The Spring 2012 season of CACAO has started!
HUMAN:APOA2
Contents |
| Species (Taxon ID) | Homo sapiens (Human). (taxon:9606) | |
| Gene Name(s) | APOA2 | |
| Protein Name(s) |
| |
| External Links | ||
| UniProt Identifier | APOA2_HUMAN | |
| UniProt Accessions | P02652, B2R524, | |
| EMBL | X04898, X00955, X02905, X02619, M29882, AY100524, AK312034, BT006786, AL590714, BC005282, | |
| PIR | A93586, | |
| RefSeq | NP_001634.1, | |
| PDB | 1L6L, 2OU1, | |
| Ensembl | ENST00000367990, | |
| Pfam | PF04711, | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0042627 |
chylomicron |
IDA: Inferred from Direct Assay |
C |
Source: UniProtKB |
||||
| GO:0005788 |
endoplasmic reticulum lumen |
EXP: Inferred from Experiment |
C |
Source: Reactome |
||||
| GO:0034364 |
high-density lipoprotein particle |
IEA |
C |
Source: UniProtKB-KW |
||||
| GO:0034361 |
very-low-density lipoprotein particle |
IDA: Inferred from Direct Assay |
C |
Source: UniProtKB |
||||
| GO:0034190 |
apolipoprotein receptor binding |
IPI: Inferred from Physical Interaction |
F |
Source: UniProtKB |
||||
| GO:0015485 |
cholesterol binding |
IDA: Inferred from Direct Assay |
F |
Source: UniProtKB |
||||
| GO:0055102 |
lipase inhibitor activity |
IDA: Inferred from Direct Assay |
F |
Source: UniProtKB |
||||
| GO:0005319 |
lipid transporter activity |
IDA: Inferred from Direct Assay |
F |
Source: UniProtKB |
||||
| GO:0031210 |
phosphatidylcholine binding |
IDA: Inferred from Direct Assay |
F |
Source: UniProtKB |
||||
| GO:0060228 |
phosphatidylcholine-sterol O-acyltransferas... |
IDA: Inferred from Direct Assay |
F |
Source: UniProtKB |
||||
| GO:0046982 |
protein heterodimerization activity |
IPI: Inferred from Physical Interaction |
F |
Source: UniProtKB |
||||
| GO:0042803 |
protein homodimerization activity |
IDA: Inferred from Direct Assay |
F |
Source: UniProtKB |
||||
| GO:0046340 |
diacylglycerol catabolic process |
IDA: Inferred from Direct Assay |
P |
Source: UniProtKB |
required field missing | |||
| GO:0033344 |
cholesterol efflux |
IDA: Inferred from Direct Assay |
P |
Source: UniProtKB |
||||
| GO:0042632 |
cholesterol homeostasis |
IDA: Inferred from Direct Assay |
P |
Source: UniProtKB |
||||
| GO:0034380 |
high-density lipoprotein particle assembly |
IDA: Inferred from Direct Assay |
P |
Source: UniProtKB |
||||
| GO:0042157 |
lipoprotein metabolic process |
IEA |
P |
Source: InterPro |
||||
| GO:0034381 |
lipoprotein particle clearance |
TAS: Traceable Author Statement |
P |
Source: UniProtKB |
||||
| GO:0032375 |
negative regulation of cholesterol transport |
IMP: Inferred from Mutant Phenotype |
P |
Source: UniProtKB |
||||
| GO:0060192 |
negative regulation of lipase activity |
IDA: Inferred from Direct Assay |
P |
Source: UniProtKB |
||||
| GO:0050995 |
negative regulation of lipid catabolic process |
IDA: Inferred from Direct Assay |
P |
Source: UniProtKB |
||||
| GO:0006656 |
phosphatidylcholine biosynthetic process |
IDA: Inferred from Direct Assay |
P |
Source: UniProtKB |
||||
| GO:0033700 |
phospholipid efflux |
IDA: Inferred from Direct Assay |
P |
Source: UniProtKB |
||||
| GO:0032375 |
negative regulation of cholesterol transport |
IDA: Inferred from Direct Assay |
P |
required field missing | ||||
| GO:0009749 |
response to glucose stimulus |
IDA: Inferred from Direct Assay |
P |
Source: UniProtKB |
||||
| GO:0043691 |
reverse cholesterol transport |
IDA: Inferred from Direct Assay |
P |
Source: UniProtKB |
||||
| GO:0034375 |
high-density lipoprotein particle remodeling |
IDA: Inferred from Direct Assay |
P |
required field missing | ||||
| GO:0006641 |
triglyceride metabolic process |
TAS: Traceable Author Statement |
P |
Source: UniProtKB |
||||
| GO:0034384 |
high-density lipoprotein particle clearance |
IDA: Inferred from Direct Assay |
P |
required field missing | ||||
| GO:0034370 |
triglyceride-rich lipoprotein particle remo... |
IDA: Inferred from Direct Assay |
P |
Source: UniProtKB |
||||
| GO:0010873 |
positive regulation of cholesterol esterification |
IDA: Inferred from Direct Assay |
P |
required field missing | ||||
| GO:0009395 |
phospholipid catabolic process |
IDA: Inferred from Direct Assay |
P |
required field missing | ||||
| GO:0010903 |
negative regulation of very-low-density lipoprotein particle remodeling |
IDA: Inferred from Direct Assay |
P |
required field missing | ||||
| GO:0032410 |
negative regulation of transporter activity |
IDA: Inferred from Direct Assay |
P |
required field missing | ||||
| GO:0034374 |
low-density lipoprotein particle remodeling |
IDA: Inferred from Direct Assay |
P |
required field missing | ||||
| GO:0050996 |
positive regulation of lipid catabolic process |
IDA: Inferred from Direct Assay |
P |
required field missing | ||||
| GO:0002526 |
acute inflammatory response |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000004662 |
P |
||||
| GO:0002740 |
negative regulation of cytokine secretion involved in immune response |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0005319 |
lipid transporter activity |
IDA: Inferred from Direct Assay |
F |
|||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0005543 |
phospholipid binding |
IDA: Inferred from Direct Assay |
F |
|||||
| GO:0005576 |
extracellular region |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0005576 |
extracellular region |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0005576 |
extracellular region |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0243 |
C |
||||
| GO:0005576 |
extracellular region |
NAS: Non-traceable Author Statement |
C |
|||||
| GO:0005576 |
extracellular region |
Reactome:REACT_22360 |
TAS: Traceable Author Statement |
C |
||||
| GO:0005576 |
extracellular region |
Reactome:REACT_6727 |
TAS: Traceable Author Statement |
C |
||||
| GO:0005576 |
extracellular region |
Reactome:REACT_6734 |
TAS: Traceable Author Statement |
C |
||||
| GO:0005576 |
extracellular region |
Reactome:REACT_6813 |
TAS: Traceable Author Statement |
C |
||||
| GO:0005576 |
extracellular region |
Reactome:REACT_6852 |
TAS: Traceable Author Statement |
C |
||||
| GO:0005788 |
endoplasmic reticulum lumen |
Reactome:REACT_6813 |
TAS: Traceable Author Statement |
C |
||||
| GO:0005788 |
endoplasmic reticulum lumen |
Reactome:REACT_6915 |
TAS: Traceable Author Statement |
C |
||||
| GO:0006457 |
protein folding |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0006629 |
lipid metabolic process |
Reactome:REACT_602 |
TAS: Traceable Author Statement |
P |
||||
| GO:0006641 |
triglyceride metabolic process |
TAS: Traceable Author Statement |
P |
|||||
| GO:0006656 |
phosphatidylcholine biosynthetic process |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0006810 |
transport |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0006869 |
lipid transport |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0006869 |
lipid transport |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0008289 |
lipid binding |
IEA: Inferred from Electronic Annotation |
F |
|||||
| GO:0008289 |
lipid binding |
IDA: Inferred from Direct Assay |
F |
|||||
| GO:0009395 |
phospholipid catabolic process |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0009749 |
response to glucose stimulus |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0010873 |
positive regulation of cholesterol esterification |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0010903 |
negative regulation of very-low-density lipoprotein particle remodeling |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0015485 |
cholesterol binding |
IDA: Inferred from Direct Assay |
F |
|||||
| GO:0017127 |
cholesterol transporter activity |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000004662 |
F |
||||
| GO:0030301 |
cholesterol transport |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000004662 |
P |
||||
| GO:0031100 |
organ regeneration |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000004662 |
P |
||||
| GO:0031210 |
phosphatidylcholine binding |
IDA: Inferred from Direct Assay |
F |
|||||
| GO:0031647 |
regulation of protein stability |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0032375 |
negative regulation of cholesterol transport |
IMP: Inferred from Mutant Phenotype |
P |
|||||
| GO:0033344 |
cholesterol efflux |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0033700 |
phospholipid efflux |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0034190 |
apolipoprotein receptor binding |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0034361 |
very-low-density lipoprotein particle |
IDA: Inferred from Direct Assay |
C |
|||||
| GO:0034364 |
high-density lipoprotein particle |
IEA: Inferred from Electronic Annotation |
C |
|||||
| GO:0034364 |
high-density lipoprotein particle |
IDA: Inferred from Direct Assay |
C |
|||||
| GO:0034364 |
high-density lipoprotein particle |
IDA: Inferred from Direct Assay |
C |
|||||
| GO:0034364 |
high-density lipoprotein particle |
IDA: Inferred from Direct Assay |
C |
|||||
| GO:0034366 |
spherical high-density lipoprotein particle |
IDA: Inferred from Direct Assay |
C |
|||||
| GO:0034370 |
triglyceride-rich lipoprotein particle remodeling |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0034374 |
low-density lipoprotein particle remodeling |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0034375 |
high-density lipoprotein particle remodeling |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0034375 |
high-density lipoprotein particle remodeling |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0034380 |
high-density lipoprotein particle assembly |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0034384 |
high-density lipoprotein particle clearance |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0042157 |
lipoprotein metabolic process |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0042157 |
lipoprotein metabolic process |
Reactome:REACT_6823 |
TAS: Traceable Author Statement |
P |
||||
| GO:0042157 |
lipoprotein metabolic process |
Reactome:REACT_6841 |
TAS: Traceable Author Statement |
P |
||||
| GO:0042493 |
response to drug |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000004662 |
P |
||||
| GO:0042627 |
chylomicron |
IDA: Inferred from Direct Assay |
C |
|||||
| GO:0042632 |
cholesterol homeostasis |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0042803 |
protein homodimerization activity |
IDA: Inferred from Direct Assay |
F |
|||||
| GO:0043627 |
response to estrogen stimulus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000004662 |
P |
||||
| GO:0043691 |
reverse cholesterol transport |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0044255 |
cellular lipid metabolic process |
Reactome:REACT_22279 |
TAS: Traceable Author Statement |
P |
||||
| GO:0044419 |
interspecies interaction between organisms |
IEA: Inferred from Electronic Annotation |
P |
|||||
| GO:0045416 |
positive regulation of interleukin-8 biosynthetic process |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0046340 |
diacylglycerol catabolic process |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0046982 |
protein heterodimerization activity |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0046982 |
protein heterodimerization activity |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0046982 |
protein heterodimerization activity |
IPI: Inferred from Physical Interaction |
F |
|||||
| GO:0050995 |
negative regulation of lipid catabolic process |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0050996 |
positive regulation of lipid catabolic process |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0051384 |
response to glucocorticoid stimulus |
IEA: Inferred from Electronic Annotation |
Ensembl:ENSRNOP00000004662 |
P |
||||
| GO:0055102 |
lipase inhibitor activity |
IDA: Inferred from Direct Assay |
F |
|||||
| GO:0060192 |
negative regulation of lipase activity |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0060228 |
phosphatidylcholine-sterol O-acyltransferase activator activity |
IDA: Inferred from Direct Assay |
F |
|||||
| GO:0060621 |
negative regulation of cholesterol import |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0060695 |
negative regulation of cholesterol transporter activity |
IDA: Inferred from Direct Assay |
P |
|||||
| GO:0070653 |
high-density lipoprotein particle receptor binding |
IPI: Inferred from Physical Interaction |
F |
|||||
|
contributes_to |
GO:0017127 |
cholesterol transporter activity |
IDA: Inferred from Direct Assay |
F |
| |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Furlaneto CJ et al. (2002) Apolipoproteins A-I and A-II downregulate neutrophil functions. Lipids 37: 925-8 PubMed GONUTS page
- ↑ Bekaert ED et al. (1992) Isolation and partial characterization of lipoprotein A-II (LP-A-II) particles of human plasma. Biochim Biophys Acta 1126: 105-13 PubMed GONUTS page
- ↑ Ritter M et al. (2002) Cloning and characterization of a novel apolipoprotein A-I binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I. Genomics 79: 693-702 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Ritter MC & Scanu AM (1979) Apolipoprotein A-II and structure of human serum high density lipoproteins. An approach by reassembly techniques. J Biol Chem 254: 2517-25 PubMed GONUTS page
- ↑ Anderson NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol Cell Proteomics 3: 311-26 PubMed GONUTS page
- ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 6.11 6.12 6.13 6.14 6.15 Boucher J et al. (2004) Apolipoprotein A-II regulates HDL stability and affects hepatic lipase association and activity. J Lipid Res 45: 849-58 PubMed GONUTS page
- ↑ van 't Hooft FM et al. (2001) Human evidence that the apolipoprotein a-II gene is implicated in visceral fat accumulation and metabolism of triglyceride-rich lipoproteins. Circulation 104: 1223-8 PubMed GONUTS page
- ↑ Sauvaget D et al. (2004) In vitro transcriptional induction of the human apolipoprotein A-II gene by glucose. Diabetes 53: 672-8 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Silva RA et al. (2007) The structure of apolipoprotein A-II in discoidal high density lipoproteins. J Biol Chem 282: 9713-21 PubMed GONUTS page
- ↑ Marzal-Casacuberta A et al. (1996) Functional lecithin:cholesterol acyltransferase deficiency and high density lipoprotein deficiency in transgenic mice overexpressing human apolipoprotein A-II. J Biol Chem 271: 6720-8 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 Remaley AT et al. (2001) Apolipoprotein specificity for lipid efflux by the human ABCAI transporter. Biochem Biophys Res Commun 280: 818-23 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 12.3 Connelly PW et al. (1993) Identification of disulfide-linked apolipoprotein species in human lipoproteins. J Lipid Res 34: 1717-27 PubMed GONUTS page
- ↑ Weisgraber KH & Mahley RW (1978) Apoprotein (E--A-II) complex of human plasma lipoproteins. I. Characterization of this mixed disulfide and its identification in a high density lipoprotein subfraction. J Biol Chem 253: 6281-8 PubMed GONUTS page
- ↑ Cheung MC et al. (1986) Distribution and localization of lecithin:cholesterol acyltransferase and cholesteryl ester transfer activity in A-I-containing lipoproteins. J Lipid Res 27: 1135-44 PubMed GONUTS page
- ↑ Christoffersen C et al. (2006) Isolation and characterization of human apolipoprotein M-containing lipoproteins. J Lipid Res 47: 1833-43 PubMed GONUTS page
- ↑ 16.0 16.1 16.2 Lagrost L et al. (1994) Influence of apolipoprotein composition of high density lipoprotein particles on cholesteryl ester transfer protein activity. Particles containing various proportions of apolipoproteins AI and AII. J Biol Chem 269: 3189-97 PubMed GONUTS page
- ↑ 17.0 17.1 17.2 Pilon A et al. (2000) Apolipoprotein AII enrichment of HDL enhances their affinity for class B type I scavenger receptor but inhibits specific cholesteryl ester uptake. Arterioscler Thromb Vasc Biol 20: 1074-81 PubMed GONUTS page
- ↑ Klezovitch O et al. (2001) Stimulation of interleukin-8 production in human THP-1 macrophages by apolipoprotein(a). Evidence for a critical involvement of elements in its C-terminal domain. J Biol Chem 276: 46864-9 PubMed GONUTS page
- ↑ Yang CY et al. (1994) Structure of human apolipoprotein D: locations of the intermolecular and intramolecular disulfide links. Biochemistry 33: 12451-5 PubMed GONUTS page
- ↑ Mowri HO et al. (1996) Apolipoprotein A-II influences the substrate properties of human HDL2 and HDL3 for hepatic lipase. Arterioscler Thromb Vasc Biol 16: 755-62 PubMed GONUTS page
- ↑ Wang WQ et al. (1998) Enhanced cholesterol efflux by tyrosyl radical-oxidized high density lipoprotein is mediated by apolipoprotein AI-AII heterodimers. J Biol Chem 273: 17391-8 PubMed GONUTS page