HUMAN:AT2A2

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	ATP2A2 ( synonyms: ATP2B )
Protein Name(s)	Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 SERCA2 SR Ca(2+)-ATPase 2 Calcium pump 2 Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform Endoplasmic reticulum class 1/2 Ca(2+) ATPase
External Links
UniProt Identifier	AT2A2_HUMAN
UniProt Accessions	P16615, A6NDN7, B4DF05, P16614, Q86VJ2,
EMBL	M23114, M23116, M23115, M23278, M23116, AC006088, BC035588, AK293877, AY186578,
PIR	A31981, B31981,
RefSeq	NP_001672.1, NP_733765.1,
IntAct	P16615,
Ensembl	ENST00000313432, ENST00000377685, ENST00000395494,
Pfam	PF00689, PF00690, PF00122, PF00702,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005887	integral to plasma membrane	PMID:19150431^[1]	ND: No biological Data available		C	Sample Annotation. This is not a real annotation.	complete
	GO:0005792	microsome		TAS: Traceable Author Statement		C	Source: ProtInc
	GO:0033017	sarcoplasmic reticulum membrane		TAS: Traceable Author Statement		C	Source: BHF-UCL
	GO:0005524	ATP binding		IEA: Inferred from Electronic Annotation		F	Source: UniProtKB-KW
	GO:0005388	calcium-transporting ATPase activity		TAS: Traceable Author Statement		F	Source: ProtInc
	GO:0008022	protein C-terminus binding		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0048155	S100 alpha binding		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0006754	ATP biosynthetic process		IEA: Inferred from Electronic Annotation		P	Source: InterPro
	GO:0007155	cell adhesion		TAS: Traceable Author Statement		P	Source: ProtInc
	GO:0008544	epidermis development		TAS: Traceable Author Statement		P	Source: ProtInc
	GO:0070296	sarcoplasmic reticulum calcium ion transport		TAS: Traceable Author Statement		P	Source: BHF-UCL
	GO:0000166	nucleotide binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008250	F
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F
	GO:0003824	catalytic activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005834	F
	GO:0005388	calcium-transporting ATPase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005782	F
	GO:0005388	calcium-transporting ATPase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:3.6.3.8	F
	GO:0005388	calcium-transporting ATPase activity	PMID:2844796^[2]	TAS: Traceable Author Statement		F
	GO:0005515	protein binding	PMID:17353931^[3]	IPI: Inferred from Physical Interaction	UniProtKB:O75365	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000695	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001757	F
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018303	F
	GO:0005524	ATP binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F
	GO:0005624	membrane fraction	PMID:2844796^[2]	TAS: Traceable Author Statement		C
	GO:0005783	endoplasmic reticulum	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0256	C
	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0097	C
	GO:0005789	endoplasmic reticulum membrane	PMID:11402072^[4]	IDA: Inferred from Direct Assay		C
	GO:0005789	endoplasmic reticulum membrane	Reactome:REACT_25316	TAS: Traceable Author Statement		C
	GO:0005792	microsome	PMID:2844796^[2]	TAS: Traceable Author Statement		C
	GO:0005887	integral to plasma membrane	PMID:2844796^[2]	TAS: Traceable Author Statement		C
	GO:0006754	ATP biosynthetic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000695	P
	GO:0006754	ATP biosynthetic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001757	P
	GO:0006754	ATP biosynthetic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004014	P
	GO:0006754	ATP biosynthetic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005782	P
	GO:0006754	ATP biosynthetic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006068	P
	GO:0006754	ATP biosynthetic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018303	P
	GO:0006810	transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0813	P
	GO:0006810	transport	PMID:2844796^[2]	TAS: Traceable Author Statement		P
	GO:0006811	ion transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0406	P
	GO:0006812	cation transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004014	P
	GO:0006812	cation transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006068	P
	GO:0006816	calcium ion transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005782	P
	GO:0006816	calcium ion transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0109	P
	GO:0007155	cell adhesion	PMID:10080178^[5]	TAS: Traceable Author Statement		P
	GO:0007596	blood coagulation	Reactome:REACT_604	TAS: Traceable Author Statement		P
	GO:0008022	protein C-terminus binding	PMID:14749390^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q15035	F
	GO:0008152	metabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005834	P
	GO:0008544	epidermis development	PMID:10080178^[5]	TAS: Traceable Author Statement		P
	GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000695	F
	GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001757	F
	GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004014	F
	GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006068	F
	GO:0015662	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018303	F
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000695	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001757	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004014	C
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006068	C
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005782	C
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C
	GO:0016529	sarcoplasmic reticulum	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0703	C
	GO:0016529	sarcoplasmic reticulum	PMID:12804600^[7]	IDA: Inferred from Direct Assay		C
	GO:0016787	hydrolase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F
	GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR023306	F
	GO:0030168	platelet activation	Reactome:REACT_798	TAS: Traceable Author Statement		P
	GO:0031095	platelet dense tubular network membrane	Reactome:REACT_23784	TAS: Traceable Author Statement		C
	GO:0033017	sarcoplasmic reticulum membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0241	C
	GO:0033017	sarcoplasmic reticulum membrane	PMID:19095005^[8]	TAS: Traceable Author Statement		C
	GO:0034220	ion transmembrane transport	Reactome:REACT_25149	TAS: Traceable Author Statement		P
	GO:0034220	ion transmembrane transport	Reactome:REACT_25300	TAS: Traceable Author Statement		P
	GO:0046872	metal ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008250	F
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F
	GO:0048155	S100 alpha binding	PMID:12804600^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P23297	F
	GO:0055085	transmembrane transport	Reactome:REACT_15518	TAS: Traceable Author Statement		P
	GO:0070296	sarcoplasmic reticulum calcium ion transport	PMID:19095005^[8]	TAS: Traceable Author Statement		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Mooney RA et al. (2009) Regulator trafficking on bacterial transcription units in vivo. Mol Cell 33: 97-108 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Lytton J & MacLennan DH (1988) Molecular cloning of cDNAs from human kidney coding for two alternatively spliced products of the cardiac Ca2+-ATPase gene. J Biol Chem 263: 15024-31 PubMed GONUTS page
↑ Ewing RM et al. (2007) Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol 3: 89 PubMed GONUTS page
↑ Chami M et al. (2001) SERCA1 truncated proteins unable to pump calcium reduce the endoplasmic reticulum calcium concentration and induce apoptosis. J Cell Biol 153: 1301-14 PubMed GONUTS page
↑ ^5.0 ^5.1 Sakuntabhai A et al. (1999) Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease. Nat Genet 21: 271-7 PubMed GONUTS page
↑ Stefanovic B et al. (2004) TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. Mol Cell Biol 24: 1758-68 PubMed GONUTS page
↑ ^7.0 ^7.1 Kiewitz R et al. (2003) Ca2+ -dependent interaction of S100A1 with the sarcoplasmic reticulum Ca2+ -ATPase2a and phospholamban in the human heart. Biochem Biophys Res Commun 306: 550-7 PubMed GONUTS page
↑ ^8.0 ^8.1 Yamazaki D et al. (2009) New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes. Pharmacol Ther 121: 265-72 PubMed GONUTS page

[PMID:19150431-0] Mooney RA et al. (2009) Regulator trafficking on bacterial transcription units in vivo. Mol Cell 33: 97-108 PubMed GONUTS page

[PMID:2844796-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Lytton J & MacLennan DH (1988) Molecular cloning of cDNAs from human kidney coding for two alternatively spliced products of the cardiac Ca2+-ATPase gene. J Biol Chem 263: 15024-31 PubMed GONUTS page

[PMID:17353931-2] Ewing RM et al. (2007) Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol 3: 89 PubMed GONUTS page

[PMID:11402072-3] Chami M et al. (2001) SERCA1 truncated proteins unable to pump calcium reduce the endoplasmic reticulum calcium concentration and induce apoptosis. J Cell Biol 153: 1301-14 PubMed GONUTS page

[PMID:10080178-4] 5.0 ^5.1 Sakuntabhai A et al. (1999) Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease. Nat Genet 21: 271-7 PubMed GONUTS page

[PMID:14749390-5] Stefanovic B et al. (2004) TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. Mol Cell Biol 24: 1758-68 PubMed GONUTS page

[PMID:12804600-6] 7.0 ^7.1 Kiewitz R et al. (2003) Ca2+ -dependent interaction of S100A1 with the sarcoplasmic reticulum Ca2+ -ATPase2a and phospholamban in the human heart. Biochem Biophys Res Commun 306: 550-7 PubMed GONUTS page

[PMID:19095005-7] 8.0 ^8.1 Yamazaki D et al. (2009) New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes. Pharmacol Ther 121: 265-72 PubMed GONUTS page

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HUMAN:AT2A2

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