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HUMAN:ANM6
Contents |
| Species (Taxon ID) | Homo sapiens (Human). ([1]) | |
| Gene Name(s) | PRMT6 (synonyms: HRMT1L6) | |
| Protein Name(s) | Protein arginine N-methyltransferase 6
Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6 Histone-arginine N-methyltransferase PRMT6 | |
| External Links | ||
| EMBL | AY043278 AK001421 AK295541 AL355539 CH471156 BC002729 BC063446 BC073866 BX475300 | |
| IPI | IPI00102128 IPI00909110 | |
| RefSeq | NP_060607.2 | |
| UniGene | Hs.26006 | |
| ProteinModelPortal | Q96LA8 | |
| SMR | Q96LA8 | |
| IntAct | Q96LA8 | |
| STRING | Q96LA8 | |
| PhosphoSite | Q96LA8 | |
| PRIDE | Q96LA8 | |
| Ensembl | ENST00000370078 | |
| GeneID | 55170 | |
| KEGG | hsa:55170 | |
| CTD | 55170 | |
| GeneCards | GC01P105545 | |
| H-InvDB | HIX0000828 | |
| HGNC | HGNC:18241 | |
| MIM | 608274 | |
| neXtProt | NX_Q96LA8 | |
| PharmGKB | PA134992775 | |
| GeneTree | ENSGT00550000074406 | |
| HOGENOM | HBG715060 | |
| HOVERGEN | HBG095907 | |
| InParanoid | Q96LA8 | |
| OMA | GRFRFSC | |
| OrthoDB | EOG4R23V8 | |
| PhylomeDB | Q96LA8 | |
| NextBio | 58949 | |
| ArrayExpress | Q96LA8 | |
| Bgee | Q96LA8 | |
| CleanEx | HS_PRMT6 | |
| Genevestigator | Q96LA8 | |
| GermOnline | ENSG00000198890 | |
| GO | GO:0005634 GO:0042393 GO:0070612 GO:0070611 GO:0044020 GO:0035242 GO:0035241 GO:0006284 GO:0044419 GO:0045892 GO:0006351 | |
| KO | K11437 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
C |
Seeded From UniProt |
||||
| GO:0005634 |
nucleus |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-0191 |
C |
Seeded From UniProt |
|||
| GO:0005634 |
nucleus |
IDA: Inferred from Direct Assay |
|
C |
Seeded From UniProt |
|||
| GO:0006281 |
DNA repair |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006284 |
base-excision repair |
TAS: Traceable Author Statement |
|
P |
Seeded From UniProt |
|||
| GO:0006351 |
transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0006974 |
response to DNA damage stimulus |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0008168 |
methyltransferase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0008469 |
histone-arginine N-methyltransferase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0016568 |
chromatin modification |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0016571 |
histone methylation |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0016740 |
transferase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded From UniProt |
||||
| GO:0019919 |
peptidyl-arginine methylation, to asymmetrical-dimethyl arginine |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0019919 |
peptidyl-arginine methylation, to asymmetrical-dimethyl arginine |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0032259 |
methylation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0034969 |
histone arginine methylation |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0034970 |
histone H3-R2 methylation |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0034970 |
histone H3-R2 methylation |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0035241 |
protein-arginine omega-N monomethyltransferase activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0035241 |
protein-arginine omega-N monomethyltransferase activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0035241 |
protein-arginine omega-N monomethyltransferase activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0035242 |
protein-arginine omega-N asymmetric methyltransferase activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0035242 |
protein-arginine omega-N asymmetric methyltransferase activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0035242 |
protein-arginine omega-N asymmetric methyltransferase activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0035242 |
protein-arginine omega-N asymmetric methyltransferase activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0042054 |
histone methyltransferase activity |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0042393 |
histone binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0042393 |
histone binding |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0043985 |
histone H4-R3 methylation |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0044020 |
histone methyltransferase activity (H4-R3 specific) |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0044419 |
interspecies interaction between organisms |
IEA: Inferred from Electronic Annotation |
P |
Seeded From UniProt |
||||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
IDA: Inferred from Direct Assay |
|
P |
Seeded From UniProt |
|||
| GO:0070611 |
histone methyltransferase activity (H3-R2 specific) |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0070611 |
histone methyltransferase activity (H3-R2 specific) |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0070612 |
histone methyltransferase activity (H2A-R3 specific) |
IDA: Inferred from Direct Assay |
|
F |
Seeded From UniProt |
|||
| GO:0016274 |
protein-arginine N-methyltransferase activity |
IDA: Inferred from Direct Assay |
F |
Figure 3 |
complete | |||
| GO:0016274 |
protein-arginine N-methyltransferase activity |
IDA: Inferred from Direct Assay |
F |
Figure 4 |
complete | |||
| GO:0016274 |
protein-arginine N-methyltransferase activity |
IDA: Inferred from Direct Assay |
F |
Figure 2 |
complete | |||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Miranda TB et al. (2005) Protein arginine methyltransferase 6 specifically methylates the nonhistone chromatin protein HMGA1a. Biochem Biophys Res Commun 336: 831-5 PubMed GONUTS page
- ↑ 2.0 2.1 Sgarra R et al. (2006) The AT-hook of the chromatin architectural transcription factor high mobility group A1a is arginine-methylated by protein arginine methyltransferase 6. J Biol Chem 281: 3764-72 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 El-Andaloussi N et al. (2006) Arginine methylation regulates DNA polymerase beta. Mol Cell 22: 51-62 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Frankel A et al. (2002) The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity. J Biol Chem 277: 3537-43 PubMed GONUTS page
- ↑ 5.0 5.1 Lakowski TM & Frankel A (2009) Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4. Biochem J 421: 253-61 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 Guccione E et al. (2007) Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive. Nature 449: 933-7 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 7.7 7.8 Hyllus D et al. (2007) PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation. Genes Dev 21: 3369-80 PubMed GONUTS page
- ↑ Boulanger MC et al. (2005) Methylation of Tat by PRMT6 regulates human immunodeficiency virus type 1 gene expression. J Virol 79: 124-31 PubMed GONUTS page
- ↑ Invernizzi CF et al. (2006) PRMT6 diminishes HIV-1 Rev binding to and export of viral RNA. Retrovirology 3: 93 PubMed GONUTS page
- ↑ Xie B et al. (2007) Arginine methylation of the human immunodeficiency virus type 1 Tat protein by PRMT6 negatively affects Tat Interactions with both cyclin T1 and the Tat transactivation region. J Virol 81: 4226-34 PubMed GONUTS page
