HUMAN:AQP2

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Species (Taxon ID)	Homo sapiens (Human). ([1])
Gene Name(s)	AQP2
Protein Name(s)	Aquaporin-2 AQP-2 ADH water channel Aquaporin-CD AQP-CD Collecting duct water channel protein WCH-CD Water channel protein for renal collecting duct
External Links
EMBL	Z29491 D31846 S73196 S73197 AF147093 AF147092 BC042496
IPI	IPI00012818
PIR	A53442 I64818
RefSeq	NP_000477.1
UniGene	Hs.130730
ProteinModelPortal	P41181
SMR	P41181
STRING	P41181
TCDB	1.A.8.8.8
PhosphoSite	P41181
PRIDE	P41181
Ensembl	ENST00000199280
GeneID	359
KEGG	hsa:359
UCSC	uc001rvn.1
CTD	359
GeneCards	GC12P047376
H-InvDB	HIX0010617
HGNC	HGNC:634
HPA	CAB009866
MIM	107777 125800
neXtProt	NX_P41181
Orphanet	223
PharmGKB	PA24920
eggNOG	prNOG11204
HOGENOM	HBG705794
HOVERGEN	HBG000312
InParanoid	P41181
OMA	HEITPAN
OrthoDB	EOG4FJ89M
PhylomeDB	P41181
Reactome	REACT_15518
NextBio	1501
ArrayExpress	P41181
Bgee	P41181
CleanEx	HS_AQP2
Genevestigator	P41181
GermOnline	ENSG00000167580
GO	GO:0016324 GO:0016021 GO:0030658 GO:0015168 GO:0015250 GO:0071280 GO:0071288 GO:0007588
InterPro	IPR012269 IPR023271 IPR000425 IPR022357
Gene3D	G3DSA:1.20.1080.10
KO	K09865
PANTHER	PTHR19139
Pfam	PF00230
PRINTS	PR00783
SUPFAM	SSF81338
TIGRFAMs	TIGR00861
PROSITE	PS00221

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000267	cell fraction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000000324	C	Seeded From UniProt
	GO:0003097	renal water transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023752	P	Seeded From UniProt
	GO:0003779	actin binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000000324	F	Seeded From UniProt
	GO:0005215	transporter activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000425	F	Seeded From UniProt
	GO:0005215	transporter activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012269	F	Seeded From UniProt
	GO:0005215	transporter activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR022357	F	Seeded From UniProt
	GO:0005372	water transmembrane transporter activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000000324	F	Seeded From UniProt
	GO:0005372	water transmembrane transporter activity	PMID:8584435^[1]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0005372	water transmembrane transporter activity	PMID:9321919^[2]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0005624	membrane fraction	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023752	C	Seeded From UniProt
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000000324	C	Seeded From UniProt
	GO:0005764	lysosome	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000000324	C	Seeded From UniProt
	GO:0005769	early endosome	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000000324	C	Seeded From UniProt
	GO:0005791	rough endoplasmic reticulum	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000000324	C	Seeded From UniProt
	GO:0005802	trans-Golgi network	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000000324	C	Seeded From UniProt
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C	Seeded From UniProt
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023752	C	Seeded From UniProt
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000000324	C	Seeded From UniProt
	GO:0005886	plasma membrane	PMID:7532304^[3]	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005886	plasma membrane	PMID:9321919^[2]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0005886	plasma membrane	Reactome:REACT_23788	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005886	plasma membrane	Reactome:REACT_23851	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005886	plasma membrane	Reactome:REACT_23858	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0005886	plasma membrane	Reactome:REACT_23863	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0006810	transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000425	P	Seeded From UniProt
	GO:0006810	transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012269	P	Seeded From UniProt
	GO:0006810	transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR022357	P	Seeded From UniProt
	GO:0006810	transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0813	P	Seeded From UniProt
	GO:0006833	water transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012269	P	Seeded From UniProt
	GO:0006833	water transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023752	P	Seeded From UniProt
	GO:0006833	water transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000000324	P	Seeded From UniProt
	GO:0006833	water transport	PMID:8140421^[4]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0006833	water transport	PMID:8584435^[1]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0006833	water transport	PMID:9321919^[2]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0006833	water transport	Reactome:REACT_23826	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0006833	water transport	Reactome:REACT_23887	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0006833	water transport	Reactome:REACT_24023	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0006884	cell volume homeostasis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000000324	P	Seeded From UniProt
	GO:0006915	apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000000324	P	Seeded From UniProt
	GO:0006972	hyperosmotic response	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000000324	P	Seeded From UniProt
	GO:0007565	female pregnancy	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000000324	P	Seeded From UniProt
	GO:0007568	aging	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000000324	P	Seeded From UniProt
	GO:0007588	excretion	PMID:7532304^[3]	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0009414	response to water deprivation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000000324	P	Seeded From UniProt
	GO:0009651	response to salt stress	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000000324	P	Seeded From UniProt
	GO:0009725	response to hormone stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000000324	P	Seeded From UniProt
	GO:0010226	response to lithium ion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000000324	P	Seeded From UniProt
	GO:0015168	glycerol transmembrane transporter activity	PMID:8584435^[1]	IDA: Inferred from Direct Assay		F	Seeded From UniProt
	GO:0015250	water channel activity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023752	F	Seeded From UniProt
	GO:0015250	water channel activity	PMID:7532304^[3]	TAS: Traceable Author Statement		F	Seeded From UniProt
	GO:0015250	water channel activity	Reactome:REACT_23788	EXP: Inferred from Experiment		F	Seeded From UniProt
	GO:0015793	glycerol transport	PMID:8584435^[1]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000425	C	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR022357	C	Seeded From UniProt
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C	Seeded From UniProt
	GO:0016021	integral to membrane	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012269	C	Seeded From UniProt
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C	Seeded From UniProt
	GO:0016323	basolateral plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000000324	C	Seeded From UniProt
	GO:0016324	apical plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023752	C	Seeded From UniProt
	GO:0016324	apical plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000000324	C	Seeded From UniProt
	GO:0016324	apical plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0015	C	Seeded From UniProt
	GO:0016324	apical plasma membrane	GO_REF:0000024	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P34080	C	Seeded From UniProt
	GO:0016324	apical plasma membrane	PMID:16928804^[5]	IDA: Inferred from Direct Assay		C	Seeded From UniProt
	GO:0030042	actin filament depolymerization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000000324	P	Seeded From UniProt
	GO:0030133	transport vesicle	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000000324	C	Seeded From UniProt
	GO:0030136	clathrin-coated vesicle	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000000324	C	Seeded From UniProt
	GO:0030165	PDZ domain binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000000324	F	Seeded From UniProt
	GO:0030658	transport vesicle membrane	Reactome:REACT_23840	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0030658	transport vesicle membrane	Reactome:REACT_23863	TAS: Traceable Author Statement		C	Seeded From UniProt
	GO:0030659	cytoplasmic vesicle membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0089	C	Seeded From UniProt
	GO:0031410	cytoplasmic vesicle	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0968	C	Seeded From UniProt
	GO:0031410	cytoplasmic vesicle	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023752	C	Seeded From UniProt
	GO:0032496	response to lipopolysaccharide	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000000324	P	Seeded From UniProt
	GO:0033762	response to glucagon stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000000324	P	Seeded From UniProt
	GO:0042594	response to starvation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000000324	P	Seeded From UniProt
	GO:0042631	cellular response to water deprivation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023752	P	Seeded From UniProt
	GO:0042631	cellular response to water deprivation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000000324	P	Seeded From UniProt
	GO:0043234	protein complex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000000324	C	Seeded From UniProt
	GO:0051592	response to calcium ion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000000324	P	Seeded From UniProt
	GO:0051928	positive regulation of calcium ion transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000000324	P	Seeded From UniProt
	GO:0055037	recycling endosome	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023752	C	Seeded From UniProt
	GO:0055085	transmembrane transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012269	P	Seeded From UniProt
	GO:0055085	transmembrane transport	Reactome:REACT_15518	TAS: Traceable Author Statement		P	Seeded From UniProt
	GO:0070382	exocytic vesicle	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000000324	C	Seeded From UniProt
	GO:0071280	cellular response to copper ion	PMID:8584435^[1]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0071288	cellular response to mercury ion	PMID:8584435^[1]	IDA: Inferred from Direct Assay		P	Seeded From UniProt
	GO:0072205	metanephric collecting duct development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000023752	P	Seeded From UniProt
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Abrami L et al. (1996) Glycerol permeability of mutant aquaporin 1 and other AQP-MIP proteins: inhibition studies. Pflugers Arch 431: 408-14 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Mulders SM et al. (1997) Importance of the mercury-sensitive cysteine on function and routing of AQP1 and AQP2 in oocytes. Am J Physiol 273: F451-6 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Nielsen S et al. (1995) Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane. Proc Natl Acad Sci U S A 92: 1013-7 PubMed GONUTS page
↑ Deen PM et al. (1994) Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urine. Science 264: 92-5 PubMed GONUTS page
↑ Han KH et al. (2006) Expression of the ammonia transporter, rh C glycoprotein, in normal and neoplastic human kidney. J Am Soc Nephrol 17: 2670-9 PubMed GONUTS page

[PMID:8584435-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Abrami L et al. (1996) Glycerol permeability of mutant aquaporin 1 and other AQP-MIP proteins: inhibition studies. Pflugers Arch 431: 408-14 PubMed GONUTS page

[PMID:9321919-1] 2.0 ^2.1 ^2.2 Mulders SM et al. (1997) Importance of the mercury-sensitive cysteine on function and routing of AQP1 and AQP2 in oocytes. Am J Physiol 273: F451-6 PubMed GONUTS page

[PMID:7532304-2] 3.0 ^3.1 ^3.2 Nielsen S et al. (1995) Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane. Proc Natl Acad Sci U S A 92: 1013-7 PubMed GONUTS page

[PMID:8140421-3] Deen PM et al. (1994) Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urine. Science 264: 92-5 PubMed GONUTS page

[PMID:16928804-4] Han KH et al. (2006) Expression of the ammonia transporter, rh C glycoprotein, in normal and neoplastic human kidney. J Am Soc Nephrol 17: 2670-9 PubMed GONUTS page

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[2]

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[5]

HUMAN:AQP2

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