HUMAN:APOA4

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	APOA4
Protein Name(s)	Apolipoprotein A-IV Apo-AIV ApoA-IV Apolipoprotein A4
External Links
UniProt Identifier	APOA4_HUMAN
UniProt Accessions	P06727, A8MSL6, Q14CW8, Q6Q787,
EMBL	M13654, M14642, J02758, X13629, AY422950, AY555191, AP006216, BC074764, BC113594, BC113596, M14566,
PIR	A94137,
Ensembl	ENST00000357780,
Pfam	PF01442,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0042627	chylomicron		IEA		C	Source: UniProtKB-KW
	GO:0005737	cytoplasm		IDA: Inferred from Direct Assay		C	Source: HPA
	GO:0005788	endoplasmic reticulum lumen		EXP: Inferred from Experiment		C	Source: Reactome
	GO:0034364	high-density lipoprotein particle		IEA		C	Source: UniProtKB-KW
	GO:0005634	nucleus		IDA: Inferred from Direct Assay		C	Source: HPA
	GO:0034361	very-low-density lipoprotein particle		IDA: Inferred from Direct Assay		C	Source: UniProtKB
	GO:0016209	antioxidant activity		IDA: Inferred from Direct Assay		F	Source: HGNC
	GO:0017127	cholesterol transporter activity		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0005507	copper ion binding		IDA: Inferred from Direct Assay		F	Source: HGNC
	GO:0031210	phosphatidylcholine binding		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0060228	phosphatidylcholine-sterol O-acyltransferas...		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0042803	protein homodimerization activity		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0033344	cholesterol efflux		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0042632	cholesterol homeostasis		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0008203	cholesterol metabolic process		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0044240	multicellular organismal lipid catabolic pr...		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0034445	negative regulation of plasma lipoprotein o...		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0046470	phosphatidylcholine metabolic process		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0033700	phospholipid efflux		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0065005	protein-lipid complex assembly		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB
	GO:0032374	regulation of cholesterol transport		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0051006	positive regulation of lipoprotein lipase activity		IDA: Inferred from Direct Assay		P		required field missing
	GO:0034375	high-density lipoprotein particle remodeling		IC: Inferred by Curator		P		required field missing
	GO:0010898	positive regulation of triglyceride catabolic process		IDA: Inferred from Direct Assay		P		required field missing
	GO:0010873	positive regulation of cholesterol esterification		IDA: Inferred from Direct Assay		P	Source: UniProtKB	required field missing
	GO:0045723	positive regulation of fatty acid biosynthetic process		IDA: Inferred from Direct Assay		P		required field missing
	GO:0043691	reverse cholesterol transport		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0034372	very-low-density lipoprotein particle remodeling		IDA: Inferred from Direct Assay		P		required field missing
	GO:0034371	chylomicron remodeling		IC: Inferred by Curator		P		required field missing
	GO:0002227	innate immune response in mucosa	PMID:15254593^[1]	IDA: Inferred from Direct Assay		P
	GO:0005319	lipid transporter activity	PMID:3080432^[2]	TAS: Traceable Author Statement		F
	GO:0005507	copper ion binding	PMID:16945374^[3]	IDA: Inferred from Direct Assay		F
	GO:0005576	extracellular region	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000074	C
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C
	GO:0005576	extracellular region	PMID:14718574^[4]	NAS: Non-traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_6727	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_6734	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_6813	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_6852	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_75876	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_75905	TAS: Traceable Author Statement		C
	GO:0005615	extracellular space	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034585	C
	GO:0005615	extracellular space	PMID:1935934^[5]	IDA: Inferred from Direct Assay		C
	GO:0005615	extracellular space	PMID:20551380^[6]	IDA: Inferred from Direct Assay		C
	GO:0005788	endoplasmic reticulum lumen	Reactome:REACT_6813	TAS: Traceable Author Statement		C
	GO:0005788	endoplasmic reticulum lumen	Reactome:REACT_6915	TAS: Traceable Author Statement		C
	GO:0006629	lipid metabolic process	Reactome:REACT_602	TAS: Traceable Author Statement		P
	GO:0006810	transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0813	P
	GO:0006869	lipid transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000074	P
	GO:0006869	lipid transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0445	P
	GO:0006869	lipid transport	PMID:1935934^[5]	IDA: Inferred from Direct Assay		P
	GO:0006869	lipid transport	PMID:3080432^[2]	TAS: Traceable Author Statement		P
	GO:0006869	lipid transport	PMID:3095477^[7]	IDA: Inferred from Direct Assay		P
	GO:0006982	response to lipid hydroperoxide	PMID:16945374^[3]	IDA: Inferred from Direct Assay		P
	GO:0007159	leukocyte cell-cell adhesion	PMID:15254593^[1]	IDA: Inferred from Direct Assay		P
	GO:0008203	cholesterol metabolic process	PMID:1935934^[5]	IDA: Inferred from Direct Assay		P
	GO:0008289	lipid binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000074	F
	GO:0008289	lipid binding	PMID:16159879^[8]	IMP: Inferred from Mutant Phenotype		F
	GO:0010873	positive regulation of cholesterol esterification	PMID:1935934^[5]	IDA: Inferred from Direct Assay		P
	GO:0010898	positive regulation of triglyceride catabolic process	PMID:2307668^[9]	IDA: Inferred from Direct Assay		P
	GO:0016209	antioxidant activity	PMID:16945374^[3]	IDA: Inferred from Direct Assay		F
	GO:0017127	cholesterol transporter activity	PMID:1935934^[5]	IDA: Inferred from Direct Assay		F
	GO:0019430	removal of superoxide radicals	PMID:16945374^[3]	IDA: Inferred from Direct Assay		P
	GO:0030300	regulation of intestinal cholesterol absorption	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034585	P
	GO:0031210	phosphatidylcholine binding	PMID:11940599^[10]	IDA: Inferred from Direct Assay		F
	GO:0031210	phosphatidylcholine binding	PMID:1935934^[5]	IDA: Inferred from Direct Assay		F
	GO:0032374	regulation of cholesterol transport	PMID:11940599^[10]	IDA: Inferred from Direct Assay		P
	GO:0033344	cholesterol efflux	PMID:11162594^[11]	IDA: Inferred from Direct Assay		P
	GO:0033344	cholesterol efflux	PMID:1935934^[5]	IDA: Inferred from Direct Assay		P
	GO:0033700	phospholipid efflux	PMID:11162594^[11]	IDA: Inferred from Direct Assay		P
	GO:0034361	very-low-density lipoprotein particle	PMID:17154273^[12]	IDA: Inferred from Direct Assay		C
	GO:0034361	very-low-density lipoprotein particle	PMID:3095477^[7]	IDA: Inferred from Direct Assay		C
	GO:0034364	high-density lipoprotein particle	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0345	C
	GO:0034364	high-density lipoprotein particle	PMID:3095477^[7]	IDA: Inferred from Direct Assay		C
	GO:0034371	chylomicron remodeling	PMID:2307668^[9]	IC: Inferred by Curator	GO:0051006	P
	GO:0034372	very-low-density lipoprotein particle remodeling	PMID:2307668^[9]	IDA: Inferred from Direct Assay		P
	GO:0034375	high-density lipoprotein particle remodeling	PMID:1935934^[5]	IC: Inferred by Curator	GO:0060228	P
	GO:0034378	chylomicron assembly	PMID:16159879^[8]	TAS: Traceable Author Statement		P
	GO:0034445	negative regulation of plasma lipoprotein particle oxidation	PMID:16945374^[3]	IDA: Inferred from Direct Assay		P
	GO:0042157	lipoprotein metabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000074	P
	GO:0042157	lipoprotein metabolic process	Reactome:REACT_6823	TAS: Traceable Author Statement		P
	GO:0042157	lipoprotein metabolic process	Reactome:REACT_6841	TAS: Traceable Author Statement		P
	GO:0042627	chylomicron	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0162	C
	GO:0042627	chylomicron	PMID:3095477^[7]	IDA: Inferred from Direct Assay		C
	GO:0042632	cholesterol homeostasis	PMID:1935934^[5]	IDA: Inferred from Direct Assay		P
	GO:0042744	hydrogen peroxide catabolic process	PMID:16945374^[3]	IDA: Inferred from Direct Assay		P
	GO:0042803	protein homodimerization activity	PMID:1935934^[5]	IDA: Inferred from Direct Assay		F
	GO:0043691	reverse cholesterol transport	PMID:3095477^[7]	IDA: Inferred from Direct Assay		P
	GO:0044240	multicellular organismal lipid catabolic process	PMID:3095477^[7]	IDA: Inferred from Direct Assay		P
	GO:0045723	positive regulation of fatty acid biosynthetic process	PMID:2307668^[9]	IDA: Inferred from Direct Assay		P
	GO:0046470	phosphatidylcholine metabolic process	PMID:1935934^[5]	IDA: Inferred from Direct Assay		P
	GO:0051006	positive regulation of lipoprotein lipase activity	PMID:2307668^[9]	IDA: Inferred from Direct Assay		P
	GO:0055088	lipid homeostasis	PMID:3095477^[7]	IDA: Inferred from Direct Assay		P
	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity	PMID:1935934^[5]	IDA: Inferred from Direct Assay		F
	GO:0065005	protein-lipid complex assembly	PMID:16159879^[8]	IMP: Inferred from Mutant Phenotype		P
colocalizes_with	GO:0009986	cell surface	PMID:1935934^[5]	IDA: Inferred from Direct Assay		C
contributes_to	GO:0043499	eukaryotic cell surface binding	PMID:1935934^[5]	IDA: Inferred from Direct Assay		F
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Vowinkel T et al. (2004) Apolipoprotein A-IV inhibits experimental colitis. J Clin Invest 114: 260-9 PubMed GONUTS page
↑ ^2.0 ^2.1 Elshourbagy NA et al. (1986) The nucleotide and derived amino acid sequence of human apolipoprotein A-IV mRNA and the close linkage of its gene to the genes of apolipoproteins A-I and C-III. J Biol Chem 261: 1998-2002 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Wong WM et al. (2007) Common variants of apolipoprotein A-IV differ in their ability to inhibit low density lipoprotein oxidation. Atherosclerosis 192: 266-74 PubMed GONUTS page
↑ Anderson NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol Cell Proteomics 3: 311-26 PubMed GONUTS page
↑ ^5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 ^5.12 ^5.13 Duverger N et al. (1991) Functional characterization of human recombinant apolipoprotein AIV produced in Escherichia coli. Eur J Biochem 201: 373-83 PubMed GONUTS page
↑ Didangelos A et al. (2010) Proteomics characterization of extracellular space components in the human aorta. Mol Cell Proteomics 9: 2048-62 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Ghiselli G et al. (1986) Plasma metabolism of apolipoprotein A-IV in humans. J Lipid Res 27: 813-27 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Pearson K et al. (2005) Specific sequences in the N and C termini of apolipoprotein A-IV modulate its conformation and lipid association. J Biol Chem 280: 38576-82 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Goldberg IJ et al. (1990) Lipoprotein ApoC-II activation of lipoprotein lipase. Modulation by apolipoprotein A-IV. J Biol Chem 265: 4266-72 PubMed GONUTS page
↑ ^10.0 ^10.1 Weinberg RB et al. (2002) Interfacial exclusion pressure determines the ability of apolipoprotein A-IV truncation mutants to activate cholesterol ester transfer protein. J Biol Chem 277: 21549-53 PubMed GONUTS page
↑ ^11.0 ^11.1 Remaley AT et al. (2001) Apolipoprotein specificity for lipid efflux by the human ABCAI transporter. Biochem Biophys Res Commun 280: 818-23 PubMed GONUTS page
↑ Mancone C et al. (2007) Proteomic analysis of human very low-density lipoprotein by two-dimensional gel electrophoresis and MALDI-TOF/TOF. Proteomics 7: 143-54 PubMed GONUTS page

[PMID:15254593-0] 1.0 ^1.1 Vowinkel T et al. (2004) Apolipoprotein A-IV inhibits experimental colitis. J Clin Invest 114: 260-9 PubMed GONUTS page

[PMID:3080432-1] 2.0 ^2.1 Elshourbagy NA et al. (1986) The nucleotide and derived amino acid sequence of human apolipoprotein A-IV mRNA and the close linkage of its gene to the genes of apolipoproteins A-I and C-III. J Biol Chem 261: 1998-2002 PubMed GONUTS page

[PMID:16945374-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Wong WM et al. (2007) Common variants of apolipoprotein A-IV differ in their ability to inhibit low density lipoprotein oxidation. Atherosclerosis 192: 266-74 PubMed GONUTS page

[PMID:14718574-3] Anderson NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol Cell Proteomics 3: 311-26 PubMed GONUTS page

[PMID:1935934-4] 5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 ^5.10 ^5.11 ^5.12 ^5.13 Duverger N et al. (1991) Functional characterization of human recombinant apolipoprotein AIV produced in Escherichia coli. Eur J Biochem 201: 373-83 PubMed GONUTS page

[PMID:20551380-5] Didangelos A et al. (2010) Proteomics characterization of extracellular space components in the human aorta. Mol Cell Proteomics 9: 2048-62 PubMed GONUTS page

[PMID:3095477-6] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Ghiselli G et al. (1986) Plasma metabolism of apolipoprotein A-IV in humans. J Lipid Res 27: 813-27 PubMed GONUTS page

[PMID:16159879-7] 8.0 ^8.1 ^8.2 Pearson K et al. (2005) Specific sequences in the N and C termini of apolipoprotein A-IV modulate its conformation and lipid association. J Biol Chem 280: 38576-82 PubMed GONUTS page

[PMID:2307668-8] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Goldberg IJ et al. (1990) Lipoprotein ApoC-II activation of lipoprotein lipase. Modulation by apolipoprotein A-IV. J Biol Chem 265: 4266-72 PubMed GONUTS page

[PMID:11940599-9] 10.0 ^10.1 Weinberg RB et al. (2002) Interfacial exclusion pressure determines the ability of apolipoprotein A-IV truncation mutants to activate cholesterol ester transfer protein. J Biol Chem 277: 21549-53 PubMed GONUTS page

[PMID:11162594-10] 11.0 ^11.1 Remaley AT et al. (2001) Apolipoprotein specificity for lipid efflux by the human ABCAI transporter. Biochem Biophys Res Commun 280: 818-23 PubMed GONUTS page

[PMID:17154273-11] Mancone C et al. (2007) Proteomic analysis of human very low-density lipoprotein by two-dimensional gel electrophoresis and MALDI-TOF/TOF. Proteomics 7: 143-54 PubMed GONUTS page

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HUMAN:APOA4

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