HUMAN:APOA1

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	APOA1
Protein Name(s)	Apolipoprotein A-I Apo-AI ApoA-I Apolipoprotein A1 Apolipoprotein A-I(1-242)
External Links
UniProt Identifier	APOA1_HUMAN
UniProt Accessions	P02647, A8K866, Q6LDN9, Q6Q785, Q9UCS8, Q9UCT8,
EMBL	J00098, X01038, X02162, X00566, M11791, X07496, M27875, M29068, AY422952, AY555191, A14829, AK292231, EF444948, EF444948, EF444948, EF444948, EF444948, CH471065, BC005380, BC110286,
PIR	A90947,
RefSeq	NP_000030.1,
PDB	1AV1, 1GW3, 1GW4, 1ODP, 1ODQ, 1ODR, 2A01, 3J00, 3K2S,
IntAct	P02647,
Ensembl	ENST00000236850, ENST00000359492, ENST00000375320, ENST00000375323,
Pfam	PF01442,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0030139	endocytic vesicle		IDA: Inferred from Direct Assay		C	Source: UniProtKB
	GO:0005788	endoplasmic reticulum lumen		EXP: Inferred from Experiment		C	Source: Reactome
	GO:0034364	high-density lipoprotein particle		IEA		C	Source: UniProtKB-KW
	GO:0034191	apolipoprotein A-I receptor binding		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0001540	beta-amyloid binding		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0015485	cholesterol binding		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0017127	cholesterol transporter activity		IMP: Inferred from Mutant Phenotype		F	Source: UniProtKB
	GO:0019899	enzyme binding		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0042802	identical protein binding		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0070325	lipoprotein receptor binding		IPI: Inferred from Physical Interaction		F	Source: UniProtKB
	GO:0060228	phosphatidylcholine-sterol O-acyltransferas...		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0005543	phospholipid binding		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0033344	cholesterol efflux		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0042632	cholesterol homeostasis		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB
	GO:0008203	cholesterol metabolic process		IDA: Inferred from Direct Assay		P	Source: UniProtKB-KW	required field missing
	GO:0034380	high-density lipoprotein particle assembly		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0042157	lipoprotein metabolic process		IEA		P	Source: InterPro
	GO:0006656	phosphatidylcholine biosynthetic process		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0033700	phospholipid efflux		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0010873	positive regulation of cholesterol esterifi...		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0034384	high-density lipoprotein particle clearance		IDA: Inferred from Direct Assay		P		required field missing
	GO:0051345	positive regulation of hydrolase activity		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0050821	protein stabilization		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling		IDA: Inferred from Direct Assay		P		required field missing
	GO:0043691	reverse cholesterol transport		IMP: Inferred from Mutant Phenotype		P	Source: UniProtKB
	GO:0070508	cholesterol import		IMP: Inferred from Mutant Phenotype		P		required field missing
	GO:0001540	beta-amyloid binding	PMID:11297421^[1]	IDA: Inferred from Direct Assay		F
	GO:0002576	platelet degranulation	Reactome:REACT_318	TAS: Traceable Author Statement		P
	GO:0002740	negative regulation of cytokine secretion involved in immune response	PMID:12458630^[2]	IDA: Inferred from Direct Assay		P
	GO:0005515	protein binding	PMID:11297421^[1]	IPI: Inferred from Physical Interaction	UniProtKB:P05067	F
	GO:0005515	protein binding	PMID:11991719^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q8NCW5	F
	GO:0005515	protein binding	PMID:12084722^[4]	IPI: Inferred from Physical Interaction	UniProtKB:O95477	F
	GO:0005543	phospholipid binding	PMID:12810715^[5]	IDA: Inferred from Direct Assay		F
	GO:0005576	extracellular region	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000074	C
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C
	GO:0005576	extracellular region	Reactome:REACT_13407	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_13408	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_13459	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_13548	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_13575	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_13604	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_13610	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_13674	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_13678	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_13688	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_13706	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_13717	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_13735	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_13762	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_13783	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_13803	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_21324	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_22360	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_6727	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_6734	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_6813	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_6852	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_75876	TAS: Traceable Author Statement		C
	GO:0005576	extracellular region	Reactome:REACT_75905	TAS: Traceable Author Statement		C
	GO:0005615	extracellular space	PMID:20551380^[6]	IDA: Inferred from Direct Assay		C
	GO:0005788	endoplasmic reticulum lumen	Reactome:REACT_6813	TAS: Traceable Author Statement		C
	GO:0005788	endoplasmic reticulum lumen	Reactome:REACT_6915	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_13459	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_13575	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_13602	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_13622	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_13627	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_13688	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_13762	TAS: Traceable Author Statement		C
	GO:0005886	plasma membrane	Reactome:REACT_15367	TAS: Traceable Author Statement		C
	GO:0006629	lipid metabolic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0443	P
	GO:0006629	lipid metabolic process	Reactome:REACT_602	TAS: Traceable Author Statement		P
	GO:0006656	phosphatidylcholine biosynthetic process	PMID:4335615^[7]	IDA: Inferred from Direct Assay		P
	GO:0006810	transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0813	P
	GO:0006869	lipid transport	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000074	P
	GO:0006869	lipid transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0445	P
	GO:0007186	G-protein coupled receptor protein signaling pathway	PMID:16443932^[8]	IDA: Inferred from Direct Assay		P
	GO:0007596	blood coagulation	Reactome:REACT_604	TAS: Traceable Author Statement		P
	GO:0008202	steroid metabolic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0753	P
	GO:0008203	cholesterol metabolic process	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0153	P
	GO:0008203	cholesterol metabolic process	PMID:15464323^[9]	IMP: Inferred from Mutant Phenotype		P
	GO:0008289	lipid binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000074	F
	GO:0010873	positive regulation of cholesterol esterification	PMID:4335615^[7]	IDA: Inferred from Direct Assay		P
	GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling	PMID:14967812^[10]	IDA: Inferred from Direct Assay		P
	GO:0015485	cholesterol binding	PMID:15464323^[9]	IDA: Inferred from Direct Assay		F
	GO:0017127	cholesterol transporter activity	PMID:15464323^[9]	IMP: Inferred from Mutant Phenotype		F
	GO:0019899	enzyme binding	PMID:1587806^[11]	IPI: Inferred from Physical Interaction	UniProtKB:P04180	F
	GO:0030139	endocytic vesicle	PMID:14747463^[12]	IDA: Inferred from Direct Assay		C
	GO:0030141	stored secretory granule	Reactome:REACT_21324	TAS: Traceable Author Statement		C
	GO:0030168	platelet activation	Reactome:REACT_798	TAS: Traceable Author Statement		P
	GO:0030301	cholesterol transport	PMID:10559507^[13]	IDA: Inferred from Direct Assay		P
	GO:0031410	cytoplasmic vesicle	PMID:14703508^[14]	IDA: Inferred from Direct Assay		C
	GO:0032488	Cdc42 protein signal transduction	PMID:16443932^[8]	IDA: Inferred from Direct Assay		P
	GO:0033344	cholesterol efflux	PMID:11162594^[15]	IDA: Inferred from Direct Assay		P
	GO:0033344	cholesterol efflux	PMID:14703508^[14]	IDA: Inferred from Direct Assay		P
	GO:0033344	cholesterol efflux	PMID:16443932^[8]	IDA: Inferred from Direct Assay		P
	GO:0033700	phospholipid efflux	PMID:11162594^[15]	IDA: Inferred from Direct Assay		P
	GO:0033700	phospholipid efflux	PMID:14703508^[14]	IDA: Inferred from Direct Assay		P
	GO:0034190	apolipoprotein receptor binding	PMID:11162594^[15]	IPI: Inferred from Physical Interaction	UniProtKB:O95477	F
	GO:0034191	apolipoprotein A-I receptor binding	PMID:16443932^[8]	IPI: Inferred from Physical Interaction	UniProtKB:O95477	F
	GO:0034361	very-low-density lipoprotein particle	PMID:17154273^[16]	IDA: Inferred from Direct Assay		C
	GO:0034364	high-density lipoprotein particle	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0345	C
	GO:0034364	high-density lipoprotein particle	PMID:15464323^[9]	IDA: Inferred from Direct Assay		C
	GO:0034364	high-density lipoprotein particle	PMID:210174^[17]	IDA: Inferred from Direct Assay		C
	GO:0034364	high-density lipoprotein particle	PMID:3104518^[18]	IDA: Inferred from Direct Assay		C
	GO:0034366	spherical high-density lipoprotein particle	PMID:16682745^[19]	IDA: Inferred from Direct Assay		C
	GO:0034375	high-density lipoprotein particle remodeling	PMID:4335615^[7]	IC: Inferred by Curator	GO:0060228	P
	GO:0034380	high-density lipoprotein particle assembly	PMID:190223^[20]	IDA: Inferred from Direct Assay		P
	GO:0034384	high-density lipoprotein particle clearance	PMID:12651854^[21]	IC: Inferred by Curator	GO:0070325	P
	GO:0042157	lipoprotein metabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000074	P
	GO:0042157	lipoprotein metabolic process	Reactome:REACT_13621	TAS: Traceable Author Statement		P
	GO:0042157	lipoprotein metabolic process	Reactome:REACT_6823	TAS: Traceable Author Statement		P
	GO:0042157	lipoprotein metabolic process	Reactome:REACT_6841	TAS: Traceable Author Statement		P
	GO:0042632	cholesterol homeostasis	PMID:15464323^[9]	IMP: Inferred from Mutant Phenotype		P
	GO:0042802	identical protein binding	PMID:8049247^[22]	IPI: Inferred from Physical Interaction	UniProtKB:P02647	F
	GO:0043691	reverse cholesterol transport	PMID:15464323^[9]	IMP: Inferred from Mutant Phenotype		P
	GO:0044255	cellular lipid metabolic process	Reactome:REACT_22279	TAS: Traceable Author Statement		P
	GO:0050713	negative regulation of interleukin-1 beta secretion	PMID:12458630^[2]	IDA: Inferred from Direct Assay		P
	GO:0050821	protein stabilization	PMID:17655203^[23]	IDA: Inferred from Direct Assay		P
	GO:0051345	positive regulation of hydrolase activity	PMID:7638166^[24]	IDA: Inferred from Direct Assay		P
	GO:0055085	transmembrane transport	Reactome:REACT_15480	TAS: Traceable Author Statement		P
	GO:0055085	transmembrane transport	Reactome:REACT_15518	TAS: Traceable Author Statement		P
	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity	PMID:4335615^[7]	IDA: Inferred from Direct Assay		F
	GO:0070508	cholesterol import	PMID:14718538^[25]	IMP: Inferred from Mutant Phenotype		P
	GO:0070653	high-density lipoprotein particle receptor binding	PMID:10764676^[26]	IPI: Inferred from Physical Interaction	UniProtKB:Q8WTV0	F
	GO:0070653	high-density lipoprotein particle receptor binding	PMID:12651854^[21]	IPI: Inferred from Physical Interaction	UniProtKB:Q8WTV0	F
contributes_to	GO:0017127	cholesterol transporter activity	PMID:9651324^[27]	IDA: Inferred from Direct Assay		F
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Koldamova RP et al. (2001) Apolipoprotein A-I directly interacts with amyloid precursor protein and inhibits A beta aggregation and toxicity. Biochemistry 40: 3553-60 PubMed GONUTS page
↑ ^2.0 ^2.1 Furlaneto CJ et al. (2002) Apolipoproteins A-I and A-II downregulate neutrophil functions. Lipids 37: 925-8 PubMed GONUTS page
↑ Ritter M et al. (2002) Cloning and characterization of a novel apolipoprotein A-I binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I. Genomics 79: 693-702 PubMed GONUTS page
↑ Fitzgerald ML et al. (2002) Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I. J Biol Chem 277: 33178-87 PubMed GONUTS page
↑ Weinberg RB et al. (2003) Structure and interfacial properties of human apolipoprotein A-V. J Biol Chem 278: 34438-44 PubMed GONUTS page
↑ Didangelos A et al. (2010) Proteomics characterization of extracellular space components in the human aorta. Mol Cell Proteomics 9: 2048-62 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Fielding CJ et al. (1972) A protein cofactor of lecithin:cholesterol acyltransferase. Biochem Biophys Res Commun 46: 1493-8 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Nofer JR et al. (2006) Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter. J Lipid Res 47: 794-803 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Hovingh GK et al. (2004) A novel apoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease. J Am Coll Cardiol 44: 1429-35 PubMed GONUTS page
↑ Boucher J et al. (2004) Apolipoprotein A-II regulates HDL stability and affects hepatic lipase association and activity. J Lipid Res 45: 849-58 PubMed GONUTS page
↑ Furukawa Y et al. (1992) Interaction of rat lecithin-cholesterol acyltransferase with rat apolipoprotein A-I and with lecithin-cholesterol vesicles. J Biochem 111: 413-8 PubMed GONUTS page
↑ Neufeld EB et al. (2004) The ABCA1 transporter modulates late endocytic trafficking: insights from the correction of the genetic defect in Tangier disease. J Biol Chem 279: 15571-8 PubMed GONUTS page
↑ Fournier N et al. (1999) Fractional efflux and net change in cellular cholesterol content mediated by sera from mice expressing both human apolipoprotein AI and human lecithin:cholesterol acyltransferase genes. Atherosclerosis 147: 227-35 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Smith JD et al. (2004) ABCA1 mediates concurrent cholesterol and phospholipid efflux to apolipoprotein A-I. J Lipid Res 45: 635-44 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Remaley AT et al. (2001) Apolipoprotein specificity for lipid efflux by the human ABCAI transporter. Biochem Biophys Res Commun 280: 818-23 PubMed GONUTS page
↑ Mancone C et al. (2007) Proteomic analysis of human very low-density lipoprotein by two-dimensional gel electrophoresis and MALDI-TOF/TOF. Proteomics 7: 143-54 PubMed GONUTS page
↑ Weisgraber KH & Mahley RW (1978) Apoprotein (E--A-II) complex of human plasma lipoproteins. I. Characterization of this mixed disulfide and its identification in a high density lipoprotein subfraction. J Biol Chem 253: 6281-8 PubMed GONUTS page
↑ Cheung MC et al. (1986) Distribution and localization of lecithin:cholesterol acyltransferase and cholesteryl ester transfer activity in A-I-containing lipoproteins. J Lipid Res 27: 1135-44 PubMed GONUTS page
↑ Christoffersen C et al. (2006) Isolation and characterization of human apolipoprotein M-containing lipoproteins. J Lipid Res 47: 1833-43 PubMed GONUTS page
↑ Ritter MC & Scanus AM (1977) Role of apolipoprotein A-I in the structure of human serum high density lipoproteins. Reconstitution studies. J Biol Chem 252: 1208-16 PubMed GONUTS page
↑ ^21.0 ^21.1 Vishnyakova TG et al. (2003) Binding and internalization of lipopolysaccharide by Cla-1, a human orthologue of rodent scavenger receptor B1. J Biol Chem 278: 22771-80 PubMed GONUTS page
↑ Gong EL et al. (1994) Structural and functional properties of human and mouse apolipoprotein A-I. Biochim Biophys Acta 1213: 335-42 PubMed GONUTS page
↑ Mukhamedova N et al. (2007) The role of different regions of ATP-binding cassette transporter A1 in cholesterol efflux. Biochemistry 46: 9388-98 PubMed GONUTS page
↑ Sorenson RC et al. (1995) Reconsideration of the catalytic center and mechanism of mammalian paraoxonase/arylesterase. Proc Natl Acad Sci U S A 92: 7187-91 PubMed GONUTS page
↑ Thuahnai ST et al. (2004) Scavenger receptor class B type I-mediated cholesteryl ester-selective uptake and efflux of unesterified cholesterol. Influence of high density lipoprotein size and structure. J Biol Chem 279: 12448-55 PubMed GONUTS page
↑ Pilon A et al. (2000) Apolipoprotein AII enrichment of HDL enhances their affinity for class B type I scavenger receptor but inhibits specific cholesteryl ester uptake. Arterioscler Thromb Vasc Biol 20: 1074-81 PubMed GONUTS page
↑ Wang WQ et al. (1998) Enhanced cholesterol efflux by tyrosyl radical-oxidized high density lipoprotein is mediated by apolipoprotein AI-AII heterodimers. J Biol Chem 273: 17391-8 PubMed GONUTS page

[PMID:11297421-0] 1.0 ^1.1 Koldamova RP et al. (2001) Apolipoprotein A-I directly interacts with amyloid precursor protein and inhibits A beta aggregation and toxicity. Biochemistry 40: 3553-60 PubMed GONUTS page

[PMID:12458630-1] 2.0 ^2.1 Furlaneto CJ et al. (2002) Apolipoproteins A-I and A-II downregulate neutrophil functions. Lipids 37: 925-8 PubMed GONUTS page

[PMID:11991719-2] Ritter M et al. (2002) Cloning and characterization of a novel apolipoprotein A-I binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I. Genomics 79: 693-702 PubMed GONUTS page

[PMID:12084722-3] Fitzgerald ML et al. (2002) Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I. J Biol Chem 277: 33178-87 PubMed GONUTS page

[PMID:12810715-4] Weinberg RB et al. (2003) Structure and interfacial properties of human apolipoprotein A-V. J Biol Chem 278: 34438-44 PubMed GONUTS page

[PMID:20551380-5] Didangelos A et al. (2010) Proteomics characterization of extracellular space components in the human aorta. Mol Cell Proteomics 9: 2048-62 PubMed GONUTS page

[PMID:4335615-6] 7.0 ^7.1 ^7.2 ^7.3 Fielding CJ et al. (1972) A protein cofactor of lecithin:cholesterol acyltransferase. Biochem Biophys Res Commun 46: 1493-8 PubMed GONUTS page

[PMID:16443932-7] 8.0 ^8.1 ^8.2 ^8.3 Nofer JR et al. (2006) Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter. J Lipid Res 47: 794-803 PubMed GONUTS page

[PMID:15464323-8] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Hovingh GK et al. (2004) A novel apoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease. J Am Coll Cardiol 44: 1429-35 PubMed GONUTS page

[PMID:14967812-9] Boucher J et al. (2004) Apolipoprotein A-II regulates HDL stability and affects hepatic lipase association and activity. J Lipid Res 45: 849-58 PubMed GONUTS page

[PMID:1587806-10] Furukawa Y et al. (1992) Interaction of rat lecithin-cholesterol acyltransferase with rat apolipoprotein A-I and with lecithin-cholesterol vesicles. J Biochem 111: 413-8 PubMed GONUTS page

[PMID:14747463-11] Neufeld EB et al. (2004) The ABCA1 transporter modulates late endocytic trafficking: insights from the correction of the genetic defect in Tangier disease. J Biol Chem 279: 15571-8 PubMed GONUTS page

[PMID:10559507-12] Fournier N et al. (1999) Fractional efflux and net change in cellular cholesterol content mediated by sera from mice expressing both human apolipoprotein AI and human lecithin:cholesterol acyltransferase genes. Atherosclerosis 147: 227-35 PubMed GONUTS page

[PMID:14703508-13] 14.0 ^14.1 ^14.2 Smith JD et al. (2004) ABCA1 mediates concurrent cholesterol and phospholipid efflux to apolipoprotein A-I. J Lipid Res 45: 635-44 PubMed GONUTS page

[PMID:11162594-14] 15.0 ^15.1 ^15.2 Remaley AT et al. (2001) Apolipoprotein specificity for lipid efflux by the human ABCAI transporter. Biochem Biophys Res Commun 280: 818-23 PubMed GONUTS page

[PMID:17154273-15] Mancone C et al. (2007) Proteomic analysis of human very low-density lipoprotein by two-dimensional gel electrophoresis and MALDI-TOF/TOF. Proteomics 7: 143-54 PubMed GONUTS page

[PMID:210174-16] Weisgraber KH & Mahley RW (1978) Apoprotein (E--A-II) complex of human plasma lipoproteins. I. Characterization of this mixed disulfide and its identification in a high density lipoprotein subfraction. J Biol Chem 253: 6281-8 PubMed GONUTS page

[PMID:3104518-17] Cheung MC et al. (1986) Distribution and localization of lecithin:cholesterol acyltransferase and cholesteryl ester transfer activity in A-I-containing lipoproteins. J Lipid Res 27: 1135-44 PubMed GONUTS page

[PMID:16682745-18] Christoffersen C et al. (2006) Isolation and characterization of human apolipoprotein M-containing lipoproteins. J Lipid Res 47: 1833-43 PubMed GONUTS page

[PMID:190223-19] Ritter MC & Scanus AM (1977) Role of apolipoprotein A-I in the structure of human serum high density lipoproteins. Reconstitution studies. J Biol Chem 252: 1208-16 PubMed GONUTS page

[PMID:12651854-20] 21.0 ^21.1 Vishnyakova TG et al. (2003) Binding and internalization of lipopolysaccharide by Cla-1, a human orthologue of rodent scavenger receptor B1. J Biol Chem 278: 22771-80 PubMed GONUTS page

[PMID:8049247-21] Gong EL et al. (1994) Structural and functional properties of human and mouse apolipoprotein A-I. Biochim Biophys Acta 1213: 335-42 PubMed GONUTS page

[PMID:17655203-22] Mukhamedova N et al. (2007) The role of different regions of ATP-binding cassette transporter A1 in cholesterol efflux. Biochemistry 46: 9388-98 PubMed GONUTS page

[PMID:7638166-23] Sorenson RC et al. (1995) Reconsideration of the catalytic center and mechanism of mammalian paraoxonase/arylesterase. Proc Natl Acad Sci U S A 92: 7187-91 PubMed GONUTS page

[PMID:14718538-24] Thuahnai ST et al. (2004) Scavenger receptor class B type I-mediated cholesteryl ester-selective uptake and efflux of unesterified cholesterol. Influence of high density lipoprotein size and structure. J Biol Chem 279: 12448-55 PubMed GONUTS page

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HUMAN:APOA1

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