HUMAN:APOC2

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	APOC2 ( synonyms: APC2 )
Protein Name(s)	Apolipoprotein C-II Apo-CII ApoC-II Apolipoprotein C2
External Links
UniProt Identifier	APOC2_HUMAN
UniProt Accessions	P02655, C0JYY4, Q9BS39, Q9UDE3, Q9UNK3,
EMBL	X05151, X00568, J02698, AY422955, BT006708, FJ525875, CH471126, BC005348, M29844, M10612, AF113884,
PIR	A24238,
RefSeq	NP_000474.2,
PDB	1BY6, 1I5J, 1O8T, 1SOH,
Ensembl	ENST00000252490, ENST00000419266,
Pfam	PF05355,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0042627	chylomicron		IEA		C	Source: InterPro
	GO:0034363	intermediate-density lipoprotein particle		IDA: Inferred from Direct Assay		C	Source: UniProtKB
	GO:0034362	low-density lipoprotein particle		IDA: Inferred from Direct Assay		C	Source: UniProtKB
	GO:0034361	very-low-density lipoprotein particle		IEA		C	Source: UniProtKB-KW
	GO:0055102	lipase inhibitor activity		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0008289	lipid binding		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0060230	lipoprotein lipase activator activity		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0016004	phospholipase activator activity		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0043274	phospholipase binding		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0046982	protein heterodimerization activity		IMP: Inferred from Mutant Phenotype		F	Source: UniProtKB
	GO:0042803	protein homodimerization activity		IMP: Inferred from Mutant Phenotype		F	Source: UniProtKB
	GO:0033344	cholesterol efflux		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0016042	lipid catabolic process		IEA		P	Source: UniProtKB-KW
	GO:0045833	negative regulation of lipid metabolic process		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0048261	negative regulation of receptor-mediated en...		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0033700	phospholipid efflux		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0009395	phospholipid catabolic process		IDA: Inferred from Direct Assay		P	Source: UniProtKB	required field missing
	GO:0051006	positive regulation of lipoprotein lipase a...		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0010898	positive regulation of triglyceride catabolic process		IDA: Inferred from Direct Assay		P	Source: UniProtKB	required field missing
	GO:0010518	positive regulation of phospholipase activity		IDA: Inferred from Direct Assay		P		required field missing
	GO:0010916	negative regulation of very-low-density lipoprotein particle clearance		IDA: Inferred from Direct Assay		P		required field missing
	GO:0032375	negative regulation of cholesterol transport		IMP: Inferred from Mutant Phenotype		P		required field missing
	GO:0034372	very-low-density lipoprotein particle remodeling		TAS: Traceable Author Statement		P		required field missing
	GO:0034382	chylomicron remnant clearance		IDA: Inferred from Direct Assay		P		required field missing
	GO:0034384	high-density lipoprotein particle clearance		IMP: Inferred from Mutant Phenotype		P		required field missing
	GO:0043691	reverse cholesterol transport		IC: Inferred by Curator		P		required field missing
	GO:0045723	positive regulation of fatty acid biosynthetic process		IDA: Inferred from Direct Assay		P		required field missing
	GO:0034371	chylomicron remodeling		IC: Inferred by Curator		P		required field missing
	GO:0010902	positive regulation of very-low-density lipoprotein particle remodeling		IC: Inferred by Curator		P		required field missing
	GO:0042632	cholesterol homeostasis		IC: Inferred by Curator		P		required field missing
	GO:0070328	triglyceride homeostasis		IMP: Inferred from Mutant Phenotype		P		required field missing
	GO:0034370	triglyceride-rich lipoprotein particle remodeling		TAS: Traceable Author Statement		P		required field missing
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C
	GO:0005576	extracellular region	PMID:14718574^[1]	NAS: Non-traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_13783	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_6727	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_6734	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_6852	TAS: Traceable Author Statement		C
	GO:0005615	extracellular space	PMID:10727238^[2]	IDA: Inferred from Direct Assay		C
	GO:0006629	lipid metabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008019	P
	GO:0006629	lipid metabolic process	Reactome:REACT_602	TAS: Traceable Author Statement		P
	GO:0006810	transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0813	P
	GO:0006869	lipid transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008019	P
	GO:0006869	lipid transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0445	P
	GO:0008047	enzyme activator activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008019	F
	GO:0008289	lipid binding	PMID:10727238^[2]	IDA: Inferred from Direct Assay		F
	GO:0010518	positive regulation of phospholipase activity	PMID:10727238^[2]	IDA: Inferred from Direct Assay		P
	GO:0010898	positive regulation of triglyceride catabolic process	PMID:10727238^[2]	IDA: Inferred from Direct Assay		P
	GO:0010902	positive regulation of very-low-density lipoprotein particle remodeling	PMID:10727238^[2]	IC: Inferred by Curator	GO:0051006	P
	GO:0010916	negative regulation of very-low-density lipoprotein particle clearance	PMID:1917954^[3]	IDA: Inferred from Direct Assay		P
	GO:0016004	phospholipase activator activity	PMID:10727238^[2]	IDA: Inferred from Direct Assay		F
	GO:0016042	lipid catabolic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0442	P
	GO:0032375	negative regulation of cholesterol transport	PMID:15778093^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0033344	cholesterol efflux	PMID:11162594^[5]	IDA: Inferred from Direct Assay		P
	GO:0033700	phospholipid efflux	PMID:11162594^[5]	IDA: Inferred from Direct Assay		P
	GO:0034361	very-low-density lipoprotein particle	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0850	C
	GO:0034361	very-low-density lipoprotein particle	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000003071	C
	GO:0034361	very-low-density lipoprotein particle	PMID:8245722^[6]	IDA: Inferred from Direct Assay		C
	GO:0034362	low-density lipoprotein particle	PMID:8245722^[6]	IDA: Inferred from Direct Assay		C
	GO:0034363	intermediate-density lipoprotein particle	PMID:17336988^[7]	IDA: Inferred from Direct Assay		C
	GO:0034366	spherical high-density lipoprotein particle	PMID:16682745^[8]	IDA: Inferred from Direct Assay		C
	GO:0034370	triglyceride-rich lipoprotein particle remodeling	PMID:17018885^[9]	TAS: Traceable Author Statement		P
	GO:0034371	chylomicron remodeling	PMID:10727238^[2]	IC: Inferred by Curator	GO:0051006	P
	GO:0034372	very-low-density lipoprotein particle remodeling	PMID:15778093^[4]	TAS: Traceable Author Statement		P
	GO:0034382	chylomicron remnant clearance	PMID:4020294^[10]	IDA: Inferred from Direct Assay		P
	GO:0034384	high-density lipoprotein particle clearance	PMID:15778093^[4]	IMP: Inferred from Mutant Phenotype		P
	GO:0042157	lipoprotein metabolic process	Reactome:REACT_13621	TAS: Traceable Author Statement		P
	GO:0042157	lipoprotein metabolic process	Reactome:REACT_6823	TAS: Traceable Author Statement		P
	GO:0042157	lipoprotein metabolic process	Reactome:REACT_6841	TAS: Traceable Author Statement		P
	GO:0042493	response to drug	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000024800	P
	GO:0042627	chylomicron	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008019	C
	GO:0042627	chylomicron	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0162	C
	GO:0042627	chylomicron	PMID:8245722^[6]	IDA: Inferred from Direct Assay		C
	GO:0042632	cholesterol homeostasis	PMID:15778093^[4]	IC: Inferred by Curator	GO:0032375	P
	GO:0042803	protein homodimerization activity	PMID:8245722^[6]	IMP: Inferred from Mutant Phenotype		F
	GO:0042953	lipoprotein transport	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000024800	P
	GO:0043085	positive regulation of catalytic activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR008019	P
	GO:0043274	phospholipase binding	PMID:10727238^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P11151	F
	GO:0043691	reverse cholesterol transport	PMID:15778093^[4]	IC: Inferred by Curator	GO:0034384	P
	GO:0045723	positive regulation of fatty acid biosynthetic process	PMID:10727238^[2]	IDA: Inferred from Direct Assay		P
	GO:0045833	negative regulation of lipid metabolic process	PMID:182536^[11]	IDA: Inferred from Direct Assay		P
	GO:0048261	negative regulation of receptor-mediated endocytosis	PMID:1917954^[3]	IDA: Inferred from Direct Assay		P
	GO:0051006	positive regulation of lipoprotein lipase activity	PMID:10727238^[2]	IDA: Inferred from Direct Assay		P
	GO:0051006	positive regulation of lipoprotein lipase activity	PMID:15878877^[12]	IDA: Inferred from Direct Assay		P
	GO:0055102	lipase inhibitor activity	PMID:182536^[11]	IDA: Inferred from Direct Assay		F
	GO:0060230	lipoprotein lipase activator activity	PMID:10727238^[2]	IDA: Inferred from Direct Assay		F
	GO:0060697	positive regulation of phospholipid catabolic process	PMID:10727238^[2]	IDA: Inferred from Direct Assay		P
	GO:0070328	triglyceride homeostasis	PMID:17018885^[9]	IMP: Inferred from Mutant Phenotype		P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Anderson NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol Cell Proteomics 3: 311-26 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 MacPhee CE et al. (2000) Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding. Biochemistry 39: 3433-40 PubMed GONUTS page
↑ ^3.0 ^3.1 Sehayek E & Eisenberg S (1991) Mechanisms of inhibition by apolipoprotein C of apolipoprotein E-dependent cellular metabolism of human triglyceride-rich lipoproteins through the low density lipoprotein receptor pathway. J Biol Chem 266: 18259-67 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Huard K et al. (2005) Apolipoproteins C-II and C-III inhibit selective uptake of low- and high-density lipoprotein cholesteryl esters in HepG2 cells. Int J Biochem Cell Biol 37: 1308-18 PubMed GONUTS page
↑ ^5.0 ^5.1 Remaley AT et al. (2001) Apolipoprotein specificity for lipid efflux by the human ABCAI transporter. Biochem Biophys Res Commun 280: 818-23 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Connelly PW et al. (1993) Identification of disulfide-linked apolipoprotein species in human lipoproteins. J Lipid Res 34: 1717-27 PubMed GONUTS page
↑ Meyer BJ et al. (2007) Fractionation of cholesteryl ester rich intermediate density lipoprotein subpopulations by chondroitin sulphate. Atherosclerosis 195: e28-34 PubMed GONUTS page
↑ Christoffersen C et al. (2006) Isolation and characterization of human apolipoprotein M-containing lipoproteins. J Lipid Res 47: 1833-43 PubMed GONUTS page
↑ ^9.0 ^9.1 Pulawa LK et al. (2007) Reduction of plasma triglycerides in apolipoprotein C-II transgenic mice overexpressing lipoprotein lipase in muscle. J Lipid Res 48: 145-51 PubMed GONUTS page
↑ Windler E & Havel RJ (1985) Inhibitory effects of C apolipoproteins from rats and humans on the uptake of triglyceride-rich lipoproteins and their remnants by the perfused rat liver. J Lipid Res 26: 556-65 PubMed GONUTS page
↑ ^11.0 ^11.1 Kinnunen PK & Ehnolm C (1976) Effect of serum and C-apoproteins from very low density lipoproteins on human postheparin plasma hepatic lipase. FEBS Lett 65: 354-7 PubMed GONUTS page
↑ Lookene A et al. (2005) Apolipoprotein A-V-heparin interactions: implications for plasma lipoprotein metabolism. J Biol Chem 280: 25383-7 PubMed GONUTS page

[PMID:14718574-0] Anderson NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol Cell Proteomics 3: 311-26 PubMed GONUTS page

[PMID:10727238-1] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 MacPhee CE et al. (2000) Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding. Biochemistry 39: 3433-40 PubMed GONUTS page

[PMID:1917954-2] 3.0 ^3.1 Sehayek E & Eisenberg S (1991) Mechanisms of inhibition by apolipoprotein C of apolipoprotein E-dependent cellular metabolism of human triglyceride-rich lipoproteins through the low density lipoprotein receptor pathway. J Biol Chem 266: 18259-67 PubMed GONUTS page

[PMID:15778093-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Huard K et al. (2005) Apolipoproteins C-II and C-III inhibit selective uptake of low- and high-density lipoprotein cholesteryl esters in HepG2 cells. Int J Biochem Cell Biol 37: 1308-18 PubMed GONUTS page

[PMID:11162594-4] 5.0 ^5.1 Remaley AT et al. (2001) Apolipoprotein specificity for lipid efflux by the human ABCAI transporter. Biochem Biophys Res Commun 280: 818-23 PubMed GONUTS page

[PMID:8245722-5] 6.0 ^6.1 ^6.2 ^6.3 Connelly PW et al. (1993) Identification of disulfide-linked apolipoprotein species in human lipoproteins. J Lipid Res 34: 1717-27 PubMed GONUTS page

[PMID:17336988-6] Meyer BJ et al. (2007) Fractionation of cholesteryl ester rich intermediate density lipoprotein subpopulations by chondroitin sulphate. Atherosclerosis 195: e28-34 PubMed GONUTS page

[PMID:16682745-7] Christoffersen C et al. (2006) Isolation and characterization of human apolipoprotein M-containing lipoproteins. J Lipid Res 47: 1833-43 PubMed GONUTS page

[PMID:17018885-8] 9.0 ^9.1 Pulawa LK et al. (2007) Reduction of plasma triglycerides in apolipoprotein C-II transgenic mice overexpressing lipoprotein lipase in muscle. J Lipid Res 48: 145-51 PubMed GONUTS page

[PMID:4020294-9] Windler E & Havel RJ (1985) Inhibitory effects of C apolipoproteins from rats and humans on the uptake of triglyceride-rich lipoproteins and their remnants by the perfused rat liver. J Lipid Res 26: 556-65 PubMed GONUTS page

[PMID:182536-10] 11.0 ^11.1 Kinnunen PK & Ehnolm C (1976) Effect of serum and C-apoproteins from very low density lipoproteins on human postheparin plasma hepatic lipase. FEBS Lett 65: 354-7 PubMed GONUTS page

[PMID:15878877-11] Lookene A et al. (2005) Apolipoprotein A-V-heparin interactions: implications for plasma lipoprotein metabolism. J Biol Chem 280: 25383-7 PubMed GONUTS page

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HUMAN:APOC2

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