HUMAN:APOM

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	APOM ( synonyms: G3A, NG20 )
Protein Name(s)	Apolipoprotein M Apo-M ApoM Protein G3a
External Links
UniProt Identifier	APOM_HUMAN
UniProt Accessions	O95445, B0UX98, Q9P046, Q9UMP6,
EMBL	AF118393, AJ245434, AF161454, AF129756, BA000025, AL662801, AL670886, AL805934, BX511262, CR753842, CR354443, CR759761, CH471081, BC020683,
RefSeq	NP_061974.2,
PDB	2WEW, 2WEX, 2YG2,
IntAct	O95445,
Ensembl	ENST00000375916, ENST00000383438, ENST00000426800, ENST00000430282, ENST00000432598, ENST00000436931, ENST00000441436,
Pfam	PF11032,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0034364	high-density lipoprotein particle		IEA		C	Source: UniProtKB-KW
	GO:0005887	integral to plasma membrane		TAS: Traceable Author Statement		C	Source: ProtInc
	GO:0005319	lipid transporter activity		TAS: Traceable Author Statement		F	Source: ProtInc
	GO:0042632	cholesterol homeostasis		IC: Inferred by Curator		P	Source: UniProtKB	required field missing
	GO:0043691	reverse cholesterol transport		ISS: Inferred from Sequence or Structural Similarity		P	Source: UniProtKB	required field missing
	GO:0033344	cholesterol efflux		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB	required field missing
	GO:0034375	high-density lipoprotein particle remodeling		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB	required field missing
	GO:0034380	high-density lipoprotein particle assembly		ISS: Inferred from Sequence or Structural Similarity		P	Source: UniProtKB	required field missing
	GO:0034384	high-density lipoprotein particle clearance		ISS: Inferred from Sequence or Structural Similarity		P	Source: UniProtKB	required field missing
	GO:0005319	lipid transporter activity	PMID:16682745^[1]	IDA: Inferred from Direct Assay		F
	GO:0005488	binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR012674	F
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C
	GO:0005615	extracellular space	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001126	C
	GO:0005887	integral to plasma membrane	PMID:10531326^[2]	TAS: Traceable Author Statement		C
	GO:0006810	transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0813	P
	GO:0006869	lipid transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0445	P
	GO:0009749	response to glucose stimulus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000001126	P
	GO:0033344	cholesterol efflux	PMID:15793583^[3]	IMP: Inferred from Mutant Phenotype		P
	GO:0033344	cholesterol efflux	PMID:16682745^[1]	IDA: Inferred from Direct Assay		P
	GO:0034361	very-low-density lipoprotein particle	PMID:17154273^[4]	IDA: Inferred from Direct Assay		C
	GO:0034362	low-density lipoprotein particle	PMID:16682745^[1]	IDA: Inferred from Direct Assay		C
	GO:0034364	high-density lipoprotein particle	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0345	C
	GO:0034365	discoidal high-density lipoprotein particle	PMID:15793583^[3]	IDA: Inferred from Direct Assay		C
	GO:0034366	spherical high-density lipoprotein particle	PMID:16682745^[1]	IDA: Inferred from Direct Assay		C
	GO:0034375	high-density lipoprotein particle remodeling	PMID:18006500^[5]	IMP: Inferred from Mutant Phenotype		P
	GO:0034380	high-density lipoprotein particle assembly	PMID:15793583^[3]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9Z1R3	P
	GO:0034384	high-density lipoprotein particle clearance	PMID:15793583^[3]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9Z1R3	P
	GO:0034445	negative regulation of plasma lipoprotein particle oxidation	PMID:16682745^[1]	IDA: Inferred from Direct Assay		P
	GO:0042632	cholesterol homeostasis	PMID:15793583^[3]	IC: Inferred by Curator	GO:0033344	P
	GO:0043691	reverse cholesterol transport	PMID:15793583^[3]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:Q9Z1R3	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Christoffersen C et al. (2006) Isolation and characterization of human apolipoprotein M-containing lipoproteins. J Lipid Res 47: 1833-43 PubMed GONUTS page
↑ Xu N & Dahlbäck B (1999) A novel human apolipoprotein (apoM). J Biol Chem 274: 31286-90 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Wolfrum C et al. (2005) Apolipoprotein M is required for prebeta-HDL formation and cholesterol efflux to HDL and protects against atherosclerosis. Nat Med 11: 418-22 PubMed GONUTS page
↑ Mancone C et al. (2007) Proteomic analysis of human very low-density lipoprotein by two-dimensional gel electrophoresis and MALDI-TOF/TOF. Proteomics 7: 143-54 PubMed GONUTS page
↑ Christoffersen C et al. (2008) Effect of apolipoprotein M on high density lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knock-out mice. J Biol Chem 283: 1839-47 PubMed GONUTS page

[PMID:16682745-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Christoffersen C et al. (2006) Isolation and characterization of human apolipoprotein M-containing lipoproteins. J Lipid Res 47: 1833-43 PubMed GONUTS page

[PMID:10531326-1] Xu N & Dahlbäck B (1999) A novel human apolipoprotein (apoM). J Biol Chem 274: 31286-90 PubMed GONUTS page

[PMID:15793583-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Wolfrum C et al. (2005) Apolipoprotein M is required for prebeta-HDL formation and cholesterol efflux to HDL and protects against atherosclerosis. Nat Med 11: 418-22 PubMed GONUTS page

[PMID:17154273-3] Mancone C et al. (2007) Proteomic analysis of human very low-density lipoprotein by two-dimensional gel electrophoresis and MALDI-TOF/TOF. Proteomics 7: 143-54 PubMed GONUTS page

[PMID:18006500-4] Christoffersen C et al. (2008) Effect of apolipoprotein M on high density lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knock-out mice. J Biol Chem 283: 1839-47 PubMed GONUTS page

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HUMAN:APOM

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