein TREB36
External Links
UniProt Identifier	ATF1_HUMAN
UniProt Accessions	P18846, P25168, Q9H4A8,
EMBL	X55544, BC029619, AJ295163,
PIR	S12560,
RefSeq	NP_005162.1,
IntAct	P18846,
Ensembl	ENST00000262053,
Pfam	PF00170, PF02173,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0006350	transcription		IEA: Inferred from Electronic Annotation		P	Source: UniProtKB-KW
	GO:0035326	enhancer binding	PMID:17565989^[1]	IDA: Inferred from Direct Assay		F	figure 1	complete
	GO:0005515	protein binding	PMID:17565989^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P02794 UniProtKB:Q9Y6X2	F	figure 1, 3	complete
	GO:0016481	negative regulation of transcription	PMID:17565989^[1]	IMP: Inferred from Mutant Phenotype		P	Fig.2B,C	complete
	GO:0016925	protein sumoylation	PMID:17565989^[1]	IDA: Inferred from Direct Assay		P	Fig. S1	complete
	GO:0002224	toll-like receptor signaling pathway	Reactome:REACT_8006	TAS: Traceable Author Statement		P
	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	Reactome:REACT_27215	TAS: Traceable Author Statement		P
	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	Reactome:REACT_6788	TAS: Traceable Author Statement		P
	GO:0002756	MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6782	TAS: Traceable Author Statement		P
	GO:0002756	MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6809	TAS: Traceable Author Statement		P
	GO:0003677	DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001630	F
	GO:0003677	DNA binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F
	GO:0003677	DNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023769	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001630	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004827	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011616	F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:2196176^[2]	TAS: Traceable Author Statement		F
	GO:0003700	sequence-specific DNA binding transcription factor activity	PMID:8401579^[3]	TAS: Traceable Author Statement		F
	GO:0003705	sequence-specific enhancer binding RNA polymerase II transcription factor activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000052256	F
	GO:0005515	protein binding	PMID:10567391^[4]	IPI: Inferred from Physical Interaction	UniProtKB:O60869-1	F
	GO:0005634	nucleus	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001630	C
	GO:0005634	nucleus	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0539	C
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000052256	C
	GO:0005634	nucleus	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0191	C
	GO:0005634	nucleus	PMID:8798441^[5]	IDA: Inferred from Direct Assay		C
	GO:0005654	nucleoplasm	Reactome:REACT_12437	TAS: Traceable Author Statement		C
	GO:0005667	transcription factor complex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023769	C
	GO:0005667	transcription factor complex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000052256	C
	GO:0006351	transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P
	GO:0006351	transcription, DNA-dependent	PMID:2196176^[2]	TAS: Traceable Author Statement		P
	GO:0006351	transcription, DNA-dependent	PMID:8401579^[3]	TAS: Traceable Author Statement		P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001630	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003102	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004827	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011616	P
	GO:0006355	regulation of transcription, DNA-dependent	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0805	P
	GO:0006355	regulation of transcription, DNA-dependent	PMID:2196176^[2]	TAS: Traceable Author Statement		P
	GO:0006355	regulation of transcription, DNA-dependent	PMID:8401579^[3]	TAS: Traceable Author Statement		P
	GO:0008063	Toll signaling pathway	Reactome:REACT_6894	TAS: Traceable Author Statement		P
	GO:0010976	positive regulation of neuron projection development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000052256	P
	GO:0014070	response to organic cyclic compound	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000052256	P
	GO:0032025	response to cobalt ion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000052256	P
	GO:0032403	protein complex binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000052256	F
	GO:0034130	toll-like receptor 1 signaling pathway	Reactome:REACT_8005	TAS: Traceable Author Statement		P
	GO:0034134	toll-like receptor 2 signaling pathway	Reactome:REACT_7980	TAS: Traceable Author Statement		P
	GO:0034138	toll-like receptor 3 signaling pathway	Reactome:REACT_6783	TAS: Traceable Author Statement		P
	GO:0034142	toll-like receptor 4 signaling pathway	Reactome:REACT_6890	TAS: Traceable Author Statement		P
	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004827	F
	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011616	F
	GO:0043565	sequence-specific DNA binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000052256	F
	GO:0043623	cellular protein complex assembly	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000052256	P
	GO:0045087	innate immune response	Reactome:REACT_6802	TAS: Traceable Author Statement		P
	GO:0045740	positive regulation of DNA replication	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000052256	P
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000052256	P
	GO:0046982	protein heterodimerization activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000052256	F
	GO:0046983	protein dimerization activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011616	F
	GO:0048011	nerve growth factor receptor signaling pathway	Reactome:REACT_11061	TAS: Traceable Author Statement		P
	GO:0051403	stress-activated MAPK cascade	Reactome:REACT_21308	TAS: Traceable Author Statement		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Iwasaki K et al. (2007) PIAS3 interacts with ATF1 and regulates the human ferritin H gene through an antioxidant-responsive element. J Biol Chem 282: 22335-43 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Yoshimura T et al. (1990) Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain. EMBO J 9: 2537-42 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Zucman J et al. (1993) EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts. Nat Genet 4: 341-5 PubMed GONUTS page
↑ Kabe Y et al. (1999) The role of human MBF1 as a transcriptional coactivator. J Biol Chem 274: 34196-202 PubMed GONUTS page
↑ Ji L et al. (1996) CREB proteins function as positive regulators of the translocated bcl-2 allele in t(14;18) lymphomas. J Biol Chem 271: 22687-91 PubMed GONUTS page

[PMID:17565989-0] 1.0 ^1.1 ^1.2 ^1.3 Iwasaki K et al. (2007) PIAS3 interacts with ATF1 and regulates the human ferritin H gene through an antioxidant-responsive element. J Biol Chem 282: 22335-43 PubMed GONUTS page

[PMID:2196176-1] 2.0 ^2.1 ^2.2 Yoshimura T et al. (1990) Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain. EMBO J 9: 2537-42 PubMed GONUTS page

[PMID:8401579-2] 3.0 ^3.1 ^3.2 Zucman J et al. (1993) EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts. Nat Genet 4: 341-5 PubMed GONUTS page

[PMID:10567391-3] Kabe Y et al. (1999) The role of human MBF1 as a transcriptional coactivator. J Biol Chem 274: 34196-202 PubMed GONUTS page

[PMID:8798441-4] Ji L et al. (1996) CREB proteins function as positive regulators of the translocated bcl-2 allele in t(14;18) lymphomas. J Biol Chem 271: 22687-91 PubMed GONUTS page

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HUMAN:ATF1

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