It is now the 5th OPEN Period for CACAO Fall 2017! It will end on Sunday November 19, 2017 at 11:59 pm CST
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

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HUMAN:APC

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) APC (synonyms: DP2.5)
Protein Name(s) Adenomatous polyposis coli protein

Protein APC Deleted in polyposis 2.5

External Links
UniProt P25054
EMBL M73548
M73548
M74088
CH471086
CH471086
S78214
CCDS CCDS4107.1
PIR A37261
RefSeq NP_000029.2
NP_001120982.1
UniGene Hs.158932
PDB 1DEB
1EMU
1JPP
1M5I
1T08
1TH1
1V18
2RQU
3AU3
3NMW
3NMX
3NMZ
3QHE
3RL7
3RL8
3T7U
4G69
PDBsum 1DEB
1EMU
1JPP
1M5I
1T08
1TH1
1V18
2RQU
3AU3
3NMW
3NMX
3NMZ
3QHE
3RL7
3RL8
3T7U
4G69
DisProt DP00519
ProteinModelPortal P25054
SMR P25054
BioGrid 106821
DIP DIP-33556N
IntAct P25054
MINT MINT-88204
STRING 9606.ENSP00000257430
PhosphoSite P25054
DMDM 97535708
MaxQB P25054
PaxDb P25054
PRIDE P25054
DNASU 324
Ensembl ENST00000257430
ENST00000508376
GeneID 324
KEGG hsa:324
UCSC uc003kpy.4
CTD 324
GeneCards GC05P112101
GeneReviews APC
HGNC HGNC:583
HPA CAB025994
HPA013349
MIM 114550
135290
155255
175100
276300
611731
613659
neXtProt NX_P25054
Orphanet 247806
873
261584
79665
99818
PharmGKB PA24875
eggNOG NOG259696
GeneTree ENSGT00530000063749
HOVERGEN HBG004264
InParanoid P25054
KO K02085
OMA IEDCPIN
PhylomeDB P25054
TreeFam TF106496
BioCyc MetaCyc:ENSG00000134982-MONOMER
Reactome REACT_107
REACT_11063
REACT_11065
REACT_200610
REACT_200731
REACT_228060
REACT_228137
REACT_228143
REACT_228159
REACT_228196
REACT_228251
REACT_228261
REACT_228285
REACT_228314
SignaLink P25054
ChiTaRS APC
EvolutionaryTrace P25054
GeneWiki Adenomatous_polyposis_coli
GenomeRNAi 324
NextBio 1329
PRO PR:P25054
Proteomes UP000005640
Bgee P25054
CleanEx HS_APC
ExpressionAtlas P25054
Genevestigator P25054
GO GO:0005912
GO:0044295
GO:0030877
GO:0005813
GO:0005737
GO:0005881
GO:0005829
GO:0000776
GO:0030027
GO:0016328
GO:0035371
GO:0005634
GO:0005886
GO:0032587
GO:0005923
GO:0008013
GO:0045295
GO:0008017
GO:0051010
GO:0019901
GO:0019887
GO:0009952
GO:0006915
GO:0009798
GO:0007409
GO:0060070
GO:0044336
GO:0044337
GO:0007155
GO:0007050
GO:0016477
GO:0006921
GO:0006974
GO:0051276
GO:0031122
GO:0009953
GO:0001942
GO:0001822
GO:0007091
GO:0000281
GO:0007094
GO:0046716
GO:0090090
GO:0008285
GO:0045736
GO:0060770
GO:0043409
GO:0007026
GO:0042483
GO:0043065
GO:0045785
GO:0051781
GO:0030335
GO:0030858
GO:0031116
GO:0045732
GO:0031274
GO:0006461
GO:0009954
GO:0051988
GO:0032886
GO:0051171
GO:0045667
GO:0045670
GO:0060041
GO:0035019
GO:0033077
GO:0048538
GO:0070830
Gene3D 1.25.10.10
InterPro IPR026836
IPR009240
IPR009234
IPR009223
IPR026831
IPR026818
IPR011989
IPR016024
IPR000225
IPR009232
IPR009224
PANTHER PTHR12607
PTHR12607:SF11
Pfam PF05972
PF05956
PF05923
PF00514
PF05937
PF05924
PF11414
SMART SM00185
SUPFAM SSF48371
PROSITE PS50176

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000281

cytokinesis after mitosis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0000281

cytokinesis after mitosis

PMID:17570218[1]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0000776

kinetochore

PMID:11283619[2]

IDA: Inferred from Direct Assay

C

complete

GO:0001822

kidney development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0001942

hair follicle development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0005488

binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011989

F

complete

GO:0005488

binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR016024

F

complete

Contributes to

GO:0007076

mitotic chromosome condensation

PMID:22719865[3]

IDA: Inferred from Direct Assay

P

APC depletion increases chromatin condensation in HeLa cells.

complete

GO:0005515

protein binding

PMID:10656683[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q12959

F

complete

GO:0016342

catenin complex

PMID:7806582[5]

IDA: Inferred from Direct Assay

C

Fig 5c lane 2 shows bindig of alpha catenin and formation of a catenin complex

complete
CACAO 2914

GO:0005515

protein binding

PMID:10947987[6]

IPI: Inferred from Physical Interaction

UniProtKB:Q9NR80

F

complete

GO:0005515

protein binding

PMID:11283619[2]

IPI: Inferred from Physical Interaction

UniProtKB:O43684

F

complete

GO:0005515

protein binding

PMID:11389840[7]

IPI: Inferred from Physical Interaction

UniProtKB:Q8IUQ4

F

complete

GO:0005515

protein binding

PMID:11943150[8]

IPI: Inferred from Physical Interaction

UniProtKB:Q15691

F

complete

GO:0005515

protein binding

PMID:11943150[8]

IPI: Inferred from Physical Interaction

UniProtKB:Q15691

F

complete

GO:0005515

protein binding

PMID:11972058[9]

IPI: Inferred from Physical Interaction

UniProtKB:P19784

F

complete

GO:0005515

protein binding

PMID:11972058[9]

IPI: Inferred from Physical Interaction

UniProtKB:P68400

F

complete

GO:0005515

protein binding

PMID:15327768[10]

IPI: Inferred from Physical Interaction

UniProtKB:Q02248

F

complete

GO:0005515

protein binding

PMID:16611247[11]

IPI: Inferred from Physical Interaction

UniProtKB:Q14160

F

complete

GO:0005515

protein binding

PMID:17218255[12]

IPI: Inferred from Physical Interaction

UniProtKB:P49674

F

complete

GO:0005515

protein binding

PMID:17588722[13]

IPI: Inferred from Physical Interaction

UniProtKB:Q96EY1

F

complete

GO:0005515

protein binding

PMID:17599059[14]

IPI: Inferred from Physical Interaction

UniProtKB:Q96N96

F

complete

GO:0000281

mitotic cytokinesis

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR026836

P

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:18281465[15]

IPI: Inferred from Physical Interaction

UniProtKB:Q9UGI0

F

complete

GO:0000281

mitotic cytokinesis

PMID:17570218[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:18502210[16]

IPI: Inferred from Physical Interaction

UniProtKB:O43815

F

complete

GO:0000776

kinetochore

PMID:11283619[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:18502210[16]

IPI: Inferred from Physical Interaction

UniProtKB:Q13033

F

complete

GO:0001822

kidney development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:18502210[16]

IPI: Inferred from Physical Interaction

UniProtKB:Q9NRL3

F

complete

GO:0001942

hair follicle development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:19632184[17]

IPI: Inferred from Physical Interaction

UniProtKB:Q15691

F

complete

GO:0005515

protein binding

PMID:10656683[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q12959

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:9601641[18]

IPI: Inferred from Physical Interaction

UniProtKB:O15169

F

complete

GO:0005515

protein binding

PMID:10947987[6]

IPI: Inferred from Physical Interaction

UniProtKB:Q9NR80

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

C

complete

GO:0005515

protein binding

PMID:11283619[2]

IPI: Inferred from Physical Interaction

UniProtKB:O43684

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000027691

C

complete

GO:0005515

protein binding

PMID:11389840[7]

IPI: Inferred from Physical Interaction

UniProtKB:Q8IUQ4

F

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:11035805[19]

IDA: Inferred from Direct Assay

C

complete

GO:0005515

protein binding

PMID:11425858[20]

IPI: Inferred from Physical Interaction

UniProtKB:O14640

F

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:12072559[21]

IDA: Inferred from Direct Assay

C

complete

GO:0005515

protein binding

PMID:11425858[20]

IPI: Inferred from Physical Interaction

UniProtKB:P49674

F

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:12955080[22]

IDA: Inferred from Direct Assay

C

complete

GO:0005515

protein binding

PMID:11943150[8]

IPI: Inferred from Physical Interaction

UniProtKB:Q15691

F

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

complete

GO:0005515

protein binding

PMID:11943150[8]

IPI: Inferred from Physical Interaction

UniProtKB:Q15691

F

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

C

complete

GO:0005515

protein binding

PMID:11972058[9]

IPI: Inferred from Physical Interaction

UniProtKB:P19784

F

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000027691

C

complete

GO:0005515

protein binding

PMID:11972058[9]

IPI: Inferred from Physical Interaction

UniProtKB:P68400

F

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

complete

GO:0005515

protein binding

PMID:15327768[10]

IPI: Inferred from Physical Interaction

UniProtKB:P35222

F

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:11035805[19]

IDA: Inferred from Direct Assay

C

complete

GO:0005515

protein binding

PMID:15327768[10]

IPI: Inferred from Physical Interaction

UniProtKB:Q02248

F

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:12955080[22]

IDA: Inferred from Direct Assay

C

complete

GO:0005515

protein binding

PMID:15327769[23]

IPI: Inferred from Physical Interaction

UniProtKB:P35222

F

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:20937854[24]

IDA: Inferred from Direct Assay

C

complete

GO:0005515

protein binding

PMID:16212417[25]

IPI: Inferred from Physical Interaction

UniProtKB:P35222

F

Seeded From UniProt

complete

GO:0005813

centrosome

PMID:11283619[2]

IDA: Inferred from Direct Assay

C

complete

GO:0005515

protein binding

PMID:16293619[26]

IPI: Inferred from Physical Interaction

UniProtKB:Q02248

F

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_10017

TAS: Traceable Author Statement

C

complete

GO:0005515

protein binding

PMID:16611247[11]

IPI: Inferred from Physical Interaction

UniProtKB:Q14160

F

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_10082

TAS: Traceable Author Statement

C

complete

GO:0005515

protein binding

PMID:16611247[11]

IPI: Inferred from Physical Interaction

UniProtKB:Q14160

F

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_10111

TAS: Traceable Author Statement

C

complete

GO:0005515

protein binding

PMID:17218255[12]

IPI: Inferred from Physical Interaction

UniProtKB:P49674

F

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_10127

TAS: Traceable Author Statement

C

complete

GO:0005515

protein binding

PMID:17318191[27]

IPI: Inferred from Physical Interaction

UniProtKB:P35222

F

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_10134

TAS: Traceable Author Statement

C

complete

GO:0005515

protein binding

PMID:17588722[13]

IPI: Inferred from Physical Interaction

UniProtKB:Q96EY1

F

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_12012

TAS: Traceable Author Statement

C

complete

GO:0005515

protein binding

PMID:17599059[14]

IPI: Inferred from Physical Interaction

UniProtKB:Q96N96

F

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_9955

TAS: Traceable Author Statement

C

complete

GO:0005515

protein binding

PMID:17925383[28]

IPI: Inferred from Physical Interaction

UniProtKB:Q5JTC6

F

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_9959

TAS: Traceable Author Statement

C

complete

GO:0005515

protein binding

PMID:18281465[15]

IPI: Inferred from Physical Interaction

UniProtKB:Q9UGI0

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:18502210[16]

IPI: Inferred from Physical Interaction

UniProtKB:O43815

F

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_9977

TAS: Traceable Author Statement

C

complete

GO:0005515

protein binding

PMID:18502210[16]

IPI: Inferred from Physical Interaction

UniProtKB:Q13033

F

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_9978

TAS: Traceable Author Statement

C

complete

GO:0005515

protein binding

PMID:18502210[16]

IPI: Inferred from Physical Interaction

UniProtKB:Q9NRL3

F

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_9983

TAS: Traceable Author Statement

C

complete

GO:0005515

protein binding

PMID:19632184[17]

IPI: Inferred from Physical Interaction

UniProtKB:Q15691

F

Seeded From UniProt

complete

GO:0005829

cytosol

Reactome:REACT_9987

TAS: Traceable Author Statement

C

complete

GO:0005515

protein binding

PMID:19632184[17]

IPI: Inferred from Physical Interaction

UniProtKB:Q15691

F

Seeded From UniProt

complete

GO:0005856

cytoskeleton

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0206

C

complete

GO:0005515

protein binding

PMID:20224554[29]

IPI: Inferred from Physical Interaction

UniProtKB:O14640

F

Seeded From UniProt

complete

GO:0005856

cytoskeleton

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0090

C

complete

GO:0005515

protein binding

PMID:20224554[29]

IPI: Inferred from Physical Interaction

UniProtKB:P54792

F

Seeded From UniProt

complete

GO:0005874

microtubule

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0493

C

complete

GO:0005515

protein binding

PMID:20936779[30]

IPI: Inferred from Physical Interaction

UniProtKB:P14923

F

Seeded From UniProt

complete

GO:0005874

microtubule

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000027691

C

complete

GO:0005515

protein binding

PMID:20936779[30]

IPI: Inferred from Physical Interaction

UniProtKB:P35221

F

Seeded From UniProt

complete

GO:0005881

cytoplasmic microtubule

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

C

complete

GO:0005515

protein binding

PMID:22128170[31]

IPI: Inferred from Physical Interaction

UniProtKB:Q8N7J2

F

Seeded From UniProt

complete

GO:0005886

plasma membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

complete

GO:0005515

protein binding

PMID:22682247[32]

IPI: Inferred from Physical Interaction

UniProtKB:P35222

F

Seeded From UniProt

complete

GO:0005886

plasma membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0039

C

complete

GO:0005515

protein binding

PMID:24251807[33]

IPI: Inferred from Physical Interaction

UniProtKB:Q8N944

F

Seeded From UniProt

complete

GO:0005886

plasma membrane

PMID:20937854[24]

IDA: Inferred from Direct Assay

C

complete

GO:0005515

protein binding

PMID:25241761[34]

IPI: Inferred from Physical Interaction

UniProtKB:P14923

F

Seeded From UniProt

complete

GO:0005912

adherens junction

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0009

C

complete

GO:0005515

protein binding

PMID:25241761[34]

IPI: Inferred from Physical Interaction

UniProtKB:P35221

F

Seeded From UniProt

complete

GO:0005923

tight junction

PMID:18502210[16]

IDA: Inferred from Direct Assay

C

complete

GO:0005515

protein binding

PMID:25241761[34]

IPI: Inferred from Physical Interaction

UniProtKB:P35222

F

Seeded From UniProt

complete

GO:0006461

protein complex assembly

PMID:16188939[35]

IDA: Inferred from Direct Assay

P

Figure 6 shows Neuroligin surface cluseters are decreased in dn- expressubg in CG neurons. Figure 6 also shows how APC works in unison with Beta-Cat and S-Scam to decrease NL sypnatic accumulation.

complete
CACAO 6384

GO:0005515

protein binding

PMID:25241761[34]

IPI: Inferred from Physical Interaction

UniProtKB:P49674

F

Seeded From UniProt

complete

GO:0006915

apoptosis

Reactome:REACT_578

TAS: Traceable Author Statement

P

complete

GO:0005515

protein binding

PMID:8638126[36]

IPI: Inferred from Physical Interaction

UniProtKB:P35222

F

Seeded From UniProt

complete

GO:0006921

cellular component disassembly involved in apoptosis

Reactome:REACT_995

TAS: Traceable Author Statement

P

complete

GO:0005515

protein binding

PMID:9601641[18]

IPI: Inferred from Physical Interaction

UniProtKB:O15169

F

Seeded From UniProt

complete

GO:0006974

response to DNA damage stimulus

PMID:14728717[37]

IDA: Inferred from Direct Assay

P

complete

GO:0005515

protein binding

PMID:9707618[38]

IPI: Inferred from Physical Interaction

UniProtKB:P35222

F

Seeded From UniProt

complete

GO:0007026

negative regulation of microtubule depolymerization

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR026836

C

Seeded From UniProt

complete

GO:0007026

negative regulation of microtubule depolymerization

PMID:11166179[39]

IDA: Inferred from Direct Assay

P

complete

GO:0005634

nucleus

PMID:11035805[19]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0007026

negative regulation of microtubule depolymerization

PMID:17192415[40]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0005634

nucleus

PMID:12072559[21]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0007050

cell cycle arrest

PMID:8521819[41]

IDA: Inferred from Direct Assay

P

complete

GO:0005634

nucleus

PMID:12955080[22]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0007091

mitotic metaphase/anaphase transition

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0005654

nucleoplasm

Reactome:REACT_263945

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0007094

mitotic cell cycle spindle assembly checkpoint

PMID:17227893[42]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0005654

nucleoplasm

Reactome:REACT_264360

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0007155

cell adhesion

PMID:8259518[43]

NAS: Non-traceable Author Statement

P

complete

GO:0005737

cytoplasm

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR026836

C

Seeded From UniProt

complete

GO:0007163

establishment or maintenance of cell polarity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000027691

P

complete

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

GO:0007389

pattern specification process

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0005737

cytoplasm

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

GO:0007409

axonogenesis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0005737

cytoplasm

PMID:11035805[19]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0008013

beta-catenin binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009224

F

complete

GO:0005737

cytoplasm

PMID:12955080[22]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0008013

beta-catenin binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009232

F

complete

GO:0005737

cytoplasm

PMID:20937854[24]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0008013

beta-catenin binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009240

F

complete

GO:0005813

centrosome

PMID:11283619[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0008013

beta-catenin binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

F

complete

GO:0005829

cytosol

Reactome:REACT_10111

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0008013

beta-catenin binding

PMID:10773885[44]

IPI: Inferred from Physical Interaction

UniProtKB:P35222

F

complete

GO:0005829

cytosol

Reactome:REACT_10127

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0008013

beta-catenin binding

PMID:11533658[45]

IPI: Inferred from Physical Interaction

UniProtKB:P35222

F

complete

GO:0005829

cytosol

Reactome:REACT_10134

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0008013

beta-catenin binding

PMID:7890674[46]

IPI: Inferred from Physical Interaction

UniProtKB:P35222

F

complete

GO:0005829

cytosol

Reactome:REACT_12012

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0008013

beta-catenin binding

PMID:9707618[38]

IPI: Inferred from Physical Interaction

UniProtKB:P35222

F

complete

GO:0005829

cytosol

Reactome:REACT_263921

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0008017

microtubule binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009234

F

complete

GO:0005829

cytosol

Reactome:REACT_263929

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0008017

microtubule binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000027691

F

complete

GO:0005829

cytosol

Reactome:REACT_263946

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0008017

microtubule binding

PMID:11166179[39]

IDA: Inferred from Direct Assay

F

complete

GO:0005829

cytosol

Reactome:REACT_264107

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0008017

microtubule binding

PMID:16188939[35]

IDA: Inferred from Direct Assay

F

complete

GO:0005829

cytosol

Reactome:REACT_264298

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0008285

negative regulation of cell proliferation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0005829

cytosol

Reactome:REACT_264345

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0008285

negative regulation of cell proliferation

PMID:8521819[41]

IDA: Inferred from Direct Assay

P

complete

GO:0005829

cytosol

Reactome:REACT_264369

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0009798

axis specification

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0005829

cytosol

Reactome:REACT_264453

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0009952

anterior/posterior pattern formation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0005829

cytosol

Reactome:REACT_264457

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0009953

dorsal/ventral pattern formation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0005829

cytosol

Reactome:REACT_264475

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0009954

proximal/distal pattern formation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0005829

cytosol

Reactome:REACT_264510

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

complete

GO:0005829

cytosol

Reactome:REACT_264576

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0016055

Wnt receptor signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009223

P

complete

GO:0005829

cytosol

Reactome:REACT_264628

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0016055

Wnt receptor signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009224

P

complete

GO:0005829

cytosol

Reactome:REACT_264632

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0016055

Wnt receptor signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009232

P

complete

GO:0005829

cytosol

Reactome:REACT_264639

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0016055

Wnt receptor signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009234

P

complete

GO:0005829

cytosol

Reactome:REACT_9955

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0016055

Wnt receptor signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009240

P

complete

GO:0005829

cytosol

Reactome:REACT_9959

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0016055

Wnt receptor signaling pathway

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0879

P

complete

GO:0005829

cytosol

Reactome:REACT_9978

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0016055

Wnt receptor signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0005829

cytosol

Reactome:REACT_9983

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0016328

lateral plasma membrane

PMID:12072559[21]

IDA: Inferred from Direct Assay

C

complete

GO:0005829

cytosol

Reactome:REACT_9987

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0016477

cell migration

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0005856

cytoskeleton

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

GO:0016477

cell migration

PMID:19151759[47]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0005856

cytoskeleton

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

GO:0019827

stem cell maintenance

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0005874

microtubule

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0493

C

Seeded From UniProt

complete

GO:0019887

protein kinase regulator activity

PMID:11972058[9]

IDA: Inferred from Direct Assay

F

complete

GO:0005881

cytoplasmic microtubule

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

C

Seeded From UniProt

complete

GO:0019901

protein kinase binding

PMID:8638126[36]

IPI: Inferred from Physical Interaction

UniProtKB:P49841

F

complete

GO:0005886

plasma membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-1003

C

Seeded From UniProt

complete

GO:0030027

lamellipodium

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0291

C

complete

GO:0005886

plasma membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

GO:0030027

lamellipodium

PMID:19151759[47]

IDA: Inferred from Direct Assay

C

complete

GO:0005886

plasma membrane

PMID:20937854[24]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0030054

cell junction

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0965

C

complete

GO:0005912

adherens junction

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0009

C

Seeded From UniProt

complete

GO:0030178

negative regulation of Wnt receptor signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0005923

bicellular tight junction

PMID:18502210[16]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0030334

regulation of cell migration

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0006461

protein complex assembly

PMID:16188939[35]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0030335

positive regulation of cell migration

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0006915

apoptotic process

Reactome:REACT_578

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0030335

positive regulation of cell migration

PMID:17192415[40]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0006921

cellular component disassembly involved in execution phase of apoptosis

Reactome:REACT_995

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0030426

growth cone

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

C

complete

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR026836

P

Seeded From UniProt

complete

GO:0030426

growth cone

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000027691

C

complete

GO:0006974

cellular response to DNA damage stimulus

PMID:14728717[37]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0030856

regulation of epithelial cell differentiation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0007026

negative regulation of microtubule depolymerization

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR026836

P

Seeded From UniProt

complete

GO:0030858

positive regulation of epithelial cell differentiation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0007026

negative regulation of microtubule depolymerization

PMID:11166179[39]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0030877

beta-catenin destruction complex

PMID:16188939[35]

IDA: Inferred from Direct Assay

C

complete

GO:0007026

negative regulation of microtubule depolymerization

PMID:17192415[40]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030877

beta-catenin destruction complex

PMID:9601641[18]

IDA: Inferred from Direct Assay

C

complete

GO:0007050

cell cycle arrest

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR026836

P

Seeded From UniProt

complete

GO:0031016

pancreas development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000027691

P

complete

GO:0007050

cell cycle arrest

PMID:8521819[41]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0031116

positive regulation of microtubule polymerization

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0007091

metaphase/anaphase transition of mitotic cell cycle

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0031122

cytoplasmic microtubule organization

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0007094

mitotic spindle assembly checkpoint

PMID:17227893[42]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0031175

neuron projection development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000027691

P

complete

GO:0007155

cell adhesion

PMID:8259518[43]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0031253

cell projection membrane

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

C

complete

GO:0007389

pattern specification process

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0031274

positive regulation of pseudopodium assembly

PMID:17192415[40]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0007409

axonogenesis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0032587

ruffle membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0301

C

complete

GO:0008013

beta-catenin binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009224
InterPro:IPR009232
InterPro:IPR009240
InterPro:IPR026818
InterPro:IPR026836

F

Seeded From UniProt

complete

GO:0032587

ruffle membrane

PMID:19151759[47]

IDA: Inferred from Direct Assay

C

complete

GO:0008013

beta-catenin binding

PMID:10773885[44]

IPI: Inferred from Physical Interaction

UniProtKB:P35222

F

Seeded From UniProt

complete

GO:0032886

regulation of microtubule-based process

PMID:20937854[24]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0008013

beta-catenin binding

PMID:11533658[45]

IPI: Inferred from Physical Interaction

UniProtKB:P35222

F

Seeded From UniProt

complete

GO:0033077

T cell differentiation in thymus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0008013

beta-catenin binding

PMID:7890674[46]

IPI: Inferred from Physical Interaction

UniProtKB:P35222

F

Seeded From UniProt

complete

GO:0033267

axon part

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

C

complete

GO:0008013

beta-catenin binding

PMID:9707618[38]

IPI: Inferred from Physical Interaction

UniProtKB:P35222

F

Seeded From UniProt

complete

GO:0034742

APC-Axin-1-beta-catenin complex

PMID:16188939[35]

IDA: Inferred from Direct Assay

C

complete

GO:0008017

microtubule binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009234

F

Seeded From UniProt

complete

GO:0034747

Axin-APC-beta-catenin-GSK3B complex

PMID:16188939[35]

IDA: Inferred from Direct Assay

C

complete

GO:0008017

microtubule binding

PMID:11166179[39]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0034747

Axin-APC-beta-catenin-GSK3B complex

PMID:8638126[36]

IDA: Inferred from Direct Assay

C

complete

GO:0008017

microtubule binding

PMID:16188939[35]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0035019

somatic stem cell maintenance

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0008285

negative regulation of cell proliferation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR026836

P

Seeded From UniProt

complete

GO:0035371

microtubule plus end

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

C

complete

GO:0008285

negative regulation of cell proliferation

PMID:8521819[41]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0042483

negative regulation of odontogenesis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0009798

axis specification

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0042493

response to drug

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000027691

P

complete

GO:0009952

anterior/posterior pattern specification

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0042981

regulation of apoptosis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0009953

dorsal/ventral pattern formation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0042995

cell projection

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0966

C

complete

GO:0009954

proximal/distal pattern formation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0042995

cell projection

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

C

complete

GO:0012501

programmed cell death

Reactome:REACT_268456

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0043005

neuron projection

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000027691

C

complete

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0043025

neuronal cell body

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000027691

C

complete

GO:0016055

Wnt signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009223
InterPro:IPR009224
InterPro:IPR009232
InterPro:IPR009234
InterPro:IPR009240

P

Seeded From UniProt

complete

GO:0043065

positive regulation of apoptosis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0016055

Wnt signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0043065

positive regulation of apoptosis

PMID:17227893[42]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0016055

Wnt signaling pathway

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0879

P

Seeded From UniProt

complete

GO:0043066

negative regulation of apoptosis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0016328

lateral plasma membrane

PMID:12072559[21]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0043409

negative regulation of MAPKKK cascade

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0016342

catenin complex

PMID:7806582[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0043588

skin development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0016477

cell migration

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR026836

P

Seeded From UniProt

complete

GO:0044295

axonal growth cone

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

C

complete

GO:0016477

cell migration

PMID:19151759[47]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045202

synapse

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000027691

C

complete

GO:0019827

stem cell maintenance

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0045295

gamma-catenin binding

PMID:7890674[46]

IPI: Inferred from Physical Interaction

UniProtKB:P14923

F

complete

GO:0019887

protein kinase regulator activity

PMID:11972058[9]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0045595

regulation of cell differentiation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0019901

protein kinase binding

PMID:8638126[36]

IPI: Inferred from Physical Interaction

UniProtKB:P49841

F

Seeded From UniProt

complete

GO:0045597

positive regulation of cell differentiation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0030027

lamellipodium

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0291

C

Seeded From UniProt

complete

GO:0045667

regulation of osteoblast differentiation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0030027

lamellipodium

PMID:19151759[47]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0045670

regulation of osteoclast differentiation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0030054

cell junction

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0965

C

Seeded From UniProt

complete

GO:0045732

positive regulation of protein catabolic process

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0030178

negative regulation of Wnt signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR026818
InterPro:IPR026836

P

Seeded From UniProt

complete

GO:0045732

positive regulation of protein catabolic process

PMID:12952940[48]

IGI: Inferred from Genetic Interaction

UniProtKB:O43255

P

complete

GO:0030178

negative regulation of Wnt signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0045732

positive regulation of protein catabolic process

PMID:12952940[48]

IGI: Inferred from Genetic Interaction

UniProtKB:P41221

P

complete

GO:0030334

regulation of cell migration

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0045732

positive regulation of protein catabolic process

PMID:16188939[35]

IC: Inferred by Curator

GO:0030877

P

complete

GO:0030335

positive regulation of cell migration

PMID:17192415[40]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045736

negative regulation of cyclin-dependent protein kinase activity

PMID:8521819[41]

IDA: Inferred from Direct Assay

P

complete

GO:0030424

axon

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

C

Seeded From UniProt

complete

GO:0045785

positive regulation of cell adhesion

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0046716

muscle cell homeostasis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0030426

growth cone

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

C

Seeded From UniProt

complete

GO:0048538

thymus development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0030856

regulation of epithelial cell differentiation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0050680

negative regulation of epithelial cell proliferation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0030858

positive regulation of epithelial cell differentiation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0051010

microtubule plus-end binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

F

complete

GO:0030877

beta-catenin destruction complex

PMID:16188939[35]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0051010

microtubule plus-end binding

PMID:19632184[17]

IDA: Inferred from Direct Assay

F

complete

GO:0030877

beta-catenin destruction complex

PMID:16188939[35]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0051171

regulation of nitrogen compound metabolic process

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0030877

beta-catenin destruction complex

PMID:8638126[36]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0051276

chromosome organization

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0030877

beta-catenin destruction complex

PMID:9601641[18]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0051726

regulation of cell cycle

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0031116

positive regulation of microtubule polymerization

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0051781

positive regulation of cell division

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0031122

cytoplasmic microtubule organization

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0051988

regulation of attachment of spindle microtubules to kinetochore

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0031253

cell projection membrane

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

C

Seeded From UniProt

complete

GO:0051988

regulation of attachment of spindle microtubules to kinetochore

PMID:11283619[2]

NAS: Non-traceable Author Statement

P

complete

GO:0031274

positive regulation of pseudopodium assembly

PMID:17192415[40]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0051988

regulation of attachment of spindle microtubules to kinetochore

PMID:17227893[42]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0032587

ruffle membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0301

C

Seeded From UniProt

complete

GO:0060041

retina development in camera-type eye

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0032587

ruffle membrane

PMID:19151759[47]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0060070

canonical Wnt receptor signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0032886

regulation of microtubule-based process

PMID:20937854[24]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0060070

canonical Wnt receptor signaling pathway

PMID:11035805[19]

NAS: Non-traceable Author Statement

P

complete

GO:0033077

T cell differentiation in thymus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0060070

canonical Wnt receptor signaling pathway

PMID:9601641[18]

IC: Inferred by Curator

GO:0030877

P

complete

GO:0035019

somatic stem cell maintenance

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0060770

negative regulation of epithelial cell proliferation involved in prostate gland development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

complete

GO:0035371

microtubule plus-end

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

C

Seeded From UniProt

complete

GO:0070830

tight junction assembly

PMID:18502210[16]

NAS: Non-traceable Author Statement

P

complete

GO:0042483

negative regulation of odontogenesis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0090090

negative regulation of canonical Wnt receptor signaling pathway

PMID:12952940[48]

IGI: Inferred from Genetic Interaction

UniProtKB:O43255

P

complete

GO:0042995

cell projection

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

C

Seeded From UniProt

complete

GO:0090090

negative regulation of canonical Wnt receptor signaling pathway

PMID:12952940[48]

IGI: Inferred from Genetic Interaction

UniProtKB:P41221

P

complete

GO:0042995

cell projection

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0966

C

Seeded From UniProt

complete

NOT

GO:0045296

cadherin binding

PMID:7890674[46]

IDA: Inferred from Direct Assay

F

complete

GO:0043065

positive regulation of apoptotic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR026836

P

Seeded From UniProt

complete

colocalizes_with

GO:0005886

plasma membrane

PMID:16611247[11]

IDA: Inferred from Direct Assay

C

complete

GO:0043065

positive regulation of apoptotic process

PMID:17227893[42]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

colocalizes_with

GO:0005913

cell-cell adherens junction

PMID:16611247[11]

IDA: Inferred from Direct Assay

C

complete

GO:0043066

negative regulation of apoptotic process

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0043409

negative regulation of MAPK cascade

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0043588

skin development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0044295

axonal growth cone

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

C

Seeded From UniProt

complete

GO:0044336

canonical Wnt signaling pathway involved in negative regulation of apoptotic process

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0044337

canonical Wnt signaling pathway involved in positive regulation of apoptotic process

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0045295

gamma-catenin binding

PMID:7890674[46]

IPI: Inferred from Physical Interaction

UniProtKB:P14923

F

Seeded From UniProt

complete

GO:0045595

regulation of cell differentiation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0045597

positive regulation of cell differentiation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0045667

regulation of osteoblast differentiation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0045670

regulation of osteoclast differentiation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0045732

positive regulation of protein catabolic process

PMID:12952940[48]

IGI: Inferred from Genetic Interaction

UniProtKB:O43255

P

Seeded From UniProt

complete

GO:0045732

positive regulation of protein catabolic process

PMID:12952940[48]

IGI: Inferred from Genetic Interaction

UniProtKB:P41221

P

Seeded From UniProt

complete

GO:0045732

positive regulation of protein catabolic process

PMID:16188939[35]

IC: Inferred by Curator

GO:0030877

P

Seeded From UniProt

complete

GO:0045736

negative regulation of cyclin-dependent protein serine/threonine kinase activity

PMID:8521819[41]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0045785

positive regulation of cell adhesion

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0046716

muscle cell cellular homeostasis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0048538

thymus development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0050680

negative regulation of epithelial cell proliferation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0051010

microtubule plus-end binding

PMID:19632184[17]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0051171

regulation of nitrogen compound metabolic process

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0051276

chromosome organization

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0051726

regulation of cell cycle

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0051781

positive regulation of cell division

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0051988

regulation of attachment of spindle microtubules to kinetochore

PMID:11283619[2]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0051988

regulation of attachment of spindle microtubules to kinetochore

PMID:17227893[42]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0060041

retina development in camera-type eye

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0060070

canonical Wnt signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0060070

canonical Wnt signaling pathway

PMID:11035805[19]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0060070

canonical Wnt signaling pathway

PMID:9601641[18]

IC: Inferred by Curator

GO:0030877

P

Seeded From UniProt

complete

GO:0060770

negative regulation of epithelial cell proliferation involved in prostate gland development

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000078337

P

Seeded From UniProt

complete

GO:0070830

bicellular tight junction assembly

PMID:18502210[16]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0090090

negative regulation of canonical Wnt signaling pathway

PMID:12952940[48]

IGI: Inferred from Genetic Interaction

UniProtKB:O43255

P

Seeded From UniProt

complete

GO:0090090

negative regulation of canonical Wnt signaling pathway

PMID:12952940[48]

IGI: Inferred from Genetic Interaction

UniProtKB:P41221

P

Seeded From UniProt

complete

GO:0090263

positive regulation of canonical Wnt signaling pathway

Reactome:REACT_264034

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

NOT

GO:0045296

cadherin binding

PMID:7890674[46]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

colocalizes_with

GO:0005886

plasma membrane

PMID:16611247[11]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

colocalizes_with

GO:0005913

cell-cell adherens junction

PMID:16611247[11]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Abal, M et al. (2007) APC inactivation associates with abnormal mitosis completion and concomitant BUB1B/MAD2L1 up-regulation. Gastroenterology 132 2448-58 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Kaplan, KB et al. (2001) A role for the Adenomatous Polyposis Coli protein in chromosome segregation. Nat. Cell Biol. 3 429-32 PubMed GONUTS page
  3. Dikovskaya, D et al. (2012) The adenomatous polyposis coli protein contributes to normal compaction of mitotic chromatin. PLoS ONE 7 e38102 PubMed GONUTS page
  4. 4.0 4.1 Ishidate, T et al. (2000) The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase. Oncogene 19 365-72 PubMed GONUTS page
  5. 5.0 5.1 Hülsken, J et al. (1994) E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. J. Cell Biol. 127 2061-9 PubMed GONUTS page
  6. 6.0 6.1 Kawasaki, Y et al. (2000) Asef, a link between the tumor suppressor APC and G-protein signaling. Science 289 1194-7 PubMed GONUTS page
  7. 7.0 7.1 Liu, J et al. (2001) Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein. Mol. Cell 7 927-36 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 Nakamura, M et al. (2002) Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle. FEBS Lett. 514 193-8 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 9.4 9.5 Homma, MK et al. (2002) Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein. Proc. Natl. Acad. Sci. U.S.A. 99 5959-64 PubMed GONUTS page
  10. 10.0 10.1 10.2 Ha, NC et al. (2004) Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation. Mol. Cell 15 511-21 PubMed GONUTS page
  11. 11.0 11.1 11.2 11.3 11.4 11.5 11.6 Takizawa, S et al. (2006) Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli. Genes Cells 11 453-64 PubMed GONUTS page
  12. 12.0 12.1 Xu, Y et al. (2007) Modeling of a human circadian mutation yields insights into clock regulation by PER2. Cell 128 59-70 PubMed GONUTS page
  13. 13.0 13.1 Kurzik-Dumke, U & Czaja, J (2007) Htid-1, the human homolog of the Drosophila melanogaster l(2)tid tumor suppressor, defines a novel physiological role of APC. Cell. Signal. 19 1973-85 PubMed GONUTS page
  14. 14.0 14.1 Kawasaki, Y et al. (2007) Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42. Oncogene 26 7620-267 PubMed GONUTS page
  15. 15.0 15.1 Tran, H et al. (2008) Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains. Genes Dev. 22 528-42 PubMed GONUTS page
  16. 16.0 16.1 16.2 16.3 16.4 16.5 16.6 16.7 16.8 16.9 Breitman, M et al. (2008) The armadillo repeat domain of the APC tumor suppressor protein interacts with Striatin family members. Biochim. Biophys. Acta 1783 1792-802 PubMed GONUTS page
  17. 17.0 17.1 17.2 17.3 17.4 Honnappa, S et al. (2009) An EB1-binding motif acts as a microtubule tip localization signal. Cell 138 366-76 PubMed GONUTS page
  18. 18.0 18.1 18.2 18.3 18.4 18.5 Hart, MJ et al. (1998) Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta. Curr. Biol. 8 573-81 PubMed GONUTS page
  19. 19.0 19.1 19.2 19.3 19.4 19.5 Neufeld, KL et al. (2000) Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm. Proc. Natl. Acad. Sci. U.S.A. 97 12085-90 PubMed GONUTS page
  20. 20.0 20.1 Kishida, M et al. (2001) Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase Iepsilon. J. Biol. Chem. 276 33147-55 PubMed GONUTS page
  21. 21.0 21.1 21.2 21.3 Anderson, CB et al. (2002) Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon. Proc. Natl. Acad. Sci. U.S.A. 99 8683-8 PubMed GONUTS page
  22. 22.0 22.1 22.2 22.3 Fagman, H et al. (2003) Nuclear accumulation of full-length and truncated adenomatous polyposis coli protein in tumor cells depends on proliferation. Oncogene 22 6013-22 PubMed GONUTS page
  23. Xing, Y et al. (2004) Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function. Mol. Cell 15 523-33 PubMed GONUTS page
  24. 24.0 24.1 24.2 24.3 24.4 24.5 Zaoui, K et al. (2010) ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells. Proc. Natl. Acad. Sci. U.S.A. 107 18517-22 PubMed GONUTS page
  25. Catimel, B et al. () Biosensor-based micro-affinity purification for the proteomic analysis of protein complexes. J. Proteome Res. 4 1646-56 PubMed GONUTS page
  26. Choi, HJ et al. (2006) Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity. J. Biol. Chem. 281 1027-38 PubMed GONUTS page
  27. Coluccia, AM et al. (2007) Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation. EMBO J. 26 1456-66 PubMed GONUTS page
  28. Grohmann, A et al. (2007) AMER1 regulates the distribution of the tumor suppressor APC between microtubules and the plasma membrane. J. Cell. Sci. 120 3738-47 PubMed GONUTS page
  29. 29.0 29.1 Matsumoto, S et al. (2010) Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells. EMBO J. 29 1192-204 PubMed GONUTS page
  30. 30.0 30.1 Bandyopadhyay, S et al. (2010) A human MAP kinase interactome. Nat. Methods 7 801-5 PubMed GONUTS page
  31. Pfister, AS et al. (2012) Amer2 protein is a novel negative regulator of Wnt/β-catenin signaling involved in neuroectodermal patterning. J. Biol. Chem. 287 1734-41 PubMed GONUTS page
  32. Li, VS et al. (2012) Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex. Cell 149 1245-56 PubMed GONUTS page
  33. Brauburger, K et al. (2014) Adenomatous polyposis coli (APC) membrane recruitment 3, a member of the APC membrane recruitment family of APC-binding proteins, is a positive regulator of Wnt-β-catenin signalling. FEBS J. 281 787-801 PubMed GONUTS page
  34. 34.0 34.1 34.2 34.3 Chen, TC et al. (2014) Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J. Proteome Res. 13 5339-46 PubMed GONUTS page
  35. 35.00 35.01 35.02 35.03 35.04 35.05 35.06 35.07 35.08 35.09 35.10 Penman, GA et al. (2005) The adenomatous polyposis coli protein (APC) exists in two distinct soluble complexes with different functions. J. Cell. Sci. 118 4741-50 PubMed GONUTS page
  36. 36.0 36.1 36.2 36.3 36.4 Rubinfeld, B et al. (1996) Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. Science 272 1023-6 PubMed GONUTS page
  37. 37.0 37.1 Jaiswal, AS et al. (2004) N-methyl-N'-nitro-N-nitrosoguanidine-induced senescence-like growth arrest in colon cancer cells is associated with loss of adenomatous polyposis coli protein, microtubule organization, and telomeric DNA. Mol. Cancer 3 3 PubMed GONUTS page
  38. 38.0 38.1 38.2 Tanaka, S et al. (1998) A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. Proc. Natl. Acad. Sci. U.S.A. 95 10164-9 PubMed GONUTS page
  39. 39.0 39.1 39.2 39.3 Zumbrunn, J et al. (2001) Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation. Curr. Biol. 11 44-9 PubMed GONUTS page
  40. 40.0 40.1 40.2 40.3 40.4 40.5 Kroboth, K et al. (2007) Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability. Mol. Biol. Cell 18 910-8 PubMed GONUTS page
  41. 41.0 41.1 41.2 41.3 41.4 41.5 Baeg, GH et al. (1995) The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase. EMBO J. 14 5618-25 PubMed GONUTS page
  42. 42.0 42.1 42.2 42.3 42.4 42.5 Dikovskaya, D et al. (2007) Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. J. Cell Biol. 176 183-95 PubMed GONUTS page
  43. 43.0 43.1 Rubinfeld, B et al. (1993) Association of the APC gene product with beta-catenin. Science 262 1731-4 PubMed GONUTS page
  44. 44.0 44.1 Askham, JM et al. (2000) Regulation and function of the interaction between the APC tumour suppressor protein and EB1. Oncogene 19 1950-8 PubMed GONUTS page
  45. 45.0 45.1 Ryo, A et al. (2001) Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC. Nat. Cell Biol. 3 793-801 PubMed GONUTS page
  46. 46.0 46.1 46.2 46.3 46.4 46.5 Rubinfeld, B et al. (1995) The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin. J. Biol. Chem. 270 5549-55 PubMed GONUTS page
  47. 47.0 47.1 47.2 47.3 47.4 47.5 Sagara, M et al. (2009) Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration. Oncogene 28 1357-65 PubMed GONUTS page
  48. 48.0 48.1 48.2 48.3 48.4 48.5 48.6 48.7 Topol, L et al. (2003) Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation. J. Cell Biol. 162 899-908 PubMed GONUTS page