HUMAN:APC

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	APC ( synonyms: DP2.5 )
Protein Name(s)	Adenomatous polyposis coli protein Protein APC Deleted in polyposis 2.5
External Links
UniProt Identifier	APC_HUMAN
UniProt Accessions	P25054, D3DT03, Q15162, Q15163, Q93042,
EMBL	M73548, M73548, M74088, CH471086, CH471086, S78214,
PIR	A37261,
RefSeq	NP_000029.2, NP_001120982.1,
PDB	1DEB, 1EMU, 1JPP, 1M5I, 1T08, 1TH1, 1V18, 2RQU,
IntAct	P25054,
Ensembl	ENST00000257430, ENST00000395617, ENST00000457016,
Pfam	PF05972, PF05956, PF05923, PF00514, PF05937, PF05924,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000281	cytokinesis after mitosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0000281	cytokinesis after mitosis	PMID:17570218^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0000776	kinetochore	PMID:11283619^[2]	IDA: Inferred from Direct Assay		C
	GO:0001822	kidney development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0001942	hair follicle development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0005488	binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011989	F
	GO:0005488	binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016024	F
	GO:0005515	protein binding	PMID:10656683^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q12959	F
	GO:0005515	protein binding	PMID:10947987^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NR80	F
	GO:0005515	protein binding	PMID:11283619^[2]	IPI: Inferred from Physical Interaction	UniProtKB:O43684	F
	GO:0005515	protein binding	PMID:11389840^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q8IUQ4	F
	GO:0005515	protein binding	PMID:11943150^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q15691	F
	GO:0005515	protein binding	PMID:11943150^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q15691	F
	GO:0005515	protein binding	PMID:11972058^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P19784	F
	GO:0005515	protein binding	PMID:11972058^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P68400	F
	GO:0005515	protein binding	PMID:15327768^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q02248	F
	GO:0005515	protein binding	PMID:16611247^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q14160	F
	GO:0005515	protein binding	PMID:17218255^[10]	IPI: Inferred from Physical Interaction	UniProtKB:P49674	F
	GO:0005515	protein binding	PMID:17588722^[11]	IPI: Inferred from Physical Interaction	UniProtKB:Q96EY1	F
	GO:0005515	protein binding	PMID:17599059^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q96N96	F
	GO:0005515	protein binding	PMID:18281465^[13]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UGI0	F
	GO:0005515	protein binding	PMID:18502210^[14]	IPI: Inferred from Physical Interaction	UniProtKB:O43815	F
	GO:0005515	protein binding	PMID:18502210^[14]	IPI: Inferred from Physical Interaction	UniProtKB:Q13033	F
	GO:0005515	protein binding	PMID:18502210^[14]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NRL3	F
	GO:0005515	protein binding	PMID:19632184^[15]	IPI: Inferred from Physical Interaction	UniProtKB:Q15691	F
	GO:0005515	protein binding	PMID:9601641^[16]	IPI: Inferred from Physical Interaction	UniProtKB:O15169	F
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	C
	GO:0005634	nucleus	PMID:11035805^[17]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:12072559^[18]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:12955080^[19]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	C
	GO:0005737	cytoplasm	PMID:11035805^[17]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	PMID:12955080^[19]	IDA: Inferred from Direct Assay		C
	GO:0005813	centrosome	PMID:11283619^[2]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	PMID:11955436^[20]	EXP: Inferred from Experiment		C
	GO:0005829	cytosol	PMID:12000790^[21]	EXP: Inferred from Experiment		C
	GO:0005829	cytosol	PMID:12820959^[22]	EXP: Inferred from Experiment		C
	GO:0005829	cytosol	PMID:15327769^[23]	EXP: Inferred from Experiment		C
	GO:0005829	cytosol	PMID:16753179^[24]	EXP: Inferred from Experiment		C
	GO:0005829	cytosol	Reactome:REACT_10134	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_12012	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_9977	TAS: Traceable Author Statement		C
	GO:0005856	cytoskeleton	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0206	C
	GO:0005856	cytoskeleton	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0090	C
	GO:0005874	microtubule	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0493	C
	GO:0005874	microtubule	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000027691	C
	GO:0005881	cytoplasmic microtubule	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	C
	GO:0005912	adherens junction	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0009	C
	GO:0005923	tight junction	PMID:18502210^[14]	IDA: Inferred from Direct Assay		C
	GO:0006461	protein complex assembly	PMID:16188939^[25]	IDA: Inferred from Direct Assay		P
	GO:0006915	apoptosis	Reactome:REACT_578	TAS: Traceable Author Statement		P
	GO:0006921	cellular component disassembly involved in apoptosis	Reactome:REACT_995	TAS: Traceable Author Statement		P
	GO:0006974	response to DNA damage stimulus	PMID:14728717^[26]	IDA: Inferred from Direct Assay		P
	GO:0007026	negative regulation of microtubule depolymerization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0007026	negative regulation of microtubule depolymerization	PMID:11166179^[27]	IDA: Inferred from Direct Assay		P
	GO:0007026	negative regulation of microtubule depolymerization	PMID:17192415^[28]	IMP: Inferred from Mutant Phenotype		P
	GO:0007050	cell cycle arrest	PMID:8521819^[29]	IDA: Inferred from Direct Assay		P
	GO:0007091	mitotic metaphase/anaphase transition	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0007094	mitotic cell cycle spindle assembly checkpoint	PMID:17227893^[30]	IMP: Inferred from Mutant Phenotype		P
	GO:0007155	cell adhesion	PMID:8259518^[31]	NAS: Non-traceable Author Statement		P
	GO:0007163	establishment or maintenance of cell polarity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000027691	P
	GO:0007389	pattern specification process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0007409	axonogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0008013	beta-catenin binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009224	F
	GO:0008013	beta-catenin binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009232	F
	GO:0008013	beta-catenin binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009240	F
	GO:0008013	beta-catenin binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	F
	GO:0008013	beta-catenin binding	PMID:10773885^[32]	IPI: Inferred from Physical Interaction	UniProtKB:P35222	F
	GO:0008013	beta-catenin binding	PMID:11533658^[33]	IPI: Inferred from Physical Interaction	UniProtKB:P35222	F
	GO:0008013	beta-catenin binding	PMID:7890674^[34]	IPI: Inferred from Physical Interaction	UniProtKB:P35222	F
	GO:0008013	beta-catenin binding	PMID:9707618^[35]	IPI: Inferred from Physical Interaction	UniProtKB:P35222	F
	GO:0008017	microtubule binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009234	F
	GO:0008017	microtubule binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000027691	F
	GO:0008017	microtubule binding	PMID:11166179^[27]	IDA: Inferred from Direct Assay		F
	GO:0008017	microtubule binding	PMID:16188939^[25]	IDA: Inferred from Direct Assay		F
	GO:0008285	negative regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0008285	negative regulation of cell proliferation	PMID:8521819^[29]	IDA: Inferred from Direct Assay		P
	GO:0009798	axis specification	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0009952	anterior/posterior pattern formation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0009953	dorsal/ventral pattern formation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0009954	proximal/distal pattern formation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009223	P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009224	P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009232	P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009234	P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009240	P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0879	P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0016328	lateral plasma membrane	PMID:12072559^[18]	IDA: Inferred from Direct Assay		C
	GO:0016477	cell migration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0016477	cell migration	PMID:19151759^[36]	IMP: Inferred from Mutant Phenotype		P
	GO:0019827	stem cell maintenance	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0019887	protein kinase regulator activity	PMID:11972058^[7]	IDA: Inferred from Direct Assay		F
	GO:0019901	protein kinase binding	PMID:8638126^[37]	IPI: Inferred from Physical Interaction	UniProtKB:P49841	F
	GO:0030027	lamellipodium	PMID:19151759^[36]	IDA: Inferred from Direct Assay		C
	GO:0030054	cell junction	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0965	C
	GO:0030178	negative regulation of Wnt receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0030334	regulation of cell migration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0030335	positive regulation of cell migration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0030335	positive regulation of cell migration	PMID:17192415^[28]	IMP: Inferred from Mutant Phenotype		P
	GO:0030426	growth cone	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	C
	GO:0030426	growth cone	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000027691	C
	GO:0030856	regulation of epithelial cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0030858	positive regulation of epithelial cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0030877	beta-catenin destruction complex	PMID:16188939^[25]	IDA: Inferred from Direct Assay		C
	GO:0030877	beta-catenin destruction complex	PMID:9601641^[16]	IDA: Inferred from Direct Assay		C
	GO:0031016	pancreas development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000027691	P
	GO:0031116	positive regulation of microtubule polymerization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0031122	cytoplasmic microtubule organization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0031175	neuron projection development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000027691	P
	GO:0031253	cell projection membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	C
	GO:0031274	positive regulation of pseudopodium assembly	PMID:17192415^[28]	IMP: Inferred from Mutant Phenotype		P
	GO:0032587	ruffle membrane	PMID:19151759^[36]	IDA: Inferred from Direct Assay		C
	GO:0033077	T cell differentiation in thymus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0033267	axon part	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	C
	GO:0034742	APC-Axin-1-beta-catenin complex	PMID:16188939^[25]	IDA: Inferred from Direct Assay		C
	GO:0034747	Axin-APC-beta-catenin-GSK3B complex	PMID:16188939^[25]	IDA: Inferred from Direct Assay		C
	GO:0034747	Axin-APC-beta-catenin-GSK3B complex	PMID:8638126^[37]	IDA: Inferred from Direct Assay		C
	GO:0034750	Scrib-APC-beta-catenin complex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	C
	GO:0035019	somatic stem cell maintenance	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0035371	microtubule plus end	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	C
	GO:0042483	negative regulation of odontogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0042493	response to drug	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000027691	P
	GO:0042981	regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0042995	cell projection	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	C
	GO:0043005	neuron projection	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000027691	C
	GO:0043025	neuronal cell body	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000027691	C
	GO:0043065	positive regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0043065	positive regulation of apoptosis	PMID:17227893^[30]	IMP: Inferred from Mutant Phenotype		P
	GO:0043066	negative regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0043409	negative regulation of MAPKKK cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0043588	skin development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0044295	axonal growth cone	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	C
	GO:0045202	synapse	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000027691	C
	GO:0045295	gamma-catenin binding	PMID:7890674^[34]	IPI: Inferred from Physical Interaction	UniProtKB:P14923	F
	GO:0045595	regulation of cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0045597	positive regulation of cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0045667	regulation of osteoblast differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0045670	regulation of osteoclast differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0045732	positive regulation of protein catabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0045732	positive regulation of protein catabolic process	PMID:12952940^[38]	IGI: Inferred from Genetic Interaction	UniProtKB:O43255	P
	GO:0045732	positive regulation of protein catabolic process	PMID:12952940^[38]	IGI: Inferred from Genetic Interaction	UniProtKB:P41221	P
	GO:0045732	positive regulation of protein catabolic process	PMID:16188939^[25]	IC: Inferred by Curator	GO:0030877	P
	GO:0045736	negative regulation of cyclin-dependent protein kinase activity	PMID:8521819^[29]	IDA: Inferred from Direct Assay		P
	GO:0045785	positive regulation of cell adhesion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0046716	muscle cell homeostasis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0048538	thymus development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0051010	microtubule plus-end binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	F
	GO:0051010	microtubule plus-end binding	PMID:19632184^[15]	IDA: Inferred from Direct Assay		F
	GO:0051171	regulation of nitrogen compound metabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0051276	chromosome organization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0051726	regulation of cell cycle	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0051781	positive regulation of cell division	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0051988	regulation of attachment of spindle microtubules to kinetochore	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0051988	regulation of attachment of spindle microtubules to kinetochore	PMID:11283619^[2]	NAS: Non-traceable Author Statement		P
	GO:0051988	regulation of attachment of spindle microtubules to kinetochore	PMID:17227893^[30]	IMP: Inferred from Mutant Phenotype		P
	GO:0060041	retina development in camera-type eye	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0060070	canonical Wnt receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0060070	canonical Wnt receptor signaling pathway	PMID:11035805^[17]	NAS: Non-traceable Author Statement		P
	GO:0060070	canonical Wnt receptor signaling pathway	PMID:9601641^[16]	IC: Inferred by Curator	GO:0030877	P
	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0070830	tight junction assembly	PMID:18502210^[14]	NAS: Non-traceable Author Statement		P
	GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	PMID:12952940^[38]	IGI: Inferred from Genetic Interaction	UniProtKB:O43255	P
	GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	PMID:12952940^[38]	IGI: Inferred from Genetic Interaction	UniProtKB:P41221	P
	GO:0045296	cadherin binding	PMID:7890674^[34]	IDA: Inferred from Direct Assay		F
	GO:0005886	plasma membrane	PMID:16611247^[9]	IDA: Inferred from Direct Assay		C
	GO:0005913	cell-cell adherens junction	PMID:16611247^[9]	IDA: Inferred from Direct Assay		C
	GO:0000281	cytokinesis after mitosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0000281	cytokinesis after mitosis	PMID:17570218^[1]	IMP: Inferred from Mutant Phenotype		P
	GO:0000776	kinetochore	PMID:11283619^[2]	IDA: Inferred from Direct Assay		C
	GO:0001822	kidney development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0001942	hair follicle development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0005488	binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011989	F
	GO:0005488	binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016024	F
	GO:0005515	protein binding	PMID:10656683^[3]	IPI: Inferred from Physical Interaction	UniProtKB:Q12959	F
	GO:0016342	catenin complex	PMID:7806582^[39]	IDA: Inferred from Direct Assay		C	Fig 5c lane 2 shows bindig of alpha catenin and formation of a catenin complex	complete
	GO:0005515	protein binding	PMID:10947987^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NR80	F
	GO:0005515	protein binding	PMID:11283619^[2]	IPI: Inferred from Physical Interaction	UniProtKB:O43684	F
	GO:0005515	protein binding	PMID:11389840^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q8IUQ4	F
	GO:0005515	protein binding	PMID:11943150^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q15691	F
	GO:0005515	protein binding	PMID:11943150^[6]	IPI: Inferred from Physical Interaction	UniProtKB:Q15691	F
	GO:0005515	protein binding	PMID:11972058^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P19784	F
	GO:0005515	protein binding	PMID:11972058^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P68400	F
	GO:0005515	protein binding	PMID:15327768^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q02248	F
	GO:0005515	protein binding	PMID:16611247^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q14160	F
	GO:0005515	protein binding	PMID:17218255^[10]	IPI: Inferred from Physical Interaction	UniProtKB:P49674	F
	GO:0005515	protein binding	PMID:17588722^[11]	IPI: Inferred from Physical Interaction	UniProtKB:Q96EY1	F
	GO:0005515	protein binding	PMID:17599059^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q96N96	F
	GO:0005515	protein binding	PMID:18281465^[13]	IPI: Inferred from Physical Interaction	UniProtKB:Q9UGI0	F
	GO:0005515	protein binding	PMID:18502210^[14]	IPI: Inferred from Physical Interaction	UniProtKB:O43815	F
	GO:0005515	protein binding	PMID:18502210^[14]	IPI: Inferred from Physical Interaction	UniProtKB:Q13033	F
	GO:0005515	protein binding	PMID:18502210^[14]	IPI: Inferred from Physical Interaction	UniProtKB:Q9NRL3	F
	GO:0005515	protein binding	PMID:19632184^[15]	IPI: Inferred from Physical Interaction	UniProtKB:Q15691	F
	GO:0005515	protein binding	PMID:9601641^[16]	IPI: Inferred from Physical Interaction	UniProtKB:O15169	F
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	C
	GO:0005634	nucleus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000027691	C
	GO:0005634	nucleus	PMID:11035805^[17]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:12072559^[18]	IDA: Inferred from Direct Assay		C
	GO:0005634	nucleus	PMID:12955080^[19]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000027691	C
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C
	GO:0005737	cytoplasm	PMID:11035805^[17]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	PMID:12955080^[19]	IDA: Inferred from Direct Assay		C
	GO:0005737	cytoplasm	PMID:20937854^[40]	IDA: Inferred from Direct Assay		C
	GO:0005813	centrosome	PMID:11283619^[2]	IDA: Inferred from Direct Assay		C
	GO:0005829	cytosol	Reactome:REACT_10017	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_10082	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_10111	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_10127	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_10134	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_12012	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_9955	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_9959	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_9977	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_9978	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_9983	TAS: Traceable Author Statement		C
	GO:0005829	cytosol	Reactome:REACT_9987	TAS: Traceable Author Statement		C
	GO:0005856	cytoskeleton	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0206	C
	GO:0005856	cytoskeleton	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0090	C
	GO:0005874	microtubule	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0493	C
	GO:0005874	microtubule	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000027691	C
	GO:0005881	cytoplasmic microtubule	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	C
	GO:0005886	plasma membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C
	GO:0005886	plasma membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0039	C
	GO:0005886	plasma membrane	PMID:20937854^[40]	IDA: Inferred from Direct Assay		C
	GO:0005912	adherens junction	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0009	C
	GO:0005923	tight junction	PMID:18502210^[14]	IDA: Inferred from Direct Assay		C
	GO:0006461	protein complex assembly	PMID:16188939^[25]	IDA: Inferred from Direct Assay		P
	GO:0006915	apoptosis	Reactome:REACT_578	TAS: Traceable Author Statement		P
	GO:0006921	cellular component disassembly involved in apoptosis	Reactome:REACT_995	TAS: Traceable Author Statement		P
	GO:0006974	response to DNA damage stimulus	PMID:14728717^[26]	IDA: Inferred from Direct Assay		P
	GO:0007026	negative regulation of microtubule depolymerization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0007026	negative regulation of microtubule depolymerization	PMID:11166179^[27]	IDA: Inferred from Direct Assay		P
	GO:0007026	negative regulation of microtubule depolymerization	PMID:17192415^[28]	IMP: Inferred from Mutant Phenotype		P
	GO:0007050	cell cycle arrest	PMID:8521819^[29]	IDA: Inferred from Direct Assay		P
	GO:0007091	mitotic metaphase/anaphase transition	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0007094	mitotic cell cycle spindle assembly checkpoint	PMID:17227893^[30]	IMP: Inferred from Mutant Phenotype		P
	GO:0007155	cell adhesion	PMID:8259518^[31]	NAS: Non-traceable Author Statement		P
	GO:0007163	establishment or maintenance of cell polarity	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000027691	P
	GO:0007389	pattern specification process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0007409	axonogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0008013	beta-catenin binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009224	F
	GO:0008013	beta-catenin binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009232	F
	GO:0008013	beta-catenin binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009240	F
	GO:0008013	beta-catenin binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	F
	GO:0008013	beta-catenin binding	PMID:10773885^[32]	IPI: Inferred from Physical Interaction	UniProtKB:P35222	F
	GO:0008013	beta-catenin binding	PMID:11533658^[33]	IPI: Inferred from Physical Interaction	UniProtKB:P35222	F
	GO:0008013	beta-catenin binding	PMID:7890674^[34]	IPI: Inferred from Physical Interaction	UniProtKB:P35222	F
	GO:0008013	beta-catenin binding	PMID:9707618^[35]	IPI: Inferred from Physical Interaction	UniProtKB:P35222	F
	GO:0008017	microtubule binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009234	F
	GO:0008017	microtubule binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000027691	F
	GO:0008017	microtubule binding	PMID:11166179^[27]	IDA: Inferred from Direct Assay		F
	GO:0008017	microtubule binding	PMID:16188939^[25]	IDA: Inferred from Direct Assay		F
	GO:0008285	negative regulation of cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0008285	negative regulation of cell proliferation	PMID:8521819^[29]	IDA: Inferred from Direct Assay		P
	GO:0009798	axis specification	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0009952	anterior/posterior pattern formation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0009953	dorsal/ventral pattern formation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0009954	proximal/distal pattern formation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009223	P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009224	P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009232	P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009234	P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR009240	P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0879	P
	GO:0016055	Wnt receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0016328	lateral plasma membrane	PMID:12072559^[18]	IDA: Inferred from Direct Assay		C
	GO:0016477	cell migration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0016477	cell migration	PMID:19151759^[36]	IMP: Inferred from Mutant Phenotype		P
	GO:0019827	stem cell maintenance	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0019887	protein kinase regulator activity	PMID:11972058^[7]	IDA: Inferred from Direct Assay		F
	GO:0019901	protein kinase binding	PMID:8638126^[37]	IPI: Inferred from Physical Interaction	UniProtKB:P49841	F
	GO:0030027	lamellipodium	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0291	C
	GO:0030027	lamellipodium	PMID:19151759^[36]	IDA: Inferred from Direct Assay		C
	GO:0030054	cell junction	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0965	C
	GO:0030178	negative regulation of Wnt receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0030334	regulation of cell migration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0030335	positive regulation of cell migration	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0030335	positive regulation of cell migration	PMID:17192415^[28]	IMP: Inferred from Mutant Phenotype		P
	GO:0030426	growth cone	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	C
	GO:0030426	growth cone	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000027691	C
	GO:0030856	regulation of epithelial cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0030858	positive regulation of epithelial cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0030877	beta-catenin destruction complex	PMID:16188939^[25]	IDA: Inferred from Direct Assay		C
	GO:0030877	beta-catenin destruction complex	PMID:9601641^[16]	IDA: Inferred from Direct Assay		C
	GO:0031016	pancreas development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000027691	P
	GO:0031116	positive regulation of microtubule polymerization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0031122	cytoplasmic microtubule organization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0031175	neuron projection development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000027691	P
	GO:0031253	cell projection membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	C
	GO:0031274	positive regulation of pseudopodium assembly	PMID:17192415^[28]	IMP: Inferred from Mutant Phenotype		P
	GO:0032587	ruffle membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0301	C
	GO:0032587	ruffle membrane	PMID:19151759^[36]	IDA: Inferred from Direct Assay		C
	GO:0032886	regulation of microtubule-based process	PMID:20937854^[40]	IMP: Inferred from Mutant Phenotype		P
	GO:0033077	T cell differentiation in thymus	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0033267	axon part	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	C
	GO:0034742	APC-Axin-1-beta-catenin complex	PMID:16188939^[25]	IDA: Inferred from Direct Assay		C
	GO:0034747	Axin-APC-beta-catenin-GSK3B complex	PMID:16188939^[25]	IDA: Inferred from Direct Assay		C
	GO:0034747	Axin-APC-beta-catenin-GSK3B complex	PMID:8638126^[37]	IDA: Inferred from Direct Assay		C
	GO:0035019	somatic stem cell maintenance	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0035371	microtubule plus end	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	C
	GO:0042483	negative regulation of odontogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0042493	response to drug	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000027691	P
	GO:0042981	regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0042995	cell projection	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0966	C
	GO:0042995	cell projection	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	C
	GO:0043005	neuron projection	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000027691	C
	GO:0043025	neuronal cell body	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000027691	C
	GO:0043065	positive regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0043065	positive regulation of apoptosis	PMID:17227893^[30]	IMP: Inferred from Mutant Phenotype		P
	GO:0043066	negative regulation of apoptosis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0043409	negative regulation of MAPKKK cascade	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0043588	skin development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0044295	axonal growth cone	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	C
	GO:0045202	synapse	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000027691	C
	GO:0045295	gamma-catenin binding	PMID:7890674^[34]	IPI: Inferred from Physical Interaction	UniProtKB:P14923	F
	GO:0045595	regulation of cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0045597	positive regulation of cell differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0045667	regulation of osteoblast differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0045670	regulation of osteoclast differentiation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0045732	positive regulation of protein catabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0045732	positive regulation of protein catabolic process	PMID:12952940^[38]	IGI: Inferred from Genetic Interaction	UniProtKB:O43255	P
	GO:0045732	positive regulation of protein catabolic process	PMID:12952940^[38]	IGI: Inferred from Genetic Interaction	UniProtKB:P41221	P
	GO:0045732	positive regulation of protein catabolic process	PMID:16188939^[25]	IC: Inferred by Curator	GO:0030877	P
	GO:0045736	negative regulation of cyclin-dependent protein kinase activity	PMID:8521819^[29]	IDA: Inferred from Direct Assay		P
	GO:0045785	positive regulation of cell adhesion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0046716	muscle cell homeostasis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0048538	thymus development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0051010	microtubule plus-end binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	F
	GO:0051010	microtubule plus-end binding	PMID:19632184^[15]	IDA: Inferred from Direct Assay		F
	GO:0051171	regulation of nitrogen compound metabolic process	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0051276	chromosome organization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0051726	regulation of cell cycle	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0051781	positive regulation of cell division	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0051988	regulation of attachment of spindle microtubules to kinetochore	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0051988	regulation of attachment of spindle microtubules to kinetochore	PMID:11283619^[2]	NAS: Non-traceable Author Statement		P
	GO:0051988	regulation of attachment of spindle microtubules to kinetochore	PMID:17227893^[30]	IMP: Inferred from Mutant Phenotype		P
	GO:0060041	retina development in camera-type eye	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0060070	canonical Wnt receptor signaling pathway	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0060070	canonical Wnt receptor signaling pathway	PMID:11035805^[17]	NAS: Non-traceable Author Statement		P
	GO:0060070	canonical Wnt receptor signaling pathway	PMID:9601641^[16]	IC: Inferred by Curator	GO:0030877	P
	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000078337	P
	GO:0070830	tight junction assembly	PMID:18502210^[14]	NAS: Non-traceable Author Statement		P
	GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	PMID:12952940^[38]	IGI: Inferred from Genetic Interaction	UniProtKB:O43255	P
	GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	PMID:12952940^[38]	IGI: Inferred from Genetic Interaction	UniProtKB:P41221	P
NOT	GO:0045296	cadherin binding	PMID:7890674^[34]	IDA: Inferred from Direct Assay		F
colocalizes_with	GO:0005886	plasma membrane	PMID:16611247^[9]	IDA: Inferred from Direct Assay		C
colocalizes_with	GO:0005913	cell-cell adherens junction	PMID:16611247^[9]	IDA: Inferred from Direct Assay		C
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Abal M et al. (2007) APC inactivation associates with abnormal mitosis completion and concomitant BUB1B/MAD2L1 up-regulation. Gastroenterology 132: 2448-58 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Kaplan KB et al. (2001) A role for the Adenomatous Polyposis Coli protein in chromosome segregation. Nat Cell Biol 3: 429-32 PubMed GONUTS page
↑ ^3.0 ^3.1 Ishidate T et al. (2000) The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase. Oncogene 19: 365-72 PubMed GONUTS page
↑ ^4.0 ^4.1 Kawasaki Y et al. (2000) Asef, a link between the tumor suppressor APC and G-protein signaling. Science 289: 1194-7 PubMed GONUTS page
↑ ^5.0 ^5.1 Liu J et al. (2001) Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein. Mol Cell 7: 927-36 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Nakamura M et al. (2002) Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle. FEBS Lett 514: 193-8 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Homma MK et al. (2002) Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein. Proc Natl Acad Sci U S A 99: 5959-64 PubMed GONUTS page
↑ ^8.0 ^8.1 Ha NC et al. (2004) Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation. Mol Cell 15: 511-21 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Takizawa S et al. (2006) Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli. Genes Cells 11: 453-64 PubMed GONUTS page
↑ ^10.0 ^10.1 Xu Y et al. (2007) Modeling of a human circadian mutation yields insights into clock regulation by PER2. Cell 128: 59-70 PubMed GONUTS page
↑ ^11.0 ^11.1 Kurzik-Dumke U & Czaja J (2007) Htid-1, the human homolog of the Drosophila melanogaster l(2)tid tumor suppressor, defines a novel physiological role of APC. Cell Signal 19: 1973-85 PubMed GONUTS page
↑ ^12.0 ^12.1 Kawasaki Y et al. (2007) Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42. Oncogene 26: 7620-267 PubMed GONUTS page
↑ ^13.0 ^13.1 Tran H et al. (2008) Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains. Genes Dev 22: 528-42 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 ^14.8 ^14.9 Breitman M et al. (2008) The armadillo repeat domain of the APC tumor suppressor protein interacts with Striatin family members. Biochim Biophys Acta 1783: 1792-802 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 Honnappa S et al. (2009) An EB1-binding motif acts as a microtubule tip localization signal. Cell 138: 366-76 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 Hart MJ et al. (1998) Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta. Curr Biol 8: 573-81 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 Neufeld KL et al. (2000) Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm. Proc Natl Acad Sci U S A 97: 12085-90 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 Anderson CB et al. (2002) Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon. Proc Natl Acad Sci U S A 99: 8683-8 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 Fagman H et al. (2003) Nuclear accumulation of full-length and truncated adenomatous polyposis coli protein in tumor cells depends on proliferation. Oncogene 22: 6013-22 PubMed GONUTS page
↑ Liu C et al. (2002) Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108: 837-47 PubMed GONUTS page
↑ Amit S et al. (2002) Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway. Genes Dev 16: 1066-76 PubMed GONUTS page
↑ Wu G et al. (2003) Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase. Mol Cell 11: 1445-56 PubMed GONUTS page
↑ Xing Y et al. (2004) Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function. Mol Cell 15: 523-33 PubMed GONUTS page
↑ Liu J et al. (2006) The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin. J Mol Biol 360: 133-44 PubMed GONUTS page
↑ ^25.00 ^25.01 ^25.02 ^25.03 ^25.04 ^25.05 ^25.06 ^25.07 ^25.08 ^25.09 ^25.10 ^25.11 Penman GA et al. (2005) The adenomatous polyposis coli protein (APC) exists in two distinct soluble complexes with different functions. J Cell Sci 118: 4741-50 PubMed GONUTS page
↑ ^26.0 ^26.1 Jaiswal AS et al. (2004) N-methyl-N'-nitro-N-nitrosoguanidine-induced senescence-like growth arrest in colon cancer cells is associated with loss of adenomatous polyposis coli protein, microtubule organization, and telomeric DNA. Mol Cancer 3: 3 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 ^27.3 Zumbrunn J et al. (2001) Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation. Curr Biol 11: 44-9 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 ^28.3 ^28.4 ^28.5 Kroboth K et al. (2007) Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability. Mol Biol Cell 18: 910-8 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 ^29.3 ^29.4 ^29.5 Baeg GH et al. (1995) The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase. EMBO J 14: 5618-25 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 ^30.3 ^30.4 ^30.5 Dikovskaya D et al. (2007) Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. J Cell Biol 176: 183-95 PubMed GONUTS page
↑ ^31.0 ^31.1 Rubinfeld B et al. (1993) Association of the APC gene product with beta-catenin. Science 262: 1731-4 PubMed GONUTS page
↑ ^32.0 ^32.1 Askham JM et al. (2000) Regulation and function of the interaction between the APC tumour suppressor protein and EB1. Oncogene 19: 1950-8 PubMed GONUTS page
↑ ^33.0 ^33.1 Ryo A et al. (2001) Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC. Nat Cell Biol 3: 793-801 PubMed GONUTS page
↑ ^34.0 ^34.1 ^34.2 ^34.3 ^34.4 ^34.5 Rubinfeld B et al. (1995) The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin. J Biol Chem 270: 5549-55 PubMed GONUTS page
↑ ^35.0 ^35.1 Tanaka S et al. (1998) A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. Proc Natl Acad Sci U S A 95: 10164-9 PubMed GONUTS page
↑ ^36.0 ^36.1 ^36.2 ^36.3 ^36.4 ^36.5 Sagara M et al. (2009) Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration. Oncogene 28: 1357-65 PubMed GONUTS page
↑ ^37.0 ^37.1 ^37.2 ^37.3 Rubinfeld B et al. (1996) Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. Science 272: 1023-6 PubMed GONUTS page
↑ ^38.0 ^38.1 ^38.2 ^38.3 ^38.4 ^38.5 ^38.6 ^38.7 Topol L et al. (2003) Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation. J Cell Biol 162: 899-908 PubMed GONUTS page
↑ Hülsken J et al. (1994) E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. J Cell Biol 127: 2061-9 PubMed GONUTS page
↑ ^40.0 ^40.1 ^40.2 Zaoui K et al. (2010) ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells. Proc Natl Acad Sci U S A 107: 18517-22 PubMed GONUTS page

[PMID:17570218-0] 1.0 ^1.1 Abal M et al. (2007) APC inactivation associates with abnormal mitosis completion and concomitant BUB1B/MAD2L1 up-regulation. Gastroenterology 132: 2448-58 PubMed GONUTS page

[PMID:11283619-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Kaplan KB et al. (2001) A role for the Adenomatous Polyposis Coli protein in chromosome segregation. Nat Cell Biol 3: 429-32 PubMed GONUTS page

[PMID:10656683-2] 3.0 ^3.1 Ishidate T et al. (2000) The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase. Oncogene 19: 365-72 PubMed GONUTS page

[PMID:10947987-3] 4.0 ^4.1 Kawasaki Y et al. (2000) Asef, a link between the tumor suppressor APC and G-protein signaling. Science 289: 1194-7 PubMed GONUTS page

[PMID:11389840-4] 5.0 ^5.1 Liu J et al. (2001) Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein. Mol Cell 7: 927-36 PubMed GONUTS page

[PMID:11943150-5] 6.0 ^6.1 ^6.2 ^6.3 Nakamura M et al. (2002) Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle. FEBS Lett 514: 193-8 PubMed GONUTS page

[PMID:11972058-6] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Homma MK et al. (2002) Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein. Proc Natl Acad Sci U S A 99: 5959-64 PubMed GONUTS page

[PMID:15327768-7] 8.0 ^8.1 Ha NC et al. (2004) Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation. Mol Cell 15: 511-21 PubMed GONUTS page

[PMID:16611247-8] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Takizawa S et al. (2006) Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli. Genes Cells 11: 453-64 PubMed GONUTS page

[PMID:17218255-9] 10.0 ^10.1 Xu Y et al. (2007) Modeling of a human circadian mutation yields insights into clock regulation by PER2. Cell 128: 59-70 PubMed GONUTS page

[PMID:17588722-10] 11.0 ^11.1 Kurzik-Dumke U & Czaja J (2007) Htid-1, the human homolog of the Drosophila melanogaster l(2)tid tumor suppressor, defines a novel physiological role of APC. Cell Signal 19: 1973-85 PubMed GONUTS page

[PMID:17599059-11] 12.0 ^12.1 Kawasaki Y et al. (2007) Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42. Oncogene 26: 7620-267 PubMed GONUTS page

[PMID:18281465-12] 13.0 ^13.1 Tran H et al. (2008) Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains. Genes Dev 22: 528-42 PubMed GONUTS page

[PMID:18502210-13] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 ^14.8 ^14.9 Breitman M et al. (2008) The armadillo repeat domain of the APC tumor suppressor protein interacts with Striatin family members. Biochim Biophys Acta 1783: 1792-802 PubMed GONUTS page

[PMID:19632184-14] 15.0 ^15.1 ^15.2 ^15.3 Honnappa S et al. (2009) An EB1-binding motif acts as a microtubule tip localization signal. Cell 138: 366-76 PubMed GONUTS page

[PMID:9601641-15] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 Hart MJ et al. (1998) Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta. Curr Biol 8: 573-81 PubMed GONUTS page

[PMID:11035805-16] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 Neufeld KL et al. (2000) Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm. Proc Natl Acad Sci U S A 97: 12085-90 PubMed GONUTS page

[PMID:12072559-17] 18.0 ^18.1 ^18.2 ^18.3 Anderson CB et al. (2002) Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon. Proc Natl Acad Sci U S A 99: 8683-8 PubMed GONUTS page

[PMID:12955080-18] 19.0 ^19.1 ^19.2 ^19.3 Fagman H et al. (2003) Nuclear accumulation of full-length and truncated adenomatous polyposis coli protein in tumor cells depends on proliferation. Oncogene 22: 6013-22 PubMed GONUTS page

[PMID:11955436-19] Liu C et al. (2002) Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108: 837-47 PubMed GONUTS page

[PMID:12000790-20] Amit S et al. (2002) Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway. Genes Dev 16: 1066-76 PubMed GONUTS page

[PMID:12820959-21] Wu G et al. (2003) Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase. Mol Cell 11: 1445-56 PubMed GONUTS page

[PMID:15327769-22] Xing Y et al. (2004) Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function. Mol Cell 15: 523-33 PubMed GONUTS page

[PMID:16753179-23] Liu J et al. (2006) The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin. J Mol Biol 360: 133-44 PubMed GONUTS page

[PMID:16188939-24] 25.00 ^25.01 ^25.02 ^25.03 ^25.04 ^25.05 ^25.06 ^25.07 ^25.08 ^25.09 ^25.10 ^25.11 Penman GA et al. (2005) The adenomatous polyposis coli protein (APC) exists in two distinct soluble complexes with different functions. J Cell Sci 118: 4741-50 PubMed GONUTS page

[PMID:14728717-25] 26.0 ^26.1 Jaiswal AS et al. (2004) N-methyl-N'-nitro-N-nitrosoguanidine-induced senescence-like growth arrest in colon cancer cells is associated with loss of adenomatous polyposis coli protein, microtubule organization, and telomeric DNA. Mol Cancer 3: 3 PubMed GONUTS page

[PMID:11166179-26] 27.0 ^27.1 ^27.2 ^27.3 Zumbrunn J et al. (2001) Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation. Curr Biol 11: 44-9 PubMed GONUTS page

[PMID:17192415-27] 28.0 ^28.1 ^28.2 ^28.3 ^28.4 ^28.5 Kroboth K et al. (2007) Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability. Mol Biol Cell 18: 910-8 PubMed GONUTS page

[PMID:8521819-28] 29.0 ^29.1 ^29.2 ^29.3 ^29.4 ^29.5 Baeg GH et al. (1995) The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase. EMBO J 14: 5618-25 PubMed GONUTS page

[PMID:17227893-29] 30.0 ^30.1 ^30.2 ^30.3 ^30.4 ^30.5 Dikovskaya D et al. (2007) Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. J Cell Biol 176: 183-95 PubMed GONUTS page

[PMID:8259518-30] 31.0 ^31.1 Rubinfeld B et al. (1993) Association of the APC gene product with beta-catenin. Science 262: 1731-4 PubMed GONUTS page

[PMID:10773885-31] 32.0 ^32.1 Askham JM et al. (2000) Regulation and function of the interaction between the APC tumour suppressor protein and EB1. Oncogene 19: 1950-8 PubMed GONUTS page

[PMID:11533658-32] 33.0 ^33.1 Ryo A et al. (2001) Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC. Nat Cell Biol 3: 793-801 PubMed GONUTS page

[PMID:7890674-33] 34.0 ^34.1 ^34.2 ^34.3 ^34.4 ^34.5 Rubinfeld B et al. (1995) The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin. J Biol Chem 270: 5549-55 PubMed GONUTS page

[PMID:9707618-34] 35.0 ^35.1 Tanaka S et al. (1998) A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. Proc Natl Acad Sci U S A 95: 10164-9 PubMed GONUTS page

[PMID:19151759-35] 36.0 ^36.1 ^36.2 ^36.3 ^36.4 ^36.5 Sagara M et al. (2009) Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration. Oncogene 28: 1357-65 PubMed GONUTS page

[PMID:8638126-36] 37.0 ^37.1 ^37.2 ^37.3 Rubinfeld B et al. (1996) Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. Science 272: 1023-6 PubMed GONUTS page

[PMID:12952940-37] 38.0 ^38.1 ^38.2 ^38.3 ^38.4 ^38.5 ^38.6 ^38.7 Topol L et al. (2003) Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation. J Cell Biol 162: 899-908 PubMed GONUTS page

[PMID:7806582-38] Hülsken J et al. (1994) E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. J Cell Biol 127: 2061-9 PubMed GONUTS page

[PMID:20937854-39] 40.0 ^40.1 ^40.2 Zaoui K et al. (2010) ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells. Proc Natl Acad Sci U S A 107: 18517-22 PubMed GONUTS page

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