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HUMAN:APOA2

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Contents

Species (Taxon ID) Homo sapiens (Human). (taxon:9606)
Gene Name(s) APOA2
Protein Name(s)
  • Apolipoprotein A-II
  • Apo-AII
  • ApoA-II
  • Apolipoprotein A2
  • Apolipoprotein A-II(1-76)
External Links
UniProt Identifier APOA2_HUMAN
UniProt Accessions P02652, B2R524,
EMBL X04898, X00955, X02905, X02619, M29882, AY100524, AK312034, BT006786, AL590714, BC005282,
PIR A93586,
RefSeq NP_001634.1,
PDB 1L6L, 2OU1,
Ensembl ENST00000367990,
Pfam PF04711,

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0042627

chylomicron

IDA: Inferred from Direct Assay

C

Source: UniProtKB

GO:0005788

endoplasmic reticulum lumen

EXP: Inferred from Experiment

C

Source: Reactome

GO:0034364

high-density lipoprotein particle

IEA

C

Source: UniProtKB-KW

GO:0034361

very-low-density lipoprotein particle

IDA: Inferred from Direct Assay

C

Source: UniProtKB

GO:0034190

apolipoprotein receptor binding

IPI: Inferred from Physical Interaction

F

Source: UniProtKB

GO:0015485

cholesterol binding

IDA: Inferred from Direct Assay

F

Source: UniProtKB

GO:0055102

lipase inhibitor activity

IDA: Inferred from Direct Assay

F

Source: UniProtKB

GO:0005319

lipid transporter activity

IDA: Inferred from Direct Assay

F

Source: UniProtKB

GO:0031210

phosphatidylcholine binding

IDA: Inferred from Direct Assay

F

Source: UniProtKB

GO:0060228

phosphatidylcholine-sterol O-acyltransferas...

IDA: Inferred from Direct Assay

F

Source: UniProtKB

GO:0046982

protein heterodimerization activity

IPI: Inferred from Physical Interaction

F

Source: UniProtKB

GO:0042803

protein homodimerization activity

IDA: Inferred from Direct Assay

F

Source: UniProtKB

GO:0046340

diacylglycerol catabolic process

IDA: Inferred from Direct Assay

P

Source: UniProtKB

required field missing

GO:0033344

cholesterol efflux

IDA: Inferred from Direct Assay

P

Source: UniProtKB

GO:0042632

cholesterol homeostasis

IDA: Inferred from Direct Assay

P

Source: UniProtKB

GO:0034380

high-density lipoprotein particle assembly

IDA: Inferred from Direct Assay

P

Source: UniProtKB

GO:0042157

lipoprotein metabolic process

IEA

P

Source: InterPro

GO:0034381

lipoprotein particle clearance

TAS: Traceable Author Statement

P

Source: UniProtKB

GO:0032375

negative regulation of cholesterol transport

IMP: Inferred from Mutant Phenotype

P

Source: UniProtKB

GO:0060192

negative regulation of lipase activity

IDA: Inferred from Direct Assay

P

Source: UniProtKB

GO:0050995

negative regulation of lipid catabolic process

IDA: Inferred from Direct Assay

P

Source: UniProtKB

GO:0006656

phosphatidylcholine biosynthetic process

IDA: Inferred from Direct Assay

P

Source: UniProtKB

GO:0033700

phospholipid efflux

IDA: Inferred from Direct Assay

P

Source: UniProtKB

GO:0032375

negative regulation of cholesterol transport

IDA: Inferred from Direct Assay

P

required field missing

GO:0009749

response to glucose stimulus

IDA: Inferred from Direct Assay

P

Source: UniProtKB

GO:0043691

reverse cholesterol transport

IDA: Inferred from Direct Assay

P

Source: UniProtKB

GO:0034375

high-density lipoprotein particle remodeling

IDA: Inferred from Direct Assay

P

required field missing

GO:0006641

triglyceride metabolic process

TAS: Traceable Author Statement

P

Source: UniProtKB

GO:0034384

high-density lipoprotein particle clearance

IDA: Inferred from Direct Assay

P

required field missing

GO:0034370

triglyceride-rich lipoprotein particle remo...

IDA: Inferred from Direct Assay

P

Source: UniProtKB

GO:0010873

positive regulation of cholesterol esterification

IDA: Inferred from Direct Assay

P

required field missing

GO:0009395

phospholipid catabolic process

IDA: Inferred from Direct Assay

P

required field missing

GO:0010903

negative regulation of very-low-density lipoprotein particle remodeling

IDA: Inferred from Direct Assay

P

required field missing

GO:0032410

negative regulation of transporter activity

IDA: Inferred from Direct Assay

P

required field missing

GO:0034374

low-density lipoprotein particle remodeling

IDA: Inferred from Direct Assay

P

required field missing

GO:0050996

positive regulation of lipid catabolic process

IDA: Inferred from Direct Assay

P

required field missing

GO:0002526

acute inflammatory response

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000004662

P

GO:0002740

negative regulation of cytokine secretion involved in immune response

PMID:12458630[1]

IDA: Inferred from Direct Assay

P

GO:0005319

lipid transporter activity

PMID:1606170[2]

IDA: Inferred from Direct Assay

F

GO:0005515

protein binding

PMID:11991719[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q8NCW5

F

GO:0005543

phospholipid binding

PMID:218942[4]

IDA: Inferred from Direct Assay

F

GO:0005576

extracellular region

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006801

C

GO:0005576

extracellular region

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0964

C

GO:0005576

extracellular region

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0243

C

GO:0005576

extracellular region

PMID:14718574[5]

NAS: Non-traceable Author Statement

C

GO:0005576

extracellular region

Reactome:REACT_22360

TAS: Traceable Author Statement

C

GO:0005576

extracellular region

Reactome:REACT_6727

TAS: Traceable Author Statement

C

GO:0005576

extracellular region

Reactome:REACT_6734

TAS: Traceable Author Statement

C

GO:0005576

extracellular region

Reactome:REACT_6813

TAS: Traceable Author Statement

C

GO:0005576

extracellular region

Reactome:REACT_6852

TAS: Traceable Author Statement

C

GO:0005788

endoplasmic reticulum lumen

Reactome:REACT_6813

TAS: Traceable Author Statement

C

GO:0005788

endoplasmic reticulum lumen

Reactome:REACT_6915

TAS: Traceable Author Statement

C

GO:0006457

protein folding

PMID:14967812[6]

IDA: Inferred from Direct Assay

P

GO:0006629

lipid metabolic process

Reactome:REACT_602

TAS: Traceable Author Statement

P

GO:0006641

triglyceride metabolic process

PMID:11551871[7]

TAS: Traceable Author Statement

P

GO:0006656

phosphatidylcholine biosynthetic process

PMID:14967812[6]

IDA: Inferred from Direct Assay

P

GO:0006810

transport

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0813

P

GO:0006869

lipid transport

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006801

P

GO:0006869

lipid transport

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0445

P

GO:0008289

lipid binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006801

F

GO:0008289

lipid binding

PMID:14967812[6]

IDA: Inferred from Direct Assay

F

GO:0009395

phospholipid catabolic process

PMID:14967812[6]

IDA: Inferred from Direct Assay

P

GO:0009749

response to glucose stimulus

PMID:14988251[8]

IDA: Inferred from Direct Assay

P

GO:0010873

positive regulation of cholesterol esterification

PMID:14967812[6]

IDA: Inferred from Direct Assay

P

GO:0010903

negative regulation of very-low-density lipoprotein particle remodeling

PMID:14967812[6]

IDA: Inferred from Direct Assay

P

GO:0015485

cholesterol binding

PMID:218942[4]

IDA: Inferred from Direct Assay

F

GO:0017127

cholesterol transporter activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000004662

F

GO:0030301

cholesterol transport

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000004662

P

GO:0031100

organ regeneration

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000004662

P

GO:0031210

phosphatidylcholine binding

PMID:17264082[9]

IDA: Inferred from Direct Assay

F

GO:0031647

regulation of protein stability

PMID:14967812[6]

IDA: Inferred from Direct Assay

P

GO:0032375

negative regulation of cholesterol transport

PMID:8636092[10]

IMP: Inferred from Mutant Phenotype

P

GO:0033344

cholesterol efflux

PMID:11162594[11]

IDA: Inferred from Direct Assay

P

GO:0033700

phospholipid efflux

PMID:11162594[11]

IDA: Inferred from Direct Assay

P

GO:0034190

apolipoprotein receptor binding

PMID:11162594[11]

IPI: Inferred from Physical Interaction

UniProtKB:O95477

F

GO:0034361

very-low-density lipoprotein particle

PMID:8245722[12]

IDA: Inferred from Direct Assay

C

GO:0034364

high-density lipoprotein particle

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0345

C

GO:0034364

high-density lipoprotein particle

PMID:17264082[9]

IDA: Inferred from Direct Assay

C

GO:0034364

high-density lipoprotein particle

PMID:210174[13]

IDA: Inferred from Direct Assay

C

GO:0034364

high-density lipoprotein particle

PMID:3104518[14]

IDA: Inferred from Direct Assay

C

GO:0034366

spherical high-density lipoprotein particle

PMID:16682745[15]

IDA: Inferred from Direct Assay

C

GO:0034370

triglyceride-rich lipoprotein particle remodeling

PMID:14967812[6]

IDA: Inferred from Direct Assay

P

GO:0034374

low-density lipoprotein particle remodeling

PMID:8106353[16]

IDA: Inferred from Direct Assay

P

GO:0034375

high-density lipoprotein particle remodeling

PMID:14967812[6]

IDA: Inferred from Direct Assay

P

GO:0034375

high-density lipoprotein particle remodeling

PMID:8106353[16]

IDA: Inferred from Direct Assay

P

GO:0034380

high-density lipoprotein particle assembly

PMID:218942[4]

IDA: Inferred from Direct Assay

P

GO:0034384

high-density lipoprotein particle clearance

PMID:10764676[17]

IDA: Inferred from Direct Assay

P

GO:0042157

lipoprotein metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006801

P

GO:0042157

lipoprotein metabolic process

Reactome:REACT_6823

TAS: Traceable Author Statement

P

GO:0042157

lipoprotein metabolic process

Reactome:REACT_6841

TAS: Traceable Author Statement

P

GO:0042493

response to drug

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000004662

P

GO:0042627

chylomicron

PMID:8245722[12]

IDA: Inferred from Direct Assay

C

GO:0042632

cholesterol homeostasis

PMID:14967812[6]

IDA: Inferred from Direct Assay

P

GO:0042803

protein homodimerization activity

PMID:17264082[9]

IDA: Inferred from Direct Assay

F

GO:0043627

response to estrogen stimulus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000004662

P

GO:0043691

reverse cholesterol transport

PMID:14967812[6]

IDA: Inferred from Direct Assay

P

GO:0044255

cellular lipid metabolic process

Reactome:REACT_22279

TAS: Traceable Author Statement

P

GO:0044419

interspecies interaction between organisms

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0945

P

GO:0045416

positive regulation of interleukin-8 biosynthetic process

PMID:11591715[18]

IDA: Inferred from Direct Assay

P

GO:0046340

diacylglycerol catabolic process

PMID:14967812[6]

IDA: Inferred from Direct Assay

P

GO:0046982

protein heterodimerization activity

PMID:7918467[19]

IPI: Inferred from Physical Interaction

UniProtKB:P05090

F

GO:0046982

protein heterodimerization activity

PMID:8245722[12]

IPI: Inferred from Physical Interaction

UniProtKB:P02649

F

GO:0046982

protein heterodimerization activity

PMID:8245722[12]

IPI: Inferred from Physical Interaction

UniProtKB:P04114

F

GO:0050995

negative regulation of lipid catabolic process

PMID:14967812[6]

IDA: Inferred from Direct Assay

P

GO:0050996

positive regulation of lipid catabolic process

PMID:8640403[20]

IDA: Inferred from Direct Assay

P

GO:0051384

response to glucocorticoid stimulus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000004662

P

GO:0055102

lipase inhibitor activity

PMID:14967812[6]

IDA: Inferred from Direct Assay

F

GO:0060192

negative regulation of lipase activity

PMID:14967812[6]

IDA: Inferred from Direct Assay

P

GO:0060228

phosphatidylcholine-sterol O-acyltransferase activator activity

PMID:14967812[6]

IDA: Inferred from Direct Assay

F

GO:0060621

negative regulation of cholesterol import

PMID:10764676[17]

IDA: Inferred from Direct Assay

P

GO:0060695

negative regulation of cholesterol transporter activity

PMID:8106353[16]

IDA: Inferred from Direct Assay

P

GO:0070653

high-density lipoprotein particle receptor binding

PMID:10764676[17]

IPI: Inferred from Physical Interaction

UniProtKB:Q8WTV0

F

contributes_to

GO:0017127

cholesterol transporter activity

PMID:9651324[21]

IDA: Inferred from Direct Assay

F


Notes

References

See Help:References for how to manage references in GONUTS.

  1. Furlaneto CJ et al. (2002) Apolipoproteins A-I and A-II downregulate neutrophil functions. Lipids 37: 925-8 PubMed GONUTS page
  2. Bekaert ED et al. (1992) Isolation and partial characterization of lipoprotein A-II (LP-A-II) particles of human plasma. Biochim Biophys Acta 1126: 105-13 PubMed GONUTS page
  3. Ritter M et al. (2002) Cloning and characterization of a novel apolipoprotein A-I binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I. Genomics 79: 693-702 PubMed GONUTS page
  4. 4.0 4.1 4.2 Ritter MC & Scanu AM (1979) Apolipoprotein A-II and structure of human serum high density lipoproteins. An approach by reassembly techniques. J Biol Chem 254: 2517-25 PubMed GONUTS page
  5. Anderson NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol Cell Proteomics 3: 311-26 PubMed GONUTS page
  6. 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 6.11 6.12 6.13 6.14 6.15 Boucher J et al. (2004) Apolipoprotein A-II regulates HDL stability and affects hepatic lipase association and activity. J Lipid Res 45: 849-58 PubMed GONUTS page
  7. van 't Hooft FM et al. (2001) Human evidence that the apolipoprotein a-II gene is implicated in visceral fat accumulation and metabolism of triglyceride-rich lipoproteins. Circulation 104: 1223-8 PubMed GONUTS page
  8. Sauvaget D et al. (2004) In vitro transcriptional induction of the human apolipoprotein A-II gene by glucose. Diabetes 53: 672-8 PubMed GONUTS page
  9. 9.0 9.1 9.2 Silva RA et al. (2007) The structure of apolipoprotein A-II in discoidal high density lipoproteins. J Biol Chem 282: 9713-21 PubMed GONUTS page
  10. Marzal-Casacuberta A et al. (1996) Functional lecithin:cholesterol acyltransferase deficiency and high density lipoprotein deficiency in transgenic mice overexpressing human apolipoprotein A-II. J Biol Chem 271: 6720-8 PubMed GONUTS page
  11. 11.0 11.1 11.2 Remaley AT et al. (2001) Apolipoprotein specificity for lipid efflux by the human ABCAI transporter. Biochem Biophys Res Commun 280: 818-23 PubMed GONUTS page
  12. 12.0 12.1 12.2 12.3 Connelly PW et al. (1993) Identification of disulfide-linked apolipoprotein species in human lipoproteins. J Lipid Res 34: 1717-27 PubMed GONUTS page
  13. Weisgraber KH & Mahley RW (1978) Apoprotein (E--A-II) complex of human plasma lipoproteins. I. Characterization of this mixed disulfide and its identification in a high density lipoprotein subfraction. J Biol Chem 253: 6281-8 PubMed GONUTS page
  14. Cheung MC et al. (1986) Distribution and localization of lecithin:cholesterol acyltransferase and cholesteryl ester transfer activity in A-I-containing lipoproteins. J Lipid Res 27: 1135-44 PubMed GONUTS page
  15. Christoffersen C et al. (2006) Isolation and characterization of human apolipoprotein M-containing lipoproteins. J Lipid Res 47: 1833-43 PubMed GONUTS page
  16. 16.0 16.1 16.2 Lagrost L et al. (1994) Influence of apolipoprotein composition of high density lipoprotein particles on cholesteryl ester transfer protein activity. Particles containing various proportions of apolipoproteins AI and AII. J Biol Chem 269: 3189-97 PubMed GONUTS page
  17. 17.0 17.1 17.2 Pilon A et al. (2000) Apolipoprotein AII enrichment of HDL enhances their affinity for class B type I scavenger receptor but inhibits specific cholesteryl ester uptake. Arterioscler Thromb Vasc Biol 20: 1074-81 PubMed GONUTS page
  18. Klezovitch O et al. (2001) Stimulation of interleukin-8 production in human THP-1 macrophages by apolipoprotein(a). Evidence for a critical involvement of elements in its C-terminal domain. J Biol Chem 276: 46864-9 PubMed GONUTS page
  19. Yang CY et al. (1994) Structure of human apolipoprotein D: locations of the intermolecular and intramolecular disulfide links. Biochemistry 33: 12451-5 PubMed GONUTS page
  20. Mowri HO et al. (1996) Apolipoprotein A-II influences the substrate properties of human HDL2 and HDL3 for hepatic lipase. Arterioscler Thromb Vasc Biol 16: 755-62 PubMed GONUTS page
  21. Wang WQ et al. (1998) Enhanced cholesterol efflux by tyrosyl radical-oxidized high density lipoprotein is mediated by apolipoprotein AI-AII heterodimers. J Biol Chem 273: 17391-8 PubMed GONUTS page
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