HUMAN:ANXA2

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Species (Taxon ID)	Homo sapiens (Human). (taxon:9606)
Gene Name(s)	ANXA2 ( synonyms: ANX2, ANX2L4, CAL1H, LPC2D )
Protein Name(s)	Annexin A2 Annexin II Annexin-2 Calpactin I heavy chain Calpactin-1 heavy chain Chromobindin-8 Lipocortin II Placental anticoagulant protein IV PAP-IV Protein I p36
External Links
UniProt Identifier	ANXA2_HUMAN
UniProt Accessions	P07355, Q567R4, Q6N0B3, Q8TBV2, Q96DD5, Q9UDH8,
EMBL	D00017, BT007432, BX640598, AC087385, BC001388, BC009564, BC015834, BC016774, BC021114, BC023990, BC052558, BC052567, BC066955, BC068065, BC093056,
PIR	A23942,
RefSeq	NP_001002857.1, NP_001002858.1, NP_001129487.1, NP_004030.1,
PDB	1W7B, 1XJL, 2HYU, 2HYV, 2HYW,
IntAct	P07355,
Ensembl	ENST00000332680, ENST00000396024, ENST00000421017, ENST00000451270,
Pfam	PF00191,

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005604	basement membrane		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-SubCell
	GO:0042470	melanosome		IEA: Inferred from Electronic Annotation		C	Source: UniProtKB-SubCell
	GO:0005625	soluble fraction		TAS: Traceable Author Statement		C	Source: ProtInc
	GO:0005509	calcium ion binding		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0005544	calcium-dependent phospholipid binding		IDA: Inferred from Direct Assay		F	Source: UniProtKB
	GO:0008092	cytoskeletal protein binding		IEA: Inferred from Electronic Annotation		F	Source: InterPro
	GO:0004859	phospholipase inhibitor activity		TAS: Traceable Author Statement		F	Source: ProtInc
	GO:0031340	positive regulation of vesicle fusion		IDA: Inferred from Direct Assay		P	Source: UniProtKB
	GO:0001501	skeletal system development		TAS: Traceable Author Statement		P	Source: ProtInc
	GO:0016310	phosphorylation	PMID:18990701^[1]	IMP: Inferred from Mutant Phenotype		P	Fig.1A,C	complete
	GO:0005829	cytosol	PMID:18990701^[1]	IMP: Inferred from Mutant Phenotype		C	Fig.2A,C	complete
	GO:0005769	early endosome	PMID:18990701^[1]	IMP: Inferred from Mutant Phenotype		C	Fig.2A,B,4	complete
	GO:0016020	membrane	PMID:18990701^[1]	IMP: Inferred from Mutant Phenotype		C	Fig.2C	complete
	GO:0008289	lipid binding	PMID:18990701^[1]	IMP: Inferred from Mutant Phenotype		F	Fig.5A-D	complete
	GO:0003779	actin binding	PMID:18990701^[1]	IMP: Inferred from Mutant Phenotype		F	Figure S2	complete
	GO:0045022	early endosome to late endosome transport	PMID:18990701^[1]	IMP: Inferred from Mutant Phenotype		P	Fig.6	complete
	GO:0001501	skeletal system development	PMID:7961821^[2]	TAS: Traceable Author Statement		P
	GO:0001525	angiogenesis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034756	P
	GO:0001525	angiogenesis	PMID:11866539^[3]	IEP: Inferred from Expression Pattern		P
	GO:0004859	phospholipase inhibitor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002389	F
	GO:0004859	phospholipase inhibitor activity	PMID:3013422^[4]	TAS: Traceable Author Statement		F
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001464	F
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002389	F
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018252	F
	GO:0005509	calcium ion binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018502	F
	GO:0005515	protein binding	PMID:17353931^[5]	IPI: Inferred from Physical Interaction	UniProtKB:O75688	F
	GO:0005515	protein binding	PMID:19724273^[6]	IPI: Inferred from Physical Interaction	UniProtKB:P06703	F
	GO:0005515	protein binding	PMID:20706999^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P40692	F
	GO:0005544	calcium-dependent phospholipid binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR001464	F
	GO:0005544	calcium-dependent phospholipid binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002389	F
	GO:0005544	calcium-dependent phospholipid binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018252	F
	GO:0005544	calcium-dependent phospholipid binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR018502	F
	GO:0005544	calcium-dependent phospholipid binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0111	F
	GO:0005544	calcium-dependent phospholipid binding	PMID:2138016^[8]	IDA: Inferred from Direct Assay		F
	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000038428	F
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C
	GO:0005578	proteinaceous extracellular matrix	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0272	C
	GO:0005604	basement membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0084	C
	GO:0005604	basement membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0025	C
	GO:0005625	soluble fraction	PMID:7961821^[2]	TAS: Traceable Author Statement		C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034756	C
	GO:0005737	cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000038428	C
	GO:0005769	early endosome	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034756	C
	GO:0005886	plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000038428	C
	GO:0005886	plasma membrane	PMID:10809787^[9]	TAS: Traceable Author Statement		C
	GO:0007589	body fluid secretion	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000038428	P
	GO:0008092	cytoskeletal protein binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002389	F
	GO:0017137	Rab GTPase binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000038428	F
	GO:0019897	extrinsic to plasma membrane	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034756	C
	GO:0030199	collagen fibril organization	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034756	P
	GO:0030496	midbody	PMID:15166316^[10]	IDA: Inferred from Direct Assay		C
	GO:0031340	positive regulation of vesicle fusion	PMID:2138016^[8]	IDA: Inferred from Direct Assay		P
	GO:0042383	sarcolemma	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034756	C
	GO:0042470	melanosome	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0161	C
	GO:0042730	fibrinolysis	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034756	P
	GO:0043234	protein complex	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000038428	C
	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSRNOP00000038428	C
	GO:0051099	positive regulation of binding	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034756	P
	GO:0071229	cellular response to acid	GO_REF:0000019	IEA: Inferred from Electronic Annotation	Ensembl:ENSMUSP00000034756	P
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Morel E & Gruenberg J (2009) Annexin A2 binding to endosomes and functions in endosomal transport are regulated by tyrosine 23 phosphorylation. J Biol Chem 284: 1604-11 PubMed GONUTS page
↑ ^2.0 ^2.1 Takahashi S et al. (1994) Cloning and identification of annexin II as an autocrine/paracrine factor that increases osteoclast formation and bone resorption. J Biol Chem 269: 28696-701 PubMed GONUTS page
↑ Aitkenhead M et al. (2002) Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM. Microvasc Res 63: 159-71 PubMed GONUTS page
↑ Huang KS et al. (1986) Two human 35 kd inhibitors of phospholipase A2 are related to substrates of pp60v-src and of the epidermal growth factor receptor/kinase. Cell 46: 191-9 PubMed GONUTS page
↑ Ewing RM et al. (2007) Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol 3: 89 PubMed GONUTS page
↑ Nedjadi T et al. (2009) S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility. Br J Cancer 101: 1145-54 PubMed GONUTS page
↑ Brieger A et al. (2010) Cytoskeletal scaffolding proteins interact with Lynch-Syndrome associated mismatch repair protein MLH1. Proteomics 10: 3343-55 PubMed GONUTS page
↑ ^8.0 ^8.1 Blackwood RA & Ernst JD (1990) Characterization of Ca2(+)-dependent phospholipid binding, vesicle aggregation and membrane fusion by annexins. Biochem J 266: 195-200 PubMed GONUTS page
↑ Ma K et al. (2000) High affinity binding of beta 2-glycoprotein I to human endothelial cells is mediated by annexin II. J Biol Chem 275: 15541-8 PubMed GONUTS page
↑ Skop AR et al. (2004) Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Science 305: 61-6 PubMed GONUTS page

[PMID:18990701-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Morel E & Gruenberg J (2009) Annexin A2 binding to endosomes and functions in endosomal transport are regulated by tyrosine 23 phosphorylation. J Biol Chem 284: 1604-11 PubMed GONUTS page

[PMID:7961821-1] 2.0 ^2.1 Takahashi S et al. (1994) Cloning and identification of annexin II as an autocrine/paracrine factor that increases osteoclast formation and bone resorption. J Biol Chem 269: 28696-701 PubMed GONUTS page

[PMID:11866539-2] Aitkenhead M et al. (2002) Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM. Microvasc Res 63: 159-71 PubMed GONUTS page

[PMID:3013422-3] Huang KS et al. (1986) Two human 35 kd inhibitors of phospholipase A2 are related to substrates of pp60v-src and of the epidermal growth factor receptor/kinase. Cell 46: 191-9 PubMed GONUTS page

[PMID:17353931-4] Ewing RM et al. (2007) Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol 3: 89 PubMed GONUTS page

[PMID:19724273-5] Nedjadi T et al. (2009) S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility. Br J Cancer 101: 1145-54 PubMed GONUTS page

[PMID:20706999-6] Brieger A et al. (2010) Cytoskeletal scaffolding proteins interact with Lynch-Syndrome associated mismatch repair protein MLH1. Proteomics 10: 3343-55 PubMed GONUTS page

[PMID:2138016-7] 8.0 ^8.1 Blackwood RA & Ernst JD (1990) Characterization of Ca2(+)-dependent phospholipid binding, vesicle aggregation and membrane fusion by annexins. Biochem J 266: 195-200 PubMed GONUTS page

[PMID:10809787-8] Ma K et al. (2000) High affinity binding of beta 2-glycoprotein I to human endothelial cells is mediated by annexin II. J Biol Chem 275: 15541-8 PubMed GONUTS page

[PMID:15166316-9] Skop AR et al. (2004) Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Science 305: 61-6 PubMed GONUTS page

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HUMAN:ANXA2

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